21,878 results match your criteria case emerging


Autochthonous Thelazia callipaeda Infection in Dog, New York, USA, 2020.

Emerg Infect Dis 2021 May 12;27(7). Epub 2021 May 12.

We report a case of autochthonous infection of the eye worm Thelazia callipaeda in a dog in the northeastern United States. Integrated morphologic identification and molecular diagnosis confirmed the species. Phylogenetic analysis suggested introduction from Europe. Read More

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Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1)-Quinolones with Single Dose Cures.

J Med Chem 2021 May 12. Epub 2021 May 12.

Department of Chemistry, University of South Florida, CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.

Preclinical and clinical development of numerous small molecules is prevented by their poor aqueous solubility, limited absorption, and oral bioavailability. Herein, we disclose a general prodrug approach that converts promising lead compounds into aminoalkoxycarbonyloxymethyl (amino AOCOM) ether-substituted analogues that display significantly improved aqueous solubility and enhanced oral bioavailability, restoring key requirements typical for drug candidate profiles. The prodrug is completely independent of biotransformations and animal-independent because it becomes an active compound via a pH-triggered intramolecular cyclization-elimination reaction. Read More

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Frequency, signs and symptoms, and criteria adopted for long COVID: a systematic review.

Int J Clin Pract 2021 May 11:e14357. Epub 2021 May 11.

Researcher at Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.

Aims: to identify, systematically evaluate and summarise the best available evidence on the frequency of long COVID (post-acute COVID-19 syndrome), its clinical manifestations and the criteria used for diagnosis.

Methods: Systematic review conducted with a comprehensive search including formal databases, COVID-19 or SARS-CoV-2 data sources, grey literature, and manual search. We considered for inclusion clinical trials, observational longitudinal comparative and non-comparative studies, cross-sectional, before-and-after and case series. Read More

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Complement-Mediated Thrombotic Microangiopathy Associated with Lupus Nephritis Treated with Eculizumab: A Case Report.

Case Rep Nephrol Dial 2021 Jan-Apr;11(1):95-102. Epub 2021 Mar 31.

Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California, Irvine, California, USA.

Thrombotic microangiopathies (TMAs) involve multiple organ systems due to the presence of microangiopathic hemolysis. One such condition, atypical hemolytic uremic syndrome (aHUS), is a complement-mediated process that is part of a spectrum of disorders that have underlying complement dysfunction of the alternative pathway due to overactivity or decreased self-nonself discrimination by innate immunity. Complement-amplifying conditions such as pregnancy may unmask a diagnosis of aHUS. Read More

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Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka.

Case Rep Infect Dis 2021 21;2021:5555613. Epub 2021 Apr 21.

National Hospital-Kandy, Kandy, Sri Lanka.

Hantaviruses are a large family of enveloped viruses with two medically important families Cricetidae and Muridae which are known to cause rodent-borne diseases worldwide. Some strains cause clinical syndromes with multiorgan involvement in humans such as hantavirus haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which is also known as hantavirus pulmonary syndrome. Clinical differentiation of this infection from other endemic infections in Sri Lanka such as leptospirosis and rickettsial infections is extremely difficult due to overlapping clinical and epidemiologic features such as exposure to rodents and farming. Read More

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The Diagnostic Conundrum of Retinitis and a Pigmented Scar.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):164-168. Epub 2021 Apr 12.

Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

We report a finding of a pigmented chorioretinal scar with acute retinal necrosis (ARN) caused by herpes simplex virus 2 (HSV-2) infection rather than toxoplasma, creating an initial diagnostic dilemma. A 53-year-old functionally monocular male presented with painless floaters and blurry vision in his seeing eye over a period of 4 days. An exam demonstrated anterior chamber (AC) reaction, vitritis, multifocal patches of whitening, and an occlusive retinal vasculitis. Read More

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Frontotemporal Dementia with Parkinsonism and Epilepsy Associated with VGKC Antibodies: Case Report and Literature Review.

Case Rep Neurol 2021 Jan-Apr;13(1):205-210. Epub 2021 Mar 19.

Department of Neurology, Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom.

Antibodies directed against the voltage-gated potassium channel complex (anti-VGKCs) are implicated in several autoimmune conditions including limbic encephalitis and epilepsy. However, emerging evidence suggests that only specific subtypes of anti-VGKCs are pathogenic. We present the case of a 55-year-old man who initially presented with focal unaware seizures and behavioural changes mimicking anti-VGKC-seropositive encephalitis that further progressed to parkinsonism with evidence of frontotemporal dementia and pre-synaptic dopaminergic deficit. Read More

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Combination of Crizotinib and Osimertinib in T790M+ EGFR-Mutant Non-Small Cell Lung Cancer with Emerging MET Amplification Post-Osimertinib Progression in a 10-Year Survivor: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):477-482. Epub 2021 Mar 18.

Department of Thoracic Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany.

Tyrosine kinase inhibitors (TKIs) represent the standard treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agents such as oncogene amplification. This report describes the successful results obtained with the combination of the third-generation TKI osimertinib with the multitargeted TKI and MET inhibitor crizotinib in a patient with EGFR-mutant NSCLC with emerging MET amplification with a tolerable toxicity profile. Read More

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The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data.

Drug Des Devel Ther 2021 3;15:1811-1817. Epub 2021 May 3.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.

Zonisamide is an anti-epileptic medication with multiple mechanisms of action and a favorable safety profile. Zonisamide may interact with Lewy body dementia pathophysiology through a mechanism unrelated to its original indication. Zonisamide has shown efficacy as adjunct therapy for the management of motor symptoms in patients with Parkinson's disease (PD). Read More

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coinfection as source of pyogenic liver abscess.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Internal Medicine, Michigan State University, East Lansing, Michigan, USA.

, a non-fermenting gram-negative bacterium, is emerging as an important multidrug resistant opportunistic pathogen. It has been described in cases of bacteremia, pleuritis, keratitis and peritoneal dialysis-associated peritonitis. We describe, for the first time, a case of pyogenic liver abscess caused by coinfection of and , and briefly review pyogenic liver abscesses and the literature regarding . Read More

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Bibliometric assessment and key messages of sporotrichosis research (1945-2018).

F1000Res 2020 29;9:654. Epub 2020 Jun 29.

Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 21040900, Brazil.

Sporotrichosis has recently emerged as an important mycosis worldwide, with diverse transmission and epidemiologic profiles. For instance, in Brazil most cases are related to zoonotic transmission from naturally infected cats, and the majority of cases in China are due to external injury with environmental materials. Publications on sporotrichosis and on its etiologic agent may guide the direction of the research in this field. Read More

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Nonclassic fibrodysplasia ossificans progressiva: A child from Angola with an ACVR1 variant.

Am J Med Genet A 2021 May 11. Epub 2021 May 11.

Departments of Orthopaedic Surgery, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Little is known about FOP in Africa and few cases of nonclassic fibrodysplasia ossificans progressiva (FOP) have been reported on the continent. Here we report a three-year-old girl from Angola with a nonclassic FOP clinical presentation that is characterized by complex malformations of the toes and fingers, reduction defects of the digits, absence of nails, progressive heterotopic ossification, and a confirmed heterozygous ACVR1 variant at c.983G > A. Read More

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A minimalist model for coevolving supply and drainage networks.

R Soc Open Sci 2021 Feb 17;8(2):201407. Epub 2021 Feb 17.

Princeton Environmental Institute and Department of Civil and Environmental Engineering, Princeton University, Princeton, NJ, USA.

Numerous complex systems, both natural and artificial, are characterized by the presence of intertwined supply and/or drainage networks. Here, we present a minimalist model of such coevolving networks in a spatially continuous domain, where the obtained networks can be interpreted as a part of either the counter-flowing drainage or co-flowing supply and drainage mechanisms. The model consists of three coupled, nonlinear partial differential equations that describe spatial density patterns of input and output materials by modifying a mediating scalar field, on which supply and drainage networks are carved. Read More

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February 2021

Taking stock of the availability and functions of National Ethics Committees worldwide.

BMC Med Ethics 2021 May 10;22(1):56. Epub 2021 May 10.

Health Ethics and Governance Unit, Research for Health Department, World Health Organization, 20, Avenue Appia, 1211, Geneva 27, Switzerland.

Background: National Ethics Committees (NECs) offer important oversight and guidance functions and facilitate public debate on bioethical issues. In an increasingly globalized world where technological advances, multi-national research collaborations, and pandemics are creating ethical dilemmas that transcend national borders, coordination and the joining of efforts among NECs are key. The purpose of this study is to take stock of the current NEC landscape, their varying roles and missions, and the range of bioethical topics on which they deliberated since their inception. Read More

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Efficient and effective removal of emerging contaminants through the parallel coupling of rapid adsorption and photocatalytic degradation: A case study of fluoroquinolones.

Chemosphere 2021 May 5;280:130770. Epub 2021 May 5.

School of Chemistry, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, 510006, PR China. Electronic address:

The development of efficient, effective, and large-scale treatment methods to address high-risk emerging contaminants (ECs) is a growing challenge in environmental remediation. Herein, a novel parallel coupling strategy of adsorption separation and photodegradation regeneration (parallel ASPR) is proposed; subsequently, an adsorptive photocatalyst (Zn-doped BiOI) is designed to demonstrate how to effectively eliminate fluoroquinolones (FQs) from water with the proposed ASPR scheme. Compared with pure BiOI, the addition of Zn during synthesis has a significant influence on the morphology and structure of the products, resulting in Zn-doped BiOI samples with up to 5 times the specific surface area, 32 times the adsorption capacity, and 20 times the photocurrent intensity. Read More

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Cryptosporidium chipmunk genotype I - An emerging cause of human cryptosporidiosis in Sweden.

Infect Genet Evol 2021 May 7:104895. Epub 2021 May 7.

Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden; European Public Health Microbiology Training Programme (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.

Most cases of cryptosporidiosis in humans are caused by Cryptosporidium parvum or Cryptosporidium hominis. However, more uncommon species are increasingly being recognised to cause infection in humans. Here we report that Cryptosporidium chipmunk genotype I, which has various rodents as its natural host, is the third most common source of human cryptosporidiosis in Sweden. Read More

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Correction to Scarpina et al. (2020).

Authors:

Neuropsychology 2021 Mar;35(3):334

Reports an error in "Is bimanual interference affected in the case of a central proprioceptive loss? New insight from a left-brain-damaged single-case study" by Federica Scarpina, Sofia Tagini, Marco Rabuffetti, Giovanni Albani, Francesca Garbarini and Alessandro Mauro (, 2020[May], Vol 34[4], 479-492). In the article "Is Bimanual Interference Affected in the Case of a Central Proprioceptive Loss? New Insight From a Left-Brain-Damaged Single-Case Study," by Federica Scarpina, Sofia Tagini, Marco Rabuffetti, Giovanni Albani, Francesca Garbarini, and Alessandro Mauro (Neuropsychology, 2020, Vol. 34, No. Read More

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The Role of the Pharmacist in Optimizing Cancer Immunotherapy: A Retrospective Study of Nivolumab Adverse Events.

J Pharm Pract 2021 Jun 5;34(3):386-396. Epub 2019 Sep 5.

School of Pharmacy and Medical Sciences, 1067University of South Australia, North Terrace, Adelaide, South Australia, Australia.

Background: Immune checkpoint inhibitors (ICIs) are an emerging treatment in cancer therapy for prolonging life, minimizing symptoms, and selectively targeting cancer. Program death 1 (PD-1) inhibitors, such as nivolumab, fall within this class, enabling the patient's immune system to detect and destroy cancer. The introduction of ICIs is changing cancer therapy, with new drugs and new toxicities-an evolving area encountered by pharmacists. Read More

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Molecular Epidemiology of Salmonellosis in Florida, USA, 2017-2018.

Front Med (Lausanne) 2021 22;8:656827. Epub 2021 Apr 22.

Animal Sciences Department, Emerging Pathogens Institute, Food Systems Institute, University of Florida, Gainesville, FL, United States.

The state of Florida reports a high burden of non-typhoidal with approximately two times higher than the national incidence. We retrospectively analyzed the population structure and molecular epidemiology of 1,709 clinical isolates from 2017 and 2018. We found 115 different serotypes. Read More

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Leptospirosis, a Re-emerging Threat.

Cureus 2021 Apr 5;13(4):e14295. Epub 2021 Apr 5.

Intensive Care Unit, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.

Leptospirosis is a zoonosis transmitted by an animal vector and caused by the spirochete bacteria Leptospira. Human infection is rare and acquired by exposure to environmental sources (animal urine, contaminated water, soil, or infected animal tissue). It can have an extremely broad presentation, ranging from asymptomatic to serious illness. Read More

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Alveolar hemorrhage in the setting of COVID-19: Report of a successful vascular intervention and embolization.

Radiol Case Rep 2021 Jul 4;16(7):1777-1779. Epub 2021 May 4.

Department of Radiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

The coronavirus disease 2019 (COVID-19) is characterized by viral pneumonia with mild to moderate symptoms. Emerging studies suggest that some patients may experience uncommon complications, such as thrombotic or hemorrhagic episodes. Here we present a 59-year-old male patient who had a hemorrhage episode from a branch of the pulmonary arteries and was treated by interventional embolization. Read More

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COVID-19 and arterial thrombosis: Report of 2 cases.

Radiol Case Rep 2021 Jul 29;16(7):1603-1607. Epub 2021 Apr 29.

Department of Hematology & Oncology Saint Joseph's University Medical Center Paterson, New Jersey, U.S.A.

The SARS-CoV-2 infection has been predominately associated with lung disease. However, emerging evidence has associated the COVID-19 infection with a hypercoagulable state. This hypercoagulable state can occur despite the use of anticoagulants and antiplatelets. Read More

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Case Report: Stepwise Anti-Inflammatory and Anti-SARS-CoV-2 Effects Following Convalescent Plasma Therapy With Full Clinical Recovery.

Front Immunol 2021 21;12:613502. Epub 2021 Apr 21.

Interregional Blood Transfusion SRC, Epalinges, Switzerland.

In these times of COVID-19 pandemic, concern has been raised about the potential effects of SARS-CoV-2 infection on immunocompromised patients, particularly on those receiving B-cell depleting agents and having therefore a severely depressed humoral response. Convalescent plasma can be a therapeutic option for these patients. Understanding the underlying mechanisms of convalescent plasma is crucial to optimize such therapeutic approach. Read More

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Rhinomaxillary mucormycosis presenting as palatal ulcer: A case report with comprehensive pathophysiology.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):558-562. Epub 2021 Jan 9.

Department of Oral Medicine Geetanjali Dental and Research Institute, Udaipur, Rajasthan, India.

Mucormycosis is an emerging fungal infection which has exceptionally high mortality rates in immunocompromised patients and remains a life-threatening infection in uncontrolled diabetics. The reported cases in literature may be less in number due to its frequent misdiagnosis. Imaging techniques in the early stages are usually nondiagnostic and cytological smears are not very reliable, thus, the gold standard for definitive diagnosis remains with the histopathological examination. Read More

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January 2021

Skewness in the literature on infectious livestock diseases in an emerging economy - the case of Vietnam.

Anim Health Res Rev 2021 May 10:1-13. Epub 2021 May 10.

Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Livestock production has increased in many emerging economies, but productivity is often substantially impaired by infectious diseases. The first step towards improved livestock health and productivity is to map the presence of livestock diseases. The objective of this review was to summarize studies conducted on such diseases in an emerging economy, Vietnam, and thereby identifying knowledge gaps that may inform the design of surveillance and control programs. Read More

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Non-invasive objective tools for quantitative assessment of skin scarring.

Adv Wound Care (New Rochelle) 2021 May 8. Epub 2021 May 8.

University of Manchester, Plastic & Reconstructive Surgery Research, Manchester, United Kingdom of Great Britain and Northern Ireland.

Significance: Multiple treatment modalities are utilised in the management of skin scarring, however, due to high recurrence rates and unknown resolution rates it can be difficult to assess if treatment is suitable or effective for the individual patient in particular in the case of raised dermal scarring. Therefore, it is necessary to evaluate these treatments and provide accurate scar assessment pre- & post-therapy in order to quantify scar characteristics using objective assessment tools, particularly non-invasive devices. Recent Advances: There have been a number of emerging non-invasive objective quantitative devices which assess specific scar parameters such as pliability, firmness, volume, colour, perfusion and depth. Read More

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Data analysis strategies for the characterization of chemical contaminant mixtures. Fish as a case study.

Environ Int 2021 May 6;155:106610. Epub 2021 May 6.

Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Oniris, INRAE, F-44307 Nantes, France. Electronic address:

Thousands of chemicals are potentially contaminating the environment and food resources, covering a wide spectrum of molecular structures, physico-chemical properties, sources, environmental behavior and toxic profiles. Beyond the description of the individual chemicals, characterizing contaminant mixtures in related matrices has become a major challenge in ecological and human health risk assessments. Continuous analytical developments, in the fields of targeted (TA) and non-targeted analysis (NTA), have resulted in ever larger sets of data on associated chemical profiles. Read More

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"We Really Need This": Trauma-Informed Yoga for Veteran Women with a history of Military Sexual Trauma.

Complement Ther Med 2021 May 6:102729. Epub 2021 May 6.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Box G-BH, 700 Butler Drive, Providence, RI, 02906, United States(1); Behavioral Medicine and Addictions Research, Butler Hospital, 345 Blackstone Blvd., Providence, RI, 02906, United States. Electronic address:

Objectives: Up to 70% of women service members in the United States report military sexual trauma (MST); many develop post-traumatic stress disorder (PTSD) and co-occurring disorders. Trauma-informed yoga (TIY) is suggested to improve psychiatric symptoms and shown feasible and acceptable in emerging research, yet no work has evaluated TIY in MST survivors. The current quality improvement project aimed to examine TIY's feasibility, acceptability, and perceived effects in the context of MST. Read More

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Epidemiology and evolution of Middle East respiratory syndrome coronavirus, 2012-2020.

Infect Dis Poverty 2021 May 8;10(1):66. Epub 2021 May 8.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da Street, Fengtai District, Beijing, 100071, People's Republic of China.

Background: The ongoing transmission of the Middle East respiratory syndrome coronavirus (MERS-CoV) in the Middle East and its expansion to other regions are raising concerns of a potential pandemic. An in-depth analysis about both population and molecular epidemiology of this pathogen is needed.

Methods: MERS cases reported globally as of June 2020 were collected mainly from World Health Organization official reports, supplemented by other reliable sources. Read More

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Practical and ethical complexities of MAiD: Examples from Quebec.

Authors:
Gitte Koksvik

Wellcome Open Res 2020 23;5:227. Epub 2020 Nov 23.

Department of Philosophy and Religious Studies, Programme for Applied Ethics, Norwegian University of Science and Technology, Trondheim, Norway.

Legally practiced assisted dying is an ethically complex area in need of empirical and conceptual work. International research suggests that providing assisted dying may be experienced as rewarding and meaningful but also emotionally and psychologically taxing, associated with feelings of loss and loneliness. Yet little research has been published to date, which attends to the long-term effects of providing assisted dying. Read More

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November 2020