43,577 results match your criteria cases fever

Olfactory dysfunction in SARS-CoV-2 infection: Focus on odorant specificity and chronic persistence.

Am J Otolaryngol 2021 Apr 13;42(5):103014. Epub 2021 Apr 13.

Department of Physics and Chemistry of Materials, Faculty of Medicine/Dental Medicine, Danube Private University, Krems, Austria; Institute of Chemical Technology of Inorganic Materials, Johannes Kepler University Linz, Linz, Austria.

Background: Smell dysfunction has been recognized as an early symptom of SARS-CoV-2 infection, often occurring before the onset of core symptoms of the respiratory tract, fever or muscle pain. In most cases, olfactory dysfunction is accompanied by reduced sense of taste, is partial (microsmia) and seems to normalize after several weeks, however, especially in cases of virus-induced complete smell loss (anosmia), there are indications of persisting deficits even 2 months after recovery from the acute disease, pointing towards the possibility of chronic or even permanent smell reduction for a significant part of the patient population. To date, we have no knowledge on the specificity of anosmia towards specific odorants or chemicals and about the longer-term timeline of its persistence or reversal. Read More

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Experience of Resources Management on COVID-19 Epidemic at a Tertiary Medical Center in Northern Taiwan.

J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.

Department of Nursing, Taipei Veterans General Hospital, Taiwan, ROC Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Emergency Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.

Background: Coronavirus disease (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes infection symptoms including fever, cough, respiratory and gastrointestinal symptoms, and even loss of smell/taste, so far had caused 489,000 people to be infected with 32,000 deaths. This article aims to develop some strategies in dealing with COVID-19 epidemic to prevent nosocomial infection and ensure the safety of health care workforce and employees.

Methods: This is a prospectively registered and retrospective descriptive study investigating the clinical characteristics, results of diagnostic tests, and patients' disposition from February 1, 2020, to April 30, 2020, at a tertiary medical center in Northern Taiwan. Read More

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Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia.

Clin Infect Dis 2021 Apr 19. Epub 2021 Apr 19.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Background: Standard testing fails to identify a pathogen in most patients with febrile neutropenia (FN). We evaluated the ability of the Karius microbial cell-free DNA (mcfDNA) sequencing Test (KT) to identify infectious etiologies of FN and its impact on antimicrobial management.

Methods: This prospective study (ClinicalTrials. Read More

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Clinical features of hypertensive patients with COVID-19 compared with a normotensive group: Single-center experience in China.

Open Med (Wars) 2021 3;16(1):367-374. Epub 2021 Mar 3.

Department of Cardiovascular, Changshou people's Hospital, Chongqing 401220, China.

Background: SARS-CoV-2 has spread worldwide and poses a great threat to human health. Among COVID-19 patients, those with hypertension have been reported to have higher morbidity and mortality. This study was conducted to provide the international community with a deeper understanding of COVID-19 with hypertension. Read More

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Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.

Neurobiol Stress 2021 Apr 13:100326. Epub 2021 Apr 13.

Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, USA.

COVID-19, the infectious disease caused by the most recently discovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global pandemic. It dramatically affects people's health and daily life. Neurological complications are increasingly documented for patients with COVID-19. Read More

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Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report.

World J Clin Cases 2021 Apr;9(10):2344-2351

Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China.

Background: Granulomatosis with polyangiitis is a necrotizing inflammation of small and medium-sized vessels accompanied by formation of granuloma, involvement of primary granulomatous upper and lower respiratory tracts, glomerulonephritis, and vasculitis of small vessels.

Case Summary: Herein, we described a case of a 52-year-old man admitted with pulmonary nodules and high fever. Autoantibody workup revealed that the patient was positive for c-anti-neutrophil cytoplasmic antibodies and proteinase-3 anti-neutrophil cytoplasmic antibodies. Read More

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Adult onset type 2 familial hemophagocytic lymphohistiocytosis with c.65delC/c.163C>T compound heterozygous mutations: A case report.

World J Clin Cases 2021 Apr;9(10):2289-2295

Department of Hematology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225000, Jiangsu Province, China.

Background: Familial hemophagocytic lymphohistiocytosis (FHL) is a primary immunodefici-ency disease caused by gene defects. The onset of FHL in adolescents and adults may lead clinicians to ignore or even misdiagnose the disease. To the best of our knowledge, this is the first report to detail the clinical features of type 2 FHL (FHL2) with compound heterozygous perforin () defects involving the c. Read More

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Recurrent undifferentiated embryonal sarcoma of the liver in adult patient treated by pembrolizumab: A case report.

World J Clin Cases 2021 Apr;9(10):2281-2288

Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Background: Undifferentiated embryonal sarcoma of the liver (UESL) is a neoplasm that rarely develops in adults. The main treatments for UESL are upfront gross total surgical resection and adjuvant multiagent chemotherapy. Here, we report a case of recurrent UESL in an adult treated with pembrolizumab and discuss a method to identify proper candidates for antibody of programmed cell death protein 1 (anti-PD-1) treatment. Read More

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Prevalence and Recovery from Newly Onset Anosmia and Ageusia in Covid 19 Patients at our Teritary Care Centre.

Indian J Otolaryngol Head Neck Surg 2021 Apr 10:1-8. Epub 2021 Apr 10.

Department of ENT, Vilasrao Deshmukh Government Institute of Medical Sciences, Latur, Maharashtra India.

Anosmia (loss of smell) and Ageusia (loss of taste) are newly presenting independent symptoms in association with multiple symptoms such as Fever, Dry cough and Breathlessness in COVID 19 Patients.The Study of aims is to estimate Prevalence of Anosmia & Ageusia in Confirmed Covid 19 cases and to assess their Recovery rates. A Study conducted between June 2020 and September 2020 at a tertiary care COVID Dedicated hospital. Read More

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Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children.

Case Rep Pediatr 2021 2;2021:6618346. Epub 2021 Apr 2.

Department of Paediatrics, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Kawasaki disease (KD) is a global disease in children. The etiology and pathogenesis are unknown. Complications vary among patients. Read More

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Twice Negative PCR in a Patient With Herpes Simplex Virus Type 1 (HSV-1) Encephalitis.

Neurohospitalist 2021 Jan 22;11(1):66-70. Epub 2020 Jul 22.

Division of Neurology, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alberta, Canada.

Untreated herpes simplex virus type 1 (HSV-1) encephalitis is associated with high mortality. Missed cases can have devastating consequences. Detection of HSV-1 in cerebrospinal fluid (CSF) with polymerase chain reaction (PCR) is reported to have high sensitivity and specificity and is considered the diagnostic gold standard for HSV-1 encephalitis. Read More

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January 2021

Field Deployment of a Mobile Biosafety Laboratory Reveals the Co-Circulation of Dengue Viruses Serotype 1 and Serotype 2 in Louga City, Senegal, 2017.

J Trop Med 2021 31;2021:8817987. Epub 2021 Mar 31.

Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.

Dengue virus (DENV) is the most prevalent arboviral threat worldwide. This virus belonging to genus , family, is responsible for a wide spectrum of clinical manifestations, ranging from asymptomatic or mild febrile illness (dengue fever) to life-threatening infections (severe dengue). Many sporadic cases and outbreaks have occurred in Senegal since 1970. Read More

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ATP1A3-Related Disorders: An Ever-Expanding Clinical Spectrum.

Front Neurol 2021 1;12:637890. Epub 2021 Apr 1.

Department of Neurology and Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.

The Na+/K+ ATPases are Sodium-Potassium exchanging pumps, with a heteromeric α-β-γ protein complex. The α3 isoform is required as a rescue pump, after repeated action potentials, with a distribution predominantly in neurons of the central nervous system. This isoform is encoded by the ATP1A3 gene. Read More

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Performance of HScore in Reactive Hemophagocytic Lymphohistiocytosis.

Indian J Hematol Blood Transfus 2021 Apr 10;37(2):256-263. Epub 2020 Sep 10.

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.

Hemophagocytic lymphohistiocytosis (HLH) is a life threatening systemic hyperinflammatory disorder that leads to multiple organ damage. The most widely used diagnostic guidelines are the HLH 2004 guidelines proposed by the Histiocyte society. Recently, Fardet et al. Read More

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Bacterial meningitis after dental extraction in a 17-year-old horse.

Can Vet J 2021 Apr;62(4):403-407

William R. Pritchard Veterinary Medical Teaching Hospital (Arndt, Heney, Wong), Department of Surgical and Radiological Sciences (Kilcoyne), Department of Medicine and Epidemiology (Magdesian), School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA.

Dental extractions in horses may result in bacteremia, which can lead to systemic complications. Bacterial meningitis following oral cheek tooth extractions in a 17-year-old Thoroughbred gelding is described in this report. The bacterial meningitis was confirmed by histopathology. Read More

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[A case of tick-borne encephalitis without any sequelae].

Rinsho Shinkeigaku 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

A 43-year-old woman with a history of tick bite in the mountains in Hokkaido presented with a fever of 39°C, headache, and nausea. Cerebrospinal fluid findings indicated meningitis. On day 3 after admission, she presented with restlessness, disturbance of consciousness, and ataxic breathing, indicative of encephalitis. Read More

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Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial.

Phytomedicine 2021 May 16;85:153242. Epub 2020 May 16.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong province, 510120 PR China. Electronic address:

Background: Coronavirus disease 2019 (Covid-19) has resulted in a global outbreak. Few existing targeted medications are available. Lianhuaqingwen (LH) capsule, a repurposed marketed Chinese herb product, has been proven effective for influenza. Read More

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Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years: a case report.

J Med Case Rep 2021 Apr 19;15(1):179. Epub 2021 Apr 19.

Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Beijing Road 4, Yunyan District, Guiyang, China.

Background: Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi's sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Read More

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The Demographic Analysis of the Probable COVID-19 Cases in Terms of RT-PCR Results and Age.

Clin Lab 2021 Apr;67(4)

Background: Despite global prevention and quarantine efforts, the incidence of COVID-19 disease continues to increase. As a possible cause, our aim was to investigate which parameters increase the sensitivity or protection against COVID-19 between RT-PCR positive and RT-PCR negative cases in patients admitted to the emergency department.

Methods: In the pandemic process, patients admitted to the hospital with suspicion of COVID-19 were evaluated retrospectively. Read More

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Clinical Characteristics, Serological and Radiological Longitudinal Changes of Patients with COVID-19.

Clin Lab 2021 Apr;67(4)

Background: Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) began in Wuhan and rapidly spread globally. The speed and scope of the spread of COVID-19 makes it urgent to define clinical characteristics, serological and radiological changes of the affected patients.

Methods: Seven patients with laboratory-confirmed COVID-19 who were admitted to the Third Affiliated Hospital of Sun Yat-Sen University Yuedong Hospital from January 2020 to March 2020 were retrospectively enrolled and their clinical features, serological and radiological longitudinal changes were analyzed. Read More

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Epidemiology of 631 Cases of COVID-19 Identified in Jiangsu Province Between January 1st and March 20th 2020: Factors Associated with Disease Severity and Analysis of Zero Mortality.

Med Sci Monit 2021 Apr 17;27:e929986. Epub 2021 Apr 17.

Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China (mainland).

BACKGROUND This retrospective study aimed to investigate the factors associated with disease severity and patient outcomes in 631 patients with COVID-19 who were reported to the Jiangsu Commission of Health between January 1 and March 20, 2020. MATERIAL AND METHODS We conducted an epidemiological investigation enrolling 631 patients with laboratory-confirmed COVID-19 from our clinic from January to March 2020. Patients' information was collected through a standard questionnaire. Read More

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Clinical features and outcomes of neonatal dengue at the Children's Hospital 1, Ho Chi Minh, Vietnam.

J Clin Virol 2021 Feb 9;138:104758. Epub 2021 Feb 9.

School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan; Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address:

Objectives Neonatal dengue has been reported in the literature with contradictory findings of clinical characteristics and diagnosis; thereby, misdiagnosis of neonatal dengue has been frequently reported. We aim to delve into the epidemiology, clinical features, and outcomes of neonatal dengue, thus avoid misdiagnosis and obtain early intervention. Study design A retrospective study was conducted at Children's Hospital 1, Ho Chi Minh, Vietnam with laboratory-confirmed dengue in neonates by positive viral antigen nonstructural protein one rapid test (NS1) and positive IgM antibody for dengue by MAC-ELISA. Read More

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February 2021

Imported scrub typhus in Europe: report of three cases and a literature review.

Travel Med Infect Dis 2021 Apr 13:102062. Epub 2021 Apr 13.

Department of Infectious/Tropical Diseases and Microbiology (DITM), IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy. Electronic address:

Background: Scrub typhus is a vector-borne rickettsial infection, which can cause relevant morbidity and mortality. While the number of cases is around a million per year globally, the infection is seldom diagnosed in travellers from Europe.

Methods: We herein report three cases diagnosed in Italian travellers and review the literature about imported cases in Europe in the last 60 years. Read More

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[Acute perforated appendicitis with pre-surgical diagnosis and bilateral inguinal hernia in preterm infants].

Rev Chil Pediatr 2020 Dec 21;91(6):936-940. Epub 2020 Oct 21.

Clínica Las Condes, Santiago, Chile.

Introduction: Acute neonatal appendicitis is a rare pathology, with few reports in the last 30 years. Since its clinical presentation and imaging studies are non-specific, most cases are diagnosed during a surgical pro cedure.

Objective: To describe a neonatal case of acute perforated appendicitis associated with later appearance of inguinal hernia, with pre-surgical diagnosis and treated through laparoscopy. Read More

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December 2020

Enhanced passive surveillance dengue infection among febrile children: Prevalence, co-infections and associated factors in Cameroon.

PLoS Negl Trop Dis 2021 Apr 16;15(4):e0009316. Epub 2021 Apr 16.

"Chantal Biya" International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.

Dengue virus (DENV) causes a spectrum of diseases ranging from asymptomatic, mild febrile to a life-threatening illness: dengue hemorrhagic fever. The main clinical symptom of dengue is fever, similar to that of malaria. The prevalence of dengue virus infection, alone or in association with other endemic infectious diseases in children in Cameroon is unknown. Read More

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Leptospirosis and Rickettsial Diseases Sero-Conversion Surveillance Among U.S. Military Personnel in Honduras.

Mil Med 2021 Apr 16. Epub 2021 Apr 16.

Viral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.

Introduction: Leptospirosis and rickettsial diseases are global zoonotic diseases. In severe infection cases, mortality can range from 10% to 30%. Currently most epidemiological data available are based on outbreak investigations and hospital-based studies from endemic countries. Read More

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Seasonal dynamics of Amblyomma sculptum in two areas of the Cerrado biome midwestern Brazil, where human cases of rickettsiosis have been reported.

Exp Appl Acarol 2021 Apr 16. Epub 2021 Apr 16.

Post-graduation Program in Animal Science, Federal University of Goiás (UFG), Avenida Esperança, s/n, Campus Samambaia74.690-900, Goiânia, Goiás, Brazil.

Amblyomma sculptum is a common human-biting tick in Brazil, where it plays an important role as a vector of Rickettsia rickettsii, the agent of the Brazilian spotted fever. Herein, we studied the seasonal dynamics of A. sculptum in an urban area of the Cerrado biome in midwestern Brazil, where human rickettsiosis is endemic. Read More

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The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trial.

Phytother Res 2021 Apr 15. Epub 2021 Apr 15.

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.

The outbreak of Coronavirus disease 2019 (COVID-19) has caused a global health crisis. Nevertheless, no antiviral treatment has yet been proven effective for treating COVID-19 and symptomatic supportive cares have been the most common treatment. Therefore, the present study was designed to evaluate the effects of propolis and Hyoscyamus niger L. Read More

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Positive Therapeutic Role of Selected Foods and Plant on Ailments with a Trend Towards COVID-19: A Review.

Prev Nutr Food Sci 2021 Mar;26(1):1-11

Department of Food Science and Technology, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.

Each day since December 2019, increasing numbers of cases of the novel coronavirus 2019 (COVID-19) infection are being detected as it spreads throughout all continents of the world except Antarctica. The virus is transmitted through contact with an infected environment or person, and the symptoms include fever, cough, and difficulty breathing. The healthcare systems of many countries are overwhelmed due to limited therapeutic options and the absence of an approved vaccine. Read More

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Tyrosinemia type 1 in pediatric nephrology: Not always straightforward.

Arch Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Centre de Référence des Maladies Rénales Rares, Filières de santé maladies rares ORKID et ERK-Net, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Faculté de Médecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France; INSERM, UMR 1033, Faculté de Medecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

The main clinical features of tyrosinemia type 1 usually appear in the first months of life, including fever, diarrhea, vomiting, liver involvement, growth failure, and renal proximal tubulopathy with subsequent hypophosphatemic rickets. An early diagnosis is crucial in order to provide specific management and to prevent complications. Here, we report on two cases referred primarily to pediatric nephrologists for the diagnosis of "neonatal tubulopathy" and management of "X-linked hypophosphatemia (XLH)," respectively. Read More

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