1,778 results match your criteria case n=40

Risk factors and outcomes of postoperative aspiration pneumonia in abdominal surgery patients: An exact matching and weighting analysis.

Surgery 2021 Jun 17. Epub 2021 Jun 17.

Department of Surgery, Kantonsspital St. Gallen, CH-9007 St. Gallen, Switzerland. Electronic address:

Background: Postoperative aspiration pneumonia is a feared complication contributing significantly to postoperative morbidity and mortality. Over decades, there has been little progress in reducing incidence and mortality of postoperative aspiration pneumonia. Here, we assessed risk factors for postoperative aspiration pneumonia in general and abdominal surgery patients. Read More

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Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study.

J Laryngol Otol 2021 Jun 17:1-4. Epub 2021 Jun 17.

Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Objectives: This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals.

Method: This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18-75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Read More

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A case series of CBT-T in routine clinical practice.

Int J Eat Disord 2021 Jun 17. Epub 2021 Jun 17.

School of Education, University of Bristol, Bristol, UK.

Objective: CBT-T is a relatively new, brief cognitive behavioral therapy eating disorder treatment for non-underweight patients. This study evaluates CBT-T independently from the team that developed the protocol, and examines the relationship between eating disorder duration and CBT-T effectiveness.

Method: A case series design was used, comprising N = 40 adults with bulimia or atypical anorexia type eating disorders. Read More

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[Malnutrition in geriatric patients: risk factor residential nursing home?]

HeilberufeScience 2021 Jun 11:1-9. Epub 2021 Jun 11.

Fakultät Soziale Arbeit, Bildung und Pflege, Institut für Gesundheits- und Pflegewissenschaften, Hochschule Esslingen - University of Applied Sciences, Flandernstraße 101, 73732 Esslingen am Neckar, Deutschland.

Background: Malnutrition remains a challenging problem in hospitals, especially among geriatric patients. The background and causes are actually well known but still underestimated in clinical practice.

Aim And Methods: This study evaluated possible differences in rates of malnutrition risk and malnutrition in geriatric patients living at home and geriatric patients living in residential nursing homes. Read More

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Risk Factors Associated with Preterm Prelabor Rupture of Membranes after Cord Occlusion in Monochorionic Diamniotic Twins.

Fetal Diagn Ther 2021 Jun 15:1-7. Epub 2021 Jun 15.

BCNatal Fetal Medicine Research Center, Hospital Clínic and Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.

Introduction: Preterm prelabor rupture of membranes (PPROM) is a common complication after fetal surgeries. The aim of this study was to assess risk factors for and outcomes after PPROM following cord occlusion (CO) in monochorionic diamniotic (MCDA) pregnancies.

Methods: This was a retrospective cohort study of 188 consecutive MCDA pregnancies treated by bipolar or laser CO, either primarily because of discordant malformation (dMF) or severe selective fetal growth restriction (sFGR), or secondarily when complete bichorionization was not possible in case of twin-to-twin transfusion syndrome (TTTS) or sFGR. Read More

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Comparison of equipotent doses of intrathecal hyperbaric prilocaine 2% and hyperbaric bupivacaine 0.5% for elective caesarean section: A prospective, randomised, controlled, two-centre clinical trial.

Eur J Anaesthesiol 2021 May 18. Epub 2021 May 18.

From the Department of Anaesthesiology and Pain Medicine, University Hospital Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels (PG, RL, YV, YK), Ars Statistica, Nivelles (J-FF) and Department of Anaesthesiology, Clinique Sainte Anne-Saint Remi, CHIREC, Brussels, Belgium (PEG) Philippe Goffard and Renaud Leloup are joint first authors.

Background: Elective caesarean section is performed mainly under spinal anaesthesia using hyperbaric bupivacaine combined with opioids. Despite rapid onset, good quality anaesthesia, bupivacaine provides a long duration of motor block and is related to maternal hypotension. Current policies appeal for implementation of enhanced recovery procedures after caesarean section. Read More

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Assessment of the Macular Microvasculature in High Myopes With Swept Source Optical Coherence Tomographic Angiography.

Front Med (Lausanne) 2021 17;8:619767. Epub 2021 May 17.

Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.

The risk of pathologic myopia (PM) increases with worsening myopia and may be related to retinal microvasculature alterations. To evaluate this, we analyzed the macular microvasculature of myopes with swept source-optical coherence tomographic angiography (SS-OCTA) in adolescent and young adult Singaporeans. This is a prevalent case-control study including 93 young Chinese from the Strabismus, Amblyopia and Refractive error in Singaporean children (STARS, = 45) study and the Singapore Cohort Study of Risk Factors for Myopia (SCORM, = 48) studies. Read More

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Rate of Post-Operative Pancreatic Fistula after Robotic-Assisted Pancreaticoduodenectomy with Pancreato-Jejunostomy versus Pancreato-Gastrostomy: A Retrospective Case Matched Comparative Study.

J Clin Med 2021 May 18;10(10). Epub 2021 May 18.

Department of General Surgery, College of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland.

Background: Different techniques of pancreatic anastomosis have been described, with inconclusive results in terms of pancreatic fistula reduction. Studies comparing robotic pancreaticogastrostomy (PG) and pancreaticojejunostomy (PJ) are scarcely reported.

Methods: The present study analyzes the outcomes of two case-matched groups of patients who underwent PG ( = 20) or PJ ( = 40) after pancreaticoduodenectomy. Read More

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Calibrating Accelerometer Tags with Oxygen Consumption Rate of Rainbow Trout () and Their Use in Aquaculture Facility: A Case Study.

Animals (Basel) 2021 May 21;11(6). Epub 2021 May 21.

COISPA Tecnology & Research-Experimental Station for the Study of Sea Resources, 70126 Bari, Italy.

Metabolic rates are linked to the energetic costs of different activities of an animal's life. However, measuring the metabolic rate in free-swimming fish remains challenging due to the lack of possibilities to perform these direct measurements in the field. Thus, the calibration of acoustic transmitters with the oxygen consumption rate (MO) could be promising to counter these limitations. Read More

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Sex Difference in the Case Fatality of Older Myocardial Infarction Patients.

J Gerontol A Biol Sci Med Sci 2021 May 28. Epub 2021 May 28.

Department of Public Health, University of Turku, Turku, Finland.

Background: The female sex is associated with poorer outcomes after myocardial infarction (MI), although current evidence in older patients is limited and mixed. We sought to evaluate sex-based differences in outcome after MI in older patients.

Methods: Consecutive older (≥ 70 years) all-comer patients with out-of-hospital MI admitted to 20 hospitals in Finland between 2005-2014 were studied using national registries (n=40,654, mean age 80 years, 50% women). Read More

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Rare Adverse Events with Programmed Death-1 and Programmed Death-1 Ligand Inhibitors: Justification and Rationale for a Systematic Review.

Curr Oncol Rep 2021 May 26;23(7):86. Epub 2021 May 26.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55902, USA.

Purpose: Immune checkpoint inhibitors are a new class of cancer drug that spawn unusual adverse events that generate unusual and sometimes unexpected adverse events. Despite databases that track such adverse events, there remains a need to also generate systematic reviews to capture side effects from such agents.

Findings: We generated a systematic compendium of adverse event reports. Read More

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REM Sleep Behavior Disorder in Parkinson's Disease: Change in Cognitive, Psychiatric, and Functional Outcomes from Baseline to 16-47-Month Follow-Up.

Arch Clin Neuropsychol 2021 May 25. Epub 2021 May 25.

Research Service, VA San Diego Healthcare System, San Diego, CA, USA.

Objective: Rapid Eye Movement Sleep Behavior Disorder (RBD) is common in Parkinson's Disease (PD) and is associated with cognitive impairment; however, the majority of the evidence on the impact of RBD on multidomain cognitive batteries in PD is cross-sectional. This study evaluated the longitudinal impact of probable RBD (pRBD) on cognitive, psychiatric, and functional outcomes in people with PD.

Method: Case-control study. Read More

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Optimizing Outcomes After Cleft Palate Repair: Design and Implementation of a Perioperative Clinical Care Pathway.

Cleft Palate Craniofac J 2021 May 18:10556656211017409. Epub 2021 May 18.

Sections of Pediatric Surgery and Plastic Surgery, Department of Surgery, University of Calgary, Alberta, Canada.

Objective: To evaluate the development process and clinical impact of implementing a standardized perioperative clinical care pathway for cleft palate repair.

Design: Medical records of patients undergoing primary cleft palate repair prior to pathway implementation were retrospectively reviewed as a historical control group (N = 40). The historical cohort was compared to a prospectively collected group of patients who were treated according to the pathway (N = 40). Read More

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Salmonella Bloodstream Infections in Hospitalized Children with Acute Febrile Illness-Uganda, 2016-2019.

Am J Trop Med Hyg 2021 May 17. Epub 2021 May 17.

1Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Invasive Salmonella infection is a common cause of acute febrile illness (AFI) among children in sub-Saharan Africa; however, diagnosing Salmonella bacteremia is challenging in settings without blood culture. The Uganda AFI surveillance system includes blood culture-based surveillance for etiologies of bloodstream infection (BSIs) in hospitalized febrile children in Uganda. We analyzed demographic, clinical, blood culture, and antimicrobial resistance data from hospitalized children at six sentinel AFI sites from July 2016 to January 2019. Read More

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Risk of infection in postmenopausal women with rheumatoid arthritis and osteoporosis taking denosumab and bDMARDS.

Med J Islam Repub Iran 2021 21;35:12. Epub 2021 Jan 21.

Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

There is no clear consensus regarding the potential of denosumab for increasing the risk of infection in patients who concurrently receive biologic disease-modifying anti-rheumatic drugs (bDMARDs). In this study, we compared the rate of infection in postmenopausal women with rheumatoid arthritis who received concurrent bDMARDs and denosumab with those who received bDMARDs alone. In a case-control study, postmenopausal patients with a confirmed diagnosis of rheumatoid arthritis who received concurrent bDMARDs and denosumab for at least one year were identified and included as the case group (n=40). Read More

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January 2021

Non-invasive urine markers for the differentiation between RCCs and oncocytoma.

J Clin Lab Anal 2021 May 7;35(5):e23762. Epub 2021 May 7.

Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Recently, our group showed that Vim3 is overexpressed in tissue samples of renal oncocytomas and Mxi-2 in clear cell renal carcinoma (ccRCC). The mechanism leading to the truncation of both proteins is known and involves with two miRs, both detectable in urine. Since the analysis of miRs is time-consuming, our aim was to identify the truncated proteins in urine instead. Read More

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Remote sensing-based water quality index estimation using data-driven approaches: a case study of the Kali River in Uttar Pradesh, India.

Environ Dev Sustain 2021 Apr 21:1-26. Epub 2021 Apr 21.

Civil Engineering Department, Aligarh Muslim University, (AMU), Aligarh, India.

The present study evaluates the water quality status of 6-km-long Kali River stretch that passes through the Aligarh district in Uttar Pradesh, India, by utilizing high-resolution IRS P6 LISS IV imagery. In situ river water samples collected at 40 random locations were analyzed for seven physicochemical and four heavy metal concentrations, and the water quality index (WQI) was computed for each sampling location. A set of 11 spectral reflectance band combinations were formulated to identify the most significant band combination that is related to the observed WQI at each sampling location. Read More

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Robust Lexically Mediated Compensation for Coarticulation: Christmash Time Is Here Again.

Cogn Sci 2021 Apr;45(4):e12962

Psychological Sciences, University of Connecticut.

A long-standing question in cognitive science is how high-level knowledge is integrated with sensory input. For example, listeners can leverage lexical knowledge to interpret an ambiguous speech sound, but do such effects reflect direct top-down influences on perception or merely postperceptual biases? A critical test case in the domain of spoken word recognition is lexically mediated compensation for coarticulation (LCfC). Previous LCfC studies have shown that a lexically restored context phoneme (e. Read More

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A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.

J Vis 2021 Apr;21(4)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

To assess the relative integrity of early visual and auditory processes in autism spectrum disorder (ASD), we used frequency-tagged visual and auditory stimulation and high-density electroencephalogram recordings of unimodal and dual-modality responses in a case-control design. To test for the specificity of effects on ASD, we recorded from a smaller group of children with attention-deficit hyperactivity disorder (ADHD). Horizontal 3 cycle per degree (cpd) gratings were presented at 5 Hz, and a random stream of /ba/, /da/, /ga/ syllables was presented at 6 Hz. Read More

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Influence of Parental Factors on Tobacco Smoking among Male Adolescents.

Mymensingh Med J 2021 Apr;30(2):493-502

Dr Farzana Nusrat, Lecturer, Department of Community Medicine, Dhaka Medical College, Dhaka, Bangladesh; E-mail:

In Bangladesh, more than one-fifth (20.5 percent) of the total population, that is 30.68 million is adolescents. Read More

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Trimethylamine-N-Oxide Levels Are Similar in Asymptomatic vs. Symptomatic Cerebrovascular Atherosclerosis.

Front Neurol 2021 19;12:617944. Epub 2021 Mar 19.

Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.

Trimethylamine-N-oxide (TMAO) is correlated with atherosclerosis and vascular diseases such as coronary heart disease and ischemic stroke. The aim of the study was to investigate whether TMAO levels are different in symptomatic vs. asymptomatic cerebrovascular atherosclerosis. Read More

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Sustained clinical response and safety of etanercept in patients with early axial spondyloarthritis: 10-year results of the ESTHER trial.

Ther Adv Musculoskelet Dis 2021 29;13:1759720X20987700. Epub 2021 Jan 29.

Division of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Aims: Long-term data on TNFi treatment in patients with axSpA is scarce. The objective of this analysis was to assess long-term clinical efficacy of etanercept in early axSpA [including both non-radiographic and radiographic axSpA forms], who participated in the long-term (until year 10) extension of the ESTHER-trial.

Methods: In the previously reported ESTHER-trial, patients with early active axSpA were randomized to treatment with etanercept ( = 40) or sulfasalazine ( = 36) during the first year. Read More

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January 2021

Management of sudden sensorineural hearing loss among primary care physicians in Canada: a survey study.

J Otolaryngol Head Neck Surg 2021 Apr 1;50(1):22. Epub 2021 Apr 1.

Department of Otolaryngology-Head & Neck Surgery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada.

Background: Sudden Sensorineural Hearing Loss (SSNHL) is a medical emergency requiring immediate attention as delayed treatment can lead to permanent and devastating consequences. Primary care physicians are likely the first to be presented with SSNHL and therefore have the crucial role of recognizing it and initiating timely and appropriate management. The aim of this study was to gain insight into the current knowledge and practice trends pertaining to the diagnosis and management of SSNHL among family physicians in Canada. Read More

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How well can we assess the validity of non-randomised studies of medications? A systematic review of assessment tools.

BMJ Open 2021 03 24;11(3):e043961. Epub 2021 Mar 24.

Real World Evidence Sciences, Visible Analytics Ltd, Oxford, UK.

Objective: To determine whether assessment tools for non-randomised studies (NRS) address critical elements that influence the validity of NRS findings for comparative safety and effectiveness of medications.

Design: Systematic review and Delphi survey.

Data Sources: We searched PubMed, Embase, Google, bibliographies of reviews and websites of influential organisations from inception to November 2019. Read More

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[Monitoring and telematic control of people with kidney transplant and suspected COVID-19 infection.]

Rev Esp Salud Publica 2021 Mar 22;95. Epub 2021 Mar 22.

Servicio de Nefrología. Unidad de Trasplante Renal. Hospital del Mar. Barcelona. España.

Objective: People with Kidney Transplantation require immunosuppressant treatments and this classifies them as a population at risk for virus and/or bacterial infections. The objective of the study was to describe the follow-up of transplanted people with suspected COVID19 infection.

Methods: Descriptive, cross-sectional, observational study with prospective follow-up carried out between March and June 2020. Read More

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Existential aspects in the transition to parenthood based on interviews and a theatre workshop.

Sex Reprod Healthc 2021 Jun 12;28:100612. Epub 2021 Mar 12.

Research Unit of General Practice, Institute of Public Health, University of Southern Denmark, J.B. Winsløwsvej 9A, 5000 Odense, Denmark.

Objectives: There are multitudes of existential feelings and considerations around childbirth, with both positive and negative sources of existential meaning; often they are mixed up, but they impact parents' ideas of meaning and purpose in life. The aim of this study was to explore existential aspects of parenthood transition among new fathers and mothers in view of a potential training programme for professionals in maternity services.

Study Design: Data were generated through a user-involving two-phase process inspired by action research consisting of first, four focus group-interviews (n = 10); and second, a theatre workshop for parents, health professionals, and researchers (n = 40). Read More

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Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial.

Lancet Respir Med 2021 Mar 16. Epub 2021 Mar 16.

The Aurum Institute, Johannesburg, South Africa; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Background: Current tuberculosis treatments leave patients with clinically significant lung injury and increased all-cause mortality post-cure. Adjunctive host-directed therapies could protect the lungs, improve long-term survival, and shorten treatment duration; however, few have been tested clinically. Therefore, we aimed to assess the safety and preliminary efficacy of four host-directed therapies for tuberculosis. Read More

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Contemporary Management of Complex and Non-Complex Rhegmatogenous Retinal Detachment Due to Giant Retinal Tears.

Clin Ophthalmol 2021 8;15:1013-1022. Epub 2021 Mar 8.

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.

Purpose: To investigate the clinical features and surgical outcomes of rhegmatogenous retinal detachment (RRD) associated with giant retinal tears (GRTs) at a tertiary referral center.

Patients And Methods: A retrospective, non-consecutive interventional case series of GRT-associated RRDs that underwent primary surgical repair at the University of Michigan W.K. Read More

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Surgical service monitoring and quality control systems at district hospitals in Malawi, Tanzania and Zambia: a mixed-methods study.

BMJ Qual Saf 2021 Mar 16. Epub 2021 Mar 16.

Department of Epidemiology & Public Health, Royal College of Surgeons in Ireland Division of Population Health Sciences, Dublin, Leinster, Ireland.

Background: In low-income and middle-income countries, an estimated one in three clinical adverse events happens in non-complex situations and 83% are preventable. Poor quality of care also leads to inefficient use of human, material and financial resources for health. Improving outcomes and mitigating the risk of adverse events require effective monitoring and quality control systems. Read More

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