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Altered central and peripheral hemodynamics during rhythmic handgrip exercise in young adults with SARS-CoV-2.

Exp Physiol 2021 Jul 26. Epub 2021 Jul 26.

Department of Health & Exercise Science, Appalachian State University, Boone, NC.

New Findings: What is the central question of this study? This study sought to investigate whether central and peripheral hemodynamics during handgrip exercise were different in young adults 3-4 weeks following infection with of SARS-CoV-2 compared with young healthy adults. What is the main finding and its importance? The main findings are that exercising heart rate was higher while brachial artery blood flow and vascular conductance were lower in the SARS-CoV-2 compared with the control group. These findings provide evidence for peripheral impairments to exercise among adults with SARS-CoV-2, which may contribute to exercise limitations. Read More

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Curriculum for ERCP and endoscopic ultrasound training in Europe: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

Endoscopy 2021 Jul 26. Epub 2021 Jul 26.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, and TARGID, KU Leuven, Leuven, Belgium.

The European Society of Gastrointestinal Endoscopy (ESGE) has recognized the need to formalize and enhance training in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS). This manuscript represents the outcome of a formal Delphi process resulting in an official Position Statement of the ESGE and provides a framework to develop and maintain skills in ERCP and EUS. This curriculum is set out in terms of the prerequisites prior to training; recommended steps of training to a defined syllabus; the quality of training; and how competence should be defined and evidenced before independent practice. Read More

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Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses.

Dermatology 2021 Jul 26:1-13. Epub 2021 Jul 26.

Dermatology Service, Memorial Sloan Kettering, New York, New York, USA.

Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Read More

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Cytology of Extraneural Metastases of Nonhematolymphoid Primary Central Nervous System Tumors: Six Cases with Histopathological Correlation and Literature Update.

Acta Cytol 2021 Jul 26:1-12. Epub 2021 Jul 26.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Introduction: Extraneural/-cranial metastases (ENM) of primary central nervous system (CNS) tumors are rare and may be diagnostically challenging. We describe the cytomorphological and pertinent clinical features of ENM in a case series assessed by fine-needle aspiration (FNA). A search of the laboratory information systems of 2 tertiary care centers in Toronto (2000-2015) was performed. Read More

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Atmospheric dispersion and transmission of Legionella from wastewater treatment plants: A 6-year case-control study.

Int J Hyg Environ Health 2021 Jul 23;237:113811. Epub 2021 Jul 23.

National Institute for Public Health and the Environment (RIVM), the Netherlands; Institute for Risk Assessment Sciences, Utrecht University, the Netherlands.

Legionnaires Disease incidence has risen in the Netherlands in recent years. For the majority of the cases, the source of infection is never identified. Two Dutch wastewater treatment plants (WWTPs) have previously been identified as source of outbreaks of Legionnaires Disease (LD) among local residents. Read More

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A dynamic, convenient and accurate method for assessing the flood risk of people and vehicle.

Sci Total Environ 2021 Jul 18;797:149036. Epub 2021 Jul 18.

Beijing Capital Co Ltd, Beijing 100028, China.

With the increase of extreme rainstorm caused by climate change, and the development of urbanization and the improvement of people's living standard, there is an urgent need to draw a dynamic, convenient and accurate flood risk map for different disaster bearing bodies, so as to protect people's lives and properties, as well as improve people's risk awareness and facilitate people's lives. This study mainly researched a method of drawing a dynamic, convenient and accurate flood risk map for people and vehicle. In this study, the surface runoff is simulated by GPU (Graphics Processing Unit) Accelerated Surface Water Flow and Transport model (GAST model), meanwhile, the flood risk of people and vehicle is graded base on the incipient velocity formulas, the most unfavorable principle and grading method, finally, the method is applied in two application cases. Read More

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Clinicopathological, gene expression and genetic features of stage I lung adenocarcinoma with necrosis.

Lung Cancer 2021 Jul 16;159:74-83. Epub 2021 Jul 16.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Division of Innovative Pathology and Laboratory Medicine, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. Electronic address:

Objectives: The purpose of this study was to investigate the clinicopathological, gene expression and genetic features of stage I lung adenocarcinoma with necrosis.

Methods: We retrospectively reviewed 521 cases with pathologic stage I lung adenocarcinoma resected by lobectomy and lymph node dissection. We calculated the ratio of tumor necrotic area by digital image analysis and investigated the relationship between tumor necrosis and prognosis. Read More

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Intrathoracic giant solitary fibrous tumor of the pleura: Case report.

Int J Surg Case Rep 2021 Jul 22;85:106224. Epub 2021 Jul 22.

Department of Radiology, Addis Ababa University, Addis Ababa, Ethiopia.

Introduction: Solitary Fibrous Tumor of the Pleura(SFTP) is exceedingly rare mesenchymal tumor commonly arising from the visceral pleura and accounts for <5% of all pleural tumors. Although it commonly has benign histologic characteristics, the tumor behavior is often unpredictable and less understood due to limited number of cases.

Case Presentation: We present a rare case of Intrathoracic Giant SFTP in a 65 years old female who presented with a progressive worsening of shortness of breath of 1 year duration associated with intermittent dry cough, low grade fever, easy fatigability and loss of appetite. Read More

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Formation of the upper digestive tract by the ileum - right colon for patient with concurrent cancers of the esophagus and the stomach: A case report.

Int J Surg Case Rep 2021 Jul 21;85:106232. Epub 2021 Jul 21.

Bach Mai Hospital, Hanoi, Viet Nam; Hanoi University of Public Health, Hanoi, Viet Nam.

Introduction And Importance: A very rare case with presence of both esophageal and gastric cancers raised questions on how to perform optimal surgery for such cases. To date, reports on experimental surgery strategies for these rare cases remained sparse in the literatures.

Case Presentation: A 61-year-old male patient having epigastric abdominal pain and swallowing difficulties for a month prior to the hospital. Read More

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Safety and acceptance of "Vibwife", a new moving mattress to support mobilization during labor: Result of a clinical study.

Midwifery 2021 Jul 17;103:103096. Epub 2021 Jul 17.

University Hospital Basel, Department of Obstetrics and Gynecology, Spitalstrasse 21, 4031 Basel, Switzerland. Electronic address:

Objective: To examine the safety and acceptance "Vibwife", a new moving mattress to support mobilization of pregnant women during labor.

Design: The study was a prospective medical device clinical study without a control group. The study was designed in intervention phases, with safety evaluation by a safety review board after each intervention phase. Read More

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The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.

Ann Diagn Pathol 2021 Jul 20;54:151799. Epub 2021 Jul 20.

Department of Pathology and Laboratory Medicine Rhode Island Hospital, The Warren Alpert School of Medicine, Brown University, United States of America. Electronic address:

Lung adenocarcinoma is currently staged based on invasive tumor size, excluding areas of lepidic (in situ) growth. Invasive tumor size may be determined by pathologic assessment of a surgical specimen or radiographic assessment on computerized tomography (CT) scan. When invasive tumor size is the primary stage determinate, radiographic-pathologic discordance or discordant interpretation among pathologists may alter tumor stage and treatment. Read More

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Incidental Polyp on Colectomy Specimen is Linked with Higher Odds of Polyp on Interval Colonoscopy.

J Surg Res 2021 Jul 23;268:158-167. Epub 2021 Jul 23.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC. Electronic address:

Background: Incidentally found polyps on surgical pathology after colectomy is an underreported phenomenon, and management guidelines are lacking. Elucidation of the significance of incidental polyps is needed to determine if post-operative endoscopic surveillance modification is warranted. We sought to determine the relationship between incidental polyp on colectomy specimen and findings on post-operative colonoscopy. Read More

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Propofol misuse in Ireland - Two case reports and a review of the literature.

Forensic Sci Int 2021 Jul 21;326:110909. Epub 2021 Jul 21.

Office of the State Pathologist, Griffith Avenue, Whitehall, Dublin D09RDT8, Ireland. Electronic address:

Propofol is a rapidly acting sedative drug, which is usually administered intravenously. It is widely used in procedural sedation due to its rapid onset and easy reversibility. It has a good safety profile when used in combination with ventilation and monitoring. Read More

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Quantitative characterisation of ballistic cartridge cases from micro-CT.

Forensic Sci Int 2021 Jul 20;326:110913. Epub 2021 Jul 20.

Forensic Centre for Digital Scanning and 3D Printing, WMG, University of Warwick, Coventry CV4 7AL, UK.

Evaluation of cartridge cases is essential within forensic ballistic analysis and is used in an attempt to establish a connection to the weapon used to fire it. This study consists of two experiments. The aims of Experiment 1 were to establish whether micro-CT is appropriate and repeatable for ballistic cartridge case analysis and if measurements can be extracted repeatably and reliably. Read More

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Decontamination options for indoor surfaces contaminated with realistic fentanyl preparations.

J Environ Manage 2021 Jul 23;297:113327. Epub 2021 Jul 23.

U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Solutions and Emergency Response, Homeland Security and Materials Management Division, USA.

The significant increase in illegal use of the synthetic opioid fentanyl is leading to unintentional overdose fatalities. Spills of fentanyl where it is abused or prepared for illegal distribution can result in persistent contamination of areas. Remediation can be attempted through physical removal but may benefit greatly from application of decontamination solutions that provide in-situ degradation of fentanyl. Read More

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Efficacy and adverse events of selective serotonin noradrenaline reuptake inhibitors in the management of postoperative pain: A systematic review and meta-analysis.

J Clin Anesth 2021 Jul 23;75:110451. Epub 2021 Jul 23.

Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, BG-Universitätsklinikum Bergmannsheil gGmbH, Medical Faculty of Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, Bochum, Germany.

Study Objective: Selective-serotonin-noradrenaline-reuptake inhibitors (SSNRI) might be an interesting option for postoperative pain treatment. Objective was to investigate postoperative pain outcomes of perioperative SSNRI compared to placebo or other additives in adults undergoing surgery.

Design: Systematic review of randomised controlled trials (RCT) with meta-analysis and GRADE assessment. Read More

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First finding of Streptococcus phocae infections in mink (Neovison vison).

Res Vet Sci 2021 Jul 16;139:145-151. Epub 2021 Jul 16.

National Veterinary Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

Streptococcus phocae infection has been described in salmon, sea otters, and several families of pinnipeds. The pathology of the infected animals has mainly been located in the respiratory tract and reproductive system, and with indications of septicemia. In this study, we report the finding of S. Read More

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Interaction of multiple risk factors and population attributable fraction for type 2 diabetes and hypertension among adults aged 15-49 years in Northeast India.

Diabetes Metab Syndr 2021 Jul 21;15(5):102227. Epub 2021 Jul 21.

Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Mumbai, 400088, India.

Aims: The aim is to assess the association and population attributable fraction (PAF) of multiple risk factors combination for diabetes and hypertension among adults in the Northeast region of India.

Methods: Data used is from the Indian Demographic Health Survey conducted in 2015-16. The study comprised 107, 766 respondents (95,153 females and 12, 613 males) aged 15-49 years. Read More

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Dynamic FDG-PET in localization of focal epilepsy: A pilot study.

Epilepsy Behav 2021 Jul 23;122:108204. Epub 2021 Jul 23.

Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address:

Epilepsy surgery remains underutilized, in part because non-invasive methods of potential seizure foci localization are inadequate. We used high-resolution, parametric quantification from dynamic 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography (dFDG-PET) imaging to locate hypometabolic foci in patients whose standard clinical static PET images were normal. We obtained dFDG-PET brain images with simultaneous EEG in a one-hour acquisition on seven patients with no MRI evidence of focal epilepsy to record uptake and focal radiation decay. Read More

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Readmission and reoperation after laryngeal dilation in children: NSQIP-P analysis.

Int J Pediatr Otorhinolaryngol 2021 Jul 12;149:110838. Epub 2021 Jul 12.

Department of Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine & Biomedical Sciences at the University at Buffalo, Buffalo, NY, USA. Electronic address:

Objective: To identify specific comorbidities and their relationship to complications in children who underwent laryngeal dilation, specifically comparing children with tracheostomy versus no tracheostomy as well as differences in outcomes between age groups.

Methods: Retrospective study analyzing data collected in the American College of Surgeons National Surgical Improvement - Pediatric Database (2015-2018). Patients were selected using Current Procedural Terminology code 31528. Read More

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Clinical validation of a GPU-based Monte Carlo dose engine of a commercial treatment planning system for pencil beam scanning proton therapy.

Phys Med 2021 Jul 23;88:226-234. Epub 2021 Jul 23.

Protontherapy Department, Trento Hospital, Trento, Italy; TIFPA - Trento Institute for Fundamental Physics and Applications, 14, Via Sommarive, 38123 Povo TN, Italy.

Purpose: To perform the validation of the GPU-based (Graphical Processing Unit based) proton Monte Carlo (MC) dose engine implemented in a commercial TPS (RayStation 10B) and to report final dose calculation times for clinical cases.

Materials And Methods: 440 patients treated at the Proton Therapy Center of Trento, Italy, between 2018 and 2019 were selected for this study. 636 approved plans with 3361 beams computed with the clinically implemented CPU-MC dose engine (version 4. Read More

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Assessment of Lactobacillus casei rhamnosus (LGG) therapy in children with biliary atresia - randomized placebo controlled trial.

Clin Res Hepatol Gastroenterol 2021 Jul 23:101753. Epub 2021 Jul 23.

Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.

Background: The role of microbiota in biliary atresia (BA) remains unclear. The aim of our study was to assess efficacy and safety of LGG treatment in children with BA after HPE with special focus on bacterial cholangitis (BCH) and quantitative assessment of the gut microbiota composition and metabolism.

Methods: We performed double-blind placebo controlled trial with patients randomized into treatment group who received LGG (n=14) and placebo (n=16). Read More

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Blood First Assay Screening Trial (BFAST) in Treatment-Naïve Advanced or Metastatic Non-Small Cell Lung Cancer: Initial Results of the Phase 2 ALK-Positive Cohort.

J Thorac Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Internal Medicine, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA. Electronic address:

Introduction: The Blood First Assay Screening Trial (BFAST) is an ongoing open-label, multi-cohort study, prospectively evaluating the relationship between blood-based next-generation sequencing (NGS) detection of actionable genetic alterations and activity of targeted therapies/immunotherapy in treatment-naïve advanced/metastatic NSCLC. We present data from the ALK-positive cohort.

Methods: Patients aged ≥18 years with stage IIIB/IV NSCLC and ALK rearrangements detected by blood-based NGS using hybrid capture technology (FoundationACT™) received alectinib 600 mg twice-daily. Read More

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Poor insight in obsessive compulsive disorder (OCD): Associations with empathic concern and emotion recognition.

Psychiatry Res 2021 Jul 20;304:114129. Epub 2021 Jul 20.

Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way. Cambridge CB2 0SZ, UK.

Purpose: Insight is currently considered to be responsible for 20% to 40% of the cases of ineffective obsessive-compulsive disorder (OCD) treatment. As 15% to 36% of patients with OCD have reduced insight, we aimed to identify some of the clinical determinants of insight in OCD.

Results: Our sample consisted of 57 OCD patients, of which 34 men (59%) and 23 women (41%). Read More

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Fetus-in-Fetu: A Case of Ovarian Involvement and Residual Re-growth in a Teenager.

J Pediatr Adolesc Gynecol 2021 Jul 23. Epub 2021 Jul 23.

Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio; Department of Pediatric and Adolescent Gynecology, Nationwide Children's Hospital, Columbus, Ohio.

Background: Fetus-in-fetu (FIF) is a rare, congenital soft tissue mass typically occurring retroperitoneally in neonates under 18 months. We present a 13-year-old female with ovarian FIF occurrence and subsequent residual re-growth following resection.

Case: A 13-year-old female presented with abdominal pain and was found to have a 19-centimeter, complex, right adnexal mass. Read More

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Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects.

Reprod Toxicol 2021 Jul 23. Epub 2021 Jul 23.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address:

Accumulating studies have been focused on the independent effects of air pollutants and ambient heat exposure on congenital heart defects (CHDs) but with inconsistent results, and their interactive effect remains unclear. A case-control study including 921 cases and 9210 controls was conducted in Changsha, China in warm season in 2015-2018. The gravidas were assigned monthly averages of daily air pollutants and daily maximum temperature using the nearest monitoring station method and city-wide average method, respectively, during the first trimester of pregnancy. Read More

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Cardiopulmonary exercise testing in COVID-19 patients at 3 months follow-up.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Cardiology Unit, DICATOV - Cardiothoracic and Vascular Department, IRCCS San Martino Hospital, Genoa, Italy; Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy. Electronic address:

Background: Long-term effects of Coronavirus Disease of 2019 (COVID-19) and their sustainability are of the utmost relevance. We aimed to determine: 1) functional capacity of COVID-19 survivors by cardiopulmonary exercise testing (CPET); 2) characteristics associated with cardiopulmonary exercise testing (CPET) performance; 3) safety and tolerability of CPET.

Methods: We prospectively enrolled consecutive patients with laboratory-confirmed COVID-19 discharged alive at Azienda Sanitaria Locale-3, Genoa. Read More

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Prognostic value of androgen receptor expression and molecular alterations in metastatic triple negative or low hormone receptor breast carcinomas.

Hum Pathol 2021 Jul 23. Epub 2021 Jul 23.

Department of Pathology, Wexner Medical Center at the Ohio State University, 410 W. 10th Ave, Columbus, OH 43210. Electronic address:

Metastatic breast carcinomas (BCs) with phenotype of triple negative (TNBC) or low hormonal receptor levels [estrogen receptor (ER)/progesterone receptor (PR) < 10% and HER2-] are mainly treated with cytotoxic chemotherapy. Targeting androgen receptor (AR) pathway may represent a potential new therapeutic strategy in such group of BCs. We evaluated AR expression by immunohistochemistry and genetic alterations by next generation sequencing. Read More

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Primary Hepatic Neoplasms Arising in Cirrhotic Livers can have a Variable Spectrum of Neuroendocrine Differentiation.

Hum Pathol 2021 Jul 23. Epub 2021 Jul 23.

Department of Pathology, Duke University Medical Center, Durham, NC 27710.

Purposes: Primary hepatic neoplasms with neuroendocrine differentiation are extremely rare. Their clinicopathological features and molecular genetic basis are largely unknown.

Methods And Results: We identified four cases of primary hepatic neoplasms with neuroendocrine differentiation. Read More

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Wastewater monitoring as a supplementary surveillance tool for capturing SARS-COV-2 community spread. A case study in two Greek municipalities.

Environ Res 2021 Jul 23:111749. Epub 2021 Jul 23.

Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 22 Papakyriazi str, Larissa, Greece. Electronic address:

A pilot study was conducted from late October 2020 until mid-April 2021, aiming to examine the association between SARS-CoV-2 RNA concentrations in untreated wastewater and recorded COVID-19 cases in two Greek municipalities. A population of Random Forest and Linear Regression Machine learning models was trained and evaluated incorporating the concentrations of SARS-CoV-2 RNA in 111 wastewater samples collected from the inlets of two Wastewater Treatment Plants, along with physicochemical parameters of the wastewater influent. The model's predictions were adequately associated with the 7-day cumulative cases with the correlation coefficients (after 5-fold cross validation) ranging from 0. Read More

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