269,119 results match your criteria carrier

Studying the lifetime of charge and heat carriers due to intrinsic scattering mechanisms in FeVSb half-Heusler thermoelectric.

J Phys Condens Matter 2021 Apr 22. Epub 2021 Apr 22.

School of Engineering, Indian Institute of Technology, South Campus, Kamand, Mandi, Himachal Pradesh, 175075, INDIA.

This work, presents a study of lifetime of carriers due to intrinsic scattering mechanismselectron-electron (EEI), electron-phonon (EPI) and phonon-phonon interactions (PPI) in a promising half-Heusler thermoelectric FeVSb. Using the full-GW method, the effect of EEI and temperature on the valence and conduction band extrema and band gap are studied. The lifetime of carriers with temperature are estimated at these band extrema. Read More

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Tuning the optoelectronic properties of oligothienyl silane derivatives and their photovoltaic properties.

J Mol Graph Model 2021 Apr 6;106:107918. Epub 2021 Apr 6.

Department of Chemistry, University of Agriculture, 38000, Faisalabad, Pakistan; Punjab Bio-energy Institute, University of Agriculture, Faisalabad, 38000, Pakistan. Electronic address:

Four new Donor-Acceptor (D-A) type oligothiophenes based structures (C1-C4) were designed by substituting different acceptors moieties around tetrahedral silicon core to simulate their photovoltaic properties. Density functional theory (DFT) and time-dependent density functional theory (TD-DFT) quantum analysis were carried out to reconnoiter various parameters of solar cells. A comparative analysis has conducted between designed structures and reference molecule R to conclude our simulated results. Read More

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Micelle-contained and PEGylated Hybrid Liposomes of Combined Gemcitabine and Cisplatin Delivery for enhancing antitumor activity.

Int J Pharm 2021 Apr 19:120619. Epub 2021 Apr 19.

Department of Pharmaceutics Science, Shenyang Pharmaceutical University, Shenyang 110116, China.

Combination, synergistic chemotherapy with gemcitabine (GEM) and cisplatin (CDDP) is a common strategy, and has been recommended for tumor treatment due to its promoted therapeutic effect and reduced systemic toxicity. However, this process involves the intravenous infusion of GEM prior to that of CDDP, which is inconvenient for patients and staff. Here, a novel hybrid nano-carrier system comprised of micelles encapsulated within PEGylated liposomes is proposed, in order to combine the unique strengths of each component. Read More

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Paeonol-Loaded PLGA Nanoparticles as an Oral Drug Delivery System: Design, Optimization and Evaluation.

Int J Pharm 2021 Apr 19:120617. Epub 2021 Apr 19.

Anhui University of Chinese Medicine, Hefei, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China; Engineering Technology Research Center of Modernized Pharmaceutics Anhui Education Department (AUCM); Anhui Province Key Laboratory of Pharmaceutical Technology and Application (Anhui University of Chinese Medicine), Hefei, China.

Herein, we report a novel type of NPs by loading paeonol (Pae) into PLGA NPs, to enhance drug stability and oral bioavailability. The paeonol (Pae)-loaded polylactic-co-Gly-colic acid (PLGA) nanoparticles (Pae-PLGA-NPs) were prepared by nanoprecipitation method. The resultant NPs were in spherical shape with an average particle size around 237. Read More

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Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies using colloidal carrier systems.

Neurochem Int 2021 Apr 19:105017. Epub 2021 Apr 19.

Ruprecht-Karls University, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany. Electronic address:

The blood-brain barrier represents the major challenge for delivering drugs to the central nervous system (CNS). It separates the blood circulation from the brain tissue, thereby protecting the CNS and maintaining its ion homeostasis. Unfortunately, most drugs are not able to cross this barrier in vivo despite promising in vitro results. Read More

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Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.

Am J Hum Genet 2021 Apr 16. Epub 2021 Apr 16.

Department of Epidemiology, University of Washington, Seattle, WA 98105, USA. Electronic address:

Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and non-coding disease-causing variants, has largely been applied to clinical diagnosis of inherited disorders. Here we leveraged WGS data in up to 62,653 ethnically diverse participants from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program and assessed statistical association of variants with seven red blood cell (RBC) quantitative traits. We discovered 14 single variant-RBC trait associations at 12 genomic loci, which have not been reported previously. Read More

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Cancer-Cell-Activated In-Situ Synthesis of Mitochondria-Targeting AIE Photosensitizer for Precise Photodynamic Therapy.

Angew Chem Int Ed Engl 2021 Apr 22. Epub 2021 Apr 22.

National University of Singapore, Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117585, Singapore, SINGAPORE.

Maximization of phototoxic damage on tumor with minimized side effect on normal tissue is essential for effective anticancer photodynamic therapy (PDT). This requires highly cancer-cell-specific or even cancer-cell-organelle-specific synthesis or delivery of efficient photosensitizers (PSs) in vitro and in vivo , which is difficult to achieve. Herein, we report a strategy of cancer-cell-activated PS synthesis, by which an efficient mitochondria-targeting photosensitizer with aggregation-induced-emission (AIE) feature can be selectively synthesized as an efficient image-guided PDT agent inside cancer cells. Read More

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Functional Analysis of Mitochondrial Acyl Carrier Proteins.

Ananya Mukherjee

Plant Physiol 2020 Jun;183(2):421-422

University of Nebraska, Lincoln, Nebraska 68588.

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Preparation of Fe-filled MOF-Al-based hydrogel for efficient reclaim of phosphate from wastewater and reusing as a slow-release fertilizer.

Environ Technol 2021 Apr 22:1-29. Epub 2021 Apr 22.

Hubei Key Laboratory of Biologic Resources Protection and Utilization (Hubei Minzu University), Enshi 445000, Hubei, P.R. China.

Abtract:In this study, a novel Fe-filled MOF-Al-based hydrogel SA@Fe@MOF-Al) was prepared and charcterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TG). The SA@Fe@MOF-Al hydrogel bead was used as adsorbent to adsorb HPO from wastewater. The effects on adsorption were investigated, including pH and coexist ion. Read More

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Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine.

Nano Lett 2021 Apr 22. Epub 2021 Apr 22.

The Tianjin Key Laboratory of Biomaterials, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192, China.

Nanovaccines have emerged as promising agents for cancer immunotherapy. However, insufficient antitumor immunity caused by inefficient antigen/adjuvant loading and complicated preparation processes are the major obstacles that limit their clinical application. Herein, two adjuvants, monophosphatidyl A (MPLA) and CpG ODN, with antigens were designed into a nanovaccine to overcome the above obstacles. Read More

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A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination.

J Mater Chem B 2021 Apr 25;9(14):3200-3209. Epub 2021 Mar 25.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.

Making full use of the undeveloped bioactive natural product derivatives by selectively delivering them to target sites can effectively increase their druggability and reduce the wastage of resources. Azo-based prodrugs are widely regarded as an effective targeted delivery means for colon-related disease treatment. Herein, we report a new-type of azo-based nanoprodrug obtained from bioactive natural products, in which the readily available podophyllotoxin natural products are connected with methoxy polyethylene glycol (mPEG) via a multifunctional azobenzene group. Read More

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Specific modification and self-transport of porphyrins and their multi-mechanism cooperative antitumor studies.

J Mater Chem B 2021 Apr 23;9(14):3180-3191. Epub 2021 Mar 23.

Key Laboratory of Natural Medicine and Immune-Engineering of Henan Province, Henan University, Kaifeng, Henan 475004, People's Republic of China.

In order to reduce the toxicity and side effects of anti-tumor drugs and improve their therapeutic effect against cancer, photodynamic and chemical combination therapy has been exploited. However, the complicated preparation and metabolic toxicity of photosensitizer-loaded materials remain major obstacles for bioapplications. In this study, we designed and prepared a specific photosensitizer self-transporting drug-delivery system. Read More

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Controllable synthesis of CoFeSe/NiCoSe hybrid nanotubes with heterointerfaces and improved oxygen evolution reaction performance.

Nanoscale 2021 Mar 22;13(12):6241-6247. Epub 2021 Mar 22.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China.

The rational construction of heterointerfaces in hollow nanohybrids is considered as a promising and challenging approach for enhancing their electrocatalytic performance. Herein, we demonstrate the synthesis of CoFeSe/NiCoSe hybrid nanotubes (CFSe/NCSe HNTs) with open ends and abundant heterointerfaces. The CFSe/NCSe HNT hybrid nanotubes are obtained by using NiCo-aspartic acid nanofibres (NiCo-Asp NFs) as the templates which can be converted to the CFSe/NCSe HNTs via proton etching, three metal coprecipitation, Kirkendall effect and anion-exchange reaction. Read More

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Gain and bandwidth of InP nanowire array photodetectors with embedded photogated InAsP quantum discs.

Nanoscale 2021 Mar 22;13(12):6227-6233. Epub 2021 Mar 22.

School of Information Technology, Halmstad University, Box 823, SE-301 18 Halmstad, Sweden.

Here we report on the experimental results and advanced self-consistent real device simulations revealing a fundamental insight into the non-linear optical response of n-i-n InP nanowire array photoconductors to selective 980 nm excitation of 20 axially embedded InAsP quantum discs in each nanowire. The optical characteristics are interpreted in terms of a photogating mechanism that results from an electrostatic feedback from trapped charge on the electronic band structure of the nanowires, similar to the gate action in a field-effect transistor. From detailed analyses of the complex charge carrier dynamics in dark and under illumination was concluded that electrons are trapped in two acceptor states, located at 140 and 190 meV below the conduction band edge, at the interface between the nanowires and a radial insulating SiO cap layer. Read More

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Design and tailoring of two-dimensional Schottky, PN and tunnelling junctions for electronics and optoelectronics.

Nanoscale 2021 Apr 7;13(14):6713-6751. Epub 2021 Apr 7.

State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

Owing to their superior carrier mobility, strong light-matter interactions, and flexibility at the atomically thin thickness, two-dimensional (2D) materials are attracting wide interest for application in electronic and optoelectronic devices, including rectifying diodes, transistors, memory, photodetectors, and light-emitting diodes. At the heart of these devices, Schottky, PN, and tunneling junctions are playing an essential role in defining device function. Intriguingly, the ultrathin thickness and unique van der Waals (vdW) interlayer coupling in 2D materials has rendered enormous opportunities for the design and tailoring of various 2D junctions, e. Read More

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Oscillation in Excited State Lifetimes with Size of Sub-nanometer Neutral (TiO) Clusters Observed with Ultrafast Pump-Probe Spectroscopy.

J Phys Chem Lett 2021 Apr 22:4098-4103. Epub 2021 Apr 22.

School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States.

Neutral titanium oxide clusters of up to 1 nm in diameter (TiO), with < 10, are produced in a laser vaporization source and subsequently ionized by a sequence of femtosecond laser pulses. Using a 400 nm pump and 800 nm probe lasers, the excited state lifetimes of neutral (TiO) clusters are measured. All clusters exhibit a rapid relaxation lifetime of ∼35 fs, followed by a sub-picosecond lifetime that we attribute to carrier recombination. Read More

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Conflux of tunable Rashba effect and piezoelectricity in flexible magnesium monochalcogenide monolayers for next-generation spintronic devices.

Nanoscale 2021 Apr 22. Epub 2021 Apr 22.

Institute of Nano Science and Technology, Knowledge City, Sector 81, Manauli, Mohali, Punjab-140306, India.

The coupling of piezoelectric properties with Rashba spin-orbit coupling (SOC) has proven to be the limit breaker that paves the way for a self-powered spintronic device (ACS Nano, 2018, 12, 1811-1820). For further advancement in next-generation devices, a new class of buckled, hexagonal magnesium-based chalcogenide monolayers (MgX; X = S, Se, Te) have been predicted which are direct band gap semiconductors satisfying all the stability criteria. The MgTe monolayer shows a strong SOC with a Rashba constant of 0. Read More

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Reversed selectivity of photocatalytic CO reduction over metallic Pt and Pt(II) oxide cocatalysts.

Phys Chem Chem Phys 2021 Apr;23(15):9407-9417

State Key Laboratory of Coal Combustion, School of Energy and Power Engineering, Huazhong University of Science & Technology, 1037 Luoyu Road, Wuhan 430074, China.

The chemical state of Pt in cocatalysts has a major influence on the activity and selectivity of the photocatalytic reduction of CO2; however, the underlying mechanism is unclear owing to the co-existence of different Pt chemical states and mutual transformation between them. In this study, PtO/TiO2 catalysts were prepared through photodeposition and Pt/TiO2 was prepared by the photoreduction of PtO/TiO2 to avoid interference arising from co-existing Pt forms and different loading amounts. These catalysts exhibited completely reversed selectivity for CO and CH4 production during CO2 photoreduction: PtO/TiO2 tended to produce CO (100%), whereas Pt/TiO2 favored the production of CH4 (66. Read More

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Explanation for the conductivity difference of half-Heusler transparent conductors ionization energy.

Phys Chem Chem Phys 2021 Apr;23(15):9285-9293

School of Physical Science and Technology, Southwest Jiaotong University, Key Laboratory of Advanced Technologies of Materials, Ministry of Education of China, Chengdu 610031, People's Republic of China.

To further understand the less-studied half-Heusler transparent conductors, we have considered four 18-electron ABX compounds (TaIrGe, TaIrSn, ZrIrSb, and TiIrSb) to focus on their carrier effective masses and ionization energies. The novelty of this work lies in two aspects: (i) we discover that hole-killer defects are more likely to form in TaIrGe than in ZrIrSb, which leads to a lower concentration of the holes in TaIrGe. This is the fundamental reason for the conductivity of TaIrGe being much lower than that of ZrIrSb; (ii) we propose that the hole effective mass near the sub-valence band maximum (Sub-VBM) could be used to forecast the potential transport performance of the materials. Read More

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Strain-tunable electronic structure and anisotropic transport properties in Janus MoSSe and g-SiC van der Waals heterostructure.

Phys Chem Chem Phys 2021 Apr;23(15):9440-9447

School of Physics and Optoelectronic Engineering, Ludong University, Yantai 26425, People's Republic of China.

The van der Waals heterostructures (vdWHs) create a multi-purpose platform to design unique structures for efficient photovoltaic and optoelectronic applications. In this study, on the basis of the first-principles calculations, we present a type-II semiconducting MoSSe/g-SiC vdWH with a moderate bandgap value of 1.31 eV. Read More

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Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages.

Nanoscale 2021 Apr 22. Epub 2021 Apr 22.

Laboratory for Particles-Biology Interactions, Department of Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, 9014 St Gallen, Switzerland. and Nanoparticle Systems Engineering Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, 8092 Zurich, Switzerland.

Bacterial infections are one of the main health concerns humanity faces today and bacterial resistances and protection mechanisms are set to aggravate the issue in the coming years. An increasing number of bacterial strains evades antibiotic treatment by hiding inside cells. Conventional antimicrobial agents are unable to penetrate or be retained in the infected mammalian cells. Read More

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Interface engineering of a hierarchical ZnCdS architecture with favorable kinetics for high-performance solar water splitting.

Phys Chem Chem Phys 2021 Apr;23(15):9347-9356

AnHui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics and Materials Science, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, P. R. China.

Manipulating the charge carrier transport in photoactive materials is a big challenge toward high efficiency solar water splitting. Herein, we designed a hierarchical ZnxCd1-xS architecture for tuning the interfacial charge transfer kinetics. The in situ growth of ZnxCd1-xS nanoflakes on ZnO backbones provided low interfacial resistance for charge separation. Read More

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Termination dependence and electric field modification of band alignment in a CNT/CHNHPbI heterojunction.

Phys Chem Chem Phys 2021 Apr;23(15):9249-9258

Institute for Quantum Science and Engineering and Department of Physics, Southern University of Science and Technology, Shenzhen 518055, China.

Carbon nanotube (CNT) and perovskite composite materials possessing the combined advantages of CNTs and perovskites have drawn substantial attention due to their promising applications in photovoltaic and optoelectronic devices. Understanding the band alignment of heterojunctions is crucial for further performance improvement. Here, we systematically investigated the interfacial electronic structure and optical absorption of a semiconducting CNT/CH3NH3PbI3 heterojunction via density functional theory calculations. Read More

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Choroidal neovascularisation in a predicted female choroideraemia carrier treated with intravitreal anti-vascular endothelial growth factor.

Eur J Ophthalmol 2021 Apr;31(1_suppl):4-10

Princess Alexandra Eye Pavilion, Edinburgh, UK.

Purpose: To report a case of choroidal neovascularisation and leakage in a myopic female predicted to be a choroideraemia carrier treated with intravitreal anti-vascular endothelial growth factor (anti-VEGF).

Methods: Case report.

Results: A female magazine editor presented with sudden decrease in vision in her right eye, with Snellen visual acuities (VAs) of 1/60 and 3/60 in the right and left eyes respectively. Read More

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Magnetically Induced Aggregation of Iron Oxide Nanoparticles for Carrier Flotation Strategies.

ACS Appl Mater Interfaces 2021 Apr 22. Epub 2021 Apr 22.

Institute of Fluid Dynamics, Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany.

On the nanoscale, iron oxides can be used for multiple applications ranging from medical treatment to biotechnology. We aimed to utilize the specific properties of these nanoparticles for new process concepts in flotation. Magnetic nanoparticles were synthesized by alkaline coprecipitation, leading to a primary particle size of 9 nm, and coated with oleate. Read More

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Effects of inlet temperature and carrier concentration on spray-dried 'cempedak' (Artocarpus integer) fruit powder and its reconstitution properties.

Acta Sci Pol Technol Aliment 2021 Apr-Jun;20(2):135-148

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia.

Background: 'Cempedak' (Artocarpus integer) is an aromatic fruit which is similar to jackfruit. Although it is rich in vitamin A and is consumed fresh, the fruit has a short shelf life. Hence, it can be converted through a spray-drying process, to form powder, which is more stable. Read More

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Interplay between microstructure, defect states, and mobile charge generation in transition metal dichalcogenide heterojunctions.

Nanoscale 2021 Apr 22. Epub 2021 Apr 22.

National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, CO 80401, USA.

Two-dimensional transition metal dichalcogenides (2D-TMDCs) have gained attention for their promise in next-generation energy-harvesting and quantum computing technologies, but realizing these technologies requires a greater understanding of TMDC properties that influence their photophysics. To this end, we discuss here the interplay between TMDC microstructure and defects with the charge generation yield, lifetime, and mobility. As a model system, we compare monolayer-only and monolayer-rich MoS2 grown by chemical vapor deposition, and we employ the TMDCs in Type-II charge-separating heterojunctions with semiconducting single-walled carbon nanotubes (s-SWCNTs). Read More

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Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery.

Drug Des Devel Ther 2021 14;15:1531-1547. Epub 2021 Apr 14.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Capital Medical University, Beijing, People's Republic of China.

Background: siRNA brings hope for cancer therapy. However, there are many obstacles for application of siRNA in clinical. Because of the excellent biocompatibility, non-toxicity and non-immunogenicity of bovine serum albumin (BSA), BSA-based nanoparticles have been widely designed as a drug carrier system. Read More

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Development of a gel-in-oil emulsion as a transdermal drug delivery system for successful delivery of growth factors.

J Biosci Bioeng 2021 Apr 18. Epub 2021 Apr 18.

Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address:

Growth factors (GFs) are indispensable in regenerative medicine because of their high effectiveness. However, as GFs degenerate easily, the development of a suitable carrier with improved stability for GFs is necessary. In this study, we developed a gel-in-oil (G/O) emulsion technology for the transdermal delivery of growth factors. Read More

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Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone-graft substitute for accelerated craniofacial bone regeneration.

Biomater Res 2021 Apr 21;25(1):13. Epub 2021 Apr 21.

Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, 02841, Seoul, Korea.

Background: Bioceramic β-tricalcium phosphate (β-TCP) is used as a bone-grafting material and a therapeutic drug carrier for treatment of bone defects in the oral and maxillofacial regions due to the osteoconductivity and biocompatibility. However, the low mechanical strength and limited osteoinductivity of β-TCP agglomerate restrict bone regenerating performance in clinical settings.

Methods: Herein, a biomimetic composite is proposed as a bone morphogenetic protein-2 (BMP-2)-delivering bone graft substitute to achieve a robust bone grafting and augmented bone regeneration. Read More

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