Ecotoxicol Environ Saf 2021 Oct 11;227:112892. Epub 2021 Oct 11.
Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China; Anhui Medical University, 81 Meishan Road, Hefei 230032, China; College of Life Science, Henan Normal University, 46 Jianshe Road, Xinxiang 473007, China; School of Pharmacy, Jiamusi University, Jiamusi, Heilongjiang 154007, China. Electronic address:
Exposure to ultraviolet B (UVB) has been demonstrated to induce DNA damage as well as angiogenesis-related photo-damages, which are implicated in a variety of medical problems, including sunburn, photo-aging and skin cancers. However, the molecular mechanism related to UVB-induced photo-injuries remained fully elucidated. Here we revealed that one of the catalytic subunits of the IKK complex, IKKα, played a critical role in mediating UVB-induced apoptotic responses in two kinds of UVB sensitive cells, human keratinocyte (HaCat) and mouse embryonic fibroblasts (MEFs). Read More