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Investigating the validity of the Strengths and Difficulties Questionnaire to assess ADHD in young adulthood.

Psychiatry Res 2021 May 4;301:113984. Epub 2021 May 4.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Wales, United Kingdom. Electronic address:

Attention Deficit Hyperactivity Disorder (ADHD) symptoms typically onset early and persist into adulthood for many. Robust investigation of symptom continuity and discontinuity requires repeated assessments using the same measure, but research is lacking into whether measures used to assess ADHD symptoms in childhood are also valid in adulthood. The Strengths and Difficulties Questionnaire (SDQ) is widely used to assess ADHD symptoms in children, but little is known about its utility in adulthood. Read More

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Environmental perspective of COVID-19: Atmospheric and wastewater environment in relation to pandemic.

Ecotoxicol Environ Saf 2021 Apr 30;219:112297. Epub 2021 Apr 30.

College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China.

The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major challenge to health systems worldwide. Recently, numbers of epidemiological studies have illustrated that climate conditions and air pollutants are associated with the COVID-19 confirmed cases worldwide. Researches also suggested that the SARS-CoV-2 could be detected in fecal and wastewater samples. Read More

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Increasing age and methamphetamine use.

J Forensic Leg Med 2021 May 8;80:102181. Epub 2021 May 8.

Adelaide Medical School, The University of Adelaide, Frome Road, SA, 5000, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5005, Australia. Electronic address:

Analysis: of autopsy files at Forensic Science SA was undertaken over a 20-year period (2000-2019) in five representative time periods to determine the average ages for all adults (≥18 years) where methamphetamine was detected. There were 239 cases with statistically significant increased mean ages over the time of the study ranging from 32.6yrs in 2000 to 42. Read More

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Metal nanoparticles: Phytotoxicity on tomato and effect on symbiosis with the Fusarium solani FsK strain.

Sci Total Environ 2021 May 8;787:147606. Epub 2021 May 8.

School of Environmental Engineering, Technical University of Crete, 73100 Chania, Greece.

The effect of copper (Cu-NPs, CuO-NPs), silver (Ag-NPs) and zinc oxide (ZnO-NPs) nanoparticles (NPs) on plant growth, physiological properties of tomato plants and their symbiotic relationships with the endophytic Fusarium solani FsK strain was investigated. Fungitoxicity tests revealed that the FsK strain was significantly more sensitive to Cu-NPs and ZnO-NPs than CuO-NPs and Ag-NPs both in terms of mycelial growth and spore germination. All NPs were more toxic to FsK compared to their bulk counterparts except for AgNO, which was 8 to 9-fold more toxic than Ag-NPs. Read More

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Population-based study on the association between autoimmune disease and lymphoma: National Health Insurance Service-National Sample Cohort 2002-2015 in Korea.

J Autoimmun 2021 May 12;121:102647. Epub 2021 May 12.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea. Electronic address:

Background: We aimed to evaluate the association between autoimmune disease (AID) and lymphoma incidence in the Korean population. We also aimed to compare the overall survival (OS) in patients with AID-associated lymphoma (AAL) with that in patients with lymphoma without AID.

Material And Methods: We used National Sample Cohort 2002-2015 provided by National Health Insurance Service. Read More

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Large benign schwannoma of the greater omentum with synchronous cervical cancer: A case report.

Int J Surg Case Rep 2021 May 9;83:105961. Epub 2021 May 9.

Department of Surgery, Cebu Doctors' University Hospital, Cebu City, Philippines.

Introduction And Importance: Schwannomas are uncommon tumors of the omentum with only 16 reported cases originating from the greater omentum in the literature. We report for the first time a synchronous presentation of an omental schwannoma and cervical cancer.

Case Presentation: A 37-year-old female presented with an abdominal mass and heavy vaginal bleeding. Read More

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Exposures and associations with clinical phenotypes in hypersensitivity pneumonitis: A scoping review.

Respir Med 2021 May 6;184:106444. Epub 2021 May 6.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: https://twitter.com/KerriBerriKerri.

Antigen identification is important for establishing a confident diagnosis of hypersensitivity pneumonitis (HP). There are no systematically curated lists of HP-associated exposures that inform clinical relevance or disease phenotype. We sought to systematically identify all reported causes of HP in the literature and evaluate their clinical relevance. Read More

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Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.

Ann Diagn Pathol 2021 Apr 19;53:151744. Epub 2021 Apr 19.

Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, United States of America. Electronic address:

Objectives: Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness.

Methods: Lungs of 12 consecutive COVID-19 decedents consented for autopsy were evaluated for gross and histopathologic abnormalities. A complete Ghon "en block" dissection was performed on all cases; lung weights and gross characteristics recorded. Read More

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Clinical utility of next generation sequencing to detect IGH/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia/lymphoma.

Ann Diagn Pathol 2021 May 10;53:151761. Epub 2021 May 10.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

The t(5;14)(q31.1;q32.1) associated with B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a rare, recurrent genetic abnormality recognized as a distinct entity by the 2017 World Health Organization (WHO) classification. Read More

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Influence of age on treatment and prognosis of invasive cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2021 May 1;262:68-72. Epub 2021 May 1.

Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: Invasive cervical cancer is considered a young women's disease, however up to 20 % of cases develop cervical cancer at advanced ages. The aim was to characterize invasive cervical cancer in women aged 65 and older assessing age-specific survival differences.

Study Design: A retrospective study including cervical cancer patients was conducted at Hospital del Mar Barcelona from July-2007 to December-2016. Read More

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[Return rate to the Primary Care Emergency Service for elderly patients over 65 years old and their assistance requirements].

Aten Primaria 2021 May 12;53(8):102084. Epub 2021 May 12.

Grupo de Investigación Salud, Bienestar y Sostenibilidad Sociosanitaria (SALBIS), Departamento de Ingeniería Eléctrica y de Sistemas y Automática, Universidad de León , León, España.

Objective: To determine the unexpected return rate to the Primary Care Emergency Service of elderly patients over 65 years old within the following 72h of a previous visit, as well as to determine the clinical and assistance requirements of these patients.

Procedure: Retrospective and observational epidemiologic study.

Location: Cotolino's Primary Care Emergency Service in Cantabria, Spain. Read More

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Real-world particle and NO emissions from hybrid electric vehicles under cold weather conditions.

Environ Pollut 2021 May 10;286:117320. Epub 2021 May 10.

University of California Riverside (UCR), Department of Mechanical Engineering, Riverside, CA, 92521, USA; University of California Riverside, College of Engineering, Center for Environmental Research and Technology (CE-CERT), Riverside, CA, 92521, USA. Electronic address:

Hybrid electric vehicle (HEV) technology is critical to reduce the impact of the internal combustion engines on air pollution and greenhouse gases. HEVs have an advantage in market penetration due to their lower cost and higher driving range compared to battery electric vehicles (BEVs). On the other hand, HEVs use an internal combustion engine and still emit air pollutants. Read More

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Prevalence and distribution of lice on sheep and cattle farms in Great Britain.

Vet Parasitol 2021 May 7;294:109444. Epub 2021 May 7.

School of Biological Sciences, University of Bristol, Bristol, BS8 1TQ, UK. Electronic address:

Lice are common production-limiting ectoparasites affecting livestock. Up-to-date data on their prevalence and spatial distribution on farms in Great Britain is important given that prevalence is believed to be increasing as a result of insecticide resistance. Here the prevalence of farms reporting lice, and factors associated with louse presence, were assessed using a retrospective questionnaire. Read More

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Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Purpose: Retinal vascular occlusion is a leading cause of profound irreversible visual loss, but the understanding of the disease is insufficient. We systematically investigated the age, gender, and laterality at the onset of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) in the IRIS® Registry (Intelligent Research in Sight).

Design: A retrospective registry cohort. Read More

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Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth.

Am J Obstet Gynecol MFM 2021 May 12:100393. Epub 2021 May 12.

Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC.

Background: There is an increased awareness regarding the association between exposure to environmental contaminants and adverse pregnancy outcomes including preterm birth. Whether an individual's metabolic profile can be utilized during pregnancy to differentiate the subset of patients who are ultimately destined to deliver preterm remains uncertain but could have significant clinical implications.

Objective: We sought to objectively quantify metabolomic profiles of patients at high risk for preterm birth by evaluating mid-trimester maternal plasma, and to measure whether endogenous metabolites and exogenous environmental substances differ among those who ultimately deliver preterm compared to those who deliver at term. Read More

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Subjective value, not a gridlike code, describes neural activity in ventromedial prefrontal cortex during value-based decision-making.

Neuroimage 2021 May 12:118159. Epub 2021 May 12.

Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104 USA.

Across many studies, ventromedial prefrontal cortex (vmPFC) activity has been found to correlate with subjective value during value-based decision-making. Recently, however, vmPFC has also been shown to reflect a hexagonal gridlike code during navigation through physical and conceptual space, and such gridlike codes have been proposed to enable value-based choices between novel options. Here, we first show that, in theory, a hexagonal gridlike code can in some cases mimic vmPFC activity previously attributed to subjective value, raising the possibility that the subjective value correlates previously observed in vmPFC may have actually been a misconstrued gridlike signal. Read More

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Exploring clustering of leprosy in the Comoros and Madagascar: a geospatial analysis.

Int J Infect Dis 2021 May 12. Epub 2021 May 12.

Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: To identify patterns of spatial clustering of leprosy.

Design: We performed a baseline survey for a trial on post-exposure prophylaxis for leprosy in Comoros and Madagascar. We screened 64 villages, door-to-door, and recorded results of screening, demographic data and geographic coordinates. Read More

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Clinical evaluation of a developed paper-based Dengue NS1 rapid diagnostic test in febrile illness patients.

Int J Infect Dis 2021 May 12. Epub 2021 May 12.

School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bang Khun Thian, Bangkok 10150, Thailand. Electronic address:

Objectives: The aim of this study was to evaluate, a developed microfluidic paper based analytical device (DEN-NS1-PAD) based on rapid NS1 antigen test for diagnosing dengue at the point of care.

Methods: 219 serum samples from suspected dengue cases were tested with the developed DEN-NS1-PAD and commercial RDT by SD BIOLINE. The results were compared with the nested-PCR results. Read More

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Failure of rapid diagnostic tests in Plasmodium falciparum malaria cases in UK travellers: identification and characterisation of the parasites.

Int J Infect Dis 2021 May 12. Epub 2021 May 12.

Department of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Electronic address:

Objectives: Our objective was to systematically investigate false-negative histidine-rich protein 2 rapid diagnostic tests (HRP2-RDT) in imported Plasmodium falciparum malaria cases from travellers to the UK and Northern Ireland (RoI).

Methods: Five imported malaria cases in travellers returning to the UK and RoI from East Africa, reported to the PHE Malaria Reference Laboratory as negative by histidine-rich protein (HRP2)-RDT. We systematically investigated the cases using microscopy, RDT, molecular, genomic and in in vitro approaches. Read More

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Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage.

Clin Microbiol Infect 2021 May 12. Epub 2021 May 12.

IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, 13005 Marseille, France. Electronic address:

Objectives: Our surveillance of the SARS-CoV-2 genomic epidemiology led us to detect several variants since summer 2020. We report the recent spread of a new SARS-CoV-2 spike 501Y variant.

Methods: SARS-CoV-2 sequences obtained from human nasopharyngeal samples by Illumina next-generation sequencing were analyzed using Nextclade and an in-house Python script and compared using BLASTn to the GISAID database. Read More

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Role of genetic variants of Vitamin D receptor, Toll-like receptor 2 and Toll-like receptor 4 in extrapulmonary tuberculosis.

Microb Pathog 2021 May 12:104911. Epub 2021 May 12.

Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, J&K, India. Electronic address:

Background: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB). Vitamin D deficiency and vitamin D receptor (VDR) gene abnormalities confer susceptibility to tuberculosis. Toll-like receptors (TLRs), such as TLR-2, are also important mediators of inflammatory response against Mycobacterium tuberculosis. Read More

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Pesticides and Parkinson's disease: Current and future perspective.

J Chem Neuroanat 2021 May 12:101966. Epub 2021 May 12.

Dept. of Tissue Engineering and Applied Cell Sciences, Tehran University of Medical Sciences, Iran. Electronic address:

Inappropriate use of pesticides has globally exposed mankind to a number of health hazards. Still their production is rising at the rate of 11 % annually and, has already exceeded more than 5 million tons in 2000 (FAO 2017). Plenty of available data reveals that pesticides exposures through agricultural use and food-preservative residue consumption may lead to neurodegenerative disorders like Parkinson's and Alzheimer's diseases. Read More

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Effect of thoracic spinal cord injury on forelimb somatosensory evoked potential.

Brain Res Bull 2021 May 12. Epub 2021 May 12.

Department of Electrical Engineering, College of Engineering, American University of Sharjah, ESB-2018, Engineering Science Building, American University of Sharjah, University City, Sharjah, 26666, United Arab Emirate. Electronic address:

In this paper, we investigate the forelimbs somatosensory evoked potential (SSEP) signals, which are representative of the integrity of ascending sensory pathways and their stability as well as function, recorded from corresponding cortices, post thoracic spinal cord injury (SCI). We designed a series of distinctive transection SCI to investigate whether forelimbs SSEPs change after right T10 hemi-transection, T8 and T10 double hemi-transection and T8 complete transection in rat model of SCI. We used electrical stimuli to stimulate median nerves and recorded SSEPs from left and right somatosensory areas of both cortices. Read More

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Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies.

Int J Pharm 2021 May 12:120707. Epub 2021 May 12.

Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland. Electronic address:

Age-related eye disorders are chronic diseases that affect millions of people worldwide. They cause visual impairment and, in some cases, irreversible blindness. Drug targeting to the retina is still a challenge due to the difficulties with drug distribution, crossing eye barriers, and reaching intraocular tissues in an effective therapeutic concentration. Read More

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Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.

J Allergy Clin Immunol 2021 May 12. Epub 2021 May 12.

Department of immunology, Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust, London, United Kingdom.

Background: Accurate, detailed and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date the use of HPO has not yet been widely implemented in the field of inborn errors of immunity (IEIs), mainly due to a lack of comprehensive IEI-related terms. Read More

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Recent progress in green and biopolymer based photocatalysts for the abatement of aquatic pollutants.

Environ Res 2021 May 12:111324. Epub 2021 May 12.

Laboratorio de Investigaciones Ambientales Zonas Áridas, Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Tarapacá, Avda. General Velásquez 1775, Arica, Chile.

Enormous research studies on the abatement of anthropogenic aquatic pollutants including organic dyes, pesticides, cosmetics, antibiotics and inorganic species by using varieties of semiconductor photocatalysts have been reported in recent decades. Besides, many of these photocatalysts suffer in real applications owing to their high production cost and low stability. In many cases, the photocatalysts themselves are being considered as secondary pollutants. Read More

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Comparison of the intubation success rate between the intubating catheter and videolaryngoscope in difficult airways: a prospective randomized trial.

Braz J Anesthesiol 2021 May 12. Epub 2021 May 12.

Selcuk University Medical Faculty, Department of Anesthesiology and Intensive Care, Konya, Turkey.

Background: Several devices and algorithms have already been examined and compared for difficult airway management. However, there is no existing study comparing the success of the Intubating Catheter (IC) and the Videolaryngoscope (VL) in patients who are difficult to intubate. We aimed to compare Frova IC and McGrath VL in terms of intubation success rates in patients with difficult intubation. Read More

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Various theranostics and immunization strategies based on nanotechnology against Covid-19 pandemic: An interdisciplinary view.

Life Sci 2021 May 12:119580. Epub 2021 May 12.

Cancer and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India. Electronic address:

COVID-19 pandemic is still a major risk to human civilization. Besides the global immunization policy, more than 5lac new cases are documented every day. Some countries newly implement partial/complete nationwide lockdown to mitigate recurrent community spreading. Read More

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Invasive Fungal Infections in Immunocompromised Children: Novel Insight Following a National Study.

J Pediatr 2021 May 12. Epub 2021 May 12.

Institute of Pediatric Hematology and Oncology, Hospices Civils de Lyon, University-Lyon1, Lyon, France; Apoptosis, Cancer and Development Laboratory - INSERM U1052-CNRS UMR5286, CRCL, Lyon, France.

Objective: To obtain a national overview of the epidemiology and management of invasive fungal infections (IFIs) in France for severe immunocompromised children who were treated for acute leukemia or had undergone an allogeneic hematopoietic stem cell transplantation (a-HSCT).

Study Design: We performed a national multicenter retrospective study to collect epidemiologic data for proven and probable IFI in children with acute leukemia under first line or relapse treatment or who had undergone an a-HSCT. We also conducted a prospective practice survey to provide a national overview of IFI management in pediatric hematology units. Read More

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Intraductal Carcinoma of the Salivary Gland with NCOA4-RET: Expanding the Morphologic Spectrum and an Algorithmic Diagnostic Approach.

Hum Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, Massachusetts General Hospital; Department of Otolaryngology, Massachusetts Eye and Ear; Department of Pathology, Harvard Medical School, Boston, MA, USA. Electronic address:

Following the publication of the 2017 WHO Classification of Head and Neck Tumours, there has been increasing interest in the classification of newly categorized intraductal carcinomas. Intraductal carcinoma (IC) is an indolent tumor, typically arising in the parotid gland, with an intact myoepithelial layer and a cystic, papillary, often cribriform architecture. Early studies of IC identified a heterogeneous group of molecular alterations driving neoplasia, and recent studies have defined three primary morphological/immunohistochemical variants, subsequently linking these morphologic variants with defined molecular signatures. Read More

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