3,623,315 results match your criteria case

Impaired Fibrinolysis in the Antiphospholipid Syndrome.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.

The pathogenesis of the antiphospholipid syndrome (APS) is complex and involves the persistent presence of antiphospholipid antibodies (aPL) in the bloodstream causing a prothrombotic condition. aPL induce excessive activation of the endothelium, monocytes, and platelets in consort with aberrations in hemostasis/clotting, fibrinolytic system, and complement activation. Impaired fibrinolysis has been found in APS patients with thrombotic as well as obstetric manifestations. Read More

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[Therapy of Language Disorders in Childhood: A Guideline is long overdue].

Laryngorhinootologie 2021 Apr 20. Epub 2021 Apr 20.

Phoniatrisch/Pädaudiologische Psychologie, Georg-August-Universität Göttingen, UMG, Germany.

In speech and language therapy of developmental language disorders, it is still largely unclear how evidence from individual therapeutic expertise integrates into clinical-practical procedure. Therefore, development of a therapy guideline addressing language disorders in childhood, especially for kindergarten- and preschool children, is long overdue for two reasons and poses a particular challenge: (1) Language disorders that are not associated with a comorbidity are given varying terms; (2) all language disorders are an interface between medical, psychological, educational, linguistic and language therapeutic disciplines. The German Society for Phoniatrics and Pedaudiology has registered now an evidence-based (S3) national "Interdisciplinary Guideline for the Therapy of Language Disorders in Childhood" (in the Association of the Scientific Medical Societies AWMF; register no. Read More

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Twin Vaginal Deliveries in Labor Rooms: A Cost-Effectiveness Analysis.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Objective:  Twin vaginal deliveries (VDs) are often performed in the operating room (OR) given the theoretical risk of conversion to cesarean delivery (CD) for the aftercoming twin. We aim to evaluate the cost-effectiveness of performing VDs for twin gestations in the labor and delivery room (LDR) versus OR.

Study Design:  We conducted a cost-effectiveness analysis using a decision-analysis model that compared the costs and effectiveness of two strategies of twin deliveries undergoing a trial of labor: (1) intended delivery in the LDR and 2) delivery in the OR. Read More

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System understanding as a scientific foundation in radioactive waste disposal, legacy site and decommissioning programmes.

J Radiol Prot 2021 Apr 20. Epub 2021 Apr 20.


Ongoing national programmes and International forums have in recent decades developed and enhanced methods and strategies in how to address the characterisation of potentially suitable sites for radioactive waste repositories. Siting processes, site selection and site investigation programmes have been conducted for near surface and geological repositories and plans for construction are in progress or have already been implemented. Lessons learned from these national and international programmes are available and results are published. Read More

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Tuned AFM-FM coupling by the formation of vacancy complex in Gd0.6Ca0.4MnO3 thin film lattice.

J Phys Condens Matter 2021 Apr 20. Epub 2021 Apr 20.

Department of Physics and Astronomy, University of Turku, FI-20014 Turku, Turku, 20014, FINLAND.

The effect of in situ oxygen and vacuum annealing on the low bandwidth manganite Gd1-xCaxMnO3 (GCMO) thin film with x = 0.4 was investigated. Based on the magnetic measurements, the AFM-FM coupling is suppressed by the vacuum annealing treatment via destroying the double exchange interaction and increasing the unit cell volume by converting the Mn 4+ to the Mn 3+ . Read More

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Targeting EML4-ALK gene fusion variant 3 in thyroid cancer.

Endocr Relat Cancer 2021 Apr 1. Epub 2021 Apr 1.

H Morreau, Pathology, Leiden University Medical Center, Leiden, Netherlands.

Finding targetable gene fusions can expand the limited treatment options in radioactive iodine-refractory (RAI-r) thyroid cancer. To that end, we established a novel cell line 'JVE404' derived from an advanced RAI-r papillary thyroid cancer (PTC) patient, harboring an EML4-ALK gene fusion variant 3 (v3). Different EML4-ALK gene fusions can have different clinical repercussions. Read More

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SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.

Neoplasia 2021 Apr 17;23(5):473-487. Epub 2021 Apr 17.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland. Electronic address:

Diagnosis of salivary gland neoplasms is often challenging due to their high morphological diversity and overlaps. Several recurrent molecular alterations have been described recently, which can serve as powerful diagnostic tools and potential therapeutic targets (e.g. Read More

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Rezum therapy, a feasible and safe treatment for the larger prostate.

Int J Surg Case Rep 2021 Apr 7;82:105871. Epub 2021 Apr 7.

College of Medicine, Mohammed Bin Rashid University for Medicine and Health Sciences, Dubai, United Arab Emirates; Department of Urological Surgery, Mediclinic City Hospital, Dubai Healthcare City, Dubai, United Arab Emirates. Electronic address:

Benign prostatic hyperplasia (BPH) is the leading cause of Lower Urinary Tract Symptoms (LUTS) in men worldwide. Urinary frequency, nocturia and incomplete emptying are common symptoms experienced by men with BPH, which significantly reduce their quality of life. Treatment for this dysfunction includes surgical and non-surgical modalities such as watchful waiting, lifestyle modification and medication. Read More

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Cecal bascule - An unusual cause of intestinal obstruction: A case report.

Int J Surg Case Rep 2021 Apr 14;82:105888. Epub 2021 Apr 14.

Department of General Surgery, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. Electronic address:

Introduction: Cecal bascule is a rare type of cecal volvulus occurring in the elderly population with a male predominance. It is a condition where the cecum folds upward upon itself.

Importance: There are only a handful of case reports published about cecal bascule. Read More

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Repair of lumbar incisional hernia using polypropylene mesh strip sutures - A case report.

Int J Surg Case Rep 2021 Apr 14;82:105892. Epub 2021 Apr 14.

Fortis Hiranandani Hospital, Sector 10, Vashi, Navi Mumbai, Maharashtra, 400703, India. Electronic address:

Introduction: Lumbar hernias are considered rare and they constitute less than 1.5% of all abdominal wall hernias.

Case Report: Here we present a case of a 72-year-old female with a left flank swelling since 2-years diagnosed as a lumbar incisional hernia. Read More

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Superior sternoclavicular joint dislocation presented with shoulder motion limitation: A case report and literature review.

Int J Surg Case Rep 2021 Apr 15;82:105887. Epub 2021 Apr 15.

Joint Reconstruction Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran; Joint Reconstruction Research Center, Orthopedic Surgery Department, Imam Khomeini Hospital, End of Keshavarz Blvd, Tehran, 1419733141, Iran. Electronic address:

Introduction And Importance: Sternoclavicular joint dislocation accounts for 1 percent of the human joint dislocations. Sternoclavicular joint dislocation most commonly occurs in anterior or posterior dislocation. To the best of the authors knowledge, only six cases of superior sternoclavicular joint dislocation are reported in the literature. Read More

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Left axillary lymphadenopathy as initial presentation of metastatic prostate cancer: A rare case report.

Int J Surg Case Rep 2021 Apr 15;82:105889. Epub 2021 Apr 15.

Faculty of Medicine, Kilimanjaro Christian Medical University College, Box 2240, Moshi, Tanzania; Department of Urology, Kilimanjaro Christian Medical Centre, Box 3010, Moshi, Tanzania.

Introduction And Importance: Advanced prostate cancer often presents with lower urinary tract symptoms together with features of cancer on digital rectal examination. The commonest sites of metastasis include bone, liver and lungs. Metastasis to axillary lymph nodes is extremely unusual particularly as initial presentation of the disease. Read More

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A case of intramandibular neurofibroma resembling a radicular cyst in a neurofibromatosis type 1 patient.

Int J Surg Case Rep 2021 Apr 10;82:105883. Epub 2021 Apr 10.

Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Introduction: Neurofibromatosis is a disease that causes various abnormalities such as neurofibroma, mainly in the skin and nerves. The common sites in the oral cavity are the palate, gingiva, tongue, buccal mucosa, and lips but, occurrence in the mandible is rare.

Presentation Of Case: A 26-year-old woman was referred to our clinic because of percussion pain. Read More

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Drivers of successful implementation of integrated care for multi-morbidity: Mechanisms identified in 17 case studies from 8 European countries.

Soc Sci Med 2021 Feb 3;277:113728. Epub 2021 Feb 3.

Erasmus School of Health Policy & Management, Erasmus University Rotterdam, The Netherlands, P.O. Box 1738, 3000 DR, Rotterdam, the Netherlands; Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands, P.O. Box 1738, 3000 DR, Rotterdam, the Netherlands. Electronic address:

This paper provides a deeper understanding of the mechanisms underlying implementation strategies for integrated care. As part of the SELFIE project, 17 integrated care programmes addressing multi-morbidity from eight European countries were selected and studied. Data was extracted from 'thick descriptions' of the 17 programmes and analysed both inductively and deductively using implementation theory. Read More

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February 2021

Exponential quasi-synchronization of coupled delayed memristive neural networks via intermittent event-triggered control.

Neural Netw 2021 Feb 16;141:98-106. Epub 2021 Feb 16.

School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China, Wuhan 430074, China. Electronic address:

Firstly, an intermittent event-triggered control (IETC), as a combination of intermittent control and event-triggered control, is proposed. Then, the quasi-synchronization problem of coupled memristive neural networks with time-varying delays (CDMNN) is discussed under this IETC. To include more of the existing work, aperiodic intermittent control and event-triggered control with combined measurement errors are adopted in the IETC. Read More

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February 2021

A classification of primary care streaming pathways in UK emergency departments: Findings from a multi-methods study comprising cross-sectional survey; site visits with observations, semi-structured and informal interviews.

Int Emerg Nurs 2021 Apr 17;56:101000. Epub 2021 Apr 17.

Division of Population Medicine, Cardiff University, Heath Park, Cardiff, UK.

Background: Variation in initial assessment methods at emergency departments in with primary care service models and a conflated terminology causes difficulties in assessing relative performance, improving quality or gathering evidence about safety and clinical effectiveness. We aim to describe and classify streaming pathways in emergency departments in different models of emergency department primary care services in England and Wales.

Methods: We used a multi-stage method, including an online survey completed by 77 emergency departments across England & Wales, interviews with 21 clinical leads, and in-depth case studies of 13 emergency departments. Read More

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Intrauterine administration of peripheral blood mononuclear cells activated by human chorionic gonadotropin in patients with repeated implantation failure: A meta-analysis.

J Reprod Immunol 2021 Apr 15;145:103323. Epub 2021 Apr 15.

Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu Jinjiang Hospital for Maternal and Child Health Care, Chengdu, China. Electronic address:

The purpose of this study was to assess whether intrauterine administration of peripheral blood mononuclear cells (PBMCs) activated by human chorionic gonadotropin (hCG) could improve the pregnancy and live birth rates in women with repeated implantation failure (RIF), and whether the parameters of co-culture of hCG and PBMCs would affect the clinical outcomes. Six databases (PubMed, Ovid, Medline, NCBI, Cqvip and Wanfang) were searched up to October 2020 by two independent reviewers. Seven studies were included according to specific inclusion and exclusion criteria. Read More

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Using worker's naturalistic response to determine and analyze work zone crashes in the presence of work zone intrusion alert systems.

Accid Anal Prev 2021 Apr 17;156:106125. Epub 2021 Apr 17.

Department of Civil Engineering, University of Memphis, Memphis, TN, 38152, United States. Electronic address:

Work zone Intrusion Alert Systems (WZIAS) are alert mechanisms that detect and alert workers of vehicles intruding into a work zone. These systems pre-dominantly employ two components-sensors placed near the work zone perimeter that detect intrusions, and alarms placed closed to or carried by the workers that alerts them. This study investigates the association between layout of these components for three WZIAS on work zone crashes based on worker reaction. Read More

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Dietary flavonoid intake and risk of esophageal squamous cell carcinoma: A population-based case-control study.

Nutrition 2021 Mar 7;89:111235. Epub 2021 Mar 7.

Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address:

Objectives: The aim of this population-based case-control study was to investigate the association between dietary consumption of the total flavonoids, subclasses, and specific flavonoids and the risk of esophageal squamous cell carcinoma (ESCC) among adults in a high-risk area of China.

Methods: We recruited 820 ESCC participants and 863 control participants from Yanting County. Dietary flavonoids were assessed using a validated 76-item food frequency questionnaire. Read More

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De Novo Dural Arteriovenous Fistula on Draining Veins of Previously Treated Pial Arteriovenous Malformation: a Case Report.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105798. Epub 2021 Apr 17.

Department of Neuroradiology, AUSL Romagna, M. Bufalini Hospital, Cesena, Italy. Electronic address:

A 71-year-old man, with a pial micro-arteriovenous malformation (pAVM) draining into the confluence of the vein of Trolard and the vein of Labbé was surgically removed, sparing these cortical veins. 4-months MR and angiographic controls showed a de novo dural arteriovenous fistula (dAVF) draining into the previously spared cortical veins. It was removed using intraoperative motor evoked potentials (MEP). Read More

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Polymeric matrix hydrophobicity governs saponin packing-density on nanoparticle surface and the subsequent biological interactions.

J Colloid Interface Sci 2021 Mar 15;596:500-513. Epub 2021 Mar 15.

Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany; PEPITE EA4267, Université de Bourgogne/Franche-Comté, Besançon, France. Electronic address:

This study investigated the loading behavior of Quillaja saponin as a model surface-active cargo on (NP) nanoparticles prepared with various hydrophobic polymers and using different organic solvents through emulsification/solvent evaporation, and the impact of NP surface hydrophobicity upon the cytotoxic and hemolytic properties of the loaded entity. A superficial monolayered arrangement of saponins on NP was established (R > 0.9) for all NP, as the saponin loading values complied with the Langmuir adsorption isotherm over the entire concentration range. Read More

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The gut microbiota is associated with clinical response to statin treatment in patients with coronary artery disease.

Atherosclerosis 2021 Mar 29;325:16-23. Epub 2021 Mar 29.

Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

Background: The structure and composition of the gut microbiota influence patients' response to therapeutic interventions. It is also known that the response to statin treatment can vary greatly from one patient to another, suggesting a possible connection between microbiome composition and response to statins. In the present study, we aim to explore the influence of the microbiome composition on the response to statin treatment among patients with coronary artery disease (CAD). Read More

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Research of the structure and dynamic interactions of particles in the LiKNO- R (R = α-AlO, γ-AlO, SiO) and (LiNO-LiClO) - γ-AlO composites in various temperature conditions and phase states.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 31;257:119765. Epub 2021 Mar 31.

Analytical Center for Collective Use of the Dagestan Federal Research Center of the Russian Academy of Sciences, Russian Federation, Republic of Dagestan, 45 M.Gadzhiev St, Makhachkala, Russian Federation.

The paper presents a comprehensive study of the LiKNO- R (R = α-AlO, γ-AlO, SiO) and (LiNO - LiClO4) - γ- AlO composite salt systems by vibrational spectroscopy, X-ray diffractometry, and differential scanning calorimetry. According to the results of Raman spectra and XRD analysis, it has been found that in the case of a sufficiently small filler (15 nm-γ-AlO and SiO), an amorphous phase appears, both for systems based on LiKNO and for the nanocomposite based on (LiNO)-(LiClO). In the case of nanocomposites based on the LiKNO system, this additionally leads to the formation of the metastable KNO (R3m) phase. Read More

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Tricky diagnosis and robot-laparoscopic surgical approach of disseminated peritoneal leiomyomatosis.

J Minim Invasive Gynecol 2021 Apr 17. Epub 2021 Apr 17.

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Objective: To show the challenging diagnosis and safe robotic surgical approach of a rare case of disseminated peritoneal leiomyomatosis (DPL).

Design: A clinical case shown by a sequential demonstration of investigation, diagnosis and surgical approach, with narrated video footage.

Setting: DPL is a rare disease, with just over 150 cases reported in literature. Read More

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Laparoscopic hysterectomy without repositioning the uterus treat non-puerperal uterine inversion: a successful case.

J Minim Invasive Gynecol 2021 Apr 17. Epub 2021 Apr 17.

From the Department of Obstetrics and Gynecology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. Electronic address:

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Human mesenchymal stem cells for the management of systemic sclerosis. Systematic review.

Autoimmun Rev 2021 Apr 17:102831. Epub 2021 Apr 17.

Research Institute, Fundación Universitaria De Ciencias De La Salud, University of Health Sciences, Bogota, Colombia.

Introduction: Sistemic Sclerosis (SSc) is a heterogeneous autoimmune disease with a high rate of progression and therapeutic failure, and treatment is a challenge, new therapeutic proposals being needed, being mesenchymal stem cells (MSCs) considered as alternative therapy for SSc for its immunomodulatory capacity. We evaluated the efficacy and safety of human MSC (hMSC) in patients with SSc through a systematic literature review (SLR).

Methods: SLR (PRISMA guideline) on MEDLINE/OVID, LILACS, EMBASE, and Cochrane/OVID bases (until July 2020, without limits). Read More

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Mini-open surgical management of a type-2 jersey finger under WALANT with ultrasound assistance: A case report about a new technique.

Hand Surg Rehabil 2021 Apr 17. Epub 2021 Apr 17.

Université de Picardie - Jules Verne, 1-3 rue des Louvels, 80000 Amiens, France. Electronic address:

We describe an innovative mini-open technique for reinsertion of the flexor digitorum profundus tendon under Wide Awake Local Anesthesia No Tourniquet (WALANT) with ultrasound assistance. Ultrasound-aided detection at the surgeon's practice is used to plan the surgical tendon repair procedure so that tendon reinsertion can be performed with the smallest incision possible. Passage of the tendon through the digital sheath was accomplished with the help of a compressive tendon guide to avoid a surgical approach. Read More

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Abdominal dioctophymosis in a domestic cat from the Peruvian rainforest confirmed morphologically and molecularly.

Parasitol Int 2021 Apr 17:102359. Epub 2021 Apr 17.

Laboratorio de Epidemiologia y Economía Veterinaria, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Av. Circunvalación 2800, San Borja. Lima, Peru.

A case of abdominal dioctophymosis in a domestic cat was found in San Juan Bautista district, the Peruvian rainforest, in the Loreto department of Peru. The pet went to a veterinary clinic for a routine ovariohysterectomy during which a large nematode was found in the abdominal cavity. The nematode was morphologically identified as an adult female of Dioctophyme sp. Read More

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Predictors of Operative Duration and Complications in Single Level Posterior Interbody Fusions for Degenerative Spondylolisthesis.

World Neurosurg 2021 Apr 17. Epub 2021 Apr 17.

Center for Spine Health, Cleveland Clinic Foundation, Cleveland OH, USA; Department of Neurosurgery, Lerner College of Medicine, Cleveland Clinic, Cleveland OH, USA.

Introduction: The goal of this study was to identify predictors of prolonged operative time (OT) in patients receiving P/TLIF and examine the relationship between prolonged OT and perioperative outcomes in this population.

Methods: The ACS-NSQIP database was queried for patients undergoing single-level P/TLIF (CPT code) between 2012 and 2018. Multivariable linear regression models were constructed to identify factors independently associated with changes in OT and examine the relationship between prolonged OT and perioperative outcomes (Overall complications, surgical complications, medical complications, 30-day readmission, 30-day reoperation, length of stay [LOS]). Read More

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