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Toxic response of the freshwater green algae Chlorella pyrenoidosa to combined effect of flotation reagent butyl xanthate and nickel.

Environ Pollut 2021 May 3;286:117285. Epub 2021 May 3.

School of Water Resources and Environment, Research Center of Environmental Science and Engineering, China University of Geosciences (Beijing), 29 Xueyuan Road, Haidian District, 100083, Beijing, China.

Butyl Xanthate (BX) is a typical flotation reagent used to extract non-ferrous nickel ores, discharged into the surrounding environment of mining areas in large quantities. However, few studies have focused on the toxicity of combined pollution of BX and nickel (Ni) on aquatic plants, especially phytoplankton, the main producer of aquatic ecosystems. The toxicity and potential mechanism of single and combined pollution of BX and Ni at different concentrations (0-20 mg L) on typical freshwater algae (Chlorella pyrenoidosa) were studied. Read More

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Astaxanthin and its gold nanoparticles mitigate cadmium toxicity in rice by inhibiting cadmium translocation and uptake.

Sci Total Environ 2021 May 3;786:147496. Epub 2021 May 3.

National Key Laboratory of Rice Biology, Institute of Crop Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Cadmium (Cd) is one of the main heavy metal in rice, Cd uptake by cereal crops from soil leads to toxicity in plants and pose serious health risks due to human body's accumulation through the food chain. Astaxanthin, a natural and anti-oxidative oxycarotenoid, is widely distributed in various microorganisms and seafood. In this study, we demonstrated that astaxanthin in the form of gold nanoparticles (Ast-AuNPs) can efficiently alleviate Cd toxicity to a greater extent in hydroponically grown rice plants than single astaxanthin. Read More

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Antioxidant, histopathological and biochemical outcomes of short-term exposure to acetamiprid in liver and brain of rat: The protective role of N-acetylcysteine and S-methylcysteine.

Saudi Pharm J 2021 Mar 21;29(3):280-289. Epub 2021 Feb 21.

Department of Molecular and Cell Biology, Faculty of Basic Science. University of Mazandaran, Babolsar, Iran.

The present study was conducted to investigate the protective effects of N-Acetyl-L-cysteine (NAC) and S-methyl- L-cysteine (SMC) against hepatic oxidative stress and brain damage induced by acetamiprid (ACP) in rats, which were evaluated by histopathological changes, measuring serum biomarkers and antioxidant defense systems. In this study, 42 rats were randomly divided into 6 groups and administered by intraperitoneally for one week: the control group, the sham group (normal saline), ACP alone (5 mg/kg) (group1), NAC alone (160 mg/kg) (group2), ACP + SMC (100 mg/kg) (group3), ACP + NAC (group 4) and ACP + NAC + SMC (group 5). Our results showed that acetamiprid induces liver injures including infiltration of inflammatory cells, congestion and altered histo-architecture and brain damages including gliosis, hyperemia and necrosis. Read More

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Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats.

Metab Brain Dis 2021 May 12. Epub 2021 May 12.

Department of Biochemistry, Landmark University, PMB, Omu-aran, 1001, Nigeria.

The present study compared the effect of donepezil only and combination of donepezil and gallic acid on oxidative status and cholinesterase activity in the brain of Wistar rats administered AlCl for 60 days. Twenty-eight rats (180 - 200 g) were arbitrarily distributed into four groups of seven animals apiece. Group 1 served as normal control and received distilled water throughout the study. Read More

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Comparative evaluation of cardioprotective activity of and juice against isoprenaline-induced cardiotoxicity in rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

Objectives: Comparative evaluation of cardioprotective activity of and juice against isoprenaline induced cardiotoxicity in rats.

Methods: Rats (125-150 g) were orally administered (GA) and (FA) apple juice (3 mL/day, per oral) for 13 days. Myocardial injury was inducted on 14th and 15th day by the administration of Isoprenaline (85 mg/kg/day, subcutaneous). Read More

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Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers.

Sci Total Environ 2021 May 3;786:147479. Epub 2021 May 3.

Instituto Español de Oceanografía, Centro Oceanográfico de Baleares, Muelle de Poniente s/n, E-07015 Palma de Mallorca, Balearic Islands, Spain. Electronic address:

The constant increase in plastic pollution has attracted great attention in recent years due to its potential detrimental effects on organisms and ecosystems. While the consequences of ingestion of large plastic litter are mostly understood, the impacts resulting from a long-term exposure and a recovery period of microplastics (MPs) are still limited. The aims were to monitor oxidative stress, detoxification and inflammatory biomarkers in liver, plasma and erythrocytes of Sparus aurata exposed during 90 days to low-density polyethylene (LDPE)-MPs enriched diet (10% by weight) followed by 30 days of depuration. Read More

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Effects of Bacillus Coagulans on growth performance, antioxidant capacity, immunity function, and gut health in broilers.

Poult Sci 2021 Mar 27;100(6):101168. Epub 2021 Mar 27.

Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health and Internet Technology, College of Animal Science and Technology, Zhejiang Agriculture & Forestry University, Hangzhou 311300, China. Electronic address:

This study evaluated the effects of Bacillus coagulans (B. coagulans) as an alternative to antibiotics on growth performance, antioxidant capacity, immunity function and gut health in broilers. A total of 480 one-day-old broilers were randomly divided into 3 treatments with 8 replicates comprising 20 broilers each. Read More

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Comparative evaluation of single or combined anticoccidials on performance, antioxidant status, immune response, and intestinal architecture of broiler chickens challenged with mixed Eimeria species.

Poult Sci 2021 Mar 26;100(6):101162. Epub 2021 Mar 26.

Biological Applications Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Abu-Zaabal 13759, Egypt. Electronic address:

Poultry production faces several threats and challenges, one of the most important of which is avian coccidiosis which causes annual losses exceeding US$ 3 billion. Discovering new drugs or combinations of existing anticoccidials has become inevitable to overcome the emergence of coccidiosis resistance. This study evaluated a new combination of maduramicin and diclazuril in comparison to the well-known product Maxiban72 which consisted of narasin and nicarbazin, and the single effect of monensin as treatments for avian coccidiosis. Read More

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Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in rats.

Adv Clin Exp Med 2021 May 11. Epub 2021 May 11.

Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.

Background: Periodontitis, a chronic inflammatory disease affecting the supporting tissues around the teeth, causes significant inflammatory and oxidative changes in cardiac tissue. Crocin is the active constituent of Crocus sativus (saffron) which has antioxidant properties and is protective against cardiovascular disturbances.

Objectives: The present study aimed to investigate the protective effects of crocin on periodontitis-induced oxidative/inflammatory cardiac degeneration in rats in vivo. Read More

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Consolidation of network and experimental pharmacology to divulge the antidiabetic action of L. bark.

3 Biotech 2021 May 25;11(5):238. Epub 2021 Apr 25.

Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010 India.

A total of 21 different bioactives were identified from in which 3 molecules, i.e., apigenin, 3',4',5,7-tetrahydroxy-3-methoxyflavone, and kaempferol were predicted to target the highest number of proteins involved in diabetic pathogenesis in which protein tyrosine phosphatase 1b was primarily targeted. Read More

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Impact of nanochitosan and spp. on health, productivity and defence response in under field condition.

3 Biotech 2021 May 25;11(5):237. Epub 2021 Apr 25.

Department of Microbiology, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand India.

The role of plant growth-promoting rhizobacteria along with nanochitosan on maize productivity remains unexplored. In the present study we report the effect of nanochitosan and PGPR on growth, productivity and mechanism(s) involved in defence response in under field conditions. Application of nanochitosan (50 mg L) along with plant growth-promoting rhizobacteria enhanced seed germination, plant height, root length, leaf area, fresh and dry weight of shoot and root, chlorophyll, carotenoids, total sugar and protein content upto 1. Read More

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Effects of multicycle gonadotropin-releasing hormone antagonist protocols on oxidative stress of follicular fluid and ovarian granulosa cells.

Hum Cell 2021 May 8. Epub 2021 May 8.

Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

The effect of repeated multicycle gonadotropin-releasing hormone antagonist (GnRH-ant) protocols on oxidative stress (OS) in follicular fluid (FF) and ovarian granulosa cells (GCs) remains unclear. This study investigated the effects of repeated multicycle GnRH-ant protocols on OS markers of FF and ovarian GCs. A total of 145 patients were enrolled and divided into four groups: 1 cycle group (n = 42), 2 cycles group (n = 37), 3 cycles group (n = 45), and 4-5 cycles group (n = 21). Read More

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Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals.

Int Arch Occup Environ Health 2021 May 6. Epub 2021 May 6.

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, Qassim, Saudi Arabia.

Objectives: The present study aimed to evaluate the effects of waste anaesthetic gases on cytokines and oxidative stress of hospital health team members following exposure to waste anaesthetic gases (WAGs).

Subjects And Methods: In total, 180 participants took part in this study; 60 of these were healthy male controls and the 120 participants in the intervention group were staff who work in the operating room. This latter group comprises six occupational subgroups (1) surgeons, (2) surgical assistants, (3) anaesthesiologists (4) anaesthesiology assistants, (5) nurses and (6) janitors. Read More

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Antioxidant capacity of honey from the urban apiary: a comparison with honey from the rural apiary.

Sci Rep 2021 May 6;11(1):9695. Epub 2021 May 6.

Research Team of Animal Physiology and Ecotoxicology, Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia, Bankowa 9, 40-007, Katowice, Poland.

Honey is a source of natural antioxidant compounds exerting several health-beneficial effects. Since urban beekeeping is quite common, the fear among potential consumers about the quality and the safety of honey produced exclusively in the cities is observed. However, the antioxidant properties of urban honey have not yet been tested. Read More

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Mesorhizobium ciceri as biological tool for improving physiological, biochemical and antioxidant state of Cicer aritienum (L.) under fungicide stress.

Sci Rep 2021 May 6;11(1):9655. Epub 2021 May 6.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Fungicides among agrochemicals are consistently used in high throughput agricultural practices to protect plants from damaging impact of phytopathogens and hence to optimize crop production. However, the negative impact of fungicides on composition and functions of soil microbiota, plants and via food chain, on human health is a matter of grave concern. Considering such agrochemical threats, the present study was undertaken to know that how fungicide-tolerant symbiotic bacterium, Mesorhizobium ciceri affects the Cicer arietinum crop while growing in kitazin (KITZ) stressed soils under greenhouse conditions. Read More

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Integrating transcriptome and metabolome analyses of the response to cold stress in pumpkin (Cucurbita maxima).

PLoS One 2021 6;16(5):e0249108. Epub 2021 May 6.

Qingdao Institute of Agricultural Science Research, Qingdao, Shandong, China.

Cucurbita maxima belong to the genus Cucurbita and are of nutritional and economic importance. Physiological activity, transcriptome, and metabolome analyses of leaf samples from the C. maxima inbreding line IL7 treated at 5 °C and 25 °C were performed. Read More

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Prevalence, Antimicrobial Susceptibility Patterns, and Risk Factors Associated with Enterococci among Pediatric Patients at Dessie Referral Hospital, Northeastern Ethiopia.

Biomed Res Int 2021 16;2021:5549847. Epub 2021 Apr 16.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: species, which is previously considered as medically not important, now becomes one of the leading causes of nosocomial infections. Even though it becomes the most public health concern and emerging multidrug-resistant pathogen, there is no enough data in the study area.

Objective: To determine the prevalence, antimicrobial resistance pattern, and associated risk factors of enterococci infection in pediatric patients. Read More

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The Effects of Low-Dose-Rate γ-irradiation on Forced Swim Test-Induced Immobility and Oxidative Stress in Mice.

Acta Med Okayama 2021 Apr;75(2):169-175

Graduate School of Health Sciences, Okayama University.

The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Read More

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Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

Poult Sci 2021 Mar 26;100(6):101172. Epub 2021 Mar 26.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

The present study was designed to assess the impact of dietary supplementation of lemongrass essential oil (LGEO) on growth performance, carcass traits, liver and kidney function, immunity, antioxidant indices and caecal microbiota of growing quail. A total of 200 Japanese quails at 1-week-old were haphazardly allotted to 5 groups of 40 chicks in five replicates (8 per replicate). The first group was the control group, while LGEO was added at levels of 150, 300, 450, and 600 mg/kg diet in the 2nd, 3rd, 4th and 5th groups, respectively. Read More

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UV-B exposure and exogenous hydrogen peroxide application lead to cross-tolerance toward drought in Nicotiana tabacum L.

Physiol Plant 2021 May 4. Epub 2021 May 4.

Biosystems Engineering, School of Engineering, Autonomous University of Queretaro-Campus Amazcala, Querétaro, Mexico.

Acclimation of plants to water deficit involves biochemical and physiological adjustments. Here, we studied how UV-B exposure and exogenously applied hydrogen peroxide (H O ) potentiates drought tolerance in tobacco (Nicotiana tabacum L. cv. Read More

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Effect of lycopene on AsO induced oxidative stress in SH-SY5Y cells.

Mol Biol Rep 2021 May 4. Epub 2021 May 4.

Department of Biochemistry, Faculty of Medicine, İstanbul Medeniyet University, İstanbul, Turkey.

It is known that oxidative stress may cause neuronal injury and several experimental models showed that AsO exposure causes oxidative stress. Lycopene, a carotenoid, has been shown to have protective effect in neurological disease models due to antioxidant activity, but its effect on AsO-induced neurotoxicity is not identified yet. The aim of this study is to investigate the effects of lycopene on AsO-induced neuronal damage and the related mechanisms. Read More

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Preventive effect of Bacillus mojavensis levan against carbon tetrachloride and cisplatin toxicity: in vivo study.

Environ Sci Pollut Res Int 2021 May 5. Epub 2021 May 5.

Laboratory of Plants Improvement and Valorization of Agroressources, National School of Engineering of Sfax (ENIS), University of Sfax, 3038, Sfax, Tunisia.

This study is the first to investigate the hepato- and nephron-preventive effect of levan from Bacillus mojavensis (BM-levan) against toxicity induced by carbon tetrachloride (CCl) and cisplatin. Thirty-six male albino rats weighing between 230 and 250 g were used for this experiment. The groups received multiples doses of BM-levan and were compared to the untreated group. Read More

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Potential Use of Amla ( L.) Fruit Extract to Protect Skin Keratinocytes from Inflammation and Apoptosis after UVB Irradiation.

Antioxidants (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

Ultraviolet B (UVB) exposure is the primary risk factor for the deadliest type of skin cancer-melanoma. Incorporating natural antioxidants in skin protection products is currently a favored research theme. For this study, we selected L. Read More

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Antioxidants and Bioactive Compounds in Licorice Root Extract Potentially Contribute to Improving Growth, Bulb Quality and Yield of Onion ().

Molecules 2021 Apr 30;26(9). Epub 2021 Apr 30.

Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.

The increasing culinary use of onion () raises pressure on the current production rate, demanding sustainable approaches for increasing its productivity worldwide. Here, we aimed to investigate the beneficial effects of licorice () root extract (LRE) in improving growth, yield, nutritional status, and antioxidant properties of two high-yielding onion cultivars, Shandaweel and Giza 20, growing under field conditions in two consecutive years. Our results revealed that pretreatments of both onion cultivars with LRE exhibited improved growth indices (plant height and number of leaves) and yield-related features (bulb length, bulb diameter, and bulb weight) in comparison with the corresponding LRE-devoid control plants. Read More

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Mitigation of bacterial spot disease induced biotic stress in Capsicum annuum L. cultivars via antioxidant enzymes and isoforms.

Sci Rep 2021 May 3;11(1):9445. Epub 2021 May 3.

Department of Soil Science, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Multan, 60800, Pakistan.

Bacterial spot, caused by a group of Xanthomonads (Xanthomonas spp.), is a devastating disease. It can adversely affect the Capsicum annum productivity. Read More

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Prevalence and antibiotics susceptibility profiles of Streptococcus pyogenes among pediatric patients with acute pharyngitis at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia.

BMC Microbiol 2021 May 3;21(1):135. Epub 2021 May 3.

Department of Medical laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, P.O.Box: 79, Bahir Dar, Ethiopia.

Background: Streptococcus pyogenes (S. pyogenes) is a Gram positive bacterium which is a leading cause of pharyngitis, skin and soft tissue infection and post streptococcal syndromes. Due to lack of β-lactamase enzyme production, it was considered universally susceptible to penicillin group and later generation of β-lactam antibiotics. Read More

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Oxidative and antioxidative stress markers in dry eye disease: A systematic review and meta-analysis.

Acta Ophthalmol 2021 May 2. Epub 2021 May 2.

Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, Witty Fit, Clermont-Ferrand, France.

Purpose: To conduct a systematic review and meta-analysis on the levels of oxidative stress markers and antioxidants in dry eye disease (DED) compared with healthy subject.

Method: The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 10 January 2021 for studies reporting oxidative and antioxidative stress markers in DED and healthy controls. Main meta-analysis was stratified by type of biomarkers, type of samples (tears, conjunctival cells or biopsies), Sjögren's syndrome (SS) (patients with or without SS) and by geographical zones (Asia or Europe). Read More

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Chronic Exposure to Continuous Brightness or Darkness Modulates Immune Responses and Ameliorates the Antioxidant Enzyme System in Male Rats.

Amira Moustafa

Front Vet Sci 2021 15;8:621188. Epub 2021 Apr 15.

Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Circadian rhythms are considered vital regulators of immune functions. This study aims to elucidate the effects of chronic circadian disruption on immune functions, clock genes expression, and antioxidant enzymes levels in lymphoid tissues. Adult male Sprague-Dawley rats were subjected to a normal light/dark cycle or either continuous light (LL) or continuous dark (DD) for 8 weeks. Read More

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Aflatoxicosis in Pekin duckling and the effects of treatments with lycopene and silymarin.

Vet World 2021 Mar 29;14(3):788-793. Epub 2021 Mar 29.

Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Egypt.

Background And Aim: Aflatoxins (AFs) are potent toxic metabolites produced from species. Whose existence in poultry ration leads to drastic economic losses, notably in duck, as the most susceptible poultry species. This study aimed to determine tissue residues of AFs, alterations in selected clinical chemistry variables in serum, mainly during the exposure period, and lycopene and silymarin's possible roles as herbal treatments against aflatoxicosis in Pekin duckling. Read More

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Characterization of putative pathogenic isolated from ballast water.

Vet World 2021 Mar 19;14(3):678-688. Epub 2021 Mar 19.

Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.

Background And Aim: is ubiquitous in marine-associated environments and has been increasingly recognized as a significant human pathogen that can cause serious infections mainly associated with exposure to seawater and ingestion of raw seafood. This study aimed to isolate and characterize from ballast water of ships berthed at Port Klang, Malaysia.

Materials And Methods: Ballast water was sampled from nine ships docked at Port Klang, Malaysia. Read More

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