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The Poor Prognosis of Patients with Stage III Gastric Cancer after D2 Dissection Is Mainly due to Lymphatic Metastasis, Especially the Metastasis of No.12a LN: A Nested Case-Control Study.

Oncol Res Treat 2021 May 4:1-7. Epub 2021 May 4.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect.

Methods: We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopathological features between these 2 groups. Read More

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Cost-effectiveness of feedback-informed psychological treatment: Evidence from the IAPT-FIT trial.

Behav Res Ther 2021 Apr 24;142:103873. Epub 2021 Apr 24.

Department of Health Sciences and Hull York Medical School, University of York, United Kingdom; Department of Epidemiology and Biostatistics, Western University, Canada.

Background: Feedback-informed treatment (FIT) involves using computerized routine outcome monitoring technology to alert therapists to cases that are not responding well to psychotherapy, prompting them to identify and resolve obstacles to improvement. In this study, we present the first health economic evaluation of FIT, compared to usual care, to enable decision makers to judge whether this approach represents a good investment for health systems.

Methods: This randomised controlled trial included 2233 patients clustered within 77 therapists who were randomly assigned to a FIT group (n = 1176) or a usual care control group (n = 1057). Read More

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The drive as paradigm-Laplanche's as paradigm shift.

Int J Psychoanal 2019 Dec 23;100(6):1199-1215. Epub 2019 Dec 23.

⁣Membre habilité, La sociétié psychanalytique de Montréal.

This paper begins with the argument that Freud's concept of the drive can be viewed epistemologically as a "paradigm" using the definition developed by Agamben. A paradigm is an analogical form of knowledge where the grouping of a set of examples makes phenomena more intelligible without there being a general rule for membership in the group. Next, this view of the drive as paradigm is used to argue that Laplanche's development of his concept of "le sexual" in French, rendered in English as the [in italics], is a paradigm shift for Anglophone psychoanalysis. Read More

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December 2019

Fanaticism: Reflections based on phenomena in the analytic field.

Int J Psychoanal 2019 Dec;100(6):1338-1357

Brazilian Psychoanalytic Society of São Paulo and Campinas Psychoanalytic Study Group, Campinas, Brazil.

The paper presents and discusses hypotheses related to the manifestation of fanatical aspects in the analytical field. Initially, fanaticism is discussed as a social phenomenon. In sequence, clinical facts are presented. Read More

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December 2019

Home birth preference, childbirth, and newborn care practices in rural Peruvian Amazon.

PLoS One 2021 4;16(5):e0250702. Epub 2021 May 4.

Epidemiology, STD, HIV Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.

Home birth is very common in the Peruvian Amazon. In rural areas of the Loreto region, home to indigenous populations such as the Kukama-Kukamiria, birth takes place at home constantly. This study aims to understand the preference for home births as well as childbirth and newborn care practices among Kukama-Kukamiria women in rural Loreto. Read More

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genetic testing in melanoma-prone families in Sweden in the years 2015-2020: implications for novel national recommendations.

Acta Oncol 2021 May 4:1-9. Epub 2021 May 4.

Department of Oncology and Pathology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Inherited pathogenic variants (PVs) in the gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the testing, carried out in Sweden in the years 2015-2020, was evaluated. Read More

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MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies.

Expert Opin Ther Targets 2021 May 4. Epub 2021 May 4.

Division of Medical Oncology, Department of Medicine, Montefiore Hospital and Medical Center, Bronx, NY, USA 10467-2490.

IntroductionThe gene and its pathway normally plays a crucial role in cell homeostasis, motility, and apoptosis. However, when the gene is altered, there is an imbalance towards cell proliferation and invasion commonly seen in numerous different types of cancers. The heterogeneous group of alterations that includes amplification, exon 14 skipping mutation, and fusions has been difficult to diagnose and treat. Read More

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Clinical Results of Acetabular Fracture via the Pararectus versus Ilioinguinal Approach.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopaedics, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Objective: To compare the clinical efficacy of pararectus and ilioinguinal approach in the treatment of acetabular fractures.

Methods: A retrospective analysis of the clinical data of 60 patients with acetabular fractures treated by the pararectus approach or the ilioinguinal approach from January 2016 to January 2019 was performed to record all data by comparing the length of the surgical incision, the time to expose the fracture and the amount of blood loss during the operation. Patients were routinely followed up at 1, 6 and 12 months postoperatively. Read More

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Social complexity and the fractal structure of group size in primate social evolution.

Biol Rev Camb Philos Soc 2021 May 4. Epub 2021 May 4.

Department of Earth and Environmental Sciences, Michael Smith Building, University of Manchester, Manchester, M13 9PT, UK.

Compared to most other mammals and birds, anthropoid primates have unusually complex societies characterised by bonded social groups. Among primates, this effect is encapsulated in the social brain hypothesis: the robust correlation between various indices of social complexity (social group size, grooming clique size, tactical behaviour, coalition formation) and brain size. Hitherto, this has always been interpreted as a simple, unitary relationship. Read More

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Collective Reflective Equilibrium in Practice (CREP) and controversial novel technologies.

Bioethics 2021 May 4. Epub 2021 May 4.

Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland.

In this paper, we investigate how data about public preferences may be used to inform policy around the use of controversial novel technologies, using public preferences about autonomous vehicles (AVs) as a case study. We first summarize the recent 'Moral Machine' study, which generated preference data from millions of people regarding how they think AVs should respond to emergency situations. We argue that while such preferences cannot be used to directly inform policy, they should not be disregarded. Read More

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Improving forensics: Characterizing injuries among community-dwelling physically abused older adults.

J Am Geriatr Soc 2021 May 4. Epub 2021 May 4.

Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.

Background: Physical elder abuse affects a substantial number of older adults, leaving victims at increased risk for negative health outcomes. Improved detection of abuse-related injuries may increase victim access to professional support, but providers report difficulties distinguishing between accidental and abuse-related injuries, due in part to victims' pre-existing health conditions and medication use.

Objectives: To describe the spectrum and characteristics of injuries among physically abused older adults and identify injury characteristics associated with abuse. Read More

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Subacromial-subdeltoid bursitis following COVID-19 vaccination: a case of shoulder injury related to vaccine administration (SIRVA).

Skeletal Radiol 2021 May 4. Epub 2021 May 4.

Medscanlagos Radiology, Rua Manoel Francisco Valentim, 57, Cabo Frio, RJ, 28906220, Brazil.

Vaccination injection site adverse reactions are usually mild and transient, and post-vaccination musculoskeletal symptoms, such as myalgia and arthralgia, are very common. Shoulder injury related to vaccine administration (SIRVA), defined as shoulder pain and limited range of motion occurring after the administration of a vaccine intended for intramuscular administration in the upper arm, is a well-established condition in the medical literature, yet underreported. In such cases, subacromial-subdeltoid bursitis may occur, leading to shoulder dysfunction and ongoing pain. Read More

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Effects of Low-dose Mercury Exposure in Newborns on mRNA Expression Profiles.

Bull Environ Contam Toxicol 2021 May 4. Epub 2021 May 4.

School of Public Health/Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, 550025, Guiyang, China.

This study was designed to investigate the molecular mechanism of mercury (Hg) toxicity in the newborns by mRNA sequencing (mRNA-seq). A questionnaire survey, routine blood parameters of pregnant women, and umbilical cord blood (UCB) of newborns were collected. The median (25th percentile, 75th percentile) of total Hg (THg) concentrations in UCB of newborns was 3. Read More

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Extensive subcutaneous fat necrosis complicated by neonatal hypercalcaemia.

Acta Biomed 2021 Apr 30;92(S1):e2021081. Epub 2021 Apr 30.

king abdulaziz university hospital.

subcutaneous fat necrosis is a benign and often self-limiting inflammatory disorder experienced by newborns who were exposed to perinatal stress in the form of asphyxia, hypothermia, cord prolapse, and/or sepsis. lesions are usually benign and self-limiting, with complete resolution anticipated within a few weeks up to 6 months. they can be accompanied by multiple complications. Read More

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Pediatric cerebral stroke induced by Epstein-Barr virus infection: Role of Interelukin overexpression.

Acta Biomed 2021 Apr 30;92(S1):e2021135. Epub 2021 Apr 30.

Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS - Università Cattolica Sacro Cuore, Rome, Italy .

Introduction: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an increased production of cytokines have all been advocated as main factors in determining ischemic stroke. Read More

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Symmetry relations in wurtzite nitrides and oxide nitrides and the curious case of Pmc2.

Acta Crystallogr A Found Adv 2021 May 23;77(Pt 3):208-216. Epub 2021 Mar 23.

Structure and Dynamics of Energy Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany.

Binary III-V nitrides such as AlN, GaN and InN in the wurtzite-type structure have long been considered as potent semiconducting materials because of their optoelectronic properties, amongst others. With rising concerns over the utilization of scarce elements, a replacement of the trivalent cations by others in ternary and multinary nitrides has led to the development of different variants of nitrides and oxide nitrides crystallizing in lower-symmetry variants of wurtzite. This work presents the symmetry relationships between these structural types specific to nitrides and oxide nitrides and updates some prior work on this matter. Read More

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Acute disseminated encephalomyelitis due to Rickettsia conorii infection.

S Afr Med J 2021 Mar 31;111(4):307-308. Epub 2021 Mar 31.

Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated acute inflammatory demyelinating disorder, which typically occurs after viral infections or immunisation. We present a case of a man with acute Rickettsia conorii infection whose diagnosis was delayed. He presented with fever, headache, an eschar and an acute paraplegia. Read More

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Vitamin D deficiency is a risk factor for delayed tooth eruption associated with persistent primary tooth.

Acta Odontol Scand 2021 May 4:1-6. Epub 2021 May 4.

Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - Avenida do Café, São Paulo, Brazil.

Objective: To verify the association between 25(OH)D level and polymorphisms in the vitamin D receptor gene () with the disturbance in the dental development and eruption.

Design: A total of 183 children from two datasets were evaluated. The first dataset was a case-control (15:15) designed to assess if persistent primary tooth (PPT) is associate with serum 25(OH)D level and with genetic polymorphisms in . Read More

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Dydrogesterone primed luteal phase stimulation may be better than follicular phase stimulation in patients with diminished ovarian reserve.

Gynecol Endocrinol 2021 May 4:1-3. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey.

Objective: In this study, we aimed to compare the efficacy of luteal phase stimulation (LPS) and follicular phase stimulation (FPS) in two separate menstrual cycles (2-5 months intervals) of the same patient, utilizing LPS with dydrogesteron only.

Methods: This retrospective case control study was conducted with patients with diminished ovarian reserve (DOR) (Group 1) and infertile patients with Anti-Müllerian hormone >1.2 ng/mL (Group 2) undergoing two ovarian stimulations (FPS and LPS with dydrogesteron only) and two oocyte retrievals in two separate menstrual cycles (2-5 months intervals) in the Division of Reproductive Endocrinology and Infertility of Baskent University, Ankara, between April 2019 and December 2019. Read More

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Anatomical effects of intravitreal anti-vascular endothelial growth factor injections on inner layers of the lesion-free retina.

Cutan Ocul Toxicol 2021 May 4:1-5. Epub 2021 May 4.

Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Purpose: The primary aim of the study was to investigate the effects of anti-vascular endothelial growth factor (VEGF) injections on the inner retinal layer anatomy of the lesion-free retina in eyes treated for neovascular age-related macular degeneration (nAMD). The secondary aim was to compare the changes of inner retinal layers in the lesion-free region of treated eyes with the same region of the untreated, fellow eyes and, thus, to elucidate any adverse effect of anti-VEGF treatments independently of 1-year aging changes.

Methods: This was a retrospective, longitudinal, case-control study of 50 eyes of 25 patients. Read More

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Chemotherapy-induced reticulate pigmentation in three Indian patients including a case in the pediatric age group.

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):386-388

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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Women with peripartum cardiomyopathy have normal ejection fraction, but abnormal systolic strain, during pregnancy.

ESC Heart Fail 2021 May 4. Epub 2021 May 4.

Division of Cardiology, Perelman Center for Advanced Medicine, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, 2-East Pavilion, Philadelphia, PA, 19104, USA.

We report a case series of six women with peripartum cardiomyopathy (PPCM) who incidentally underwent echocardiography prior to the clinical presentation of PPCM. For comparison, we identified controls, matched 2:1 on age, race, body mass index, gestational age, and hypertensive disorder. Among the six cases, all were diagnosed with PPCM during the post-partum period. Read More

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Simultaneous or Staged Decompressions for Patients with Tandem Spinal Stenosis.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin, China.

Objective: To compare the clinical effects of cervical decompression first, lumbar decompression first, or simultaneous decompression of both lesions in the treatment of tandem spinal stenosis (TSS).

Methods: This is a retrospective analysis. From January 2013 to December 2018, 51 TSS patients underwent our surgery and postoperative investigation. Read More

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Progress in the face of cuts: a qualitative Nigerian case study of maintaining progress towards universal health coverage after losing donor assistance.

Health Policy Plan 2021 May 4. Epub 2021 May 4.

Department of Community Medicine, University of Nigeria Teaching Hospital, P M B 01129, Enugu State, Nigeria.

In the coming years, about a dozen middle-income countries are excepted to transition out of development assistance for health (DAH) based on their economic growth. This anticipated loss of external funds at a time when there is a need for accelerated progress towards universal health coverage (UHC) is a source of concern. Evaluating country readiness for transition towards country ownership of health programmes is a crucial step in making progress towards UHC. Read More

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Health gains and financial protection from human papillomavirus vaccination in Ethiopia: findings from a modelling study.

Health Policy Plan 2021 May 4. Epub 2021 May 4.

Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115, USA.

High out-of-pocket (OOP) medical expenses for cervical cancer (CC) can lead to catastrophic health expenditures (CHEs) and medical impoverishment in many low-resource settings. There are 32 million women at risk for CC in Ethiopia, where CC screening is extremely limited. An evaluation of the population health and financial risk protection benefits, and their distributional consequences across socioeconomic groups, from human papillomavirus (HPV) vaccination will be critical to support CC prevention efforts in this setting. Read More

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Is There An Association Between Bundled Payments and "Cherry Picking" and "Lemon Dropping" in Orthopaedic Surgery? A Systematic Review.

Clin Orthop Relat Res 2021 04 30. Epub 2021 Apr 30.

D. N. Bernstein, R. W. Poolman, Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands.

Background: The goal of bundled payments-lump monetary sums designed to cover the full set of services needed to provide care for a condition or medical event-is to provide a reimbursement structure that incentivizes improved value for patients. There is concern that such a payment mechanism may lead to patient screening and denying or providing orthopaedic care to patients based on the number and severity of comorbid conditions present associated with complications after surgery. Currently, however, there is no clear consensus about whether such an association exists. Read More

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Sarcomatoid carcinoma of the lung.

Lung India 2021 May-Jun;38(3):266-268

Department of Pulmonary Medicine, All India Institute of Medical Sciences, Patna, Bihar, India.

Sarcomatoid carcinoma (SC) of the lung is a rare histological subtype of nonsmall cell lung cancer and comprises a diagnostically and therapeutically challenging group of tumors. We report a patient of SC of the lung in an elderly patient who presented with a lung mass. Computed tomography-guided biopsy of the lung mass was done, which clinched the diagnosis. Read More

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Which Criterion for Wound Drain Removal is Better Following Posterior 1-Level or 2-Level Lumbar Fusion With Instrumentation: Time Driven or Output Driven?

Global Spine J 2021 May 4:21925682211013770. Epub 2021 May 4.

Department of Spine Surgery, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.

Study Design: Case-control study.

Objectives: To compare the outcomes of 2 different criteria (time driven and output driven) for wound drain removal and identify which one is better.

Methods: 743 patients who underwent posterior lumbar fusion with instrumentation involving 1 or 2 motion segments were enrolled in this study. Read More

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Artists on the Research Team: An Interdisciplinary Approach to Team Science, Research Rigor, and Creative Dialogue.

Health Promot Pract 2021 May;22(1_suppl):83S-90S

Brown University, Providence, RI, USA.

In an arts in public health research team, artists may be undervalued as key research collaborators because of the difficulties in skillful integration of experts who possess not only different bodies of knowledge but also different ways of examining and valuing the world. Under the stewardship of two Rhode Island state agencies, an innovative research-driven enterprise, comprising researchers, clinicians, and community artists, was brought together to integrate arts-based interventions into statewide public health policy and practice. Here, we examine our work with the Rhode Island Arts and Health Advisory Group as a case study to illuminate our experiences in collaborating with artists on public health policy and practice research. Read More

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Arthroscopic Internal Drainage with Cyst Wall Resection and Arthroscopic Internal Drainage with Cyst Wall Preservation to Treat Unicameral Popliteal Cysts: A Retrospective Case-Control Study.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To compare the clinical efficacy and safety of arthroscopic internal drainage for the treatment of unicameral popliteal cysts with or without cyst wall resection.

Methods: This was a retrospective case-control study of 73 patients diagnosed with unicameral popliteal cysts from January 2012 to January 2019 who received arthroscopic treatment. The study included 38 cases with cyst wall resection (CWR group) and 35 cases with cyst wall preservation (CWP group). Read More

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