68,672 results match your criteria cartilage findings

Serum cartilage oligomeric matrix protein is correlated with quantitative magnetic resonance imaging and arthroscopic cartilage findings in anterior cruciate ligament deficient knees without osteoarthritic changes.

Clin Rheumatol 2021 Jun 12. Epub 2021 Jun 12.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Introduction/objectives: To investigate the association between serum biomarker [cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3)] levels and clinical, magnetic resonance imaging (MRI), and arthroscopic findings in anterior cruciate ligament (ACL)-deficient knees without osteoarthritic changes on radiographs.

Method: Patients with ACL injury of Kellgren-Lawrence grade 0 or 1 were enrolled. Serum COMP and MMP-3 levels were measured preoperatively. Read More

View Article and Full-Text PDF

Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway.

J Cell Mol Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA) development, yet the molecular mechanisms and regulation responsible for the pathogenesis are still poorly understood. Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration and synovitis during OA. PAB, a diterpene acid, specifically inhibited NF-κB signalling and reduced the production of pro-inflammatory cytokines, which further decreased M1 polarization and vessel formation. Read More

View Article and Full-Text PDF

Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma.

Onco Targets Ther 2021 1;14:3545-3553. Epub 2021 Jun 1.

Department of Spinal Surgery, Tianjin Hospital, Tianjin, 300211, People's Republic of China.

Introduction: The transcription factor zinc finger protein 395 (ZNF395) is involved in several cellular responses and tumorigenesis. However, the potential role and clinical significance of ZNF395 in chondrosarcoma are not well investigated. This study determines the expression profile, prognostic value and biological function of ZNF395 in human chondrosarcoma. Read More

View Article and Full-Text PDF

An Unusual Foreign Body-Caused Chondral Lesion of the Talar Dome: A Case Report.

JBJS Case Connect 2021 06 10;11(2). Epub 2021 Jun 10.

Hospital for Special Surgery, Department of Foot and Ankle Surgery, New York, New York.

Case: A patient presented with chronic ankle pain and instability. Imaging revealed a talar osteochondral lesion as well as intra-articular loose bodies. Intraoperatively, an unusual, well-demarcated chondral defect was found. Read More

View Article and Full-Text PDF

A new GNPAT variant of foetal rhizomelic chondrodysplasia punctata.

Mol Genet Genomic Med 2021 Jun 10:e1733. Epub 2021 Jun 10.

Division of Prenatal Diagnosis, Meyer Children's Hospital, Florence, Italy.

Background: Rhizomelic chondrodysplasia punctata (RCDP) is a clinical entity resulting from defects of peroxisomal metabolism whose clinical phenotype is characterized by rhizomelia, calcified foci in periarticular cartilage, coronal lesions of vertebral bodies, cataracts and severe cognitive delay. Usually, survival does not exceed the first decade of life. Transmission is autosomal recessive and is related to mutations in the PEX7, GNPAT or AGPS. Read More

View Article and Full-Text PDF

Osteochondritis Dissecans: Current Understanding of Epidemiology, Etiology, Management, and Outcomes.

J Bone Joint Surg Am 2021 Jun;103(12):1132-1151

Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota.

: Osteochondritis dissecans occurs most frequently in the active pediatric and young adult populations, commonly affecting the knee, elbow, or ankle, and may lead to premature osteoarthritis.

: While generally considered an idiopathic phenomenon, various etiopathogenetic theories are being investigated, including local ischemia, aberrant endochondral ossification of the secondary subarticular physis, repetitive microtrauma, and genetic predisposition.

: Diagnosis is based on the history, physical examination, radiography, and advanced imaging, with elbow ultrasonography and novel magnetic resonance imaging protocols potentially enabling early detection and in-depth staging. Read More

View Article and Full-Text PDF

Evaluation of the Quality and Readability of Online Sources on the Diagnosis and Management of Osteochondral Lesions of the Ankle.

Cartilage 2021 Jun 10:19476035211021910. Epub 2021 Jun 10.

Department of Orthopedic Surgery, NYU Langone Health, New York, NY, USA.

Objective: Patients frequently use the internet as a source to obtain health information. The purpose of this study was to evaluate the quality and readability of online resources on the diagnosis and treatment of ankle osteochondral lesions (OCLs).

Design: Three search terms ("ankle cartilage defect," "cartilage injury," "ankle cartilage damage") were entered into 3 search engines (Google, Yahoo, and Bing). Read More

View Article and Full-Text PDF

Changes to the activity and sensitivity of nerves innervating subchondral bone contribute to pain in late-stage osteoarthritis.

Pain 2021 Jun 3. Epub 2021 Jun 3.

Department of Anatomy and Physiology, University of Melbourne, Victoria, Australia.

Abstract: Whilst it is clear that osteoarthritis (OA) pain involves activation and/or sensitization of nociceptors that innervate knee joint articular tissues, much less is known about the role of the innervation of surrounding bone. In this study, we used mono-iodoacetate (MIA)-induced OA in male rats to test the idea that pain in OA is driven by differential contributions from nerves that innervate knee joint articular tissues vs the surrounding bone. The time-course of pain behavior was assayed using the advanced dynamic weight bearing device, and histopathology was examined using H&E histology. Read More

View Article and Full-Text PDF

Long non-coding RNA KCNQ1OT1 promotes cell viability and migration as well as inhibiting degradation of CHON-001 cells by regulating miR-126-5p/TRPS1 axis.

Adv Rheumatol 2021 Jun 9;61(1):31. Epub 2021 Jun 9.

Orthopaedic Ward 2 (Trauma Surgery), Chifeng Municipal Hospital, No.1, Zhaowuda Road, Chifeng City, 024000, Inner Mongolia, China.

Background: Osteoarthritis (OA) is defined as a degenerative disease. Pivotal roles of long non-coding RNA (lncRNAs) in OA are widely elucidated. Herein, we intend to explore the function and molecular mechanism of lncRNA KCNQ1OT1 in CHON-001 cells. Read More

View Article and Full-Text PDF

Fatal outcome of cervical myelopathy caused by fibrocartilaginous embolism. Rare cause of spinal vascular damage.

Ideggyogy Sz 2021 May;74(5-6):207-210

Department of Laboratory Medicine, Semmelweis University, Budapest.

Background And Purpose: Fibrocartilaginous embolism is a rare cause of ischemic myelopathy. Authors report a case of a 39-year-old woman with progressive tetraparesis and severe autonomic dysfunction. Despite of the detailed examinations, the definite diagnosis was verified by autopsy. Read More

View Article and Full-Text PDF

3.0 T MRI findings of 104 hips of asymptomatic adults: from non-runners to ultra-distance runners.

BMJ Open Sport Exerc Med 2021 21;7(2):e000997. Epub 2021 May 21.

Department of Orthopaedics and Musculoskeletal Science, University College London, Stanmore, London, UK.

Objectives: To determine and compare the health status of hip joints of individuals undertaking various lengths of long-distance running and of those who are not running.

Methods: Fifty-two asymptomatic volunteers underwent bilateral hip 3.0 Tesla MRI: (1) 8 inactive non-runners; (2) 28 moderately active runners (average half a marathon (21 km)/week) and (3) 16 highly active runners (≥ marathon (42 km)/week). Read More

View Article and Full-Text PDF


Georgian Med News 2021 Apr(313):20-25

Bogomolets National Medical University, Department of traumatology and orthopedics Kyiv, Ukraine.

Damage of the medial meniscus root is critical, because it leads to rapid progression of knee osteoarthritis and requires surgical treatment. Purpose - to evaluate results of surgical treatment in patients with degenerative medial meniscus root tear with 1st and 2nd K-L knee osteoarthritis. The results of treatment of 55 patients with degenerative medial meniscus root tears were evaluated. Read More

View Article and Full-Text PDF

Does concurrent adenoidectomy or tonsillectomy affect the graft success rate of cartilage myringoplasty in adults?

Zhengcai Lou

BMC Surg 2021 Jun 8;21(1):287. Epub 2021 Jun 8.

Department of Otorhinolaryngology, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu, 322000, Zhejiang, China.

Background: The objective of this study was to evaluate the graft success and hearing outcomes of concurrent adenoidectomy or tonsillectomy and myringoplasty.

Methods: Medical case notes were reviewed for all adult patients with dry perforations who had undergone myringoplasty, with or without concurrent throat surgery, from December 2015 to February 2018. The study population was divided into concurrent myringoplasty and throat surgery (Group A) and single myringoplasty (Group B) groups. Read More

View Article and Full-Text PDF

[Application of endobronchial ultrasound in children: an analysis of 4 cases].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):511-515

Department No. 2 of Respiratory Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To investigate the feasibility, clinical efficacy and safety of endobronchial ultasound (EBUS) in children. The radiological features, EBUS images, pathological results and intraoperative and postoperative complications of 3 cases who underwent EBUS examination and 1 case who underwent EBUS guided transbronchial needle aspiration (EBUS-TBNA) were retrospectively analyzed. Among the 4 cases, 2 were males and 2 were females, with the onset age of 7. Read More

View Article and Full-Text PDF

Senolytics alleviate the degenerative disorders of temporomandibular joint in old age.

Aging Cell 2021 Jun 8:e13394. Epub 2021 Jun 8.

UConn Center on Aging, UConn Health, Farmington, CT, USA.

Aging is one of the major risk factors for degenerative joint disorders, including those involving the temporomandibular joint (TMJ). TMJ degeneration occurs primarily in the population over 65, significantly increasing the risk of joint discomfort, restricted joint mobility, and reduced quality of life. Unfortunately, there is currently no effective mechanism-based treatment available in the clinic to alleviate TMJ degeneration with aging. Read More

View Article and Full-Text PDF

Infrapatellar Coronal Plane Plica in a 60-Year-Old: A Case Report.

JBJS Case Connect 2021 06 8;11(2). Epub 2021 Jun 8.

Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Case: We report a rare case of coronal plane infrapatellar plica, also called "Bib-like plica," in a 60-year-old patient. The start-up pain she experienced before arthroscopic excision completely resolved after the procedure. As far as we know, this is the first case of this plica in the literature in a 60-year-old patient who had associated articular cartilage loss over the medial femoral condyle adjacent to the plica, with positive magnetic resonance imaging findings outlining the structure, possibly impinging the infrapatellar fat pad. Read More

View Article and Full-Text PDF

Interdisciplinary consensus statements on imaging of scapholunate joint instability.

Eur Radiol 2021 Jun 8. Epub 2021 Jun 8.

International Wrist Center, Clinique Bizet, 23 Rue Georges Bizet, 75116, Paris, France.

Objectives: The purpose of this agreement was to establish evidence-based consensus statements on imaging of scapholunate joint (SLJ) instability by an expert group using the Delphi technique.

Methods: Nineteen hand surgeons developed a preliminary list of questions on SLJ instability. Radiologists created statements based on the literature and the authors' clinical experience. Read More

View Article and Full-Text PDF

Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing.

Immun Ageing 2021 Jun 7;18(1):27. Epub 2021 Jun 7.

Shirley Ryan Abilitylab (Formerly the Rehabilitation Institute of Chicago), 355 E. Erie St, IL, 60611, Chicago, USA.

Background: Osteoarthritis (OA) is one of the most prevalent joint diseases of advanced age and is a leading cause of disability worldwide. Ageing is a major risk factor for the articular cartilage (AC) degeneration that leads to OA, and the age-related decline in regenerative capacity accelerates OA progression. Here we demonstrate that systemic transplantation of a unique population of adult multipotent muscle-derived stem/progenitor cells (MDSPCs), isolated from young wild-type mice, into Zmpste24 mice (a model of Hutchinson-Gilford progeria syndrome, a condition marked by accelerated ageing), prevents ageing-related homeostatic decline of AC. Read More

View Article and Full-Text PDF

Review: Mesenchymal Stem Cell Therapy in Canine Osteoarthritis Research: "Experientia Docet" (Experience Will Teach Us).

Front Vet Sci 2021 19;8:668881. Epub 2021 May 19.

Department of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Osteoarthritis (OA) is currently an incurable and progressive condition in dogs causing chronic joint pain and possibly increasing disability. Due to the poor healing capacity of cartilage lesions that occur with OA, development of effective therapeutics is difficult. For this reason, current OA therapy is mostly limited to the management of pain and inflammation, but not directed ad disease modification. Read More

View Article and Full-Text PDF

Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage.

Aging Dis 2021 Jun 1;12(3):726-731. Epub 2021 Jun 1.

1Shirley Ryan AbilityLab, Chicago, Illinois, USA.

Osteoarthritis (OA) is the most common and debilitating joint disease of advanced age and has no universally effective therapy. Here, we demonstrate that systemic transplantation of adult multipotent muscle-derived stem/progenitor cells (MDSPCs)-isolated from young mice-rejuvenates the knee articular cartilage (AC) of naturally aged mice. This intervention reduced expression of pro-inflammatory cytokines ( and ) and catabolic matrix-degrading proteinases ( and ) in aged cartilage. Read More

View Article and Full-Text PDF

Chondrosarcoma of the Thyroid Cartilage Successfully Treated With Partial Resection of the Thyroid Cartilage.

Ear Nose Throat J 2021 Jun 6:1455613211014109. Epub 2021 Jun 6.

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, Ostrava-Poruba, Czech Republic.

Chondrosarcoma of the thyroid cartilage is a sporadic disease with nonspecific clinical presentation. Smooth swelling of the supraglottic area should arouse suspicion of possible pathology. In addition to laryngoceles, which usually do not have a significant impact, otolaryngologists should consider chondrosarcoma of the thyroid cartilage and indicate computed tomography (CT). Read More

View Article and Full-Text PDF

Unilateral premature osteoarthritis of the hip with excessive anteversion of the femoral neck developing in the early second decade: two surgical cases.

BMC Musculoskelet Disord 2021 Jun 5;22(1):517. Epub 2021 Jun 5.

Department of Paediatric Orthopaedics and Orthopaedic Surgery, Jichi Children's Medical Center Tochigi, Tochigi Prefecture, Shimotsuke, Japan.

Background: Osteoarthritis (OA) of the hip rarely develops in the early second decade. As the incidence of this disease is low, no treatment method has been established. We report two patients with unilateral OA in their early teens in whom the anteversion angle of the femoral neck on the affected side was greater than that on the unaffected side. Read More

View Article and Full-Text PDF

Biomarkers for the Prediction and Diagnosis of Fibrostenosing Crohn's disease: A Systematic Review.

Clin Gastroenterol Hepatol 2021 Jun 2. Epub 2021 Jun 2.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Background And Aims: Intestinal strictures are a common complication of Crohn's disease (CD). Biomarkers of intestinal strictures would assist in their prediction, diagnosis, and monitoring. Herein we provide a comprehensive systematic review of studies assessing biomarkers that may predict or diagnose CD-associated strictures. Read More

View Article and Full-Text PDF

Return to sport following anterior cruciate ligament reconstruction: the argument for a multimodal approach to optimise decision-making: current concepts.

J ISAKOS 2021 Jun 4. Epub 2021 Jun 4.

Department of Orthopaedic Surgery, Stanford University, Redwood City, California, USA

Existing literature is varied in the methods used to make this determination in the treatment of athletes who have undergone recent anterior cruciate ligament (ACL) reconstruction. Some authors report using primarily time-based criteria, while others advocate for physical measures and kinematic testing to inform decision-making. The goal of this paper is to elucidate the most current medical evidence regarding identification of the earliest point at which a patient may safely return to sport. Read More

View Article and Full-Text PDF

A novel mutation of COL2A1 in a large Chinese family with avascular necrosis of the femoral head.

BMC Med Genomics 2021 Jun 4;14(1):147. Epub 2021 Jun 4.

Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, 600 Yi-Shan Rd., Shanghai, 200233, People's Republic of China.

Avascular necrosis of the femoral head (ANFH) is a debilitating bone disease, characterized by collapse of the femoral head and subsequent loss of hip joint function. Heterozygous mutations in COL2A1 have been identified to cause familial ANFH. Here we report on a large Chinese family with ANFH and a novel heterozygous mutation (c. Read More

View Article and Full-Text PDF

The new imaging findings: "Passing spine" without kissing.

Medicine (Baltimore) 2021 Jun;100(22):e26191

Laboratory of Statistics, Graduate School of Medicine, Osaka City University, Osaka, Japan.

Abstract: Case-control studies by examining the lumbar spine computed tomography (CT) findings focusing on the spinous processes."Passing spine" was defined as a lumbar degenerative change observed on CT images. In contrast, kissing spine, which is also an image finding, has been acknowledged as an established clinical condition. Read More

View Article and Full-Text PDF

Ultrasonographic Evaluation of Osteoarthritis-affected Knee Joints: Comparison with Kellgren-Lawrence Grading and Pain Scores.

J Med Ultrasound 2021 Jan-Mar;29(1):39-45. Epub 2021 Mar 20.

Department of Radiodiagnosis, Subharti Medical College, Meerut, Uttar Pradesh, India.

Background: The objective was to compare ultrasonographic findings with clinical and radiographic findings in osteoarthritis (OA)-affected knee joints.

Methods: This prospective study was conducted in Subharti Medical College, Meerut, after getting clearance from the ethical committee. Eighty-five symptomatic knees fulfilling American College of Rheumatology criteria for OA were included in the study. Read More

View Article and Full-Text PDF

Fabrication of a Polylactide-Glycolide/Poly-ε-Caprolactone/Dextran/Plastrum Testudinis Extract Composite Anti-Inflammation Nanofiber Membrane via Electrospinning for Annulus Fibrosus Regeneration.

J Biomed Nanotechnol 2021 May;17(5):873-888

Department of Orthopaedics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, P. R. China.

Tissue engineering is a promising approach for the treatment of chronic lower back pain (LBP) caused by intervertebral disc degeneration (IDD) resulting from degeneration and inflammation of annulus fibrosus (AF) tissue. However, scaffold with an anti-inflammatory effect on AF cells has not been reported. In this study, we fabricated a polylactide-glycolide (PLGA)/poly-ε-caprolactone (PCL)Zdextran (DEX) composite membrane loaded with plastrum testudinis extract (PTE), a Traditional Chinese Medicine herbal extract, via electrospinning. Read More

View Article and Full-Text PDF

State of the art of clinical applications of Tissue Engineering in 2021.

Tissue Eng Part B Rev 2021 Jun 3. Epub 2021 Jun 3.

Universitaire Ziekenhuizen Leuven, 60182, Plastic and Reconstructive Surgery, Leuven, Belgium;

Tissue engineering (TE) was introduced almost 30 years ago as a potential technique for regenerating human tissues. However, despite promising laboratory findings, the complexity of the human body, scientific hurdles, and lack of persistent long-term funding still hamper its translation towards clinical applications. In this report, we compile an inventory of clinically applied TE medical products relevant to surgery. Read More

View Article and Full-Text PDF

Ginkgolide J protects human synovial cells SW982 via suppression of p38‑dependent production of pro‑inflammatory mediators.

Mol Med Rep 2021 Aug 3;24(2). Epub 2021 Jun 3.

Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.

Fibroblast‑like synoviocytes (FLS) in the synovial lining play a key role in the pathological process of rheumatoid arthritis (RA), which produce pro‑inflammatory mediators to perpetuate inflammation and proteases to contribute to cartilage destruction. Ginkgolide J (GJ) is a subclass of ginkgolides (GGs) that exhibits anti‑inflammatory activity. In the present study, the protective effect of GJ on lipopolysaccharide (LPS)‑treated human synovial cells SW982 and its related mechanisms were investigated using various methods, including ELISA, Griess assay, western blotting, immunofluorescence analysis and p38 kinase activity assay. Read More

View Article and Full-Text PDF