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Study of the Prevalence of Glaucoma in Kazakhstan.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Ophthalmology, Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan.

Background: Glaucoma is one of the leading causes of permanent visual disability around the world. However, the available literature lacks data on the prevalence of glaucoma in Central Asia, particularly in the Republic of Kazakhstan.

Objective: The study was aimed at assessing the prevalence of glaucoma in the population of the Republic of Kazakhstan over 40 years old in 2019. Read More

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Epidemiology of Childhood Uveitis in a Tertiary Care Center: A 20-Year Study.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.

Purpose: To investigate demographics and causes of pediatric uveitis in a Swiss tertiary reference center over a 20-year period.

Materials And Methods: Retrospective cohort study on patients with uveitis aged less than 16 years seen at Jules-Gonin Eye Hospital between 1 January 2000 and 31 December 2019.

Results: Out of 2846 patients with uveitis seen in the Jules-Gonin Eye Hospital Ocular Immune-Infectiology Department, 317 (11. Read More

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Large-Diameter Penetrating Keratoplasties are Mostly Due to Very Severe Infectious Keratitis and Cannot Always Prevent Secondary Enucleation.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Augenheilkunde, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg (Saar), Germany.

Purpose: To report the indications and outcomes of penetrating keratoplasties with a graft diameter > 8.5 mm in severe corneal diseases at the Department of Ophthalmology at Saarland University Medical Centre.

Study Design: Retrospective (6 years), descriptive, and observational. Read More

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Use of Preoperative High-Resolution Ultrasound System to Facilitate Elevation of the Superficial Circumflex Iliac Artery Perforator Flap.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Department of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan.

Background:  During elevation of the superficial circumflex iliac artery (SCIA) perforator (SCIP) flaps, the flap pedicle must often be converted from the superficial branch to the deep branch of the SCIA, complicating and prolonging the procedure. The goal of the present study was to demonstrate the effectiveness of high-resolution ultrasonography to decrease the conversion rate on which no previous report has focused, by making a comparison with a conventional method.

Patients And Methods:  Forty-five consecutive cases where free SCIP flap transfer was performed for reconstruction were retrospectively reviewed. Read More

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Use of Single Chimeric Free Flaps or Double Free Flaps for Complex Head and Neck Reconstruction.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Background:  Free flaps have become the preferred reconstructive approach to restore form and function for patients presenting with complex head and neck defects. For composite, complex defects for which a regular free flap might not meet all reconstructive demands, adequate coverage can be achieved with either a single chimeric free flap or a double free flap.

Methods:  We performed a single-center retrospective chart review of patients who underwent either single chimeric free flap or double free flap reconstruction. Read More

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The PAP Flap Breast Reconstruction: A Practical Option for Slim Patients.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Department of Plastic and Reconstructive Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Seoul, Korea.

Background:  The posterior thigh-based profunda artery perforator (PAP) flap has been an emerging option as a secondary choice in breast reconstructions. However, whether a PAP flap could consistently serve as the secondary option in slim patients has not been investigated.

Methods:  Records of immediate unilateral breast reconstructions performed from May 2017 to June 2019 were reviewed. Read More

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Redefining the Reconstructive Ladder in Vulvoperineal Reconstruction: The Role of Pedicled Perforator Flaps.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Background:  Gynecological reconstruction is difficult, particularly in cases with recurrence and received previous surgeries and/or radiotherapy and necessitate secondary reconstruction. Perforator flaps can preserve other donor sites for potential later reconstruction, and they also can be better tailored to the defect. We hypothesized that the use of perforator-based flaps can better restore the defect with less complications. Read More

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Clinical Profile and Mutations Associated with Multiple Endocrine Neoplasia-Type1 (MEN1) and Their First-Degree Relatives at Risk of Developing MEN1: A Prospective Study.

Horm Metab Res 2021 Apr 14;53(4):245-256. Epub 2021 Apr 14.

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.

Multiple Endocrine Neoplasia type-1 (MEN1) is an autosomal dominant disorder with a combined occurrence of tumours of parathyroid glands, pancreatic islets, and anterior pituitary. About 90% of these patients carry mutations in the MEN1 gene, though the spectrum is not well defined in India. Forty clinically suspected cases of MEN1 were enrolled prospectively over six years; 32 patients (23 index-cases and nine affected relatives) with≥2 classical endocrine tumours of MEN1 were considered definite, and eight were categorised as 'MEN1-like'. Read More

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Distinct Patterns of Tissue Remodeling and Their Prognostic Role in Chronic Rhinosinusitis.

ORL J Otorhinolaryngol Relat Spec 2021 Apr 14:1-7. Epub 2021 Apr 14.

Department of Otorhinolaryngology-Head and Neck Surgery, National Medical Center, Seoul, Republic of Korea.

Introduction: Tissue remodeling refers to structural changes that occur in damaged tissue and is associated with disease severity in asthma. However, the characteristics of tissue remodeling and its prognostic role in chronic rhinosinusitis (CRS) remain unclear. In this report, we evaluated the clinical implications of tissue remodeling in CRS. Read More

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Efficacy of Lutetium-Peptide Receptor Radionuclide Therapy in Inducing Prolonged Tumour Regression in Small-Bowel Neuroendocrine Tumours: A Case of Favourable Response to Retreatment after Initial Objective Response.

Oncol Res Treat 2021 Apr 14:1-4. Epub 2021 Apr 14.

Digestive Disease Unit, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy.

Introduction: The efficacy of 177Lu-Dotatate was shown in the NETTER-1 trial, an international, open-label, multicentre phase III clinical trial that evaluated the safety and efficacy of 177Lu-Dotatate in patients with well-differentiated, advanced midgut neuroendocrine tumours (NETs) with evidence of disease progression. Recently, retreatment with peptide receptor radionuclide therapy (PRRT) has been proposed as a valid therapeutic option in patients without other effective options who had responded to initial PRRT; however, data on this therapeutic option are still inadequate.

Case Report: In this report, we present the case of a patient who achieved a delayed complete radiological response after initial 177Lu-Dotatate treatment and who had a complete tumour response with PRRT retreatment 5 years later. Read More

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What Are the Results and the Prognostic Factors of Motor Cortex Stimulation in Patients with Facial Pain? A Systematic Review of the Literature.

Eur Neurol 2021 Apr 14:1-6. Epub 2021 Apr 14.

Department of Neuroscience, Neurosurgery Section, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Introduction: Facial pain (FP) is a type of neuropathic pain which recognizes both central and peripheral causes. It can be difficult to treat because it can often become resistant to pharmacological treatments. Motor Cortex Stimulation (MCS) has been used in selected cases, but the correct indications of MCS in FP have not been fully established. Read More

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Economic Burden of Urinary Tract Infections From Antibiotic-Resistant Escherichia coli Among Hospitalized Adult Patients in Lebanon: A Prospective Cohort Study.

Value Health Reg Issues 2021 Apr 11;25:90-98. Epub 2021 Apr 11.

Quality and Safety Department, Nabatieh Governmental Hospital, Nabatieh, Lebanon.

Objectives: The rising incidence of urinary tract infections (UTIs) attributable to Escherichia coli resistant isolates is becoming a serious public health concern. Although global rates of infection vary considerably by region, the growing prevalence of this uropathogen has been associated with a high economic burden and health strain. This study aims: (1) to estimate the differences in clinical and economic outcomes between 2 groups of adult hospitalized patients with UTIs from E. Read More

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[Basic aspects of COVID-19 for management from primary care].

Aten Primaria 2020 Dec 26;53(6):101966. Epub 2020 Dec 26.

CS Ramón y Cajal, DA OESTE (SERMAS), Grupo de trabajo de enfermedades infecciosas de SoMaMFyC, Alcorcón, España.

SARS-CoV-2 is transmitted from person to person by inhalation or contact with respiratory droplets and aerosols. The median incubation period is 5.1 days. Read More

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December 2020


J Minim Invasive Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Department of Gynecology & Obstetrics, Vita Salute San Raffaele University School of Medicine, Ospedale San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.

Study Objective: To investigate the clinical appearance, morphological and ultrastructural aspect of the mucosa of the peritoneal neovagina after laparoscopic Davydov's neovaginaplasty in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome patients.

Design: The present is a prospective, observational, experimental cohort of cases treated in the same institution between 2015 and 2019. Patients were followed up at 3, 6, 12 months after surgery and then every 12 months. Read More

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Left Atrial Strain Associated with Functional Recovery in Patients Receiving Optimal Treatment for Heart Failure.

J Am Soc Echocardiogr 2021 Apr 11. Epub 2021 Apr 11.

Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.

Background: Heart failure with recovered ejection fraction (HFrecEF) has been reported in several previous studies to have a better prognosis than HF with reduced EF (HFrEF). However, the factors associated with HFrecEF have not been identified. We hypothesized that left atrial (LA) strain could help to identify patients with recovered EF among cases of HF with low EF on admission. Read More

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A predictive score of inadequate bowel preparation based on a self-administered questionnaire: PREPA-CO.

Clin Res Hepatol Gastroenterol 2021 Apr 11:101693. Epub 2021 Apr 11.

Hepato-Gastroenterology Department, Angers University Hospital, Angers, France; HIFIH Laboratory, UPRES 3859, SFR 4208, Angers University, Angers, France.

Introduction: Inadequate bowel preparation before colonoscopy has a 20 to 30% rate and impedes on the quality of the procedure. The aim of this study was to develop a predictive score of inadequate bowel preparation, using a patient questionnaire on potential risk factors.

Methods: In this single center study, consecutive patients with colonoscopy indication were enrolled. Read More

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Asymptomatic COVID-19 cases among older patients despite BNT162b2 vaccination: a case series in a geriatric rehabilitation ward during an outbreak.

J Infect 2021 Apr 11. Epub 2021 Apr 11.

Service de gériatrie à orientation cardiologique et neurologique, AP-HP, Sorbonne Universite, Hopitaux universitaires Pitie-Salpetriere-Charles Foix, F-94205 Ivry-sur-Seine, France; Univsersite Paris Est Creteil, IMSERM, IMRB, CEpiA Team(Clinical Epidemiology and Ageing), F-94010 Creteil, France. Electronic address:

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Lifestle and rehabilitation during the COVID-19 pandemic: guidance for health professionals and support for exercise and rehabilitation programs.

Expert Rev Anti Infect Ther 2021 Apr 14. Epub 2021 Apr 14.

Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Universidade Federal de Sao Carlos, UFSCar, Rod Washington Luis, KM 235, Monjolinho, CEP: 13565-905, Sao Carlos, SP, Brazil.

Introduction: The coronavirus disease 2019 (COVID-19) is a highly contagious respiratory viral disease for both the general population and health care professionals caring for infected patients. Of particular concern is the potential for significant respiratory, cardiovascular, physical, and psychological dysfunctions.

Areas Covered: In this context, the current review will focus on the following areas: 1) staying physically active during the COVID-19 pandemic; 2) highlighting the importance of understanding COVID-19 mechanisms; 3) preventing infections for healthcare workers by using personal protective equipment; 4) highlighting importance of respiratory care and physical therapy during hospitalization in patients with COVID-19; and 5) facilitating referral to a rehabilitation program in patients recovering from COVID-19. Read More

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Clinical features and follow-up of pediatric patients hospitalized for COVID-19.

Pediatr Pulmonol 2021 Apr 14. Epub 2021 Apr 14.

Medicine Research Center, Ningbo City First Hospital, Ningbo, Zhejiang Province, China.

Objective: This report summarizes the clinical features and 1-month follow-up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID-19) in Wuhan Women and Children's Hospital.

Methods: The 1-month follow-up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG and IgM tests, reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2, lung computed tomography (CT) scans, and laboratory tests.

Results: Between January 20 and March 15, 2020, 127 patients aged 0-15 years were hospitalized for COVID-19 treatment, including 3 severe cases and 124 mild or moderate cases. Read More

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Medication use and microscopic colitis: a multicentre retrospective cohort study.

Aliment Pharmacol Ther 2021 Apr 14. Epub 2021 Apr 14.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, NY, USA.

Background: Medication use has been implicated in the development of microscopic colitis (MC). However, studies have demonstrated inconsistent findings and there exist variations in design.

Aim: To measure the association between medication use and MC. Read More

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Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review.

Rev Inst Med Trop Sao Paulo 2021 12;63:e30. Epub 2021 Apr 12.

University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, Serbia.

The aim of this systematic review was to determine the causal role of Erysipelatoclostridium ramosum in specific invasive infections in humans, and to assess the clinical outcome of antibiotic therapy used to treat them. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with a systemic inflammatory response syndrome (SIRS) due to E. ramosum isolated from body fluids or tissues in which it is not normally present. Read More

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Preoperative computed tomography-guided localization of lung nodules with needle placement: a series of cases.

Rev Col Bras Cir 2021 9;48:e20202890. Epub 2021 Apr 9.

- Hospital Nossa Senhora das Graças, Serviço de Cirurgia Torácica - Curitiba - PR - Brasil.

Objective: to report the preoperative localization of pulmonary nodules with the placement of a guidewire oriented by Computed Tomography.

Methods: the nodules were marked using a needle in the shape of a hook or another in the shape of a Q, guided by tomography. The choice of the location for the marking was the shortest distance from the chest wall to the nodule. Read More

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Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19: A Review.

Clinics (Sao Paulo) 2021 9;76:e2342. Epub 2021 Apr 9.

Programa de Pos-Graduacao em Cardiologia e Ciencias Cardiovasculares, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BR.

Among the multiple uncertainties surrounding the novel coronavirus disease (COVID-19) pandemic, a research letter published in The Lancet implicated drugs that antagonize the renin-angiotensin-aldosterone system (RAAS) in an unfavorable prognosis of COVID-19. This report prompted investigations to identify mechanisms by which blocking angiotensin-converting enzyme 2 (ACE2) could lead to serious consequences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The possible association between RAAS inhibitors use and unfavorable prognosis in this disease may have been biased by the presence of underlying cardiovascular diseases. Read More

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Optimal surgeon and hospital volume thresholds to reduce mortality and length of stay for CABG.

PLoS One 2021 14;16(4):e0249750. Epub 2021 Apr 14.

Institute of Health Policy and Management, National Taiwan University, Taipei, Taiwan.

Objective: We used nationwide population-based data to identify optimal hospital and surgeon volume thresholds and to discover the effects of these volume thresholds on operative mortality and length of stay (LOS) for coronary artery bypass surgery (CABG).

Design: Retrospective cohort study.

Setting: General acute care hospitals throughout Taiwan. Read More

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Surgical outcome and prognostic factors in epilepsy patients with MR-negative focal cortical dysplasia.

PLoS One 2021 14;16(4):e0249929. Epub 2021 Apr 14.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: Focal cortical dysplasia (FCD) represents a heterogeneous group of disorders of the cortical formation and is one of the most common causes of epilepsy. Magnetic resonance imaging (MRI) is the modality of choice for detecting structural lesions, and the surgical prognosis in patients with MR lesions is favorable. However, the surgical prognosis of patients with MR-negative FCD is unknown. Read More

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Chimeric Latissimus Dorsi Flap in One-Stage Reconstruction of Depressor Muscle Dysfunction and Depression Deformity in the Perimandibular Area.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, The University of Tokyo Department of Plastic and Reconstructive Surgery, Graduate School of Science, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Depression deformity and paralysis of depressor muscles (DMs) may occur following tumor resection in the perimandibular region. Obtaining satisfactory results is challenging. The authors report 3 cases of 1-stage reconstruction by transferring neurovascular chimeric latissimus dorsi (LD) musculo-adipose flaps, with satisfactory results. Read More

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Use of Dorsal Nasal Flap in Combination With Nasolabial Perforator Propeller Flap for Reconstruction of Nasal Skin Defects of Medium to Large Size; A Simpler Alternative to Frontal Flap.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Plastic, Reconstructive and Aesthethic Surgery, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine Department of Plastic, Reconstructive and Aesthethic Surgery, University of Health Sciences, Bakirköy Sadi Konuk Education and Research Hospital Department of Plastic, Reconstructive and Aesthethic Surgery, Memorial Atasehir Hospital, Istanbul Department of Plastic, Reconstructive and Aesthethic Surgery, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir Department of Plastic, Reconstructive and Aesthethic Surgery, Kirsehir Education and Research Hospital, Kirsehir.

Abstract: Nasal reconstruction is one of the most challenging procedures in plastic surgery. To get optimal aesthetic and functional results, the surgeon should know all the options well. Forehead flap is the gold standard technique for closure of medium to large defects of the nose. Read More

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Resection of Anterior and Lateral Muscle Compartments Does Not Preclude Limb Salvage and Functions.

Adv Skin Wound Care 2021 May;34(5):268-272

In the Department of Surgery at the University of Maryland Medical Center, Baltimore, Maryland, Eleanor Dunlap, ACNP-BC, is Senior Nurse Practitioner; Suzanna Fitzpatrick, DNP, ACNP, FNP, is Senior Nurse Practitioner; Felecia Jinwala, MD, is Vascular Surgery Fellow; Charles Drucker, MD, is General Surgery Resident; and Khanjan Nagarsheth, MD, MBA, RPVI, is Attending Physician. Willie Lang, MD, is General Surgery Resident, Sinai Hospital of Baltimore, Maryland. The authors have disclosed no financial relationships related to this article. Submitted June 15, 2020; accepted in revised form September 25, 2020.

Background: Fasciotomy with resection of nonviable muscle is often necessary when there is a delay in compartment syndrome (CS) diagnosis after revascularization. The reported rate of major amputation following missed CS or delayed fasciotomy ranges from 12% to 35%. Herein, the authors present a series of critically ill patients who experienced delayed CS diagnosis and required complete resection of the anterior and/or lateral compartments but still achieved limb salvage and function. Read More

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Herpes Zoster (Shingles) Patient-Centered Wound Outcomes: A Literature Review.

Adv Skin Wound Care 2021 May;34(5):239-248

General Purpose: To present a comprehensive review of patient-centered outcomes of topical or systemic interventions applied to those with shingles or postherpetic neuralgia to inform clinical practice and identify related research needs.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will be able to:1. Read More

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