12,505 results match your criteria cases endometrial


Variables that prolong total operative time for robotic-assisted laparoscopic myomectomy: A 10-year tertiary hospital study in Korea.

Eur J Obstet Gynecol Reprod Biol 2021 May 4;262:62-67. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Study Objective: To identify factors that prolong total operative time (TOT) in robotic-assisted laparoscopic myomectomy (RALM).

Design: Retrospective cohort study.

Setting: Tertiary university hospital. Read More

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BAG2-Mediated Inhibition of CHIP Expression and Overexpression of MDM2 Contribute to the Initiation of Endometriosis by Modulating Estrogen Receptor Status.

Front Cell Dev Biol 2020 27;8:554190. Epub 2021 Apr 27.

Union Hospital, Tongji Medical College, Institute of Hematology, Huazhong University of Science and Technology, Wuhan, China.

Endometriosis is an estrogen-dependent gynecological disease primarily affecting women of childbearing age, which gives rise to pelvic pain calling for multiple operations, and sometimes leading to infertility. However, the etiology of endometriosis remains poorly understood. In this study we investigated the roles of two Ubiquitin E3 Ligases, namely hsc70-interacting protein (CHIP) and mouse double minute 2 (MDM2), in the abnormal estrogenic activity in endometriosis. Read More

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Endometrial Tumor Classification by Histomorphology and Biomarkers in the Nurses' Health Study.

J Cancer Epidemiol 2021 12;2021:8884364. Epub 2021 Mar 12.

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA 02115.

Objective: Endometrial cancers have historically been classified by histomorphologic appearance, which is subject to interobserver disagreement. As molecular and biomarker testing has become increasingly available, the prognostic significance and accuracy of histomorphologic diagnoses have been questioned. To address these issues for a large, prospective cohort study, we provide the results of a centralized pathology review and biomarker analysis of all incidental endometrial carcinomas occurring between 1976 and 2012 in the Nurses' Health Study. Read More

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Development of endometrial cancer after long-term usage of the levonorgestrel-releasing intrauterine system.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Pathology, Queen Elizabeth Hospital, London, London, UK.

A 52-year-old long-term user of the levonorgestrel-releasing intrauterine system (LNG-IUS) presented with vaginal bleeding. Endometrial biopsy was performed and revealed endometrioid adenocarcinoma. The patient had a laparoscopic hysterectomy and bilateral salpingo-oophorectomy. Read More

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The impact of race, comorbid conditions and obesity on survival endpoints in women with high grade endometrial carcinoma.

Gynecol Oncol 2021 May 10. Epub 2021 May 10.

Wayne State University School of Medicine, Department of Oncology, Detroit, MI, USA; Karmanos Cancer Institute, Population Studies and Disparities Research Program, Detroit, MI, USA. Electronic address:

Objective: To estimate overall survival, disease-specific survival, and progression-free survival among high grade endometrial carcinoma cases and to determine factors impacting survival for non-Hispanic white and non-Hispanic black women.

Methods: We identified high grade endometrial carcinoma cases among non-Hispanic white and non-Hispanic black women from ongoing institutional studies, and determined eligibility through medical record and pathologic review. We estimated effects of demographic and clinical variables on survival outcomes using Kaplan Meier methods and Cox proportional hazards modelling. Read More

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Emerging progress on diagnosis and treatment of female genital tuberculosis.

J Int Med Res 2021 May;49(5):3000605211014999

Department of Respiratory Medicine, Jingzhou Chest Hospital, Jingzhou, Hubei, China.

Female genital tuberculosis (FGTB) is an infection caused by and usually occurs secondary to pulmonary tuberculosis (TB) through the blood circulation, lymph circulation, or direct spreading from abdominal TB. FGTB is an uncommon type of TB that can destroy genital organs, and lead to menstrual disorders and infertility. The diagnosis of FGTB is often made by detection of acid-fast bacilli under microscopy, culture with endometrial biopsy, or histopathological examination of epithelioid granuloma on a biopsy. Read More

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Uterine artery pseudoaneurysm in pregnant women with previous pelvic endometriosis.

Minerva Obstet Gynecol 2021 May 12. Epub 2021 May 12.

Department of Obstetrics and Gynaecology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic.

Uterine artery pseudoaneurysm (UAP) is a rare complication during pregnancy that can cause serious consequences in both the pregnant woman and the fetus. Herein, we have described the cases of two pregnant women with UAP. Both patients had a history of laparoscopy for management of endometrioid ovarian cysts. Read More

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Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in and Molecular Analysis: Report of a Case and Review of the Literature.

J Kidney Cancer VHL 2021 21;8(2):8-19. Epub 2021 Apr 21.

Department of Pathology & Immunology.

Lynch syndrome (LS) is an autosomal dominant inherited disorder due to pathogenic variations in the mismatch repair genes, which predisposes to malignancies, most commonly colon and endometrial carcinoma. Muir-Torre syndrome is a subset of LS with cutaneous sebaceous adenoma and keratoacanthoma in addition to the malignancies. Renal cell carcinoma (RCC) in patients with LS is extremely rare. Read More

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Construction and validation of nomograms for predicting the prognosis of grade 3 endometrial endometrioid adenocarcinoma cancers: a SEER-based study.

Bioengineered 2021 Dec;12(1):1752-1765

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Most cases of endometrial adenocarcinoma (EAC) are diagnosed early and have a good prognosis; however, grade 3 (G3) EACs have poor outcomes. We retrospectively analyzed the data of 11,519 patients with G3 EACs registered between 2004 and 2015 in the Surveillance, Epidemiology, and End Results Program database and constructed a nomogram to guide clinicians in decision-making and accurate prediction of the prognosis. The caret package was used to divide samples into a training set and a validation set. Read More

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December 2021

Selective oestrogen receptor modulators (SERMs) for endometriosis.

Cochrane Database Syst Rev 2021 May 11;5:CD011169. Epub 2021 May 11.

Isala Hospitals Zwolle, Zwolle, Netherlands.

Background: Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. This chronic and recurring condition occurs in women of reproductive age. It is a common cause of pain or infertility and can cause non-specific symptoms such as lower back pain, dyspareunia (pain during or after intercourse), and dysmenorrhoea (menstrual pain). Read More

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Pan-cancer landscape of (PD-L1) copy number changes in 244 584 patient samples and the correlation with PD-L1 protein expression.

J Immunother Cancer 2021 May;9(5)

Foundation Medicine Inc, Cambridge, Massachusetts, USA.

Introduction: Several studies have shown clinical outcomes data that support the use of ) copy-number (CN) gains and/or losses as a biomarker for immune checkpoint inhibitor (ICPI). Here, we present the landscape of CN changes across a large cohort of solid tumor cases and correlate these with PD-L1 protein expression by immunohistochemistry.

Methods: We analyzed all cases that underwent comprehensive genomic profiling (CGP) testing at Foundation Medicine between August 2014 and June 2020. Read More

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Perioperative Recovery and Narcotic Use in Laparoscopic Versus Robotic Surgery for Endometrial Cancer.

J Minim Invasive Gynecol 2021 May 6. Epub 2021 May 6.

Levine Cancer Institute, Atrium Health System, Charlotte, NC.

Study Objective: To compare intra-operative and peri-operative narcotic use, recovery room time, and total hospital stay for patients treated with robotic versus laparoscopic surgery for endometrial cancer.

Design: Retrospective cohort SETTING: Teaching hospital PATIENTS: All patients having minimally invasive surgery in the division of gynecologic oncology during a 20-month period.

Intervention: Laparoscopic cases were compared to robotic assisted cases with respect to peri-operative outcome MEASUREMENT & MAIN RESULTS: Hospital billing records were used to identify all patients with endometrial cancer treated from 1/1/2018 through 7/31/2019 undergoing either laparoscopic or robotic surgery. Read More

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Umbilical Endometriosis Disguised by Seborrheic Keratosis on Punch Biopsy.

Am J Dermatopathol 2021 May 5. Epub 2021 May 5.

Department of Plastic Surgery, Copenhagen University Hospital, Herlev-Gentofte Hospital, Herlev, Denmark; and Department of Pathology, Copenhagen University Hospital, Herlev-Gentofte Hospital, Herlev, Denmark.

Abstract: Endometriosis is a benign condition of the female genital system, characterized by endometrial tissue external to the uterine cavity. Of all cases with endometriosis, the incidence of umbilical endometriosis is only 0.29%. Read More

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Primary cytoreductive surgery for advanced stage endometrial cancer: A systematic review and meta-analysis.

Am J Obstet Gynecol 2021 May 3. Epub 2021 May 3.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Objective: Endometrial cancer uncommonly presents at an advanced stage, and little prospective evidence exists to guide management. We aimed to summarize evidence on primary cytoreductive surgery (PCS) in the treatment of advanced stage endometrial cancer.

Data Sources: MEDLINE, Embase, and Scopus databases were searched from inception to September 11, 2020, using search terms representing the themes "endometrial cancer," "advanced stage," and "primary cytoreductive surgery". Read More

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The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management.

Fam Cancer 2021 May 5. Epub 2021 May 5.

Polyposis Registry, St Mark's Hospital, Harrow, London, HA1 3UJ, UK.

Pathogenic germline exonuclease domain (ED) variants of POLE and POLD1 cause the Mendelian dominant condition polymerase proof-reading associated polyposis (PPAP). We aimed to describe the clinical features of all PPAP patients with probably pathogenic variants. We identified patients with a variants mapping to the EDs of POLE or POLD1 from cancer genetics clinics, a colorectal cancer (CRC) clinical trial, and systematic review of the literature. Read More

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Vaginal mucositis related to immunotherapy in endometrial cancer.

Gynecol Oncol Rep 2021 May 31;36:100742. Epub 2021 Mar 31.

Rutgers Cancer Institute of New Jersey, United States.

Immunotherapy, specifically immune checkpoint inhibitors (ICPi), has revolutionized our approach to treating all solid tumors, including gynecologic malignancies. Compared to standard chemotherapy, the adverse events associated with immunotherapies, are often mild and localized, although more severe systemic responses can also occur. While dermatitisdermatitis is a most commonly reported side effect of ICPi therapy, cutaneous toxicities have a range of clinical manifestations and can provide a challenge in an otherwise favorable treatment protocol. Read More

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Resectoscopic Surgery Part I: Overcoming Obstacles and Mastering the Basics.

Authors:
Morris Wortman

Surg Technol Int 2021 05 4;38. Epub 2021 May 4.

Clinical Associate Professor of Gynecology, University of Rochester Medical Center, Rochester, New York.

The introduction of the continuous flow gynecologic resectoscope (CFGR) in 1989 revolutionized minimally invasive gynecologic surgery (MIGS) by introducing such intrauterine procedures as hysteroscopic myomectomy, polypectomy, and endometrial ablation. However, with the subsequent introduction of global endometrial ablation (GEA) devices and hysteroscopic morcellators (HMs), the CFGR has fallen into relative disuse-a regrettable situation since it remains ideally suited for accomplishing many procedures that are otherwise not achievable with these newer technologies. Procedures which involve greater precision and control-endomyometrial resection (EMR), hysteroscopic metroplasty, the correction of isthmoceles, the resection of intramural myomas, and the management of late-onset endometrial ablation failure-are only possible with the CFGR. Read More

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Ovarian endometrioid carcinoma and clear cell carcinoma: A 21-year retrospective study.

J Ovarian Res 2021 May 4;14(1):63. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Center of Gynecologic Oncology, Peking University People's Hospital, No. 11, South Avenue, Xi Zhi Men, Xicheng District, Beijing, 100044, China.

Objective: This study aimed to identify the clinical characteristics of Chinese patients with ovarian endometrioid carcinoma (EC) and clear cell carcinoma (CCC) and to assess the impact of concurrent endometriosis on this group.

Methods: The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of EC or CCC at our center in China between 1998 and 2018.

Results: Of 211 patients, 73 had pure EC, and 91 had pure CCC, and the remaining 47 had mixed cancer. Read More

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"Add-Ons" for Assisted Reproductive Technology: Do Patients Get Honest Information from Fertility Clinics' Websites?

Reprod Sci 2021 Apr 30. Epub 2021 Apr 30.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

"Add-on" procedures are actively promoted on some fertility clinic websites as proven means to improve IVF success rates, especially for couples with repeated implantation/IVF failures. However, the actual contribution of these interventions to live birth rates remains inconclusive. At present, little is known about the type and quality of the information provided on the IVF clinics' websites regarding the merits of "add-ons. Read More

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Avoiding Full Lymphadenectomies in Intermediate- and High-Risk Endometrial Cancer by Sentinel Lymph Node Biopsy Implementation.

Front Oncol 2021 15;11:654285. Epub 2021 Apr 15.

Gynecological Oncology Unit, La Paz University Hospital, Madrid, Spain.

Objective: To evaluate the role of sentinel lymph node biopsy (SLNB) to avoid staging lymphadenectomies by detecting nodal metastasis in intermediate- and high-risk endometrial cancer (EC).

Methods: A single institutional retrospective study was performed including all patients with intermediate- and high-risk EC who underwent surgical nodal staging between January 2012 and December 2019. Patients with disseminated disease detected on imaging techniques or at the time of surgery were excluded. Read More

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First-stage clear-cell endometrial carcinoma with paraaortic lymph node recurrence: a case report.

Prz Menopauzalny 2021 Apr 12;20(1):57-60. Epub 2021 Apr 12.

Medical University of Pleven, Bulgaria.

Introduction: Endometrial cancer (EC) is the sixth most common malignancy in women worldwide; in developed countries this oncological entity climbs to fourth place. In 2012 worldwide 319 600 new cases were registered and about 1/3 of those were diagnosed in Europe, i.e. Read More

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Pathological processes and pretreatment cytologic diagnosis of neuroendocrine carcinoma of the endometrium: addendum report of the Kansai Clinical Oncology Group/Intergroup study in Japan.

Med Mol Morphol 2021 May 2. Epub 2021 May 2.

Division of Pathology, Shikoku Cancer Center, Matsuyama-shi, Ehime, Japan.

A previous retrospective study of a neuroendocrine carcinoma of the endometrium including 42 cases employed a central pathologic review to ensure the reliability of the findings. However, the pathological processes were not described in detail. In this study, we further analyzed these processes and the results of pretreatment endometrial cytology of neuroendocrine carcinoma. Read More

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Grossly Unremarkable Cervix in Endometrial Carcinomas: LVSI and MELF Pattern may be Associated with High Incidence of Cervical Stromal Involvement.

Hum Pathol 2021 Apr 29. Epub 2021 Apr 29.

Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY; Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo; Department of Pathology, Microbiology and Immunology/University of South Carolina, Columbia, SC. Electronic address:

Accurate staging of endometrial carcinoma is crucial to optimize patients' care. A pivotal parameter that pathologists evaluate to guide staging is the presence of cervical stromal involvement. However, the standard protocol for adequate sampling of the cervix is lacking. Read More

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Aggressive Resection of Malignant Paraaortic and Pelvic Tumors Accompanied by Arterial Reconstruction with Synthetic Arterial Graft.

Am J Case Rep 2021 May 1;22:e931569. Epub 2021 May 1.

Department of Surgery, Shiga General Hospital, Moriyama, Shiga, Japan.

BACKGROUND Advanced malignancies in the lower abdomen easily invade the retroperitoneal and pelvic space and often metastasize to the paraaortic and pelvic lymph nodes (LNs), resulting in paraaortic and/or pelvic tumor (PPT). CASE REPORT A total of 7 cases of aggressive malignant PPT resection and orthotopic replacement of the abdominal aorta and/or iliac arteries with synthetic arterial graft (SAG) were experienced during 16 years. We present our experience with aggressive resection of malignant PPTs accompanied by arterial reconstruction with SAG in detail. Read More

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Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition.

BMC Med 2021 Apr 30;19(1):101. Epub 2021 Apr 30.

International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.

Methods: Targeted mass spectrometry metabolomics data from 4326 participants enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and 17 individuals from a single-arm pilot weight loss intervention (Intercept) were used in this analysis. Read More

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Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk.

Cancers (Basel) 2021 Apr 26;13(9). Epub 2021 Apr 26.

Population Sciences in the Pacific Program, Cancer Epidemiology Division, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA.

Endometrial cancer (EC) is the leading female reproductive tract malignancy in developed countries. Currently, genome-wide association studies (GWAS) have identified 17 risk loci for EC. To identify novel EC-associated proteins, we used previously reported protein quantitative trait loci for 1434 plasma proteins as instruments to evaluate associations between genetically predicted circulating protein concentrations and EC risk. Read More

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An Emerging Anti-p16 Antibody-BC42 Clone as an Alternative to the Current E6H4 for Use in the Female Genital Tract Pathological Diagnosis: Our Experience and a Review on p16ink4a Functional Significance, Role in Daily-Practice Diagnosis, Prognostic Potential, and Technical Pitfalls.

Diagnostics (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Unità di Gineco-Patologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.

Background: To date, useful diagnostic applications of p16 IHC have been documented in gynecological pathology both for HPV-related and non-HPV-related lesions. In the present article, we reported our experience with the novel anti-p16 INK4a antibody (clone BC42), whose expression was tested across all different gynecologic neoplasms; we also compared it to the traditional E6H4 clone. Moreover, we discussed and explored all the diagnostic applications of p16 IHC in gynecologic pathology. Read More

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Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes.

J Pers Med 2021 Apr 22;11(5). Epub 2021 Apr 22.

Departament de Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, Campus Bellvitge, Universitat de Barcelona, 08907 L'Hospitalet de Llobregat, Spain.

Ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) has been described in human non-pathological endometrium in both epithelial and stromal components without changes along the cycle. It was identified as a stromal marker of basalis. In the present study, we aimed to evaluate NTPDase2 distribution, using immunolabeling and in situ enzyme activity approaches, in endometrial carcinoma (EC) at different tumor grades. Read More

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The Importance of a Multi-Disciplinary Approach to the Endometriotic Patients: The Relationship between Endometriosis and Psychic Vulnerability.

J Clin Med 2021 Apr 10;10(8). Epub 2021 Apr 10.

Saint Camillus International University of Health and Medical Sciences-UniCamillus, 00131 Rome, Italy.

Endometriosis is a chronic inflammatory condition, which is distinguished by the presence of the endometrial-like glands and stroma outside the uterine cavity. Pain and infertility are the most commonly expressed symptoms, occurring in 60% and 40% of cases, respectively. Women with endometriosis, especially those with pelvic pain, also have a greater vulnerability to several psychiatric disorders. Read More

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Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development.

Cancers (Basel) 2021 Apr 7;13(8). Epub 2021 Apr 7.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.

Risk of endometrial cancer (EC) is increased ~2-fold for women with a family history of cancer, partly due to inherited pathogenic variants in mismatch repair (MMR) genes. We explored the role of additional genes as explanation for familial EC presentation by investigating germline and EC tumor sequence data from The Cancer Genome Atlas ( = 539; 308 European ancestry), and germline data from 33 suspected familial European ancestry EC patients demonstrating immunohistochemistry-detected tumor MMR proficiency. Germline variants in MMR and 26 other known/candidate EC risk genes were annotated for pathogenicity in the two EC datasets, and also for European ancestry individuals from gnomAD as a population reference set ( = 59,095). Read More

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