2,010,187 results match your criteria cases


Palmitoleic Acid Protects against Hypertension by Inhibiting NF-κB-Mediated Inflammation.

Mol Nutr Food Res 2021 Apr 17:e2001025. Epub 2021 Apr 17.

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

Scope: The role of palmitoleic acid (POA) in hypertension or blood pressure remains uncertain. We aim to investigate the epidemiological association between circulating POA and primary hypertension in humans, and subsequently evaluate the effects of exogenous POA on blood pressure and aortic remodeling in spontaneously hypertensive rats (SHRs).

Methods And Results: We conducted a case-control study of 349 hypertensive and 1396 normotensive children and adolescents, and found hypertensive cases showed significant lower erythrocyte phospholipid POA than normotensive controls (P < 0. Read More

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Safety of a Protective Funnel in Primary Breast Augmentation: A Retrospective Analysis of 380 Multicenter Cases in the United States.

Aesthet Surg J 2021 Apr 17. Epub 2021 Apr 17.

Background: Protective funnels devices are commonly used to deliver implants in primary breast augmentation (BA) yet there is a paucity of evidence-based data describing their safety in the literature.

Objectives: The purpose of the study was to assess the safety of protective funnels in primary BA within the first 30-days postoperatively.

Methods: This multi-center, Level 3 study retrospectively reviewed the surgical records of 380 consecutive patients (760 breasts) who underwent primary BA by nine board-certified plastic surgeons using the iNPLANT Funnel (Proximate Concepts LLC, Allendale, NJ, USA) for implant delivery between November 2019 and December 2020. Read More

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Inflammatory Bowel Disease as a Precondition for Stroke or TIA: A Matter of Crohn's Disease Rather than Ulcerative Colitis.

J Stroke Cerebrovasc Dis 2021 Apr 14;30(7):105787. Epub 2021 Apr 14.

Epidemiology, IQVIA, Frankfurt am Main, Germany.

Background: As a chronic systemic inflammation may be associated with an increased risk of vascular events, the aim of the present study was to assess the incidence of stroke and transient ischemic attack (TIA) in patients with inflammatory bowel disease over a period of 15 years.

Methods: This cohort study included patients for whom the initial diagnosis of an inflammatory bowel disease (IBD) (Crohn's disease: CD and ulcerative colitis: UC) was documented anonymously between 2000 and 2015 in 1,262 general practices in Germany. IBD patients were matched to patients without IBD using propensity scores based on age, sex, physician, co-diagnoses and co-therapies. Read More

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Duplicated Middle Cerebral Artery Aneurysms Treated by Coil Embolization; A Report of Two Cases and Literature Review.

J Stroke Cerebrovasc Dis 2021 Apr 14;30(7):105773. Epub 2021 Apr 14.

Department of Neurosurgery, Nara Medical University, Kashihara, Japan. Electronic address:

Background: Duplication of the middle cerebral artery (DMCA) is an anomalous vessel arising from the internal carotid artery (ICA). Aneurysms at the origin of a DMCA have been reported; however, most have been treated with clipping surgery. Here, we describe two cases of aneurysms at the origin of a DMCA treated with coil embolization. Read More

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Immediate rehabilitation of a rheumatoid arthritis patient with single-piece implants.

Int J Surg Case Rep 2021 Apr 7;82:105874. Epub 2021 Apr 7.

Dr Hedgewar Smruti Rugna Sewa Mandal Dental College and Hospital, Hingoli, India.

Introduction And Importance: The aim of this article is to report the long-term outcome of full mouth rehabilitation with single piece, smooth surface implants following immediate loading protocol on a patient suffering with RA and severe unilateral condylar resorption.

Case Presentation: Here, we present a challenging case of a patient suffering from Rheumatoid Arthritis who was stabilized and completed successfully with a 4 year follow-up period. Prosthetic management optimized the inter-occlusal relationship to maintain both function and esthetic integrity. Read More

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Chronical rhino-orbital mucormycosis in an immunocompetent host: A case report.

Int J Surg Case Rep 2021 Apr 10;82:105882. Epub 2021 Apr 10.

Faculté de Médecine et Pharmacie, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco; Service de Stomatologie et chirurgie Maxillo-faciale, Hôpital 20 Août, CHU Ibn Rochd, B.P 2698, Casablanca, Morocco.

Mucormycosis is an opportunistic fungal infection caused by molds within the order Mucorales. The rhino-orbital-cerebral localization is the most frequent. It is a destructive, necrotizing and potentially fatal disease. Read More

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Quantifying intraepithelial lymphocytes and subepithelial collagen band in microscopic colitis, extracting insights into the interrelationship of lymphocytic and collagenous colitis.

Ann Diagn Pathol 2021 Mar 31;52:151741. Epub 2021 Mar 31.

Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; Department of Medical Gastroenterology, Zealand University Hospital Koege, Lykkebækvej 1, 4600 Koege, Denmark.

Microscopic colitis (MC) is the umbrella term for the conditions termed lymphocytic colitis (LC) and collagenous colitis (CC). LC with thickening of the subepithelial collagen band or CC with increased number of intraepithelial T- lymphocytes (IELs) is often seen in MC and may lead to difficulties in correct histological classification. We investigated the extent of overlapping features of CC and LC in 60 cases of MC by measuring the exact thickness of the subepithelial collagen band in Van Gieson stained slides and quantifying number of IELs in CD3 stained slides by digital image analysis. Read More

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Towards standardization of lymph-node ratio classifications: Validation and comparison of different lymph node ratio classifications for predicting prognosis of patients with resected gastric cancer.

Ann Diagn Pathol 2021 Mar 31;52:151738. Epub 2021 Mar 31.

Complutense University of Madrid, Av. Séneca 2, 28040 Madrid, Spain; Hospital General Universitario Gregorio Marañón, c/ Dr. Esquerdo n° 46, 28007 Madrid, Spain.

Introduction: The TNM staging system is the main prognostic tool for GC, but the number of metastatic lymph nodes (LN) can be affected by surgical, pathological, tumor or host factors. Several authors have shown that lymph node ratio (LNR) may be superior to TNM staging in GC. However, cut-off values vary between studies and LNR assessment is not standardized. Read More

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Placenta pathology in recipient versus donor oocyte derivation for in vitro fertilization in a setting of hypertensive disorders of pregnancy and IUGR.

Placenta 2021 Mar 23;108:114-121. Epub 2021 Mar 23.

Department of Pathology, University of Ottawa, Children's Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada. Electronic address:

Introduction: Assisted reproductive technology including in vitro fertilization (IVF) and oocyte donation (OD) may increase risk for placenta-mediated diseases. Comprehensive analysis of histopathological placental lesions according to source of oocytes used in the IVF procedure - recipient derived (RD-IVF) vs oocyte donation (OD-IVF), has not been conducted in a population with a hypertensive disorder of pregnancy (HDP) and/or intrauterine growth restriction (IUGR).

Methods: A retrospective cohort study of archived placenta specimens from RD-IVF and OD-IVF pregnancies affected by HDP and/or IUGR was conducted with blinded histopathological placental examination. Read More

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First record of Ixodes simplex found on a human host, with a review of cases of human infestation by bat tick species occurring in Europe.

Ticks Tick Borne Dis 2021 Apr 6;12(4):101722. Epub 2021 Apr 6.

University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Faculty of Veterinary Medicine, Department of Parasitology and Parasitic Diseases, Romania; Department of Parasitology and Zoology, University of Veterinary Medicine, Budapest, Hungary. Electronic address:

Ixodes simplex is a bat tick species, a common parasite of the Schreibers' bent-winged bat, Miniopterus schreibersii. Its distribution is linked to the range of its host, free stages occurring exclusively inside the underground bat shelters. Here we present the first case of human infestation with I. Read More

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Infraoptic anterior cerebral artery or carotid-anterior cerebral artery anastomosis: A very rare embryological variation. Case series and review of literature.

Clin Imaging 2021 Mar 20;79:8-11. Epub 2021 Mar 20.

Yale New Haven Health Bridgeport Hospital, Department of Radiology, 267 Grant Street, Bridgeport, CT 06610, USA.

Purpose: An infraoptic course of the anterior cerebral artery (ACA) is a rare cerebrovascular variation that can be associated with anterior communicating artery aneurysm. The purpose of this study is: 1. Describe infraoptic ACA or Carotid-ACA anastomosis. Read More

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Impact of PTRIA (Patient Test Result Information Act) on patient follow up management.

Clin Imaging 2021 Mar 22;79:20-23. Epub 2021 Mar 22.

Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, 1, Silverstein Ste. 130, Philadelphia, PA 19104, United States of America. Electronic address: https://twitter.com/asset25.

Objective: We aim to study if direct patient notification in accordance with the Patient Test Results Information Act (Act 112) in Pennsylvania leads to decreased loss to follow up and prompt management of actionable imaging findings.

Methods: For this IRB-approved study, radiology reports were randomly identified using the Nuance mPower™ search engine. The actionable finding group (prior to Act-112) contained 300 patients for which a voice notification was sent by radiologists to alert ordering physicians about significant imaging findings. Read More

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Abdominal Computed Tomography Angiography and Venography in Evaluation of Hemorrhagic and Thrombotic lesions in Hospitalized COVID-19 patients.

Clin Imaging 2021 Apr 14;79:12-19. Epub 2021 Apr 14.

Diagnostic and Interventional Radiology Department, Alexandria Faculty of Medicine, Shamplion Street, Alexandria 21131, Egypt. Electronic address:

Purpose: To report imaging findings at computed tomography angiography (CTA) and venography (CTV) of the abdomen and pelvis in evaluation of hemorrhagic and thrombotic lesions in hospitalized patients with COVID-19.

Methods: In this retrospective observational study, patients admitted to a single tertiary care center from April 1 to July 20, 2020, who tested positive for SARS-CoV-2 and developed acute abdominal pain or decreasing hemoglobin levels over the course of hospitalization were included. Abdominal CTA/CTV imaging studies performed in these patients were reviewed, and acute hemorrhagic or thromboembolic findings were recorded. Read More

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The changes in kynurenine metabolites induced by rTMS in treatment-resistant depression: A pilot study.

J Psychiatr Res 2021 Apr 9;138:194-199. Epub 2021 Apr 9.

Department of Psychiatry, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, 849-8501, Japan.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that is considered a valuable and promising technique for improving depressive symptoms in treatment-resistant depression (TRD). However, the exact mechanism by which rTMS ameliorates depressive symptoms remains to be clarified.

Objective: The aim of the present study was to analyzed the changes in metabolites of patients with TRD in the rTMS treatment, especially focusing on the kynurenine (KYN) pathway. Read More

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Life cycle assessment of prospective sewage sludge treatment paths in Germany.

J Environ Manage 2021 Apr 14;290:112557. Epub 2021 Apr 14.

Department of Agricultural Sciences, Nutritional Sciences and Environmental Management, Justus-Liebig-University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.

Due to the amendment of the sewage sludge ordinance, both a thermal post-treatment and a phosphorous recovery from sewage sludge will become mandatory for large-scale wastewater treatment plants in Germany. This study analyzed four prospective treatment paths for sewage sludge by means of life cycle assessment. In the realm of a gate-to-cradle approach, environmental impacts were quantified for all compartments of the ReCiPe Midpoint (H) 2016 method. Read More

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Targeting of myeloid-derived suppressor cells by all-trans retinoic acid as host-directed therapy for human tuberculosis.

Cell Immunol 2021 Apr 8;364:104359. Epub 2021 Apr 8.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

Conventional anti-tuberculosis (TB) therapies comprise lengthy antibiotic treatment regimens, exacerbated by multi-drug resistant and extensively drug resistant mycobacterial strains. We assessed the ability of all-trans retinoic acid (ATRA), as repurposed compound serving as host-directed therapy (HDT), to counteract the suppressive effects of myeloid-derived suppressor cells (MDSCs) obtained from active TB cases (untreated or during week one of treatment) on T-cell responsiveness. We show for the first time that MDSCs suppress non-specific T-cell activation and production of interleukin (IL)-2, IL-4, IL-13 and GM-CSF via contact-dependent mechanisms. Read More

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Detection of SARS-CoV-2 RNA in the Danube River in Serbia associated with the discharge of untreated wastewaters.

Sci Total Environ 2021 Apr 8;783:146967. Epub 2021 Apr 8.

University of Belgrade, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, Department of Hydroecology and Water Protection, Bulevar despota Stefana 142, 11000 Belgrade, Serbia.

In Serbia less than 13% of collected municipal wastewaters is being treated before their release in the environment. This includes all municipal wastewater discharges from Belgrade (capital city of Serbia; population 1,700,000). Previous research has identified the impacts of raw wastewater discharges from Belgrade on the Danube River, and this study investigated if such discharges also provided a pathway for SARS-CoV-2 RNA material. Read More

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Plasma as an alternative COVID-19 diagnostic specimen in a hospitalized patient negative for SARS-CoV-2 by nasopharyngeal swab.

Diagn Microbiol Infect Dis 2021 Mar 4;100(3):115365. Epub 2021 Mar 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Clinical Virology Laboratory, Stanford Health Care, Stanford, CA, USA. Electronic address:

We present the case of an inpatient with pneumonia and repeatedly negative nasopharyngeal SARS-CoV-2 testing. In such challenging cases, alternative diagnostic options include lower respiratory tract and plasma SARS-CoV-2 RNA testing, of which the latter may be particularly useful where bronchoscopy is deferred due to clinical factors or transmission risk. Read More

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Mechanical characterization of abdominal aortas using multi-perspective ultrasound imaging.

J Mech Behav Biomed Mater 2021 Apr 14;119:104509. Epub 2021 Apr 14.

Photoacoustics & Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, the Netherlands.

Mechanical characterization of abdominal aortic aneurysms using personalized biomechanical models is being widely investigated as an alternative criterion to assess risk of rupture. These methods rely on accurate wall motion detection and appropriate model boundary conditions. In this study, multi-perspective ultrasound is combined with finite element models to perform mechanical characterization of abdominal aortas in volunteers. Read More

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A comparative study between the incidence and epidemiological features of Influenza-Like Illness and laboratory-confirmed COVID-19 cases in the Italian epicenter (Lombardy).

J Infect Public Health 2021 Feb 23;14(5):674-680. Epub 2021 Feb 23.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy; Interuniversity Research Center on Influenza and Other Transmissible Infections (CIRI-IT), Genoa, Italy. Electronic address:

Introduction: In Lombardy, the influenza surveillance system relies on sentinel physicians that weekly report data on the number of Influenza-Like Illness (ILI) and a part of them also collect nasopharyngeal samples for virologic analyses. This study aims at comparing the ILI incidence of 2019-2020 influenza season with the incidence of COVID-19 cases in order to better understand the current epidemic and to evaluate whether the implementation of ILI surveillance system could succeed in early detection and monitoring of COVID-19 diffusion.

Methods: The distribution of ILI cases in the seasons 2017-2018, 2018-2019 and 2019-2020 was taken in consideration and the curve trends were compared and analyzed according to geographical areas, age groups and time differences. Read More

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February 2021

Body composition and handgrip strength in patients with prediabetes: A case-control study from Haryana, North India.

Diabetes Metab Syndr 2021 Apr 9;15(3):823-827. Epub 2021 Apr 9.

Department of Medicine, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India. Electronic address:

Background And Aims: Previous studies suggest that body composition and handgrip strength are significantly altered in individuals with type 2 diabetes mellitus. Only few studies are available in prediabetic individuals. The aim is to study the change in body composition in adult individuals with prediabetes and compare it with age and sex-matched normoglycemic individuals. Read More

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Excitation functions of proton induced reactions on titanium and copper.

Appl Radiat Isot 2021 Apr 14;173:109713. Epub 2021 Apr 14.

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.

Excitation functions of the Tnati(p,x)S43,47c, V48 and Cnatu(p,x)Cu, Z62,65n reactions were measured in the energy range of 8.8-18.4 MeV by using the stacked-foil activation technique and off-line gamma spectroscopy. Read More

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Scenario analysis of COVID-19 transmission dynamics in Malaysia with the possibility of reinfection and limited medical resources scenarios.

Comput Biol Med 2021 Apr 7;133:104372. Epub 2021 Apr 7.

Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.

COVID-19 is a major health threat across the globe, which causes severe acute respiratory syndrome (SARS), and it is highly contagious with significant mortality. In this study, we conduct a scenario analysis for COVID-19 in Malaysia using a simple universality class of the SIR system and extensions thereof (i.e. Read More

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Assessing recurrence of depression using a zero-inflated negative binomial model: A secondary analysis of lifelog data.

Psychiatry Res 2021 Apr 1;300:113919. Epub 2021 Apr 1.

Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan.

When studying recurrence of depression, researchers should pay attention to cases where physicians' assessment corresponds to the patients' perception. However, they should also focus on potential signs of recurrence when the recurrence is suspected by the physicians but not the patients (false-negative zeros). Because false negatives can delay diagnosis and treatment, we aimed to investigate "sitting idly" as a predictor influencing no alert sign of recurrence and estimated the counts of recurrence of depression. Read More

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Risk factors and mechanisms of in vivo emergence of colistin resistance in carbapenem-resistant Klebsiella pneumoniae.

Int J Antimicrob Agents 2021 Apr 14:106342. Epub 2021 Apr 14.

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. Electronic address:

Colistin is one of the last-resort antibiotics for treating carbapenem-resistant Klebsiella pneumoniae (CRKP). However, colistin resistance in CRKP poses a global antimicrobial crisis as therapeutic options are limited. We investigated risk factors for in vivo emergence of colistin resistance in CRKP and explored the underlying resistance mechanisms. Read More

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Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.

J Steroid Biochem Mol Biol 2021 Apr 14:105899. Epub 2021 Apr 14.

Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, 200025, PR China. Electronic address:

Context: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive genetic diseases caused by genetic deficiency in nine genes encoding steroidogenesis enzymes and cofactors.

Objective: To establish a targeted next-generation sequencing (NGS) assay for all nine CAH candidate genes.

Methods: We developed a customized targeted NGS assay of CAH candidate genes (CYP21A2, CYP17A1, CYP11B1, StAR, CYP11A1, POR, HSD3B2, H6PD, CYP11B2) and apply this assay plus MLPA of CYP21A2 in a total of 469 patients with CAH like signs and symptoms. Read More

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Recent Trends in Human Brucellosis in the West Bank, Palestine.

Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Preventive Medicine Department, Palestinian Ministry of Health, Palestine.

Objectives: To investigate the epidemiology of human brucellosis in the West Bank over the past 20 years with a focus on recent trends in disease incidence from 2000 through 2020.

Methods: We conducted a long-term descriptive epidemiological study based on the Palestinian Ministry of Health records from 2000-2020.

Results: The total number of cases was 7935 and the average annual incidence rate (AAIR) was 9. Read More

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LAMP Assay Targeted RLEP for Detection of Mycobacterium Leprae in leprosy patients.

Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

State Key of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, China. Electronic address:

Objective: Leprosy is a chronic infectious disease caused by Mycobacterium leprae and remains a significant health problem in several parts of the world. Early and accurate diagnosis of this disease is therefore important. Previously published LAMP protocols for detection of mycobacterial species used conventional specific primers and targeted the 16S rRNA, gyrB, and insertion sequence genes. Read More

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Implementation of a Magnetic Resonance Imaging scanner dedicated to emergencies in cases of binocular diplopia: impact on patient management.

J Neuroradiol 2021 Apr 14. Epub 2021 Apr 14.

Service des Urgences, Hôpitaux Universitaires de Strasbourg, 1, Place de l'Hôpital, 67000 Strasbourg, France. Electronic address:

Rationale And Objectives: Evaluate the implementation of an MRI scanner dedicated to emergencies on the management of patients admitted in the emergency department (ED) for binocular diplopia (BD).

Material And Methods: This was a prospective non-interventional single-center study from February 2018 to February 2020. A total of 110 patients were included: 52 patients during the first stage (29 women; 23 men; mean age 65. Read More

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Effects of endodontic infections on the maxillary sinus: a case series of treatment outcome.

J Endod 2021 Apr 14. Epub 2021 Apr 14.

Member of the Endochat research group, Rio de Janeiro, RJ, Brazil; Postgraduate Program in Dentistry, University of Grande Rio (UNIGRANRIO), Rio de Janeiro, RJ, Brazil; Department of Dental Research, Faculty of Dentistry, Iguaçu University (UNIG), Nova Iguaçu, RJ, Brazil.

Introduction: This article shows the follow-up of several cases of maxillary sinusitis of dental (usually endodontic) origin, with different manifestations, diagnostic challenges and outcomes.

Methods: Cases from 14 patients from 3 countries and treated by 7 different endodontists are presented, all of them with inflammatory sinus changes represented by mucositis, osteoperiostitis, and partial/full obstruction.

Results: All cases showed dental and/or sinus signs/symptoms, that resolved after dental management. Read More

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