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Cell Death Discov 2021 Jan 18;7(1):14. Epub 2021 Jan 18.

Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Hepatocellular carcinoma (HCC) is a globally prevailing cancer with a low 5-year survival rate. Little is known about its intricate gene expression profile. Single-cell RNA sequencing is an indispensable tool to explore the genetic characteristics of HCC at a more detailed level. Read More

Heliyon 2020 Jul 14;6(7):e04440. Epub 2020 Jul 14.

Materials Research Centre, College of Engineering, Swansea University, SA1 8EN, UK.

The mechanical behaviour of three ultra-high strength steels has been assessed; AerMet100, 300M and the recently developed corrosion resistant high strength steel, MLX-17. Material heat treatment profiles have been utilised to provide performance optimised for the aerospace industry and specimens have been tested to explore tensile and fatigue properties, in particular when combined with pre-strain to simulate the effects of overload. Testing of this kind has not been reported within the literature, particularly amongst ultra-high strength and corrosion-resistant steels. Read More

Drug Dev Ind Pharm 2020 Aug 10;46(8):1362-1372. Epub 2020 Jul 10.

Medicinal  and Pharmaceutical Chemistry Department, Division of Pharmaceutical and Drug Industries Research, Industrial Pharmacy Laboratory, National Research Centre, Giza, Egypt.

Objective: Bioavailability of Meloxicam (MLX) from solid dispersions (SDs), against innovator product Mobic in humans was conducted. Furthermore, to establish a good - correlation (IVIVC); dissolution studies were carried-out in different media.

Methods: MLX/SDs was prepared using Soluplus/Poloxamer via hot-melt-extrusion (EXT-SD) and fusion melt (FUS-SD) techniques. Read More

J Environ Manage 2018 Sep 19;221:28-37. Epub 2018 May 19.

Departamento de Ciências Naturais, Universidade Federal de São João del-Rei, Campus Dom Bosco, Praça Dom Helvécio 74, Fábricas, 36301-160, São João del-Rei, Minas Gerais, Brazil. Electronic address:

The composite polyaniline/multiwalled carbon nanotube (PAni/MWCNT, 1:0.1 w/w) was developed with the intention of binding the adsorbent properties of two materials and using it to adsorb pharmaceuticals from aqueous media. PAni/MWCNT was characterized by scanning electron microscopy, thermogravimetry, infrared spectroscopy, pH at the point of zero charge, and the effect on the surface wettability of the material. Read More

Adv Pharm Bull 2017 Dec 31;7(4):569-577. Epub 2017 Dec 31.

Department of Pharmaceutics, M M College of Pharmacy, Maharishi Markandeshwar University,Mullana, Ambala-133207, Haryana, India.

A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet. Crospovidone (CPV), a hydrophilic carrier was selected for SSD preparation on the basis of 89% in- vitro MLX adsorption, 19% hydration capacity and high swelling index. SD on the other hand was made with PEG4000. Read More

Mater Sci Eng C Mater Biol Appl 2017 Jul 21;76:975-984. Epub 2017 Mar 21.

College of pharmacy, Xinxiang Medical University, 453003 Xinxiang, PR China.

To enhance the therapeutic effects of meloxicam (MLX), we developed an oral MLX-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles@hydrogel (MLX-NPs@hydrogel) preparation. The MLX-NPs were fabricated via a solvent evaporation method, and their morphologies were observed by a JEM-1011 transmission electron microscope (TEM). The poly(mPEGMA-co-MAA) hydrogels were synthesized, and studies on their pH sensibilities were carried out in pH1. Read More

Pharm Nanotechnol 2017 ;5(2):119-137

Principal K.M. Kundnani College of Pharmacy, 23, Jote Joy Building, Rambhau Salgaonkar Road, Cuffe Parade, Mumbai 40005, India.

Background: Chemoprevention is a strategy which uses drugs which are traditionally not used as anti-cancer drugs; however, they prevent the carcinogenesis. Meloxicam (MLX) is traditionally used as a non-steroidal anti-inflammatory drug (NSAID), but it has been proven to have activity against colorectal cancer. Subsequently MLX seems to be a likely candidate to be utilized in the chemopreventive therapy of colorectal cancer. Read More

Drug Dev Ind Pharm 2017 Apr 17;43(4):600-610. Epub 2017 Jan 17.

a Department of Pharmaceutics , Bombay College of Pharmacy, Kalina, Santacruz (E) , Mumbai , India.

Meloxicam, a BCS class II drug belonging to the class of NSAIDs is indicated in conditions of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis in which rapid onset of drug action is desired to reduce inflammation and pain. The objective of the study was to thus develop Self Nanoemulsifying Granules (SNEGs) of Meloxicam (MLX) for enhancement of solubility; and subsequently dissolution rate, thus aiming for a faster onset of action. Preliminary studies along with molecular modeling studies were carried out for selection of appropriate lipids, surfactants and cosurfactants for the development of MLX-loaded Self Nanoemulsifying preconcentrate (SNEP). Read More

Life Sci 2013 Nov 7;93(21):763-72. Epub 2013 Oct 7.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143104, India.

Aim: The main objective of the current investigation was to develop nanostructured lipid carriers (NLC) based gel for the enhancement of transdermal absorption of meloxicam (MLX) to achieve local as well as systemic drug action without concurrent gastrointestinal toxicity.

Main Methods: NLC gel containing MLX was prepared and characterized for particle size, polydispersity, zeta potential, pH, rheology, entrapment efficiency, occlusion factor, and thermal behavior. In vitro drug release, in vitro skin permeation and deposition studies were carried out using Franz diffusion cells. Read More

Genome Biol Evol 2011 22;3:915-37. Epub 2011 Aug 22.

Bioinformatics Research Center, North Carolina State University, USA.

Transcription factors (TFs) are essential for the regulation of gene expression and often form emergent complexes to perform vital roles in cellular processes. In this paper, we focus on the parallel Max and Mlx networks of TFs because of their critical involvement in cell cycle regulation, proliferation, growth, metabolism, and apoptosis. A basic-helix-loop-helix-zipper (bHLHZ) domain mediates the competitive protein dimerization and DNA binding among Max and Mlx network members to form a complex system of cell regulation. Read More

Acta Pharm 2010 Jun;60(2):153-63

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, India.

Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. In the present investigation, topical gel of meloxicam (MLX) was formulated using N-methyl pyrrolidone (NMP) as a solubilizer and Carbopol Ultrez 10® as a gelling polymer. MLX gel was evaluated with respect to different physicochemical parameters such as pH, viscosity and spreadability. Read More

J Chromatogr A 2009 Nov 4;1216(46):8132-40. Epub 2009 May 4.

The State Laboratory, Young's Cross, Celbridge, Co Kildare, Ireland.

A rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the simultaneous identification, confirmation and quantitation of seven licensed anti-inflammatory drugs (AIDs) in bovine milk. The method was validated in accordance with the criteria defined in Commission Decision 2002/657/EC. Two classes of AIDs were investigated, corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs). Read More

Diabetes 2004 Apr;53(4):1134-40

Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Variants in hepatocyte nuclear factor-4 alpha (HNF4 alpha), a transcription factor that influences the expression of glucose metabolic genes, have been correlated with maturity-onset diabetes of the young, a monogenic form of diabetes. Previously, in a genome scan of Ashkenazi Jewish type 2 diabetic families, we observed linkage to the chromosome 20q region encompassing HNF4 alpha. Here, haplotype-tag single nucleotide polymorphisms (htSNPs) were identified across a 78-kb region around HNF4 alpha and evaluated in an association analysis of Ashkenazi Jewish type 2 diabetic (n = 275) and control (n = 342) subjects. Read More

Thromb Haemost 2003 Aug;90(2):194-205

Biotechnology Centre of Oslo, Gaustadalléen 21, N-0349 Oslo, Norway.

The factor VII genes of five unrelated Finnish female patients, F1-F5, with moderate bleeding tendency, were screened for mutations using single strand conformational polymorphisms and DNA sequencing. Heterozygous shifts were detected in exons 5 and 8 for patient F1, and sequencing confirmed the presence of the silent dimorphism H115H, the polymorphism R353Q and the mutation A294V. The patient F1 was also heterozygous for a novel -59T/G transversion mutation in the Hepatocyte nuclear factor 4-binding site. Read More

Diabetologia 2003 Feb 8;46(2):291-5. Epub 2003 Jan 8.

Department of Paediatrics, 3rd Faculty of Medicine, Charles University, Vinohradska 159, 100-81 Prague 10, Czech Republic.

Aims/hypothesis: The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY.

Methods: We studied 61 unrelated index probands of Czech origin (28 males, 33 females) with a clinical diagnosis of MODY and 202 family members. The mean age of probands was 22. Read More

J Clin Endocrinol Metab 2002 Jun;87(6):2532-9

Pediatric Diabetes Unit, Ramón y Cajal Hospital, University of Alcalá, Carretera Comenar Viejo Km. 9.4, 28034 Madrid, Spain.

The aims of this study were to estimate the prevalence of major maturity-onset diabetes of the young (MODY) subtypes in Spanish MODY families and to analyze genotype-phenotype correlations. Twenty-two unrelated pediatric MODY patients and 97 relatives were screened for mutations in the coding region of the glucokinase (GCK), hepatic nuclear factor- HNF-1alpha and HNF4alpha genes using PCR-single strand conformation polymorphism and/or direct sequencing. In families carrying GCK mutations, the influence of genetic defects on fetal growth was investigated by comparing the birth weights of 32 offspring discordant for the mutations. Read More

J Clin Endocrinol Metab 2001 Jan;86(1):220-6

Departmento de Medicina y Unidad de Genética de la Nutrición del Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico.

The objective of this study was to investigate possible defects in the insulin sensitivity and/or the acute insulin response in a group of Mexican patients displaying early-onset type 2 diabetes and to evaluate the contribution of mutations in three of the genes linked to maturity-onset diabetes of the young. We studied 40 Mexican patients with an age of diagnosis between 20 and 40 yr in which the insulin sensitivity as well as the insulin secretory response were measured using the minimal model approach. A partial screening for possible mutations in 3 of the 5 genes linked to maturity-onset diabetes of the young was carried out by PCR-single strand conformation polymorphism analysis. Read More

Diabetologia 1999 Sep;42(9):1131-7

Department of Endocrinology, University Hospital MAS, University of Lund, Malmö, Sweden.

Aims/hypothesis: To investigate the contribution of mutations in maturity-onset diabetes of the young (MODY) and mitochondrial genes to early-onset diabetes with a strong family history of diabetes in a cohort with a high prevalence of Type I (insulin-dependent) diabetes mellitus.

Methods: Screening for sequence variants in the hepatocyte nuclear factor (HNF)-4alpha (MODY1), glucokinase (MODY2), HNF-1alpha (MODY3) genes and mitochondrial DNA was carried out in 115 Finnish and Swedish patients with early-onset ( Read More

Diabet Med 1999 Mar;16(3):193-200

Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215-5397, USA.

Aims: Mutations in hepatocyte nuclear factor (HNF)-4alpha gene located on chromosome 20q have been found to be responsible for the development of early onset Type 2 diabetes mellitus (DM). Through a national campaign, 53 families with autosomal dominant, early onset Type 2 DM (n=654) were assembled to determine the frequency of mutations in the HNF-4alpha gene and their contribution to the development of diabetes.

Methods: Twelve exons and the promoter region of the HNF-4alpha gene were screened in probands of the families by a double gradient, denaturing gradient gel electrophoresis (DG-DGGE) protocol combined with automated bi-directional sequencing of the PCR products of all heterozygous individuals. Read More

Med Clin (Barc) 1981 Mar;76(5):214-7

The authors study the usefulness of the measurement of the negative area of P in V1 (Morris' index) in patients with acute myocardial infarction. The study was carried out prospectively in 70 patients, 31 of them having a Swan-Ganz catheter inserted permitting simultaneous hemodynamic and electrocardiographic measurements. No overall correlation was found between pulmonary capillary pressure (PCP) and Morris' index (Mlx), but a correlation existed in the subgroup of patients that showed evident variations of Mlx values during the study. Read More