3,039 results match your criteria caspase-3 malondialdehyde


Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine.

Environ Sci Pollut Res Int 2021 Nov 25. Epub 2021 Nov 25.

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubiyya, 13736, Egypt.

Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular toxicity mediated by cisplatin (CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC + CP. Read More

View Article and Full-Text PDF
November 2021

Protecting Effects of N-acetyl Cysteine Supplementation Against Lead and Cadmium-Induced Brain Toxicity in Rat Models.

Biol Trace Elem Res 2021 Nov 24. Epub 2021 Nov 24.

Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

We aimed to investigate mitigating effects of N-acetylcysteine (NAC) on the oxidative stress, apoptosis and Parkinson's disease (PD)-related genes in the brain tissue of male rats exposed to continuous doses of cadmium and lead. Rats were randomly divided into five groups, including G1 (control), G2 (continuous dose of Cd), G3 (continuous dose of Pb), G4 (continuous dose of Cd + NAC), and G5 (continuous dose of Pb + NAC). Biomarkers of oxidative stress, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured. Read More

View Article and Full-Text PDF
November 2021

Curcumin Protects against Renal Ischemia/Reperfusion Injury by Regulating Oxidative Stress and Inflammatory Response.

Evid Based Complement Alternat Med 2021 13;2021:8490772. Epub 2021 Nov 13.

Department of Anesthesiology, Qingdao Women and Children's Hospital, Qingdao 266000, China.

Objective: The aim of this study was to explore the pharmacological effects of curcumin on oxidative stress and inflammatory response of renal dysfunction induced by renal ischemia/reperfusion (RIRI).

Methods: Fifty male SD rats (Sprague Dawley) were randomly divided into the sham group, RIRI group, and curcumin group (low, medium, and high). The RIRI model was established by clipping the left renal artery for 45 min and then reperfusion for 24 h and resection of the contralateral kidney. Read More

View Article and Full-Text PDF
November 2021

Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1.

J Physiol Pharmacol 2021 Jun 19;72(3). Epub 2021 Nov 19.

Pharmaceutical Sciences Department, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia.

This study investigated if kaempferol could attenuate the oxidative, inflammatory, and fibrotic damage of the left ventricles (LVs) in streptozotocin (STZ)-diabetic rats by modulating silent mating type information regulation 2 homolog 1 (SIRT1) signaling. Adult male rats were divided into 5 groups (n = 12/each) as control, control + kaempferol, STZ-induced diabetes mellitus (STZ-DM), STZ-DM + kaempferol, and STZ-DM + kaempferol + EX-527, a sirtuin 1 (SIRT1) inhibitor. Administration of kaempferol to diabetic rats significantly preserved the systolic and diastolic functions of the LVs that was associated with a significant reduction in ventricular collagen deposition, infiltration of inflammatory cells, and protein expression of Bcl2-associated X protein (Bax), cleaved caspase-3, and cytochrome-C. Read More

View Article and Full-Text PDF

Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats.

Iran J Basic Med Sci 2021 Aug;24(8):1041-1049

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Acrylamide (ACR), has wide uses in different industries. ACR induced several toxicities including neurotoxicity and hepatotoxicity. The probable protective effects of selenium on ACR-induced neurotoxicity and hepatotoxicity in rats were evaluated. Read More

View Article and Full-Text PDF

Cardioprotective effects of bosentan in 5-fluorouracil-induced cardiotoxicity.

Toxicology 2021 Nov 17;465:153042. Epub 2021 Nov 17.

Department of Pharmacology, Faculty of Medicine, Minia University, 61511, El-Minia, Egypt.

5-fluorouracil (5-FU) is a widely used chemotherapeutic agent but cardiotoxicity challenges its clinical usefulness. Thus, searching for more cardioprotective drugs is highly required to prevent the accompanied cardiac hazards. Up to date, the different mechanisms involved in 5-FU cardiotoxicity are still unclear and there is no evaluation of bosentan's role in controlling these cardiac complications. Read More

View Article and Full-Text PDF
November 2021

Liposomal chrysin attenuates hepatic ischaemia-reperfusion injury: possible mechanism via inhibiting NLRP3 inflammasome.

J Pharm Pharmacol 2021 Nov 16. Epub 2021 Nov 16.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objectives: The chrysin has properties of low aqueous solubility, bioavailability and absorption, and its effect on hepatic ischaemia-reperfusion (HIR) remains unclear. Thus, we prepared a liposomal chrysin (LC) and explored its effect and potential mechanism on HIR.

Methods: A thin-film dispersion method was used to prepare LC, and a mouse HIR model was used. Read More

View Article and Full-Text PDF
November 2021

Quercetin ameliorated remote myocardial injury induced by renal ischemia/reperfusion in rats: Role of Rho-kinase and hydrogen sulfide.

Life Sci 2021 Nov 14;287:120144. Epub 2021 Nov 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address:

Aims: This study was designated to investigate the means through which quercetin confers its cardioprotective action against remote cardiomyopathy elicited by renal ischemia/reperfusion (I/R). Potential involvement of hydrogen sulfide (HS) and its related mechanisms were accentuated herein.

Main Methods: In anesthetized male Wistar rats, renal I/R was induced by bilateral renal pedicles occlusion for 30 min (ischemia) followed by 24 h reperfusion. Read More

View Article and Full-Text PDF
November 2021

Assessment of gentamicin and cisplatin-induced kidney damage mediated via necrotic and apoptosis genes in albino rats.

BMC Vet Res 2021 Nov 16;17(1):350. Epub 2021 Nov 16.

Biochemistry Department, Faculty of Veterinary Medicine Kafrelsheikh University, Kafrelsheikh, Egypt.

Background: Gentamicin (GM) is a low-cost, low-resistance antibiotic commonly used to treat gram-negative bacterial diseases. Cisplatin (Csp) is a platinum-derived anti-neoplastic agent. This experiment aimed to identify the early signs of gentamicin and cisplatin-induced nephrotoxicity in rats. Read More

View Article and Full-Text PDF
November 2021

Butylated hydroxyl-toluene, 2,4-Di-tert-butylphenol, and phytol of Chlorella sp. protect the PC12 cell line against HO-induced neurotoxicity.

Biomed Pharmacother 2021 Nov 11;145:112415. Epub 2021 Nov 11.

Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran. Electronic address:

Oxidative stress is considered the main cause of cellular damage in a number of neurodegenerative disorders. One suitable ways to prevent cell damage is the use of the exogenous antioxidant capacity of natural products, such as microalgae. In the present study, four microalgae extracts, isolated from the Persian Gulf, were screened to analyze their potential antioxidant activity and free radical scavenging using ABTS, DPPH, and FRAP methods. Read More

View Article and Full-Text PDF
November 2021

Vitamin D enhances the effects of omega-3 oils against metabolic dysfunction-associated fatty liver disease in rat.

Biofactors 2021 Nov 12. Epub 2021 Nov 12.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.

This study investigated the effects of omega-3 oils (OM) and/or vitamin D (VD) against metabolic dysfunction-associated fatty liver disease (MAFLD). Forty rats were divided into negative (NC) and positive (PC) controls, OM, VD, and OM + VD groups, and MAFLD was induced by high-fat/high-fructose diet (12 weeks). Oral OM (415 mg/kg/day) and/or intramuscular VD (290 IU/kg/day) were given for 4 weeks (5 times/week). Read More

View Article and Full-Text PDF
November 2021

Toxicological effects of acute prothioconazole and prothioconazole-desthio administration on liver in male Chinese lizards (Eremias argus).

Chemosphere 2021 Nov 8:132825. Epub 2021 Nov 8.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing, 100085, China.

Prothioconazole (PTC) is a high effective systemic fungicide, and one of its major metabolites is prothioconazole-desthio (PTC-d). Because of its wildly use in the farmland of China, the local eco-toxicological effects of PTC as well as PTC-d are needed to be concerned. This study investigated hepatoxicity of Chinese lizards (Eremias argus), a local non-target organism, after single dose oral treated (100 mg kg BW) through pathological, enzyme activity and gene expression analysis. Read More

View Article and Full-Text PDF
November 2021

Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.

Phytomedicine 2021 Dec 23;93:153772. Epub 2021 Sep 23.

Jilin Institute of Bioloy, Changchun 130012, China.

Background: Panax ginseng (PG) and red ginseng (RG) are considered to be effective anti-aging treatments. However, evidence of their therapeutic mechanisms and difference in anti-aging effects is lacking.

Purpose: To explore the potential therapeutic mechanisms of RG and PG in brain damage in D-Gal-induced aging mice, and evaluate the difference in anti-aging effects caused by their compositional differences. Read More

View Article and Full-Text PDF
December 2021

Excessive manganese alters serum biochemical indices, induces histopathological alterations, and activates apoptosis in liver and cerebrum of Jianzhou Da'er goat (Capra hircus).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Nov 6;252:109241. Epub 2021 Nov 6.

Animal Science Academy of Sichuan Province, Chengdu 610066, China.

The present study aimed to explore the toxic effects of excessive dietary Mn in livers and cerebrums of Jianzhou Da'er goat (Capra hircus). Three-month old goats were assigned into three groups: control group, fed on basal diet; Mn I group, fed on the basal diet mixed with MnCl (2.5 g/kg); Mn II group, fed on the basal diet mixed with MnCl (5 g/kg). Read More

View Article and Full-Text PDF
November 2021

[Protective effect of oleanolic acid on L02 hepatocyte injury induced by HgCl_2].

Wei Sheng Yan Jiu 2021 Sep;50(5):781-787

School of Public Health, Weifang Medical College, Weifang 261053, China Weifang Key Laboratory of Health Inspection and Quarantine, Weifang 261053, China.

Objective: To investigate the protective effect of oleanolic acid(OA) on HgCl_2 induced liver injury.

Methods: L02 cells were divided into four groups according to different treatment, control group(Con), oleanolic acid group(OA, 10 μmol/L), HgCl_2 group(HgCl_2, 40 μmol/L) and oleanolic acid + HgCl_2 group(OA + HgCl_2). Cells of control group were given serum-free medium, cells of OA group were pretreated with OA solution for 8 hours, cells of HgCl_2 group were exposed to HgCl_2 solution for 6 hours, cells of OA + HgCl_2 group were pretreated with OA solution for 8 hours, and then exposed to HgCl_2 solution for 6 hours. Read More

View Article and Full-Text PDF
September 2021

Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability.

Drug Chem Toxicol 2021 Nov 7:1-9. Epub 2021 Nov 7.

Department of Histology, Faculty of Medicine, Minia University, Minia, Egypt.

Fluorouracil (5-FU) is a widely used chemotherapeutic agent in various malignant tumors. However, intestinal toxicity is considered the irritant unavoidable adverse effect during the course therapy. The aim of the current study was to screen the effect of a new selective histamine receptor 1 blocker and platelet-activating factor (PAF) blocker on 5-FU induced intestinal toxicity. Read More

View Article and Full-Text PDF
November 2021

Niazimicin: A thiocarbamate glycoside from Moringa oleifera Lam. seeds with a novel neuroprotective activity.

J Food Biochem 2021 Nov 7:e13992. Epub 2021 Nov 7.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Moringa oleifera (MO) known as the miracle tree is a famous nutritional source in many countries. In this study, the neuroprotective activity of MO seeds was investigated. Fractions of the 70% ethanol seed extract of MO were injected at a dose of 250 mg kg  day to albino rats for 15 days, after-which induction of dementia was done using 100 mg/kg AlCl over 30 days. Read More

View Article and Full-Text PDF
November 2021

Aluminum Chloride-Induced Reproductive Toxicity in Rats: the Protective Role of Zinc Oxide Nanoparticles.

Biol Trace Elem Res 2021 Nov 6. Epub 2021 Nov 6.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. Therefore, this study aimed to investigate the effects of zinc oxide nanoparticle (ZnONP) treatment on Al-induced reproductive toxicity in rats. Thirty-two adult male albino rats were allocated into four equal groups as follows: control, AlCl orally administered group (100 mg/kg bwt), ZnONPs injected intraperitoneally (i. Read More

View Article and Full-Text PDF
November 2021

Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways.

Front Pharmacol 2021 18;12:737764. Epub 2021 Oct 18.

Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, Thailand.

Diabetic encephalopathy is one of the serious emerging complication of diabetes. is an important medicinal plant with excellent antioxidant and anti-inflammatory properties. This study investigated the neuroprotective effects of polyphenol rich extract (SiPE) against diabetic encephalopathy in rats and elucidated the potential mechanisms of action. Read More

View Article and Full-Text PDF
October 2021

Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks.

Poult Sci 2021 Dec 26;100(12):101513. Epub 2021 Sep 26.

College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong Province, PR China. Electronic address:

Aflatoxin B1 (AFB1) is a secondary metabolite produced by Aspergillus flavus and parasitic aspergillus, mainly existing in cereals, peanuts, corn, and other crops, which seriously endanger poultry, human health, and environment. Morin, a flavonoid compound extracted from moraceae plants, possess antioxidant, antibacterial, and anti-inflammatory effects. However, whether morin has a protective effect on AFB1-induced liver and kidney damage in chicks has not been specifically reported. Read More

View Article and Full-Text PDF
December 2021

Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.

Front Pharmacol 2021 13;12:758670. Epub 2021 Oct 13.

School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.

Hesperidin (HES) is a flavonoid glycoside found in the tangerine peel and has antioxidant properties. Arsenic trioxide (ATO) is an anti-tumour drug; however, its serious cardiotoxicity limits its clinical application. In addition, the protection of HES against ATO-induced cardiotoxicity has not been explored. Read More

View Article and Full-Text PDF
October 2021

Taurine Has Potential Protective Effects against the Chronic Cardiotoxicity Induced by Doxorubicin in Mice.

Biol Pharm Bull 2021 ;44(11):1732-1737

College of Veterinary Medicine, Yangzhou University.

Doxorubicin (DOX) is an effective anticancer anthracycline drug; however, the cardiotoxicity limits its application. The aim of the present study was to investigate the potential protective effect of taurine against DOX-induced chronic cardiotoxicity in mice. We found that exogenous supplementation of taurine can inhibit the weight loss of mice caused by DOX. Read More

View Article and Full-Text PDF
January 2021

Effects of dietary inclusion of Radix Bupleuri extract on the growth performance, and ultrastructural changes and apoptosis of lung epithelial cells in broilers exposed to atmospheric ammonia.

J Anim Sci 2021 Nov;99(11)

College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

To explore whether Radix Bupleuri extract (RBE) could protect lung injury of broilers under ammonia (NH3) exposure, 360 one-d-old male broilers were randomly allocated to four groups of six replicates each in a 2 × 2 factorial design with two diets (the basal diet [control; CON] and the basal diet supplemented with RBE [RB]) and two air conditions (normal condition [<2 ppm of NH3; NOR] and NH3 exposure [70 ppm of NH3; NH70]). The RB diet contained 80 mg saikosaponins/kg diet. On day 7, the lung tissues were collected and the lung epithelial cells (LEC) were isolated. Read More

View Article and Full-Text PDF
November 2021

Effect of infection with Aeromonas hydrophila on antioxidant capacity, inflammation response, and apoptosis proteins in Chinese mitten crab (Eriocheir sinensis).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Oct 28;252:109220. Epub 2021 Oct 28.

College of Animal Science and Technology, Jilin Agricultural University, Jilin, Changchun 130118, China; Tonghua Normal University, Jilin, Tonghua 134000, China. Electronic address:

Aeromonas hydrophila (A. hydrophila) as a serious bacterial disease endangering aquaculture and the Chinese mitten crabs (Eriocheir sinensis) industry. The present study was conducted to investigate the effects of A. Read More

View Article and Full-Text PDF
October 2021

Anti-oxidant, anti-apoptotic, and mitochondrial regulatory effects of selenium nanoparticles against vancomycin induced nephrotoxicity in experimental rats.

Life Sci 2021 Oct 26:120098. Epub 2021 Oct 26.

Department of Biochemistry, Faculty of Pharmacy, Ahram Canadian University, 6 October City, Egypt.

Aim: Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment against multi-resistant Gram-positive bacteria. The present research aimed to investigate the ability of selenium nanoparticles (SeNPs) to protect against VCM-induced nephrotoxicity in rats.

Main Methods: Experimental rats were divided into five groups; the first was the normal control, the second was treated with VCM (200 mg/kg twice/day, i. Read More

View Article and Full-Text PDF
October 2021

A novel role of pirfenidone in attenuation acetic acid induced ulcerative colitis by modulation of TGF-β1 / JNK1 pathway.

Int Immunopharmacol 2021 Oct 25;101(Pt B):108289. Epub 2021 Oct 25.

Department of Pharmacology, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt. Electronic address:

Colon diseases are a major health burden, particularly ulcerative colitis, in both men and women worldwide. Environmental and genetic factors in various colonic pathologies influence the onset and outcome of diseases. As the evidence from recent research is considered, the importance of inflammation in the onset, progression, and outcome is gaining more traction. Read More

View Article and Full-Text PDF
October 2021

Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-κB and PI3K/AKT/mTOR Pathways.

J Inflamm Res 2021 14;14:5291-5304. Epub 2021 Oct 14.

Department of Immunology, School of Medicine, Yangtze University, Jingzhou, People's Republic of China.

Purpose: Capsaicin (8-methyl-N-geranyl-6-nonamide; CAP) is an alkaloid isolated from chili peppers, which has complex pharmacological properties, including beneficial effects against various diseases. The aim of this study was to investigate the role of CAP in lipopolysaccharide (LPS)-induced acute lung injury (ALI), and the possible underlying mechanisms.

Materials And Methods: ALI was induced by intranasal administration of LPS (0. Read More

View Article and Full-Text PDF
October 2021

Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.

Korean J Physiol Pharmacol 2021 Nov;25(6):517-523

Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.

The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. Thirty Sprague-Dawley rats were randomly divided into five groups, including normal diet group, and diabetes model (DM) group, DM + metformin treatment (DMM) group, DMM + hypoxia treatment (DMMH) group and DMMH + hydrogenrich water (DMMHR) group. We found that the levels of lactic acid, pyruvate and lactate dehydrogenase were significantly lower in the blood of DMMHR group than DMMH group. Read More

View Article and Full-Text PDF
November 2021

Protective Effects of Low-Dose Alcohol against Acute Stress-Induced Renal Injury in Rats: Involvement of CYP4A/20-HETE and LTB/BLT1 Pathways.

Oxid Med Cell Longev 2021 13;2021:4475968. Epub 2021 Oct 13.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

Low-dose alcohol possesses multiple bioactivities. Accordingly, we investigated the protective effect and related molecular mechanism of low-dose alcohol against acute stress- (AS-) induced renal injury. Herein, exhaustive swimming for 15 min combined with restraint stress for 3 h was performed to establish a rat acute stress model, which was verified by an open field test. Read More

View Article and Full-Text PDF
October 2021

Punicalagin prevents cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammatory response, and apoptosis in rats.

Life Sci 2021 Dec 21;286:120071. Epub 2021 Oct 21.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address:

Nephrotoxicity is a major complication that limits the therapeutic application of cisplatin (CIS). Oxidative stress and inflammation are implicated in CIS-induced acute kidney injury (AKI) and apoptotic cell death. Punicalagin (PUN), a polyphenol in pomegranate, possesses promising anti-inflammatory and antioxidant activities, and its beneficial effect against CIS-induced AKI has not been fully elucidated. Read More

View Article and Full-Text PDF
December 2021