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A familial cluster of COVID-19 infection in a northern Chinese region.

J Infect Public Health 2021 Jul 18;14(9):1127-1132. Epub 2021 Jul 18.

Department of Infectious Diseases, Gongzhuling Central Hospital, Jilin Province, 136100, China. Electronic address:

Objective: Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and become a global health concern. Here, we report a familial cluster of six patients infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) in a northern Chinese region and share our local experience with regard the control of COVID-19.

Methods: The demographic data, clinical features, laboratory examinations, and epidemiological characteristics of enrolled cases were collected and analyzed. Read More

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Analysis of COVID-19 pandemic in USA, using Topological Weighted Centroid.

Comput Biol Med 2021 Jul 21;136:104670. Epub 2021 Jul 21.

Department of Mathematical and Statistical Science, University of Colorado Denver, Denver, CO, USA.

The first case of COVID-19 in USA was reported on January 20, 2020. The number of COVID-19 confirmed cases and death has increased since the first reported case and the outbreak has appeared in all states. This paper analyzes disease outbreak using Topological Weighted Centroid (TWC), which is a data driven intelligent geographical dynamical system that models disease spread in space and time. Read More

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Actinomycosis: Case report of an unusual cause of diaphragmatic herniation.

Int J Surg Case Rep 2021 Jul 22;85:106227. Epub 2021 Jul 22.

St. Christopher's Hospital for Children, Department of Pediatric General, Thoracic, and Minimally Invasive Surgery, 160 East Erie Avenue, Philadelphia, PA 19134, USA; Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA.

Introduction: We present a case of actinomycosis which resulted in a symptomatic diaphragmatic hernia requiring operative repair, an unusual complication not found in the literature. Actinomycosis is a chronic, slowly progressive infection caused by the bacterial genus Actinomyces which characteristically causes necrosis and abscess formation in a myriad of organ systems.

Case Presentation: A 5 year old male presented with nonspecific symptoms which were, after a short delay, identified as actinomycosis and treated with appropriate antibiosis. Read More

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Facial nerve palsy due to a parotid abscess: Two case reports and a review of literature.

Int J Surg Case Rep 2021 Jul 30;85:106255. Epub 2021 Jul 30.

Department of Otorhinolaryngology and Head and Neck Surgery, Radboudumc, Nijmegen, the Netherlands.

Introduction And Importance: Parotid gland swelling with facial nerve palsy is highly suggestive of a malignancy. Facial nerve palsy is however rarely caused by a parotid abscess. We hereby present two cases, propose treatment and present a review of the literature. Read More

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Intravenous leiomyomatosis: Case series and review of the literature.

Int J Surg Case Rep 2021 Jul 31;85:106257. Epub 2021 Jul 31.

Department of Gynaecological Surgery, Hospital de Sion, Avenue du Grand-Champsec 80, 1951 Sion, Switzerland; Department of Obstetrics and Gynecology, Hôpitaux Universitaires de Genève (HUG), Rue Gabrielle-Perret-Gentil 4, 1205 Genève, Switzerland.

Introduction: Intravenous leiomyomatosis (ILV) is a rare pathology, part of leiomyoma beyond the uterus (LBU), characterized by benign smooth muscle cell tumor outside of the uterus and mainly affecting premenopausal woman with a medical history of leiomyoma or gynecologic surgical treatment. The treatment depends on the localization of the tumor, age of the patient, initial size, symptoms and the suitability for surgery but should always aims in toto surgical resection.

Case Presentation: Retrospective case series and review of literature. Read More

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Mucinous cystadenocarcinoma of pancreas mimicking gastrointestinal stromal tumor of stomach: Case report.

Int J Surg Case Rep 2021 Jul 26;85:106240. Epub 2021 Jul 26.

Department of Gastroenterology, IPGME&R, School of Digestive & Liver Diseases, Kolkata, India.

Introduction: Pancreatic mucinous cysadenocarcinoma is a rare neoplasm of pancreas which rarely presents as upper gastrointestinal bleed.

Case Report: A 45-year-old woman presented with history of repeated episodes of melena and abdominal pain. Upper gastrointestinal endoscopy revealed a growth in the body of the stomach likely to be a gastrointestinal stromal tumor (GIST). Read More

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Transoral endoscopic thyroidectomy using a self-retaining retractor as an alternative to carbon dioxide gas insufflation: A comparative analysis of 131 cases.

Oral Oncol 2021 Jul 31;121:105463. Epub 2021 Jul 31.

Department of Otolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Republic of Korea. Electronic address:

Although transoral endoscopic thyroid surgery affords several advantages, the use of carbon dioxide (CO2) gas to create and maintain the working space may cause complications such as subcutaneous emphysema and a CO2 embolism. We have used a self-retaining retractor as an alternative to CO2 gas insufflation for some time; we here report its feasibility and safety. We reviewed the medical records of 131 patients who underwent transoral endoscopic thyroid lobectomy; we compared the "CO2 group" and the "retractor" group. Read More

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A Multi-Variate framework to assess reliability and discrimination power of Bayesian estimation of Intravoxel Incoherent Motion parameters.

Phys Med 2021 Jul 31;89:11-19. Epub 2021 Jul 31.

Institute of Biomedical Technologies, Italian National Research Council (ITB-CNR), Segrate, Italy.

Purpose: To propose a multivariate multi-step framework for a systematic assessment of the estimation reliability and discriminability of Intravoxel Incoherent Motion (IVIM) model parameters.

Methods: Monte-Carlo simulations were generated on a range of SNRs and in different IVIM combinations considering: i) a dense discretization with 24 b-values; ii) a discretization with 9 b-values. A state-of-the-art Bayesian fitting method was adopted. Read More

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Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional studies.: Expression of interferon stimulated genes in systemic lupus.

Transl Res 2021 Jul 31. Epub 2021 Jul 31.

Copenhagen Lupus and Vasculitis Clinic, Rigshospitalet, Copenhagen University Hospital, Denmark. Electronic address:

Type I interferons (IFN) are central players in the pathogenesis of systemic lupus erythematosus (SLE) and the up-regulation of interferon-stimulated genes (ISGs) in SLE patients is subjected to increasing scrutiny as for its use in diagnosis, stratification and monitoring SLE patients. Determinants of this immunological phenomenon are yet to be fully charted. The purpose of this systematic review was to characterize expressions of ISGs in blood of SLE patients and to analyze if they associated with core demographic and clinical features of SLE. Read More

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Association of Coronavirus Disease-19 Hospitalization Volume and Case Growth at United States Hospitals with Patient Outcomes.

Am J Med 2021 Jul 31. Epub 2021 Jul 31.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT.

Background: Whether the volume of coronavirus disease-19 (COVID-19) hospitalizations is associated with outcomes has important implications for the organization of hospital care both during this pandemic and also future novel and rapidly evolving high-volume conditions.

Methods: We identified COVID-19 hospitalizations at US hospitals in the American Heart Association COVID-19 Cardiovascular Disease Registry with ≥10 cases between January and August 2020. We evaluated the association of (1) COVID-19 hospitalization volume and 2) weekly case growth indexed to hospital bed capacity, with hospital risk-standardized in-hospital case-fatality rate (rsCFR). Read More

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Paracentral Acute Middle Maculopathy and the Ischemic Cascade: Towards Interventional Management: Short Title: Paracentral Acute Middle Maculopathy.

Am J Ophthalmol 2021 Jul 31. Epub 2021 Jul 31.

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA.

Purpose: To present select cases of paracentral acute middle maculopathy (PAMM) demonstrating progressive vascular occlusion and the ischemic cascade, and illustrate scenarios in which therapeutic intervention may be considered.

Design: Perspective.

Methods: Review and interpretation of selected literature, with perspective on the evaluation and management of patients with PAMM lesions. Read More

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The Effect of COVID-19 on Adult Cardiac Surgery in the United States in 717,103 Patients.

Ann Thorac Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WV.

Background: COVID-19 has changed the world as we know it, and the United States continues to accumulate the largest number of COVID-related deaths worldwide. There exists a paucity of data regarding the effect of COVID-19 on adult cardiac surgery trends and outcomes on regional and national levels.

Methods: The STS Adult Cardiac Surgery Database was queried from January 1, 2018 to June 30, 2020. Read More

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Early determination of case fatality rate of COVID-19 pandemic during the ongoing Yemeni armed conflict.

Disaster Med Public Health Prep 2021 Aug 3:1-15. Epub 2021 Aug 3.

Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.

Objectives: To determine the case-fatality rate (CFR) of coronavirus disease 2019 (COVID-19) and its associated determinants in order to understand the true magnitude of the problem during ongoing conflict in Yemen.

Methods: The CFR among confirmed COVID-19 cases in Yemen was calculated. The data was retrieved from national COVID-19 surveillance between April 10, when the first COVID-19 case reported, and May 31, 2020. Read More

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Suitability of Google Trends™ for digital surveillance during ongoing COVID-19 epidemic: a case study from India.

Disaster Med Public Health Prep 2021 Aug 3:1-28. Epub 2021 Aug 3.

Department of Community & Family Medicine, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India.

Objective: Digital surveillance has shown mixed results as supplement to traditional surveillance. Google Trends™ (GT) has been used for digital surveillance of H1N1, Ebola and MERS. We used GT to correlate the information seeking on COVID-19 with number of tests and cases in India. Read More

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C-Reactive Protein, Interleukin-6, and Procalcitonin in Diagnosis of Late-Onset Bloodstream Infection in Very Preterm Infants.

J Pediatric Infect Dis Soc 2021 Aug 3. Epub 2021 Aug 3.

Department of Neonatology, Institute for the Care of Mother and Child-Neonatology, Prague, Czech Republic.

Background: Late-onset bloodstream infection (LOBSI) is common in very preterm infants. Early and accurate diagnosis is crucial for prognosis and outcome. We aimed to analyze the accuracy of routinely used inflammatory biomarkers in the diagnosis of LOBSI as compared to uninfected controls. Read More

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Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.

PLoS One 2021 3;16(8):e0255489. Epub 2021 Aug 3.

Department of Pathology, Xinxiang Medical University, Xinxiang, 453003, P.R. China.

MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We analyzed the association between MACC1 expression and lymphatic metastasis in a nested case-control study including 99 cases and 198 matched controls in CRC patients, assessed from August 2001 to March 2015. Read More

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Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients.

PLoS One 2021 3;16(8):e0255144. Epub 2021 Aug 3.

Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Perú.

Aims: The objective of this study is to analyze how the impact of Diabetes Mellitus [DM] in patients with COVID-19 varies according to altitudinal gradient.

Methods: We obtained 1,280,806 records from adult patients with COVID-19 and DM to analyze the probability of COVID-19, development of COVID-19 pneumonia, hospitalization, intubation, admission to the Intensive Care Unit [ICU] and case-fatality rates [CFR]. Variables were controlled by age, sex and altitude of residence to calculate adjusted prevalence and prevalence ratios. Read More

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Role of Emergent Nephrectomy for Grade V Blunt Renal Injuries.

Am J Case Rep 2021 Aug 3;22:e932357. Epub 2021 Aug 3.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, USA.

BACKGROUND Blunt renal injuries constitute a small proportion of solid organ trauma cases. Many American Association for the Surgery of Trauma grade IV and V lacerations are manageable with volume resuscitation and angioembolization. In select cases, emergent nephrectomy can be beneficial to patients, with little associated morbidity. Read More

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Nonspecific, Acute Pouchitis in Patients with Familial Adenomatous Polyposis: Less Common than We Think.

Dis Colon Rectum 2021 Aug 2. Epub 2021 Aug 2.

Northwestern University, Department of Surgery, Chicago, Illinois Cleveland Clinic, Department of Colorectal Surgery University of Chicago, Department of Colorectal Surgery The Ohio State University, Columbus, Ohio New York Presbyterian/Columbia University Medical Center.

Background: Nonspecific, acute, pouchitis is common in patients with ulcerative colitis who undergo ileal pouch-anal anastomosis, but there is disagreement about the rate at which this occurs in patients with familial adenomatous polyposis.

Objective: To define the rate at which nonspecific, acute, pouchitis occurs in patients with familial adenomatous polyposis.

Setting: Hereditary colorectal cancer center in a large academic medical center. Read More

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Neuromuscular rehabilitation - what to do?

Curr Opin Neurol 2021 Aug 2. Epub 2021 Aug 2.

University of Sydney School of Health Sciences, Faculty of Medicine and Health & Children's Hospital at Westmead, Sydney, Australia Clinic for Neurology, Medical Park Reithofpark, Bad Feilnbach, Germany.

Purpose Of Review: Rehabilitation for patients with neuromuscular disorders (NMDs) has undisputed health benefits and is potentially therapeutic for targeting impairments, improving quality of life, and enabling activities of daily living. Whilst rehabilitation is commonly prescribed, unequivocal evidence and disease-related guidelines are lacking. This review highlights recent studies of exercise, assistive devices, respiratory management and manual therapy and stretching for patients with NMDs. Read More

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Neonatal multidrug-resistant bacterial meningitis: a 29-year study from a tertiary hospital in Thailand.

J Infect Dev Ctries 2021 Jul 31;15(7):1021-1026. Epub 2021 Jul 31.

Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Introduction: This study aimed to compare the risks and case fatality rate (CFR) between neonatal multidrug-resistant (MDR) and non-MDR meningitis.

Methodology: a secondary analysis of a case-control studies in a Thai neonatal intensive care unit between 1990 and 2018 was performed. The pathogenic organisms causing neonatal meningitis were Staphylococcus aureus, Enterococcus spp. Read More

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Cytologic analysis of vitreous fluids: A retrospective review of our 24 years of experience.

Diagn Cytopathol 2021 Aug 3. Epub 2021 Aug 3.

Department of Pathology, University of Tennessee Medical Center Graduate School of Medicine, Knoxville, Tennessee, USA.

Background: Cytologic analysis of vitreous fluid is an important component in diagnosis of vitreitis. No standard reporting guidelines exist for these specimens. This study chronicles our 24 years experience and proposes a tentative diagnostic model. Read More

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A unique case of bleeding from esophageal varices as the first sign of essential thrombocythemia.

Clin J Gastroenterol 2021 Aug 3. Epub 2021 Aug 3.

Gastroenterology Department, Hospital Garcia de Orta, Av. Torrado da Silva, 2805-267, Almada, Portugal.

Upper gastrointestinal bleeding (UGIB) is a common cause of hospital admission and variceal hemorrhage is responsible for many UGIB cases. Esophageal and gastric varices are caused by portal hypertension (PHT), mostly due to liver cirrhosis. Portal vein thrombosis (PVT) is an important cause of non-cirrhotic PHT and can be associated with several diseases, including myeloproliferative disorders such as essential thrombocythemia (ET). Read More

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Mixed Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) of the Ovary Arising from Endometriosis: Molecular Pathology Analysis in Support of a Pathogenetic Paradigm.

Endocr Pathol 2021 Aug 3. Epub 2021 Aug 3.

Pathology Unit, Dept. of Medicine and Surgery, University of Insubria, via O. Rossi 9, 21100, Varese, Italy.

Primary ovarian neuroendocrine neoplasms (Ov-NENs) are infrequent and mainly represented by well-differentiated forms (neuroendocrine tumors - NETs - or carcinoids). Poorly differentiated neuroendocrine carcinomas (Ov-NECs) are exceedingly rare and only few cases have been reported in the literature. A subset of Ov-NECs are admixed with non-neuroendocrine carcinomas, as it occurs in other female genital organs, as well (mostly endometrium and uterine cervix), and may be assimilated to mixed neuroendocrine/non-neuroendocrine neoplasms (MiNENs) described in digestive and extra-digestive sites. Read More

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Pituitary metastases from neuroendocrine neoplasms: case report and narrative review.

Pituitary 2021 Aug 3. Epub 2021 Aug 3.

Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.

Purpose: Pituitary metastases (PM) are uncommon findings and are mainly derived from breast and lung cancers. No extensive review of PM from neuroendocrine neoplasms (NENs) is on record. Here we describe a clinical case of PM from pancreatic NEN and review the clinical features of PM from NENs reported in the literature. Read More

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Global status of neglected human Linguatula infection: a systematic review of published case reports.

Parasitol Res 2021 Aug 3. Epub 2021 Aug 3.

Toxoplasmosis Research Center, Communicable Diseases Institute, Iranian National Registry Center for Lophomoniasis (INRCL) and Toxoplasmosis (INRCT), Mazandaran University of Medical Sciences, 48471-91971, Sari, Iran.

Human linguatulosis is a rare but highly specialized pentastomid parasitic infection all around the world. The disease is caused by worm-like parasites which share some morphologic features of arthropods and annelids. The life cycle of Linguatula spp. Read More

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An IBD-based mixed model approach for QTL mapping in multiparental populations.

Theor Appl Genet 2021 Aug 3. Epub 2021 Aug 3.

Biometris, Wageningen University and Research Center, P.O Box 100, 6700 AC, Wageningen, The Netherlands.

Key Message: The identity-by-descent (IBD)-based mixed model approach introduced in this study can detect quantitative trait loci (QTLs) referring to the parental origin and simultaneously account for multilevel relatedness of individuals within and across families. This unified approach is proved to be a powerful approach for all kinds of multiparental population (MPP) designs. Multiparental populations (MPPs) have become popular for quantitative trait loci (QTL) detection. Read More

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Modeling Hepatitis C Elimination Among People Who Inject Drugs in New Hampshire.

JAMA Netw Open 2021 Aug 2;4(8):e2119092. Epub 2021 Aug 2.

Tuck School of Business at Dartmouth, Hanover, New Hampshire.

Importance: The success of direct-acting antiviral therapies for chronic hepatitis C virus (HCV) infection led the World Health Organization to set elimination targets by 2030. For the United States to achieve these benchmarks, public health responses must target high-risk populations, such as people who inject drugs (PWID), a group with high rates of HCV incidence and low rates of treatment uptake.

Objective: To evaluate potential improvements in the HCV care cascade among PWID, focusing on improved testing, treatment uptake, and access to harm reduction. Read More

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The Efficacy of Online Case-Based Assignments in Teaching Veterinary Ophthalmology.

J Vet Med Educ 2021 Aug 2:e20210005. Epub 2021 Aug 2.

Veterinarians are required to use clinical reasoning skills to successfully manage their patients with eye diseases. Case-based assignments can be an effective tool for teaching problem-solving skills. Very few models or online modules exist to deepen the instruction of veterinary ophthalmic clinical reasoning skills. Read More

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