1,519 results match your criteria cartilage relaxation


The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis.

Osteoarthritis Cartilage 2021 Nov 23. Epub 2021 Nov 23.

Department of Orthopedic Surgery, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address:

Objective: Early and non-invasive detection of osteoarthritis (OA) is required to enable early treatment and monitoring of interventions. Some of the earliest signs of OA are the change in proteoglycan and collagen composition. The aim of this study is to establish the relations between quantitative magnetic resonance imaging (MRI) and biochemical concentration and organization in knee articular cartilage. Read More

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November 2021

Simultaneous bilateral T , T , and T relaxation mapping of the hip joint with magnetic resonance fingerprinting.

NMR Biomed 2021 Nov 26:e4651. Epub 2021 Nov 26.

Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.

Quantitative MRI can detect early biochemical changes in cartilage, but its bilateral use in clinical routines is challenging. The aim of this prospective study was to demonstrate the feasibility of magnetic resonance fingerprinting for bilateral simultaneous T , T , and T mapping of the hip joint. The study population consisted of six healthy volunteers with no known trauma or pain in the hip. Read More

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November 2021

Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis-Finite element modeling and MRI follow-up of ACL reconstructed patients.

J Orthop Res 2021 Nov 24. Epub 2021 Nov 24.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

The aims of this case-control study were to: (1) Identify cartilage locations and volumes at risk of osteoarthritis (OA) using subject-specific finite element (FE) models; (2) Quantify the relationships between the simulated biomechanical parameters and T and T relaxation times of magnetic resonance imaging (MRI). We created subject-specific FE models for seven patients with anterior cruciate ligament (ACL) reconstruction and six controls based on a previous proof-of-concept study. We identified locations and cartilage volumes susceptible to OA, based on maximum principal stresses and absolute maximum shear strains in cartilage exceeding thresholds of 7 MPa and 32%, respectively. Read More

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November 2021

Quantitative T2 mapping of the sacroiliac joint cartilage at 3T in patients with axial spondyloarthropathies.

Eur Radiol 2021 Nov 19. Epub 2021 Nov 19.

Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Objective: To evaluate the diagnostic value of T2 mapping of sacroiliac joint cartilage in patients with axial spondyloarthropathies (SpA).

Methods: Thirty-seven SpA patients and 43 controls (mean age: 36.5 ± 8. Read More

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November 2021

Nuclear relaxation rate enhancement by a N quadrupole nucleus in a fluctuating electric-field gradient.

J Chem Phys 2021 Nov;155(18):184108

Univ. Grenoble Alpes, CEA, IRIG-MEM, 38000 Grenoble, France.

We consider the longitudinal quadrupole relaxation rate enhancement (QRE) of a H nucleus due to the time fluctuations of the local dipolar magnetic field created by a close quadrupole N nucleus, the electric-field gradient (EFG) Hamiltonian of which changes with time because of vibrations/distortions of its chemical environment. The QRE is analytically expressed as a linear combination of the cosine Fourier transforms of the three quantum time auto-correlation functions G(t) of the N spin components along the principal axes A = X, Y, and Z of the mean (time-averaged) EFG Hamiltonian. Denoting the three transition frequencies between the energy levels of this mean Hamiltonian by ν, the functions G(t) oscillate at frequencies ν + s/(2π) with mono-exponential decays of relaxation times τ, where the frequency dynamic shifts s and the relaxation times τ are closed expressions of the magnitude of the fluctuations of the instantaneous EFG Hamiltonian about its mean and of the characteristic fluctuation time. Read More

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November 2021

Feasibility of T2 Mapping of the Sacroiliac Joints in Healthy Control Subjects and Children and Young Adults with Sacroiliitis.

ACR Open Rheumatol 2021 Nov 10. Epub 2021 Nov 10.

The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Objective: To assess the feasibility of T2 mapping for evaluating pediatric SIJ cartilage at 3 Tesla (T) magnetic resonance imaging (MRI).

Methods: Healthy control subjects and adolescents with sacroiliitis underwent a 3T MRI dedicated pelvic protocol that included a T2 mapping sequence consisting of multislice, multiecho acquisition. Healthy control subjects were prospectively recruited from our primary care practices as part of a larger imaging study, whereas adolescents with sacroiliitis were recruited specifically for this study. Read More

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November 2021

Uncovering associations between data-driven learned qMRI biomarkers and chronic pain.

Sci Rep 2021 Nov 9;11(1):21989. Epub 2021 Nov 9.

Center for Intelligent Imaging, University of California, San Francisco, USA.

Knee pain is the most common and debilitating symptom of knee osteoarthritis (OA). While there is a perceived association between OA imaging biomarkers and pain, there are weak or conflicting findings for this relationship. This study uses Deep Learning (DL) models to elucidate associations between bone shape, cartilage thickness and T relaxation times extracted from Magnetic Resonance Images (MRI) and chronic knee pain. Read More

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November 2021

Optimization of spin-lock times in T mapping of knee cartilage: Cramér-Rao bounds versus matched sampling-fitting.

Magn Reson Med 2021 Nov 4. Epub 2021 Nov 4.

Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.

Purpose: To compare different optimization approaches for choosing the spin-lock times (TSLs), in spin-lattice relaxation time in the rotating frame (T ) mapping.

Methods: Optimization criteria for TSLs based on Cramér-Rao lower bounds (CRLB) are compared with matched sampling-fitting (MSF) approaches for T mapping on synthetic data, model phantoms, and knee cartilage. The MSF approaches are optimized using robust methods for noisy cost functions. Read More

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November 2021

Quantitative analysis of the ACL and PCL using T1rho and T2 relaxation time mapping: an exploratory, cross-sectional comparison between OA and healthy control knees.

BMC Musculoskelet Disord 2021 Oct 30;22(1):916. Epub 2021 Oct 30.

Division of Trauma & Orthopaedic Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK.

Background: Quantitative magnetic resonance imaging (MRI) methods such as T1rho and T2 mapping are sensitive to changes in tissue composition, however their use in cruciate ligament assessment has been limited to studies of asymptomatic populations or patients with posterior cruciate ligament tears only. The aim of this preliminary study was to compare T1rho and T2 relaxation times of the anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) between subjects with mild-to-moderate knee osteoarthritis (OA) and healthy controls.

Methods: A single knee of 15 patients with mild-to-moderate knee OA (Kellgren-Lawrence grades 2-3) and of 6 age-matched controls was imaged using a 3. Read More

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October 2021

Creep behavior of human knee joint determined with high-speed biplanar video-radiography and finite element simulation.

J Mech Behav Biomed Mater 2021 Oct 16;125:104905. Epub 2021 Oct 16.

Department of Biomedical Engineering, University of Kocaeli, Izmit, Kocaeli, Marmara, 41001, Turkey.

Creep and relaxation of knee cartilage and meniscus have been extensively studied at the tissue level with constitutive laws well established. At the joint level, however, both experimental and model studies have been focused on either elastic or kinematic responses of the knee, where the time-dependent response is typically neglected for simplicity. The objectives of this study were to quantify the in-vivo creep behavior of human knee joints produced by the cartilaginous tissues and to use the relevant data to validate a previously proposed poromechanical model. Read More

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October 2021

Early impairment of cartilage poroelastic properties in an animal model of ACL tear.

Orthop Traumatol Surg Res 2021 Oct 16:103116. Epub 2021 Oct 16.

Université de Paris, B3OA, UMR CNRS 7052, INSERM U1271, 10 Avenue de Verdun, 75010 Paris, France; Service de Chirurgie Orthopédique et Réparatrice de l'Enfant, APHP-Sorbonne Université, Hôpital Trousseau, 26 Avenue du Docteur Arnold-Netter, 75012 Paris, France. Electronic address:

Background: In more than 50% of cases, anterior cruciate ligament (ACL) lesions lead to post-traumatic osteoarthritis. Ligament reconstruction stabilizes the joint, but the tear seems to impair the poroelasticity of the cartilage: synovial membrane fluid inflammation is observed 3 weeks after tearing. There have been some descriptions of visible cartilage changes, but poroelasticity has never been analyzed at this early stage. Read More

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October 2021

Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping.

J Biomech 2021 Sep 27;129:110771. Epub 2021 Sep 27.

Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States; Department of Biomedical Engineering, Duke University, Durham, NC 27708, United States; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, United States. Electronic address:

Changes in cartilage structure and composition are commonly observed during the progression of osteoarthritis (OA). Importantly, quantitative magnetic resonance imaging (MRI) methods, such as T1rho relaxation imaging, can noninvasively provide in vivo metrics that reflect changes in cartilage composition and therefore have the potential for use in early OA detection. Changes in cartilage mechanical properties are also hallmarks of OA cartilage; thus, measurement of cartilage mechanical properties may also be beneficial for earlier OA detection. Read More

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September 2021

Magnetization-prepared spoiled gradient-echo snapshot imaging for efficient measurement of R -R in knee cartilage.

Magn Reson Med 2022 Feb 30;87(2):733-745. Epub 2021 Sep 30.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Purpose: To validate the potential of quantifying R -R using one pair of signals with T preparation and T preparation incorporated to magnetization-prepared angle-modulated partitioned k-space spoiled gradient-echo snapshots (MAPSS) acquisition and to find an optimal preparation time (T ) for in vivo knee MRI.

Methods: Bloch equation simulations were first performed to assess the accuracy of quantifying R -R using T - and T -prepared signals with an equivalent T . For validation of this technique in comparison to the conventional approach that calculates R -R after estimating both T and T , phantom experiments and in vivo validation with five healthy subjects and five osteoarthritis patients were performed at a clinical 3T scanner. Read More

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February 2022

Radiomics Feature Analysis of Cartilage and Subchondral Bone in Differentiating Knees Predisposed to Posttraumatic Osteoarthritis after Anterior Cruciate Ligament Reconstruction from Healthy Knees.

Biomed Res Int 2021 12;2021:4351499. Epub 2021 Sep 12.

Department of Radiology & Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Middle Wulumuqizhong Road, Shanghai 200040, China.

Objectives: To introduce a new implementation of radiomics analysis for cartilage and subchondral bone of the knee and to compare the performance of the proposed models to classic T2 relaxation time in distinguishing knees predisposed to posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction (ACLR) and healthy controls.

Methods: 114 patients following ACLR after at least 2 years and 43 healthy controls were reviewed and allocated to training ( = 110) and testing ( = 47) cohorts. Radiomics models are built for cartilage and subchondral bone regions of different compartments: lateral femur (LF), lateral tibia (LT), medial femur (MF), and medial tibia (MT) and combined models of four compartments on T2 mapping images. Read More

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September 2021

Tibiofemoral articular cartilage composition differs based on serum biochemical profiles following anterior cruciate ligament reconstruction.

Osteoarthritis Cartilage 2021 Sep 16. Epub 2021 Sep 16.

Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, NC, USA.

Objective: Biochemical joint changes contribute to posttraumatic osteoarthritis (PTOA) development following anterior cruciate ligament reconstruction (ACLR). The purpose of this longitudinal cohort study was to compare tibiofemoral cartilage composition between ACLR patients with different serum biochemical profiles. We hypothesized that profiles of increased inflammation (monocyte chemoattractant protein-1 [MCP-1]), type-II collagen turnover (type-II collagen breakdown [C2C]:synthesis [CPII]), matrix degradation (matrix metalloproteinase-3 [MMP-3] and cartilage oligomeric matrix protein [COMP]) preoperatively to 6-months post-ACLR would be associated with greater tibiofemoral cartilage T1ρ relaxation times 12-months post-ACLR. Read More

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September 2021

Open Source Software for Automatic Subregional Assessment of Knee Cartilage Degradation Using Quantitative T2 Relaxometry and Deep Learning.

Cartilage 2021 Sep 8:19476035211042406. Epub 2021 Sep 8.

Department of Bioengineering, Stanford University, Stanford, CA, USA.

Objective: We evaluated a fully automated femoral cartilage segmentation model for measuring T2 relaxation values and longitudinal changes using multi-echo spin-echo (MESE) magnetic resonance imaging (MRI). We open sourced this model and developed a web app available at https://kl.stanford. Read More

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September 2021

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage.

Radiology 2021 11 7;301(2):423-432. Epub 2021 Sep 7.

From the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).

MRI-based cartilage compositional analysis shows biochemical and microstructural changes at early stages of osteoarthritis before changes become visible with structural MRI sequences and arthroscopy. This could help with early diagnosis, risk assessment, and treatment monitoring of osteoarthritis. Spin-lattice relaxation time constant in rotating frame (T1ρ) and T2 mapping are the MRI techniques best established for assessing cartilage composition. Read More

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November 2021

Guide to mechanical characterization of articular cartilage and hydrogel constructs based on a systematic in silico parameter sensitivity analysis.

J Mech Behav Biomed Mater 2021 12 24;124:104795. Epub 2021 Aug 24.

Soft Tissue Biomechanics Group, Biomechanics Division, Mechanical Engineering Department, KU Leuven, Leuven, Belgium.

Osteoarthritis is a whole joint disease with cartilage degeneration being an important manifestation. Tissue engineering treatment is a solution for repairing cartilage defects by implantation of chondrocyte-laden hydrogel constructs within the defect. In silico models have recently been introduced to simulate and optimize the design of these constructs. Read More

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December 2021

The Influence of Running on Lower Limb Cartilage: A Systematic Review and Meta-analysis.

Sports Med 2021 Sep 3. Epub 2021 Sep 3.

Motion Analysis and Biofeedback Laboratory, University of British Columbia, Vancouver, BC, Canada.

Background: Running is a popular activity practiced worldwide. It is important to understand how running affects joint health to provide recommendations to sports medicine practitioners and runners.

Objective: Our aim was to summarize the influence of running on lower limb cartilage morphology and composition using quantitative magnetic resonance imaging (MRI). Read More

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September 2021

Sulforaphane-loaded hyaluronic acid-poloxamer hybrid hydrogel enhances cartilage protection in osteoarthritis models.

Mater Sci Eng C Mater Biol Appl 2021 Sep 31;128:112345. Epub 2021 Jul 31.

Human and Natural Sciences Center, ABC Federal University, Santo André, SP, Brazil; Drugs and Bioactives Delivery Systems Research Group - SISLIBIO, Federal University of ABC. Santo André, SP, Brazil. Electronic address:

Sulforaphane (SFN) is an isothiocyanate with anti-arthritic and immuno-regulatory activities, supported by the downregulation of NF-κB pathway, reduction on metalloproteinases expression and prevention of cytokine-induced cartilage degeneration implicated in OA progression. SFN promising pharmacological effects associated to its possible use, by intra-articular route and directly in contact to the site of action, highlight SFN as promising candidate for the development of drug-delivery systems. The association of poloxamers (PL) and hyaluronic acid (HA) supports the development of osteotrophic and chondroprotective pharmaceutical formulations. Read More

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September 2021

Review of Quantitative Knee Articular Cartilage MR Imaging.

Magn Reson Med Sci 2021 Sep 1. Epub 2021 Sep 1.

Department of Radiological Sciences, University of California, Irvine.

Osteoarthritis (OA) is one of the most prevalent disorders in today's society, resulting in significant socio-economic costs and morbidity. MRI is widely used as a non-invasive imaging tool for OA of the knee. However, conventional knee MRI has limitations to detect subtle early cartilage degeneration before morphological changes are visually apparent. Read More

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September 2021

In-Situ Cartilage Functionality Assessment Based on Advanced MRI Techniques and Precise Compartmental Knee Joint Loading through Varus and Valgus Stress.

Diagnostics (Basel) 2021 Aug 14;11(8). Epub 2021 Aug 14.

Department of Diagnostic and Interventional Radiology, Aachen University Hospital, 52074 Aachen, Germany.

Stress MRI brings together mechanical loading and MRI in the functional assessment of cartilage and meniscus, yet lacks basic scientific validation. This study assessed the response-to-loading patterns of cartilage and meniscus incurred by standardized compartmental varus and valgus loading of the human knee joint. Eight human cadaveric knee joints underwent imaging by morphologic (i. Read More

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Low-field and variable-field NMR relaxation studies of H2O and D2O molecular dynamics in articular cartilage.

PLoS One 2021 25;16(8):e0256177. Epub 2021 Aug 25.

Fachgebiet Technische Physik II/Polymerphysik, Institute of Physics, Technische Universität Ilmenau, Germany.

Osteoarthritis (OA) as the main degenerative disease of articular cartilage in joints is accompanied by structural and compositional changes in the tissue. Degeneration is a consequence of a reduction of the amount of macromolecules, the so-called proteoglycans, and of a corresponding increase in water content, both leading to structural weakening of cartilage. NMR investigations of cartilage generally address only the relaxation properties of water. Read More

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Individual and cumulative measures of knee joint load associate with T2 relaxation times of knee cartilage in young, uninjured individuals: A pilot study.

Knee 2021 Oct 6;32:19-29. Epub 2021 Aug 6.

Department of Radiology, University of Nebraska Medical Center, 981045 Nebraska Medical Center, Omaha, NE 68198-1045, United States.

Background: Articular cartilage structure and chondrocyte health are sensitive and reliant on dynamic joint loading during activities. The purpose of this pilot study was to determine the association between measures of individual and cumulative knee joint loading with T2 relaxation times in the knee cartilage of young individuals without knee injury.

Methods: Twelve participants (17-30 years old) without history of knee injury or surgery completed MRI, physical activity (PA), and biomechanical gait testing. Read More

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October 2021

Association of Jump-Landing Biomechanics With Tibiofemoral Articular Cartilage Composition 12 Months After ACL Reconstruction.

Orthop J Sports Med 2021 Jul 21;9(7):23259671211016424. Epub 2021 Jul 21.

MOTION Science Institute, Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: Excessively high joint loading during dynamic movements may negatively influence articular cartilage health and contribute to the development of posttraumatic osteoarthritis after anterior cruciate ligament reconstruction (ACLR). Little is known regarding the link between aberrant jump-landing biomechanics and articular cartilage health after ACLR.

Purpose/hypothesis: The purpose of this study was to determine the associations between jump-landing biomechanics and tibiofemoral articular cartilage composition measured using T1ρ magnetic resonance imaging (MRI) relaxation times 12 months postoperatively. Read More

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Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage.

Ann Biomed Eng 2021 Sep 2;49(9):2622-2634. Epub 2021 Aug 2.

Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Read More

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September 2021

Contribution of perichondrium to the mechanical properties of auricular cartilage.

J Biomech 2021 09 21;126:110638. Epub 2021 Jul 21.

External Ear Plastic and Reconstructive Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

The poor mechanical strength of tissue-engineered auricular cartilage which is possibly due to the lack of perichondrium limits its application in auricular reconstruction surgery. However, there is insufficient research and no reliable data to support this. This study aims to investigate the contribution of perichondrium to the mechanical strength of auricular cartilage under loading. Read More

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September 2021

Blending with Poly(l-lactic acid) Improves the Printability of Poly(l-lactide--caprolactone) and Enhances the Potential Application in Cartilage Tissue Engineering.

ACS Omega 2021 Jul 8;6(28):18300-18313. Epub 2021 Jul 8.

The Key Laboratory of Biomedical Material of Tianjin, Biomedical Barriers Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Biomedical Engineering, 236 Baidi Road, NanKai District, Tianjin 300192, P.R. China.

Poly(l-lactide--caprolactone) (PLCL, 50:50) has been used in cartilage tissue engineering because of its high elasticity. However, its mechanical properties, including its rigidity and viscoelasticity, must be improved for compatibility with native cartilage. In this study, a set of PLCL/poly(l-lactic acid) (PLLA) blends was prepared by blending with different mass ratios of PLLA that range from 10 to 50%, using thermoplastic techniques. Read More

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In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.

Clin Biomech (Bristol, Avon) 2021 Aug 14;88:105425. Epub 2021 Jul 14.

Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA. Electronic address:

Background: Spinal motion is facilitated by a "three joint complex", two facet joints and one intervertebral disc at each spinal level. Both the intervertebral discs and facet joints are subject to natural age-related degeneration, and while these processes may be linked it is not clear how. As instability in the disc could underlie facet arthritis, we evaluated the hypothesis that the discs and facet joints are mechanically coupled. Read More

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Injectable stress relaxation gelatin-based hydrogels with positive surface charge for adsorption of aggrecan and facile cartilage tissue regeneration.

J Nanobiotechnology 2021 Jul 18;19(1):214. Epub 2021 Jul 18.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, NO. 600, Yishan Rd, Shanghai, 200233, People's Republic of China.

Background: Cartilage injury and pathological degeneration are reported in millions of patients globally. Cartilages such as articular hyaline cartilage are characterized by poor self-regeneration ability due to lack of vascular tissue. Current treatment methods adopt foreign cartilage analogue implants or microfracture surgery to accelerate tissue repair and regeneration. Read More

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