1,021 results match your criteria carried 391


COVID-19 Associated Coagulopathy in an Indian Scenario: A Correlation with Disease Severity and Survival Status.

Indian J Hematol Blood Transfus 2021 Aug 19:1-11. Epub 2021 Aug 19.

Department of Pathology, ESIC Medical College, Faridabad, Haryana India.

Covid-19 pandemic reveals that the virus causes Covid-19 associated coagulopathy and it is well known that thrombotic risk is associated with ethnicity. To describe the Covid-19 associated coagulopathy in Indian population and to correlate it with the disease severity and survivor status. A cross sectional descriptive study of 391 confirmed Covid-19 cases was carried out over a period of 1. Read More

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The Clinical Efficacy and Safety of Enhanced Recovery After Surgery for Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies.

Front Med (Lausanne) 2021 2;8:694385. Epub 2021 Aug 2.

Department of Obstetrics and Gynecology, Jinan City People's Hospital, Jinan People's Hospital Affiliated to Shandong First Medical University, Shandong, China.

Enhanced recovery after surgery (ERAS) has been adopted in some maternity units and studied extensively in cesarean section (CS) in the last years, showing encouraging results in clinic practice. However, the present evidence assessing the effectiveness of ERAS for CS remains weak, and there is a paucity in the published literature, especially in improving maternal outcomes. Our study aimed to systematically evaluate the clinical efficacy and safety of ERAS protocols for CS. Read More

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Seroprevalence of the hepatitis C virus in healthcare personnel of the IMSS.

Rev Gastroenterol Mex (Engl Ed) 2021 Aug 12. Epub 2021 Aug 12.

Departamento de Gastroenterología, Hospital de Especialidades Centro Médico Nacional La Raza, Mexico City, Mexico.

Introduction: Healthcare workers (HCWs) are considered an at-risk population for hepatitis C virus (HCV) transmission. Seroprevalence of HCV in Mexico is 1.4% and is similar in HCWs at 0. Read More

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Association between cytochrome P450 2C19 polymorphism and clinical outcomes in clopidogrel-treated Uygur population with acute coronary syndrome: a retrospective study.

BMC Cardiovasc Disord 2021 08 12;21(1):391. Epub 2021 Aug 12.

Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No, 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.

Background: Acute coronary syndrome (ACS) has become a vital disease with high mortality in the Uygur populations. Clopidogrel plays an important role in reducing the risk of recurrent cardiovascular events after ACS; however, it is a prodrug that requires biotransformation by cytochrome P450 (CYP450).

Objectives: To determine the effect of genetic polymorphisms in CYP2C19*2, *3, and *17, and along with clinical, demographic factors, on variation in response to clinical outcomes in Uygur patients. Read More

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Prevalence and socio-demographic determinants of diarrhea among children below 5 years in Bondhere district Somalia.

Pan Afr Med J 2021 21;38:391. Epub 2021 Apr 21.

Department of Environmental Health, University of Kabianga, Kericho, Kenya.

Introduction: globally diarrhea is rated as the second leading cause of mortality among children below the age of five years. The highest rates of morbidity and mortality as a result of diarrhea are reported in sub-Saharan Africa and South East Asia. Studies have documented Somalia as among the countries with significant high rates of diarrhea among children below the age of 5 years. Read More

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Recurrence and disease-free survival outcomes after computed tomography-guided needle biopsy in stage IA non-small cell lung cancer patients in China: a propensity score matching analysis.

Quant Imaging Med Surg 2021 Aug;11(8):3472-3480

Treatment Center of Minimally Invasive Intervention and Radioactive Particles, First Affiliated Hospital of the Army Medical University, Chongqing, China.

Background: Whether preoperative biopsy before radical resection can lead to recurrence and impact patient survival in non-small cell lung cancer (NSCLC) remains controversial. In this study, we carried out a retrospective analysis to determine whether preoperative biopsy can cause disease recurrence and influence disease-free survival (DFS) in patients with stage IA NSCLC.

Methods: Patients diagnosed with stage IA NSCLC (solid nodule) between January 2010 and December 2014 were identified from the databases of 7 Chinese medical centers and divided into two groups: a preoperative computed tomography (CT)-guided needle biopsy (CTNB) plus radical resection group, and a non-CTNB group. Read More

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Genetic and clinical features of Chinese sporadic amyotrophic lateral sclerosis patients with TARDBP mutations.

Brain Behav 2021 08 1;11(8):e2312. Epub 2021 Aug 1.

Department of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.

Objectives: To investigate the genetic and clinical features of Chinese sporadic amyotrophic lateral sclerosis (SALS) patients with TARDBP mutations, we carried out a genetic analysis in a cohort of 391 SALS patients and explored the clinical manifestations of patients with TARDBP variants.

Materials And Methods: The coding region of all five coding exons of TARDBP, exons 2-6, were sequenced for mutations in 391 Chinese SALS patients. The clinical features of patients with TARDBP mutations were described and compared with cases in literatures. Read More

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Stepped care for the treatment of depression: a systematic review and meta-analysis.

J Affect Disord 2021 Nov 18;294:391-409. Epub 2021 Jul 18.

Health Services Research on Chronic Patients Network (REDISSEC). Tenerife, Spain; Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain.

Background: The Stepped Care Model (SCM) proposes a sequential approach in the treatment of depression, applying interventions of increasing intensity according to the level of severity of the individual.

Methods: A systematic review was carried out until January 2020 in eight electronic databases. We included randomized (RCT) and non-randomized controlled trials comparing the SCM to usual non-sequential care. Read More

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November 2021

High-density DArT-based SilicoDArT and SNP markers for genetic diversity and population structure studies in cassava (Manihot esculenta Crantz).

PLoS One 2021 27;16(7):e0255290. Epub 2021 Jul 27.

Department of Statistics and Actuarial Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Cassava (Manihot esculenta Crantz) is an important industrial and staple crop due to its high starch content, low input requirement, and resilience which makes it an ideal crop for sustainable agricultural systems and marginal lands in the tropics. However, the lack of genomic information on local genetic resources has impeded efficient conservation and improvement of the crop and the exploration of its full agronomic and breeding potential. This work was carried out to obtain information on population structure and extent of genetic variability among some local landraces conserved at the Plant Genetic Resources Research Institute, Ghana and exotic cassava accessions with Diversity Array Technology based SilicoDArT and SNP markers to infer how the relatedness in the genetic materials can be used to enhance germplasm curation and future breeding efforts. Read More

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Analysis and forecasts for trends of COVID-19 in Pakistan using Bayesian models.

PeerJ 2021 7;9:e11537. Epub 2021 Jul 7.

Department of Statistics, Islamia College, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Background: COVID-19 is currently on full flow in Pakistan. Given the health facilities in the country, there are serious threats in the upcoming months which could be very testing for all the stakeholders. Therefore, there is a need to analyze and forecast the trends of COVID-19 in Pakistan. Read More

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Relative frequency of drug-induced sleep disorders for 32 antidepressants in a large set of Internet user reviews.

Sleep 2021 Jul 12. Epub 2021 Jul 12.

Faculty of Pharmacy, University of Strasbourg, France.

Study Objectives: It is known that antidepressant drugs can induce sleep disorders in patients, but little data exist about high or low-risk molecules. The aim was to study the frequency of antidepressant drugs-induced sleep disorders (DISD) by molecule.

Methods: 77,391 patient comments for 32 antidepressant drugs were collected from drug review websites and screened for DISD. Read More

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Profiling the immune response to Beijing family infection: a perspective from the transcriptome.

Virulence 2021 12;12(1):1689-1704

Sección De Patología Experimental, Departamento De Patología, Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán, Ciudad De México, México.

Tuberculosis continues to be an important public health problem. Particularly considering Beijing-family strains of , which have been associated with drug-resistance and hypervirulence. The Beijing-like SIT190 (BL) is the most prevalent Beijing strain in Colombia. Read More

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December 2021

Antibody seropositivity for Neospora caninum in Blanco Orejinegro cattle in Colombia and factors associated with the infection.

Trop Anim Health Prod 2021 Jul 5;53(3):391. Epub 2021 Jul 5.

Grupo de Investigación Biodiversidad Y Genética Molecular (BIOGEM), Universidad Nacional de Colombia, Bogotá, Colombia.

Neosporosis is a parasitic disease that causes abortions and economic losses in bovine production systems, but no studies have been found concerning its effect on the Creole cattle breed, Blanco Orejinegro (BON). The aim of this research was to establish the serological status of Colombian BON cattle against Neospora caninum and to determine the factors associated with seropositivity. Blood samples were taken from 363 animals from 13 herds in six states of Colombia, and analyzed by indirect ELISA using a commercial test. Read More

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Production of egg white hydrolysate by digestion with pineapple bromelain: optimization, evaluation and antioxidant activity study.

J Food Sci Technol 2021 Jun 27:1-12. Epub 2021 Jun 27.

Meat and Marine Sciences Department, CSIR-Central Food Technological Research Institute, Mysuru, 570 020 India.

Chicken egg white is known to be an excellent source of good quality proteins to make hydrolysate with potential bioactive properties. Enzymatic digestion is a well-known method to produce protein hydrolysates; however, the type of enzyme determines the bioactive potential of the protein hydrolysates due to difference in their catalytic specificity. In this study, process optimization, production and evaluation of whole egg white protein hydrolysate (WEWPH) using pineapple bromelain through the Box-Behnken design were carried out. Read More

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Hepatitis C Virus Core Antigen (HCVAg): an affordable assay to monitor the efficacy of treatment in DAAs era.

New Microbiol 2021 Apr 21;44(2):89-94. Epub 2021 May 21.

UOC Microbiologia e Virologia, Universit degli Studi di Siena, and Azienda Ospedaliero-Universitaria Senese, Siena, Italy.

Hepatitis C virus (HCV) Core Antigen (HCVAg) and HCV-RNA were tested in 962 plasma/serum samples from 180 patients during Direct Antiviral Agents (DAAs) treatment and at follow-up. One hundred and eighty individuals were included: 71% carried advanced fibrosis and 43% were treatment-experienced. A Sustained Virological Response (SVR) was achieved in 166/180 (92%) individuals: 96/102 (94. Read More

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Changes in antibiotic prescription following an education strategy for acute respiratory infections.

NPJ Prim Care Respir Med 2021 06 3;31(1):34. Epub 2021 Jun 3.

Family Medicine, Servicio Murciano de Salud, Murcia, Spain.

The objective of this study was to assess the impact of an education intervention for primary health care physicians, based on the knowledge of clinical practice guidelines and availability of rapid antigen detection test for group A streptococci (GAS), on the improvement of antibiotic prescription for patients with acute respiratory tract infections. Before and after the intervention, physicians collected data from ten consecutive patients who attended during a 3-week period. This process was performed twice a year for 6 consecutive years (2012-2017). Read More

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Biodistribution and Safety Studies of a Bicistronic Plasmid for Nerve Repair.

Tissue Eng Part C Methods 2021 06;27(6):391-400

Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia.

Gene therapy is one of the promising approaches for regenerative medicine. Local and long-term expression of essential growth factors allows to achieve the desired therapeutic effect. However, some aspects of prolonged usage of genetic constructs encoding growth factors, such as toxicity, mutagenicity, genotoxicity, and ability to disseminate from the injection site and mediate ectopic expression of therapeutic proteins, are poorly investigated. Read More

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[Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):235-246

Department of Anesthesiology,Wuhan No.1 Hospital,Wuhan Hospital of Integrated Traditional Chinese and Western Medicine,Wuhan 430022,China.

Objective To explore the effect of dexmedetomidine(Dex)on sevoflurane-induced cognitive impairment in neonatal rats through Wnt signaling pathway. Methods Sixty 7-day-old SD rats were assigned into five groups:control group(without any intervention),Dex group(intraperitoneal injection of 25 μg/kg Dex),sevoflurane group(3% sevoflurane treatment for 4 hours),sevoflurane+Dex group(inhalation of 3% sevoflurane after injection of 25 μg/kg Dex for 4 hours),and sevoflurane+Dex+Wnt inhibitor group(Wnt inhibitor XAV393 and 25 μg/kg Dex were injected and 3% sevoflurane was inhaled for 4 hours).Three weeks later,Morris water maze was used to detect the cognitive function;TdT-mediated dUTP nick end labeling(TUNEL)staining was performed to detect the apoptosis of hippocampal neurons;neuronal nuclei (NeuN) staining was conducted to detect the survival of hippocampal neurons;Western blot was carried out to detect the expression of apoptosis-related proteins. Read More

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Serum Interleukin-37 Increases in Patients after Ischemic Stroke and Is Associated with Stroke Recurrence.

Oxid Med Cell Longev 2021 13;2021:5546991. Epub 2021 Apr 13.

Department of Neurology, Second Hospital of Jilin University, Changchun, China.

Background: This study seeks to assess interleukin-37 (IL-37) serum level in acute ischemic stroke and the value of predicting 3-month stroke recurrence and functional outcome in acute ischemic stroke.

Methods: From January 1, 2018, to June 30, 2019, all consecutive first-ever acute ischemic stroke patients from our hospital, China, were included. Serum samples, clinical information, and stroke severity (defined by the National Institute of Health stroke scale (NIHSS) score) were collected at baseline. Read More

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Dynamic Robustness of Semantic-Based Collaborative Knowledge Network of Open Source Project.

Entropy (Basel) 2021 Mar 25;23(4). Epub 2021 Mar 25.

School of Economics and Management, University of Science and Technology Beijing, Beijing 100083, China.

Robustness of the collaborative knowledge network (CKN) is critical to the success of open source projects. To study this robustness more comprehensively and accurately, we constructed a weighted CKN based on the semantic analysis of collaborative behavior, where (a) open source designers were the network nodes, (b) collaborative behavior among designers was the edges, and (c) collaborative text content intensity and collaborative frequency intensity were the edge weights. To study the robustness from a dynamic viewpoint, we constructed three CKNs from different stages of the project life cycle: the start-up, growth and maturation stages. Read More

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Two Archaeal Metagenome-Assembled Genomes from El Tatio Provide New Insights into the Crenarchaeota Phylum.

Genes (Basel) 2021 03 9;12(3). Epub 2021 Mar 9.

Laboratory of Molecular Applied Biology, Center of Excellence in Translational Medicine, Universidad de La Frontera, Avenida Alemania 0458, Temuco 4810296, Chile.

A phylogenomic and functional analysis of the first two Crenarchaeota MAGs belonging to El Tatio geysers fields in Chile is reported. A soil sample contiguous to a geothermal activity exposed lagoon of El Tatio was used for shotgun sequencing. Afterwards, contigs were binned into individual population-specific genomes data. Read More

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Engineered pro-peptide enhances the catalytic activity of keratinase to improve the conversion ability of feather waste.

Biotechnol Bioeng 2021 07 8;118(7):2559-2571. Epub 2021 Apr 8.

School of Biotechnology, Jiangnan University, Wuxi, China.

Keratinase is an attractive industrial enzyme that can specifically catalyze keratin waste to obtain value-added products. A challenge to the application of keratinase is improving catalytic capacity to achieve efficient hydrolysis. In this study, we effectively expressed the keratinase gene from Bacillus licheniformis BBE11-1 in Bacillus subtilis WB600 based on pro-peptide engineering. Read More

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Rural-urban disparities in knowledge, behaviors, and mental health during COVID-19 pandemic: A community-based cross-sectional survey.

Medicine (Baltimore) 2021 Apr;100(13):e25207

Department of Rehabilitation Medicine Center, West China Hospital, Sichuan University.

Abstract: To examine the knowledge level, behaviors, and psychological status of the Chinese population during the COVID-19 pandemic, and to explore the differences between urban and rural areas.We carried out a cross-sectional survey of the knowledge, behaviors related to COVID-19, and mental health in a probability sample of 3001 community residents in 30 provinces or districts across China from February 16-23, 2020. Convenience sampling and a snowball sampling were adopted. Read More

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Non-Alcoholic Fatty Liver Disease in Cuba.

MEDICC Rev 2021 Jan 30;23(1):64-71. Epub 2021 Jan 30.

Gastroenterology Institute, Medical University of Havana, Cuba.

Introduction: With a global adult prevalence of 24%, non-alcoholic fatty liver disease is a global health problem that parallels the worldwide increase of obesity. Its frequency, clinical characteristics and related diseases in Cuba remain unknown.

Objective: Describe the clinical characteristics, comorbidities and personal habits of patients with non-alcoholic fatty liver disease who are being treated in secondary and tertiary health facilities in seven Cuban provinces. Read More

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January 2021

Evidence-Based Recommendations for the Oral Health of Patients with Parkinson's Disease.

Neurol Ther 2021 Jun 18;10(1):391-400. Epub 2021 Mar 18.

Postgraduation Department, Program on Health and Environment, Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil.

Introduction: Patients with Parkinson's disease (PD) present a variety of oral disease that can be worsened by xerostomia and sialorrhea. The patients' physical limitations, for example rigidity and tremor, add to the difficulty of oral care by the general dental surgeon. The objective of the present review was to organize a list of evidence-based recommendations for the oral care of patients with PD. Read More

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Retrospective Analysis of Presentation, Treatment, and Outcomes of Multiple Myeloma at a Large Public Referral Hospital in Eldoret, Kenya.

JCO Glob Oncol 2021 03;7:391-399

International Cancer Institute, Eldoret, Kenya.

Purpose: Treatment patterns and survival outcomes of patients with multiple myeloma (MM) in Kenya have not been adequately characterized. The objectives of this study were to describe the clinical, laboratory, and imaging findings at diagnosis, to describe the treatment offered, and to determine the survival outcomes of patients with MM over an 11-year period.

Patients And Methods: A retrospective chart review was carried out for all patients who were diagnosed and treated for MM at Moi Teaching and Referral Hospital from 2009 to 2019. Read More

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A Population-Based Intervention to Improve Care Cascades of Patients With Hepatitis C Virus Infection.

Hepatol Commun 2021 03 7;5(3):387-399. Epub 2020 Nov 7.

Division of Allergy and Infectious Diseases University of Washington Seattle WA USA.

Hepatitis C virus (HCV) infection is common in the United States and leads to significant morbidity, mortality, and economic costs. Simplified screening recommendations and highly effective direct-acting antivirals for HCV present an opportunity to eliminate HCV. The objective of this study was to increase testing, linkage to care, treatment, and cure of HCV. Read More

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Pharmacological evaluation and modeling study of compounds isolated from .

Heliyon 2021 Feb 26;7(2):e06367. Epub 2021 Feb 26.

Department of Chemistry, University of Malakand, Chakdara, Dir Lower, 18800 KPK, Pakistan.

Medicines derived from plants are preferred over synthetic therapeutic agents in treating different diseases. (a member of Rhamnaceae family) is a medicinal plant used as a remedy of different diseases in Greek and Ayurveda medical systems. roots were shade dried and then subjected to extraction of bioactive compounds using different solvent systems and silica gel. Read More

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February 2021

Potential Confounders and a Modified Framingham Risk Score for the Prediction of Pregnancy-related Medical Conditions Occurrence among Pregnant Women: A Retrospective Study from Baghdad, Iraq.

J Pharm Bioallied Sci 2020 Oct-Dec;12(4):391-399. Epub 2020 Oct 8.

Department of Clinical Pharmacy, College of Pharmacy, Mustansiriya University, Baghdad, Iraq.

Background: The incidence of pregnancy-related medical conditions relied on a set of potential factors that could be available even before the term of pregnancy and may be associated with poor outcomes later in life. This study aimed to investigate the association between some potential predictive factors related to maternal, gestational, and clinical parameters and the incidence of pregnancy-related medical conditions in a sample of Iraqi pregnant women.

Materials And Methods: A retrospective, observational, single-center study was carried out on 92 pregnant women during their routine visit to the obstetric clinic in a certain distinct of Baghdad province, Iraq. Read More

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October 2020