105 results match your criteria cases age-frequency

Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study.

Viruses 2021 Jun 27;13(7). Epub 2021 Jun 27.

Department of Paediatrics and Child Health, University Teaching Hospital, Lusaka 50110, Zambia.

Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enrolled children (1-59 months) hospitalized with severe and very severe pneumonia per World Health Organization clinical criteria and age-frequency-matched community controls in seven countries. Read More

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Age, frequency of volunteering, and Present-Hedonistic time perspective predict donating items to people in need, but not money to combat COVID-19 during lock-down.

Iwona Nowakowska

Curr Psychol 2021 Jun 23:1-11. Epub 2021 Jun 23.

Institute of Psychology, The Maria Grzegorzewska University, Szczęśliwicka 40, 02-353 Warsaw, Poland.

Restrictions due to COVID-19 necessitated staying at home, but in some cases, encouraged charitable behavior, e.g., donating items to people in need (e. Read More

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Dietary acid load and lung cancer risk: A case-control study in men.

Cancer Treat Res Commun 2021 Apr 25;28:100382. Epub 2021 Apr 25.

Unit of Thoracic Oncology, National Cancer Institute, Joanicó 3265, Montevideo 11600, Uruguay.

Background: Dysregulation of the endogenous acid-base balance can contribute to inflammation and cancer development if metabolic acidosis is sustained. The epidemiologic evidence on the association between diet-dependent acid load and cancer risk is scarce and inconsistent. We aim to explore the possible role of dietary acid load in lung cancer (LC) risk. Read More

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[Population-based Study of the Effects of Adiponectin, Leptin and Soluble Leptin Receptor on Risks for Breast Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):259-266

Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the individual or combined effects of adiponectin, leptin, and soluble leptin receptor (sOB-R) on risks for premenopausal and postmenopausal breast cancer, and to provide evidence for revealing the molecular mechanism between obesity and breast cancer.

Methods: 469 newly-diagnosed breast cancer cases were sequentially recruited for the study and 469 age-frequency-matched healthy women were enrolled as the controls over the same period of time. The participant baseline information was collected with questionnaires, and plasmic levels of adiponectin, leptin and sOB-R were checked with ELISA. Read More

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Is being a 'left-behind' child associated with an increased risk of self-poisoning in adulthood? Findings from a case-control study in Sri Lanka.

BMJ Glob Health 2021 03;6(3)

South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Purpose: The long-term consequences of parental emigration on offspring self-harm risk is unknown.

Methods: We investigated the association between experiencing parental emigration in childhood with hospital presentations for self-poisoning in adulthood using a hospital case-control study. Cases were adult self-poisoning patients (≥18 year olds) admitted to the medical toxicology ward Teaching Hospital Peradeniya, Sri Lanka. Read More

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Associations between serum concentration of flavonoids and breast cancer risk among Chinese women.

Eur J Nutr 2021 Apr 18;60(3):1347-1362. Epub 2020 Jul 18.

Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.

Purpose: In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association between serum concentration of these flavonoids and breast cancer risk among Chinese women. Read More

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Silica and asbestos exposure at work and the risk of bladder cancer in Canadian men: a population-based case-control study.

BMC Cancer 2020 Mar 3;20(1):171. Epub 2020 Mar 3.

Occupational Cancer Research Centre, Cancer Care Ontario, Ontario Health, 525 University Ave, Toronto, ON, Canada.

Background: Silica and asbestos are recognized lung carcinogens. However, their role in carcinogenesis at other organs is less clear. Clearance of inhaled silica particles and asbestos fibers from the lungs may lead to translocation to sites such as the bladder where they may initiate carcinogenesis. Read More

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Cross-sectional comparison of various sleep disturbances among sex- and age-matched HIV-infected versus HIV-uninfected individuals in China.

Sleep Med 2020 01 5;65:18-25. Epub 2019 Jul 5.

Department of Epidemiology, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China. Electronic address:

Objective/background: This study assessed the prevalence and correlates of various sleep disturbances in HIV-infected patients compared to sex- and age-frequency-matched HIV-uninfected controls in China.

Methods: This cross-sectional analysis included 1469 HIV-infected cases and 2938 HIV-uninfected controls. Insomnia symptoms, poor sleep quality (Pittsburgh Sleep Quality Index [PSQI] >5) as well as their specific domains, were assessed. Read More

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January 2020

Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications.

Breast Cancer Res Treat 2020 Jan 18;179(1):185-195. Epub 2019 Sep 18.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Purpose: Female breast cancer demonstrates bimodal age frequency distribution patterns at diagnosis, interpretable as two main etiologic subtypes or groupings of tumors with shared risk factors. While RNA-based methods including PAM50 have identified well-established clinical subtypes, age distribution patterns at diagnosis as a proxy for etiologic subtype are not established for molecular and genomic tumor classifications.

Methods: We evaluated smoothed age frequency distributions at diagnosis for Carolina Breast Cancer Study cases within immunohistochemistry-based and RNA-based expression categories. Read More

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January 2020

Molecular Subtyping of Human Rhinovirus in Children from Three Sub-Saharan African Countries.

J Clin Microbiol 2019 09 26;57(9). Epub 2019 Aug 26.

Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases Chair, Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa.

The pathogenesis of human rhinovirus (HRV) during severe respiratory disease remains undefined; thus, we aimed to explore the relationship between the HRV molecular subtyping results obtained during severe and asymptomatic childhood infections. Nasopharyngeal/oropharyngeal swabs from children (1 to 59 months of age) hospitalized with pneumonia and from age-frequency-matched controls were collected between August 2011 and August 2013. Swabs were tested for respiratory pathogens, including HRV, using quantitative real-time PCR assays. Read More

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September 2019

Histopathological pattern of thyroid diseases in Zaria: A 10-year review.

Niger Postgrad Med J 2018 Jan-Mar;25(1):37-42

Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.

Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens.

Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Read More

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Modified Blatchford Score for Risk Stratification in Adult Patient with Nonvariceal Upper Gastrointestinal Haemorrhage and Their Short Term Hospital Outcome.

Mymensingh Med J 2017 07;26(3):490-497

Dr Md Saiful Islam, Medical Officer (Gastroenterology), Mymensingh Medical College Hospital (MMCH), Mymensingh.

Upper gastrointestinal hemorrhage (UGIH) is one of the most common and life-threatening gastrointestinal emergency. There are several risk scores for risk stratification in UGIB patients. The Modified Blatchford score, which relies only on clinical and laboratory parameters, is practical in the emergency setting The Modified Blatchford scoring system also known as Glasgow Blatchford Scoring (GBS) have been developed to stratify risk of non variceal upper gastrointestinal hemorrhage or need of medical or surgical intervention, endoscopic therapy. Read More

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Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival.

PLoS One 2017 7;12(6):e0178850. Epub 2017 Jun 7.

Department of Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-Sen University, Guangzhou, China.

The contribution of diabetes to breast cancer remains uncertain among Chinese females, which may result from different genetic factors. We evaluated the associations of diabetes, combined with the polymorphisms in the genes of fat mass and obesity-associated gene (FTO), interleukin 6 (IL-6), and heat shock protein 60 (HSPD1), with breast cancer risk and survival in a Chinese Han population. The information on the history of diabetes was collected from 1551 incident breast cancer cases and 1605 age-frequency matched controls in Guangzhou, China. Read More

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September 2017

Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study.

Clin Infect Dis 2017 Jun;64(suppl_3):S357-S367

Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Background.: Detection of pneumococcus by lytA polymerase chain reaction (PCR) in blood had poor diagnostic accuracy for diagnosing pneumococcal pneumonia in children in 9 African and Asian sites. We assessed the value of blood lytA quantification in diagnosing pneumococcal pneumonia. Read More

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Colonization Density of the Upper Respiratory Tract as a Predictor of Pneumonia-Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii.

Clin Infect Dis 2017 Jun;64(suppl_3):S328-S336

Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi.

Background.: There is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. We assessed this association for Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. Read More

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Allelic expression imbalance polymorphisms in susceptibility chromosome regions and the risk and survival of breast cancer.

Mol Carcinog 2017 01 29;56(1):300-311. Epub 2016 Apr 29.

Department of Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, The School of Public Health, Sun Yat-sen University, Guangzhou, China.

Allelic expression imbalance (AEI) has been applied to indicate potential function of genetic variants. Combining earlier results from global differential allele-specific expression analysis and genome wide association studies (GWASs), we select the single nuclear polymorphisms (SNPs) exhibiting AEI phenomenon located in breast cancer susceptibility chromosome regions, and evaluate their associations with breast cancer risk and survival. We examined the genotypes of 10 AEI SNPs in 1551 incident breast cancer cases and 1605 age-frequency matched controls from Guangzhou, China. Read More

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January 2017

Cigarette smoking and risk of pancreatic cancer: a clinic-based case-control study in the San Francisco Bay Area.

Ann Epidemiol 2015 Nov 29;25(11):816-23. Epub 2015 Aug 29.

Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA.

Purpose: Cigarette smoking is an established risk factor for pancreatic cancer (PC). We examined the association between cigarette smoking and PC in a San Francisco Bay Area clinic-based, case-control study.

Methods: A total of 536 cases and sex and age frequency-matched controls (n = 869) were recruited predominately from the University of California San Francisco (UCSF) medical clinics between 2006 and 2011. Read More

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November 2015

MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer.

Oncotarget 2016 May;7(22):31825-31

Department of Urology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xian, China.

The p53 gene and MDM2 gene play critical roles in cell cycle arrest and apoptosis together. Here, we evaluated the associations of prostate cancer risk and survival with the joint effects of mdm2 and p53 polymorphisms. Totally 1,193 cases and 1,310 age frequency-matched controls were included in the study. Read More

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Childhood rhabdomyosarcoma in Kano, Nigeria: a retrospective analysis of 52 cases.

Niger J Med 2015 Jan-Mar;24(1):32-6

Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in children ≤ 15 years of age. There is, however, a paucity of reports on the pattern of its occurrence in Nigeria and other parts of Africa.

Objective: The aim of this review is to highlight the age and sex distribution, anatomical location and morphological characteristics of rhabdomyosarcoma among children in Kano, northwestern Nigeria. Read More

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Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai.

PLoS One 2015 13;10(2):e0118004. Epub 2015 Feb 13.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Pancreatic cancer has been increasing in importance in Shanghai over the last four decades. The etiology of the disease is still unclear. Evidence suggests that the COX-2 pathway, an important component of inflammation, may be involved in the disease. Read More

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December 2015

Association of variants in genes related to the immune response and obesity with BPH in CLUE II.

Prostate Cancer Prostatic Dis 2014 Dec 16;17(4):353-8. Epub 2014 Sep 16.

1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA [2] Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA [3] Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (IL1B, IL6, IL8, IL10, TNF, CRP, TLR4 and RNASEL) and genes involved in obesity, including insulin regulation (LEP, ADIPOQ, PPARG and TCF7L2), with BPH. Read More

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December 2014

First-ever population-based study on status epilepticus in French Island of La Reunion (France) - incidence and fatality.

Seizure 2014 Oct 26;23(9):769-73. Epub 2014 Jun 26.

INSERM U1094, Tropical Neuroepidemiology, Limoges, France; University of Limoges, School of Medicine, Institute of Neuroepidemiology and Tropical Neurology, GEIST, Limoges, France; CHU, Limoges, France. Electronic address:

Purpose: We aimed to determine the incidence and case-fatality of first-ever status epilepticus (SE) among the general population living in La Reunion Island, a French overseas territory in the Indian Ocean near Madagascar.

Methods: We recruited cases (1st July 2004-30th June 2005) in a population-based manner using neurology, neurosurgery, electroencephalogram, emergency, paediatric and neuroradiology services; emergency medical aid service; emergency and admission service of private and public clinics; neurologists (public and private); private paediatricians and practitioners of various rural hospitals. All cases had an electroencephalogram (EEG) and were assessed by an epileptologist. Read More

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October 2014

Adolescent dietary fiber, vegetable fat, vegetable protein, and nut intakes and breast cancer risk.

Breast Cancer Res Treat 2014 Jun 16;145(2):461-70. Epub 2014 Apr 16.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8100, St. Louis, MO, 63110, USA.

The importance of early-life exposures in breast cancer development is increasingly recognized. However, limited research has evaluated the relationship between adolescent diet and subsequent risk of breast cancer and reported inconsistent results. This population-based case-control study investigated the associations of dietary fiber, vegetable protein, vegetable fat, and nuts consumed during adolescence with adult breast cancer risk. Read More

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Age at breast cancer diagnosis in populations of african and European ancestry.

Breast J 2014 Mar-Apr;20(2):180-4

Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pôle Parent-Enfant, Service de Gynécologie et Obstétrique, Pointe-à-Pitre Cedex, Guadeloupe, France; Institut National de la Santé et de la Recherche Médicale Inserm U1085 - IRSET, Pointe-à-Pitre Cedex, Guadeloupe, France.

Based on US national cancer registry data, age differences at breast cancer diagnosis have been reported between African-American women and European-American women. Such differences between populations of African and European ancestry have not been studied in other countries at a nationwide level. Here, we report and compare descriptive nationwide epidemiological indicators of invasive breast cancer for the populations of European ancestry living in the US and in mainland France and for women of African ancestry living in the US and in the French West Indies (Martinique and Guadeloupe). Read More

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Prediction of oesophageal varices in cirrhosis of liver patients by serum ascitic albumin gradient.

Mymensingh Med J 2013 Oct;22(4):669-75

Dr Ataur Rahman, Indoor Medical Officer, Department of Medicine, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

This hospital based observational study was carried out to evaluate the relation between serum ascitic albumin gradient and oesophageal varices in cirrhosis of liver disease patient. This was a hospital based observational study on 50 cases of diagnosed cirrhosis of liver disease patients in department of medicine of Mymensingh medical college Hospital, Mymensingh, Bangladesh from 8th January 2012 to 07th July 2012 for a period of 6 months. The study showed age frequency 5(10%) were from 21-30 years, 15(30%) were from 31-40 years 15(30%) were from 40-50years, and 15(30%) were from ≥51 years of age. Read More

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October 2013

Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer.

Epigenetics 2013 Jul 17;8(7):748-55. Epub 2013 Jun 17.

Cancer and Population Studies Group; Queensland Institute of Medical Research; Herston, QLD Australia.

Changes in the methylation levels of DNA from white blood cells (WBCs) are putatively associated with an elevated risk for several cancers. The aim of this study was to investigate the association between colorectal cancer (CRC) and the methylation status of three DNA repetitive elements in DNA from peripheral blood. WBC DNA from 539 CRC cases diagnosed before 60 years of age and 242 sex and age frequency-matched healthy controls from the Australasian Colorectal Cancer Family Registry were assessed for methylation across DNA repetitive elements Alu, LINE-1 and Sat2 using MethyLight. Read More

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SULT1A1 genetic polymorphisms and the association between smoking and oral cancer in a case-control study in Brazil.

Front Oncol 2012 18;2:183. Epub 2012 Dec 18.

National School of Public Health/FIOCRUZ Rio de Janeiro, Brazil.

Introduction: Oral cancer is a public health problem worldwide, being tobacco and alcohol consumption their main risk factors. Sulfotransferase (SULT) 1A1 (encoded by SULT1A1) is involved in procarcinogens metabolism, such as polycyclic aromatic hydrocarbons (PAHs) present in tobacco smoke.

Objective: The aim of this study was to explore the magnitude of association between SULT1A1 gene Arg(213)His polymorphism and oral cancer, and to explore the interaction between such polymorphism and smoking. Read More

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December 2012