165,590 results match your criteria cases evaluated

Cemented versus screw-retained posterior implant-supported single crowns: a 24- month randomized controlled clinical trial.

Clin Oral Implants Res 2021 Sep 21. Epub 2021 Sep 21.

Department of Prosthodontics and Biomaterials, RWTH University Hospital, Pauwelsstrasse 30, D-52074, Aachen, Germany.

Objectives: To compare the incidence of biological and technical complications of cemented and screw-retained monolithic lithium disilicate implant-supported posterior single crowns.

Material And Methods: Forty-one subjects with a total of 56 implants received randomly allocated 28 cemented and 28 screw-retained crowns. In the screw-retained group monolithic lithium disilicate restorations were luted to titanium bases extraorally. Read More

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September 2021

A Clinical Prediction Tool for MRI in Emergency Department Patients with Spinal Infection.

West J Emerg Med 2021 Aug 30;22(5):1156-1166. Epub 2021 Aug 30.

Massachusetts General Hospital, Department of Radiology, Boston, Massachusetts.

Introduction: Patients with pyogenic spinal Infection (PSI) are often not diagnosed at their initial presentation, and diagnostic delay is associated with increased morbidity and medical-legal risk. We derived a decision tool to estimate the risk of spinal infection and inform magnetic resonance imaging (MRI) decisions.

Methods: We conducted a two-part prospective observational cohort study that collected variables from spine pain patients over a six-year derivation phase. Read More

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Assess predictive values of a binary diagnostic test under a nested case-control design.

Yougui Wu

J Biopharm Stat 2021 Sep 21:1-11. Epub 2021 Sep 21.

Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, Florida, USA.

Predictive values of a binary diagnostic test are often evaluated under a random sample design. When the disease is rare, however, such a design might not be as efficient as a nested case-control design where the cases are oversampled from a large existing cohort. Under a nested case-control design, direct proportion estimators of predictive values are biased because cases are oversampled. Read More

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September 2021

Posterior reversible leukoencephalopathy syndrome associated with acute postinfectious glomerulonephritis: systematic review.

Pediatr Nephrol 2021 Sep 21. Epub 2021 Sep 21.

Imaging Institute of Southern Switzerland EOC, Bellinzona, Switzerland.

Background: Kidney diseases are a recognized cause of posterior reversible leukoencephalopathy syndrome, usually abbreviated as PRES. The purpose of this review was to systematically address the association between acute postinfectious glomerulonephritis and PRES.

Methods: We performed a systematic review of the literature on acute postinfectious glomerulonephritis associated with PRES. Read More

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September 2021

Diabetes Status and Association With Risk of Tuberculosis Among Korean Adults.

JAMA Netw Open 2021 Sep 1;4(9):e2126099. Epub 2021 Sep 1.

Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.

Importance: The risk of tuberculosis (TB) associated with diabetes status, considering impaired fasting glucose or duration of diabetes, has not been well established.

Objective: To evaluate the association of diabetes status with the development of TB in the general population.

Design, Setting, And Participants: This population-based cohort study used data from the Korean National Health Insurance System database. Read More

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September 2021

Gastrointestinal Cancer Stage at Diagnosis Before and During the COVID-19 Pandemic in Japan.

JAMA Netw Open 2021 Sep 1;4(9):e2126334. Epub 2021 Sep 1.

Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan.

Importance: The COVID-19 pandemic has delayed medical consultations, possibly leading to the diagnosis of gastrointestinal cancer at advanced stages.

Objective: To evaluate stage at diagnosis among patients with gastrointestinal cancer in Japan before and during the COVID-19 pandemic.

Design, Setting, And Participants: This retrospective cohort study included patients in a hospital-based cancer registry who were diagnosed with gastrointestinal cancer (ie, esophageal, gastric, colorectal, pancreatic, liver, and biliary tract cancers) between January 2016 and December 2020 at 2 tertiary Japanese hospitals. Read More

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September 2021

Incidence, Predictor, and Clinical Outcomes of Multiple Resheathing With Self-Expanding Valves During Transcatheter Aortic Valve Replacement.

J Am Heart Assoc 2021 Sep 3;10(18):e020682. Epub 2021 Sep 3.

Instituto do Coração Hospital das Clinicas HCFMUSP Faculdade de MedicinaUniversidade de Sao Paulo Sao Paulo Brazil.

Background No study has evaluated the impact of the additional manipulation demanded by multiple resheathing (MR) in patients undergoing transcatheter aortic valve replacement with repositionable self-expanding valves. Methods and Results This study included a real-world, multicenter registry involving 16 centers from Canada, Germany, Latin America, and Spain. All consecutive patients who underwent transcatheter aortic valve replacement with the Evolut R, Evolut PRO, and Portico valves were included. Read More

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September 2021

Mucin Neovascularization as a Diagnostic Aid to Distinguish Mucinous Carcinomas From Mucocele-like Lesions in Breast Core Needle Biopsies.

Am J Surg Pathol 2021 Sep 21. Epub 2021 Sep 21.

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School Department of Pathology, Brigham and Women's Hospital and Harvard Medical School Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA.

The distinction between mucinous carcinomas (MCs) and mucocele-like lesions (MLLs), particularly those containing detached epithelial fragments, can be problematic in the limited samples afforded by breast core needle biopsies (CNBs). Neovascularization of mucin has been proposed as a criterion to distinguish MC from MLL, but its value in helping to categorize mucin-producing breast lesions in CNB has not been previously investigated. To address this, we evaluated mucin neovascularization on hematoxylin and eosin (H&E)-stained sections of 140 CNB containing mucin-producing breast lesions including 52 MC, 17 mucin-producing ductal carcinoma in situ (mDCIS), and 71 MLL. Read More

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September 2021

Predicting the Effect of Variants of Unknown Significance in Molecular Tumor Boards with the VUS-Predict Pipeline.

Stud Health Technol Inform 2021 Sep;283:209-216

Dept. of Medical Bioinformatics, University Medical Center Göttingen, Germany.

Precision oncology utilizing molecular biomarkers for targeted therapies is one of the hopes to treat cancer. The availability of patient specific molecular profiling through next-generation sequencing, though, increases the amount of available data per patient to an extent that computational support is required to identify potential driver alterations for targeted therapies and rational decision-making in molecular tumor boards (MTBs). For some genetic variants evidence-based drug recommendations are available in public databases, but for the majority, the variants of unknown significance (VUS), this clinical information is missing. Read More

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September 2021

Do or Donut: A Systematic Review and Pooled Analysis on the Utility of Anastomotic Donut Pathological Evaluation in Oncological Colorectal Operations.

Colorectal Dis 2021 Sep 21. Epub 2021 Sep 21.

Division of Colorectal Surgery, Keck School of Medicine, Los Angeles, CA, USA.

Aim: End-to-end anastomosis staplers are frequently used in colorectal surgery, generating two anastomotic donuts. Whether pathological donut evaluation changes clinical practice remains unclear. We aim to identify effects of pathological evaluation of anastomotic donuts post-oncological colorectal surgery. Read More

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September 2021

Neurological Manifestations Associated with Parvovirus B19 Infection in Immunocompetent Children: Case Series and Systematic Review.

J Trop Pediatr 2021 Aug;67(4)

Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Amazonas 69040-000, Brazil.

An increasing number of reports have described human parvovirus B19 infection in association with a variety of neurological manifestations, especially in children. This study assessed the clinical and laboratory outcomes found in a case series of immunocompetent children who tested positive for parvovirus B19 by qualitative polymerase chain reaction assays of cerebrospinal fluid, in a tertiary referral center in the western Brazilian Amazon. We screened 178 children with clinically diagnosed central nervous system infections (meningoencephalitis). Read More

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Uterocutaneous Fistula after a C-Section in a Patient with Second Trimester Fetal Demise and Chorioamnionitis.

Case Rep Obstet Gynecol 2021 10;2021:3255188. Epub 2021 Sep 10.

Department of Obstetrics and Gynecology, Sion's Hospital, Valais, Switzerland.

Uterocutaneous fistulae are very rare entities with only about 120 cases reported in the literature. They are mostly described after a C-section or other pelvic surgery. We hereby describe a uterocutaneous fistula in a 41-year-old patient 5 months after a C-section because of a chorioamnionitis and a 22-week fetal demise. Read More

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September 2021

Paroxysmal Sympathetic Hyperactivity in Moderate-to-Severe Traumatic Brain Injury and the Role of Beta-Blockers: A Scoping Review.

Emerg Med Int 2021 11;2021:5589239. Epub 2021 Sep 11.

Research Department, Association of Future African Neurosurgeons, Yaounde, Cameroon.

Introduction: Most cases of paroxysmal sympathetic hyperactivity (PSH) result from traumatic brain injury (TBI). Little is known about its pathophysiology and treatment, and several neuroprotective drugs are used including beta-blockers. The aim of our study is to collate existing evidence of the role of beta-blockers in the treatment of PSH. Read More

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September 2021

Clinical Symptoms and Types of Samples Are Critical Factors for the Molecular Diagnosis of Symptomatic COVID-19 Patients: A Systematic Literature Review.

Int J Microbiol 2021 6;2021:5528786. Epub 2021 Sep 6.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Currently, a novel coronavirus found in 2019 known as SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Various parameters including clinical manifestations and molecular evaluation can affect the accuracy of diagnosis. This review aims to discuss the various clinical symptoms and molecular evaluation results in COVID-19 patients, to point out the importance of onset symptoms, type, and timing of the sampling, besides the methods that are used for detection of SARS-CoV-2. Read More

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September 2021

How has COVID-19, lockdown and social distancing changed alcohol drinking patterns? A cross-cultural perspective between britons and spaniards.

Food Qual Prefer 2022 Jan 6;95:104344. Epub 2021 Aug 6.

Instituto de Ciencias de la Vid y del Vino (CSIC-GR-UR), Department of Oenology, Finca La Grajera, Ctra. de Burgos Km. 6 (LO-20 - salida 13), E-26007 Logroño, La Rioja, Spain.

During the early months of 2020, the world experienced a novel, violent, and relentless pandemic era. By the end of the year more than seventy-seven million cases of COVID-19 had been reported around the globe. Due to it being a highly contagious disease, the recommended measures adopted by most nations to prevent infection include social distancing and quarantine. Read More

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January 2022

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.

Mod Pathol 2021 Sep 20. Epub 2021 Sep 20.

Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III Paul Sabatier, INSERM, CRCT, 31330, Toulouse, France.

Immunohistochemistry (IHC) and/or MSI-PCR (microsatellite instability-polymerase chain reaction) tests are performed routinely to detect mismatch repair deficiency (MMR-D). Classical MMR-D tumors present a loss of MLH1/PMS2 or MSH2/MSH6 with MSI-High. Other profiles of MMR-D tumors have been described but have been rarely studied. Read More

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September 2021

Chronic Thromboembolic Pulmonary Hypertension Mimicking Acute Pulmonary Embolism: A Case Report.

Am J Case Rep 2021 Sep 21;22:e933031. Epub 2021 Sep 21.

Department of Internal Diseases, Riga Stradiņš University, Riga, Latvia.

BACKGROUND Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary hypertension which is often caused by recurrent emboli. The reported prevalence in Latvia is 15.7 cases per million inhabitants. Read More

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September 2021

Significant difference between coagulation parameters and clinicopathological characteristics in breast cancer.

Zhengwu Lei Dan Guo

Blood Coagul Fibrinolysis 2021 Sep 20. Epub 2021 Sep 20.

Health management center, Second Affiliated Hospital of Chongqing Medical University and Department of Breast Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The purpose of this research is to investigate the correlation between coagulation parameters and survival on patients with breast cancer. A total of 244 patients with breast cancer and 84 patients with metastatic advanced breast cancer admitted to the Second Affiliated Hospital of Chongqing Medical University from January 2017 to February 2019 were selected as the research objects. Their age, tumor size, status of estrogen receptor and progesterone receptor status, status of Her-2 receptor and lymph node were evaluated. Read More

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September 2021

Phenotype, genotype and long-term prognosis of 40 Chinese patients with isobutyryl-CoA dehydrogenase deficiency and a review of variant spectra in ACAD8.

Orphanet J Rare Dis 2021 Sep 20;16(1):392. Epub 2021 Sep 20.

Department of Genetic and Metabolic Disease, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.

Background: Isobutyryl-CoA dehydrogenase deficiency (IBDD) is a rare autosomal recessive metabolic disorder resulting from variants in ACAD8, and is poorly understood, as only dozens of cases have been reported previously. Based on a newborn screening program, we evaluated the incidence, phenotype and genotype of IBDD as well as the prognosis. Moreover, we reviewed the variant spectrum in ACAD8 associated with IBDD. Read More

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September 2021

The TEAM instrument for measuring emergency team performance: validation of the Swedish version at two emergency departments.

Scand J Trauma Resusc Emerg Med 2021 Sep 20;29(1):139. Epub 2021 Sep 20.

Department of Emergency Medicine, Capio S:t Göran's Hospital , 112 81, Stockholm, Sweden.

Background: The Team Emergency Assessment Measure (TEAM) questionnaire is designed for rating the non-technical performance of emergency medical teams during emergencies, e.g., resuscitation or trauma management. Read More

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September 2021

Use of tyrosine kinase inhibitors during pregnancy for oncogenic-driven advanced non-small cell lung carcinoma.

Lung Cancer 2021 Sep 11;161:68-75. Epub 2021 Sep 11.

Department of Pulmonology and Thoracic Oncology, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Tenon and GRC 04 Theranoscan, Sorbonne Université, Paris 75970, France. Electronic address:

Introduction: Lung cancer associated with pregnancy is rare but on the increase. The use of tyrosine kinase inhibitor (TKI) therapy for advanced oncogenic-driven non-small cell lung carcinoma (NSCLC) has improved overall survival. Oncological and obstetric outcomes of patients diagnosed with NSCLC and treated by TKIs during pregnancy have been poorly evaluated. Read More

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September 2021

Sensing of oxidative stress biomarkers: The cardioprotective effect of taurine & grape seed extract against the poisoning induced by an agricultural pesticide aluminum phosphide.

Chemosphere 2021 Sep 14;287(Pt 3):132245. Epub 2021 Sep 14.

School of Physics, University of Electronic Science and Technology of China, Chengdu, 610054, China.

Aluminum phosphide is a well-known hazardous agent used as an agricultural pesticide to protect stored grains from insect damage. However, accidental consumption of a trivial amount of it caused irreversible damage to the human body or even death in acute cases. The present study used taurine and grape seed extract as a natural cardioprotective medicine against aluminum phosphide poisoning by decreasing oxidative stress. Read More

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September 2021

Screening mammography mitigates breast cancer disparities through early detection of triple negative breast cancer.

Clin Imaging 2021 Aug 30;80:430-437. Epub 2021 Aug 30.

Weill Cornell Medicine, Department of Breast Surgery, 425 E. 61st St., 10th Floor, New York, NY 10065, USA. Electronic address:

Purpose: Screening mammography improves breast cancer survival through early detection, but Triple Negative Breast Cancer (TNBC) is more difficult to detect on mammography and has lower survival compared to non-TNBC, even when detected at early stages. TNBC is twice as common among African American (AA) compared to White American (WA) women, thereby contributing to the 40% higher breast cancer mortality rates observed in AA women. The role of screening mammography in addressing breast cancer disparities is therefore worthy of study. Read More

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Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2.

Int J Infect Dis 2021 Sep 17. Epub 2021 Sep 17.

ICMR-National Institute of Virology, Pune, Maharashtra, Pin 411021, India. Electronic address:

Objectives: Monitoring the antibody responses to SARS-CoV-2 infection and its correlation to clinical spectrum of disease is critical in understanding the disease progression and protection against re-infection. We assessed the nucleocapsid (N) and receptor-binding-domain of spike (SRBD) protein specific IgG and neutralizing antibody (NAb) responses in COVID-19 patients up to 8 months and its correlation with diverse disease spectrum.

Methods: During the first wave of SARS-CoV-2 pandemic, from 284 COVID-19 patients, 608 samples were collected up to 8 months post infection. Read More

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September 2021

Modifiable Risk Factors Increase Length of Stay and 90-Day Cost of Care After Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Sep 17. Epub 2021 Sep 17.

Background: Baseline health conditions can negatively impact cost of care and risk of complications after joint replacement, necessitating additional care and incurring higher costs. Bundled payments have been utilized for hip and knee replacement and CMS (Centers for Medicare and Medicaid Services) is testing bundled payments for upper extremity arthroplasty. The purpose of this study was to determine the impact of pre-defined modifiable risk factors (MRF) on total encounter charges, hospital length of stay (LOS), related emergency department (ED) visits and charges, and related hospital readmissions within 90 days after shoulder arthroplasty. Read More

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September 2021

Association between oral health, pneumonia and mortality in patients of intensive care.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):468-476

Fundación Universitaria Autónoma de las Américas, Facultad de Odontología. Pereira, Risaralda, Colombia.

IntroducciÓn: Los pacientes con ventilación mecánica corren riesgo de adquirir neumonía cuando la higiene bucodental es deficiente, a causa de la colonización bacteriana del tracto respiratorio. Se sugiere verificar esta asociación para implementar acciones de prevención.

Objetivo: Identificar la asociación entre el estado de salud bucal, la neumonía asociada a ventilador y la mortalidad en pacientes con ventilación mecánica en un hospital de tercer nivel de Pereira, Colombia. Read More

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January 2020

Investigating the Association between IL-27 and Susceptibility to Preeclampsia among Iranian Women.

Clin Lab 2021 Sep;67(9)

Background: Preeclampsia (PE) is one of the most serious disorders of human pregnancy with a high rate of mortality for the fetus and mother. Several etiological factors are involved in the onset of this disease. Upregulation of IL-27 has been reported in placental tissue recovered from preeclamptic women, but the role of IL-27 has not yet been investigated in PE. Read More

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September 2021

Magnetic resonance imaging of focal fibrocartilaginous dysplasia - findings derived from a three-dimensional gradient echo sequence.

Pediatr Radiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Radiology, Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, No. 31, Xinjiekou East St., Xicheng District, Beijing, 100035, China.

Background: Focal fibrocartilaginous dysplasia is a rare benign bone lesion of young children that causes deformities in the extremities. However, the pathogenesis and treatments have not been defined and the MR manifestations have been less well described.

Objective: To describe the MR manifestations of focal fibrocartilaginous dysplasia, especially on the T1-W three-dimensional (3-D) volumetric interpolated breath-hold examination (VIBE) sequence. Read More

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September 2021

Civil-Military Collaboration to Facilitate Rapid Deployment of a Mobile Laboratory in Early Response to COVID-19: A High-Readiness Exercise.

Health Secur 2021 Sep 20. Epub 2021 Sep 20.

Erik Salaneck, MD, PhD, is an Associate Professor, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, especially when faced with high-consequence pathogens. In this article, we describe a multiagency exercise including the rapid deployment and diagnostic adaptation of the Swedish Armed Forces mobile laboratory (biological field analysis laboratory) in the context of COVID-19. Read More

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September 2021