BMC Cardiovasc Disord 2021 08 12;21(1):391. Epub 2021 Aug 12.
Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No, 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Background: Acute coronary syndrome (ACS) has become a vital disease with high mortality in the Uygur populations. Clopidogrel plays an important role in reducing the risk of recurrent cardiovascular events after ACS; however, it is a prodrug that requires biotransformation by cytochrome P450 (CYP450).
Objectives: To determine the effect of genetic polymorphisms in CYP2C19*2, *3, and *17, and along with clinical, demographic factors, on variation in response to clinical outcomes in Uygur patients. Read More