115 results match your criteria care iim


The Role of the Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

Institute of Molecular Cell Biology, Jena University Hospital, D-07745 Jena, Germany.

Microglia, the innate immune cells of the CNS, exhibit long-term response changes indicative of innate immune memory (IIM). Our previous studies revealed IIM patterns of microglia with opposing immune phenotypes: trained immunity after a low dose and immune tolerance after a high dose challenge with pathogen-associated molecular patterns (PAMP). Compelling evidence shows that innate immune cells adopt features of IIM via immunometabolic control. Read More

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The Importance of Cribriform-Lamella Angle in Endoscopic Sinus Surgery.

Indian J Otolaryngol Head Neck Surg 2021 Mar 26;73(1):66-71. Epub 2020 Sep 26.

Department of ENT-HNS, Apollo Hospitals, Opp. IIM, Bannerghatta Road, Bangalore, Karnataka 560076 India.

The aim of this study is to evaluate cribriform-lamella (CL) angle and length of lateral lamella (LL) on CT scan and to correlate CL angle with LL length and Keros classification. Retrospective study analyzing 500 CT scans of PNS was performed at a tertiary care hospital. The CT scan anatomy of anterior cranial base was evaluated for Keros, CL angle and LL length. Read More

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A Systematic Review and Meta-Analysis to Inform Cancer Screening Guidelines in Idiopathic Inflammatory Myopathies.

Rheumatology (Oxford) 2021 Feb 18. Epub 2021 Feb 18.

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Objectives: To identify clinical factors associated with cancer risk in the idiopathic inflammatory myopathies (IIMs) and to systematically review the existing evidence related to cancer screening.

Methods: A systematic literature search was carried out on Medline, Embase and Scopus. Cancer risk within the IIM population (i. Read More

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February 2021

Financing primary healthcare for rural areas.

J Family Med Prim Care 2020 Nov 30;9(11):5516-5522. Epub 2020 Nov 30.

Indian Institute of Management Udaipur, Rajasthan, India.

Context: Primary healthcare in India is provided by both public and private providers. However, access to good quality primary healthcare is lacking in underserved populations such as communities in rural and remote areas and families in low income quartiles. While there are government programs on comprehensive primary healthcare, stagnant investments restrict their reach and quality. Read More

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November 2020

High Early Mortality in Idiopathic Inflammatory Myopathies: Results from the Inception Cohort at a Tertiary Care Center in Northern India.

Rheumatology (Oxford) 2021 Jan 25. Epub 2021 Jan 25.

Assistant Professor, Department of Clinical Immunology and Rheumatology, SGPGIMS, Rae Bareilly Road, Lucknow, Uttar Pradesh, 226014, India - Email:

Objectives: We determined the mortality along with the proportion of disease related adverse events measured individually and by a composite adverse outcome (devised by including deaths, disability, relapses, and minimal response) and its predictors in an inception cohort of Idiopathic Inflammatory Myopathies (IIM).

Methods: IIM from the MyoCite cohort (December 2017-19) were reviewed for early outcomes (mortality, IMACS core set). Comparisons were drawn between those meeting the primary and secondary outcomes. Read More

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January 2021

Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.

Arthritis Res Ther 2021 01 19;23(1):33. Epub 2021 Jan 19.

Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Medical Center North T3113, 1161 21st Avenue South, Nashville, TN, 37232, USA.

Background: Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease pathogenesis, yet they have not been studied directly. We therefore aimed to characterize JBCs to better understand how they expand and function in Jo-1 ARS. Read More

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January 2021

Study protocol for a multicentre, 2×2 factorial, randomised, controlled trial evaluating the interest of intravenous iron and tranexamic acid to reduce blood transfusion in hip fracture patients (the HiFIT study).

BMJ Open 2021 01 17;11(1):e040273. Epub 2021 Jan 17.

Département Anesthésie Réanimation, Centre Hospitalier Universitaire d'Angers, Angers, France.

Introduction: Blood transfusion and anaemia are frequent and are associated with poor outcomes in patients with hip fracture (HF). We hypothesised that preoperative intravenous iron and tranexamic acid (TXA) may reduce the transfusion rate in these patients.

Methods And Analysis: The HiFIT study is a multicentre, 2×2 factorial, randomised, double-blinded, controlled trial evaluating the effect of iron isomaltoside (IIM) (20 mg/kg) vs placebo and of TXA (intravenously at inclusion and topically during surgery) versus placebo on transfusion rate during hospitalisation, in patients undergoing emergency surgery for HF and having a preoperative haemoglobin between 95 and 130 g/L. Read More

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January 2021

The prevalence, clinical features, predictive factors and investigations to screen for cancer in patients with inflammatory myositis. A case series from two tertiary care centers in Riyadh, Saudi Arabia.

Saudi Med J 2021 Jan;42(1):100-104

Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To describes the epidemiology of cancer in patients with idiopathic inflammatory myopathies (IIM) treated at 2 tertiary centers in Riyadh, Saudi Arabia.

Methods: This was a retrospective multi-center study evaluating the prevalence and the type of malignancy in an IIM population in King Saud University Medical City and King Abdulaziz Medical City between August 2017 to August 2018.

Results: In total, 60 patients were included. Read More

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January 2021

Identification of Formulation as a Nutritional Supplement to Contrast Muscle Atrophy and Sarcopenia.

Nutrients 2020 Dec 26;13(1). Epub 2020 Dec 26.

Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy.

Muscle atrophy, i.e., the loss of skeletal muscle mass and function, is an unresolved problem associated with aging (sarcopenia) and several pathological conditions. Read More

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December 2020

Utilization of myositis antibody-specific panel for diagnosis, treatment, and evaluation of disease progression.

J Community Hosp Intern Med Perspect 2020 Sep 3;10(5):462-465. Epub 2020 Sep 3.

Greater Baltimore Medical Center, Internal Medicine Residency, Towson, MD, USA.

The idiopathic inflammatory myopathies (IIM) are rare sporadic disorders with an overall annual incidence of approximately 1 in 100,000 and with a higher incidence in women. IIM is an autoimmune process leading to muscle inflammation due to a 'dysfunctional adaptive immune response evidenced by cell-mediated myocytoxicity, a high prevalence of autoantibodies and overexpression of Major Histocompatibility (MHC) I and II molecules on the muscle sarcolemma'. These autoimmune processes can be appreciated as inflammatory infiltrates in muscle biopsies. Read More

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September 2020

COVID-19 and myositis - unique challenges for patients.

Rheumatology (Oxford) 2021 02;60(2):907-910

Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Objective: The COVID-19 pandemic and the subsequent effects on healthcare systems is having a significant effect on the management of long-term autoimmune conditions. The aim of this study was to assess the problems faced by patients with idiopathic inflammatory myopathies (IIM).

Methods: An anonymized eSurvey was carried out with a focus on effects on disease control, continuity of medical care, drug procurance and prevalent fears in the patient population. Read More

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February 2021

Teleconsultation experience with the idiopathic inflammatory myopathies: a prospective observational cohort study during the COVID-19 pandemic.

Rheumatol Int 2021 01 4;41(1):67-76. Epub 2020 Nov 4.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Teleconsultation has assumed a central role in the management of chronic and disabling rheumatic diseases, such as the idiopathic inflammatory myopathies (IIM), during COVID-19. However, the feasibility, challenges encountered, and outcomes remain largely unexplored. Here, we describe our teleconsultation experience in a prospectively followed cohort of adult and juvenile IIM. Read More

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January 2021

Predicting Survival Across Acute Exacerbation of Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myositis: The GAP-ILD Model.

Rheumatol Ther 2020 Dec 26;7(4):967-978. Epub 2020 Oct 26.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: Risk prediction is challenging in patients with idiopathic inflammatory myopathies (IIM) and acute exacerbation of interstitial lung disease (AE-ILD) because of heterogeneity and patient-specific variables. Our objective was to assess whether mortality is accurately predicted in patients with IIM and AE-ILD by using the gender age physiology ILD (GAP-ILD) model, a clinical prediction model that was previously validated in patients with idiopathic pulmonary fibrosis.

Methods: A retrospective cohort study was conducted in the First Affiliated Hospital, Zhejiang University, wherein 60 consecutive patients with IIM and AE-ILD admitted between February 2011 and April 2019. Read More

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December 2020

Factors associated with treatment response in patients with idiopathic inflammatory myopathies. A registry-based study.

Arthritis Care Res (Hoboken) 2020 Oct 26. Epub 2020 Oct 26.

Division of Rheumatology, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Sweden.

Objectives: To identify predictors of response to immunosuppressive therapy after one year, with a focus on autoantibodies, in patients newly diagnosed with idiopathic inflammatory myopathies (IIM) followed longitudinally in an electronic registry.

Methods: We assessed the association between autoantibody-defined groups and improvement according to ACR/EULAR 2016 response criteria.

Results: We identified 156 patients; of them, 111 patients (71%) were positive for any autoantibody tested, 90% received glucocorticoid treatment at baseline, and 78% received immunosuppressive drugs at some follow-up point. Read More

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October 2020

The wastewater microbiome: A novel insight for COVID-19 surveillance.

Sci Total Environ 2021 Apr 9;764:142867. Epub 2020 Oct 9.

Secretaría Regional Ministerial de Salud, Region de Ñuble, Ministerio de Salud, Bulnes 620, Chillan, Chile.

Wastewater-Based Epidemiology is a tool to face and mitigate COVID-19 outbreaks by evaluating conditions in a specific community. This study aimed to analyze the microbiome profiles using nanopore technology for full-length 16S rRNA sequencing in wastewater samples collected from a penitentiary (P), a residential care home (RCH), and a quarantine or health care facilities (HCF). During the study, the wastewater samples from the RCH and the P were negative for SARS-CoV-2 based on qPCRs, except during the fourth week when was detected. Read More

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Ancient dog diets on the Pacific Northwest Coast: zooarchaeological and stable isotope modelling evidence from Tseshaht territory and beyond.

Sci Rep 2020 10 1;10(1):15630. Epub 2020 Oct 1.

Department of Geography, University of Victoria, Victoria, BC, Canada.

Domestic dogs are frequently encountered in Indigenous archaeological sites on the Northwest Coast of North America. Although dogs depended on human communities for care and provisioning, archaeologists lack information about the specific foods dogs consumed. Previous research has used stable isotope analysis of dog diets for insight into human subsistence ('canine surrogacy' model) and identified considerable use of marine resources. Read More

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October 2020

Patient insights on living with idiopathic inflammatory myopathy and the limitations of disease activity measurement methods - a qualitative study.

BMC Rheumatol 2020 21;4:47. Epub 2020 Sep 21.

NIHR Greater Manchester Patient Safety Translational Research Centre, University of Manchester, Manchester, UK.

Background: The idiopathic inflammatory myopathies (IIMs) are chronic autoimmune conditions, typically resulting in proximal muscle weakness and impacting upon quality of life. Accurate measurement of IIM disease activity is imperative for appropriate medical management and carrying out valid clinical trials. The International Myositis Assessment and Clinical Studies Group (IMACS) "Disease Activity Core Set Measures" are the current gold-standard of IIM disease activity assessment. Read More

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September 2020

Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis.

Int J Ophthalmol 2020 18;13(9):1443-1450. Epub 2020 Sep 18.

Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary.

Aim: To evaluate detailed anterior segment parameters of patients with idiopathic inflammatory myopathies (IIM), including polymyositis (PM), and dermatomyositis (DM), and to clarify the associations between these data and clinical variables of IIM.

Methods: Totally 57 PM, 41 DM patients and 62 controls were enrolled in this cross-sectional, observational, case-control study. All study participants underwent Pentacam evaluation. Read More

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September 2020

Cardiac involvement in inflammatory myopathies and inherited muscle diseases.

Curr Opin Rheumatol 2020 11;32(6):528-533

Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Purpose Of Review: To examine recent developments relating to cardiac involvement in the adult idiopathic inflammatory myopathies (IIM) and those inherited muscle diseases which may present in adulthood and mimic IIM.

Recent Findings: Cardiac involvement is a common feature of IIM and inherited muscle diseases. Frequency according to disease subtype varies, with serotype having particular influence in IIM, and genotype in the inherited muscle diseases. Read More

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November 2020

A simple and rapid method for blood plasma separation driven by capillary force with an application in protein detection.

Anal Methods 2020 05;12(20):2560-2570

School of Mechanical Engineering, Guangxi University, Nanning, Guangxi 530004, PR China.

Blood plasma separation is a vital sample pre-treatment procedure for microfluidic devices in blood diagnostics, and it requires reliability and speediness. In this work, we propose a novel and simple method for microvolume blood plasma separation driven by capillary force. Flat-shaped filter membranes combined with hydrophilic narrow capillaries are introduced into devices, in order to reduce the residual volumes of blood plasma. Read More

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Assessing the content validity of patient-reported outcome measures in adult myositis: A report from the OMERACT myositis working group.

Semin Arthritis Rheum 2020 10 17;50(5):943-948. Epub 2020 Jun 17.

Division of Rheumatology, Department of Medicine, Johns Hopkins University, 5200 Eastern Ave, MFL Bldg, Center Tower, Suite 4100, Baltimore 21224, MD, USA. Electronic address:

Objective: To investigate the content validity of several patient-reported outcome measures (PROMs) in patients with idiopathic inflammatory myopathies (IIM).

Methods: Seven individual PROM instruments were selected by the Outcome Measures in Rheumatology (OMERACT) Myositis Working Group relating to the following domains: pain, fatigue, physical function and physical activity. Twenty patients from the Johns Hopkins Myositis Center were selected for one-on-one face-to-face or phone interviews for cognitive interviewing of individual PROMs to assess comprehension and content validity. Read More

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October 2020

Prognosis of adult idiopathic inflammatory myopathy-associated interstitial lung disease: a retrospective study of 679 adult cases.

Rheumatology (Oxford) 2021 Mar;60(3):1195-1204

Department of Pulmonary and Critical Care Medicine, Central Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dongcheng District, Beijing, China.

Objectives: Few studies have investigated the prognostic factors for idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) across different clinical/serological phenotypes.

Methods: We conducted a retrospective analysis of patients diagnosed with IIM between January 2012 and December 2017.

Results: Of the 760 IIM cases registered, 679 adult cases were included in this study. Read More

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Insights into the knowledge, attitude and practices for the treatment of idiopathic inflammatory myopathy from a cross-sectional cohort survey of physicians.

Rheumatol Int 2020 Dec 2;40(12):2047-2055. Epub 2020 Sep 2.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.

The idiopathic inflammatory myopathies (IIM) are heterogeneous and lead to high morbidity and mortality. Knowledge deficits among healthcare professionals could be detrimental to clinical care. Identifying areas of deficient Knowledge, Attitude and Practice (KAP) of IIM can improve physician education and patient outcomes. Read More

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December 2020

Clinical characteristics and prognostic analysis of Chinese dermatomyositis patients with malignancies.

Medicine (Baltimore) 2020 Aug;99(34):e21899

Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, #1 Shuaifuyuan Street, Dongcheng District.

Although a strong association between idiopathic inflammatory myositis (IIM) and malignancy has been widely reported, few studies have solely focused on the concurrence of dermatomyositis (DM) and malignancies (DM-malignancy).We conducted a retrospective analysis of 37 DM-malignancy cases among 363 DM patients admitted to our hospital between January 2012 and December 2017.(1) The mean age at DM diagnosis was higher for DM-malignancy patients than for DM-non-malignancy patients [(54. Read More

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Exercise therapy in patients with idiopathic inflammatory myopathies and systemic lupus erythematosus - A systematic literature review.

Best Pract Res Clin Rheumatol 2020 04 17;34(2):101547. Epub 2020 Aug 17.

Division of Physical Therapy, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge and Allied Health Professionals Function, Medical Unit Occupational Therapy and Physical Therapy, Karolinska University Hospital, Stockholm, Sweden.

Idiopathic inflammatory myopathies (IIM) and systemic lupus erythematosus (SLE) are inflammatory connective tissue diseases (CTDs) with common features of arthritis, muscle impairment, skin rash, and heart- and lung involvement. Exercise is becoming an important part of the treatment in patients with IIM and SLE; however, there is a need for evidence-based exercise recommendations on patient-relevant outcomes. To evaluate the evidence and to present evidence-based exercise recommendations on patient-relevant outcomes in patients with IIM and SLE. Read More

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Myositis-specific Antibodies Identify A Distinct Interstitial Pneumonia with Autoimmune Features Phenotype.

Eur Respir J 2020 Jul 16. Epub 2020 Jul 16.

Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California at Davis

Interstitial pneumonia with autoimmune features (IPAF) characterises individuals with interstitial lung disease (ILD) and features of connective tissue disease (CTD) who fail to satisfy CTD criteria. Inclusion of myositis-specific antibodies (MSAs) in the IPAF criteria has generated controversy, as these patients also meet proposed criteria for an anti-synthetase syndrome. Whether MSAs and myositis associated antibodies (MAA) identify phenotypically distinct IPAF subgroups remains unclear. Read More

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MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies.

BMC Rheumatol 2020 10;4:25. Epub 2020 Jun 10.

Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Background: The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression of target mRNAs. The aim of this study was to profile miRNA and mRNA in IIM and identify miRNA-mRNA relationships which may be relevant to disease. Read More

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Evaluation of a New Skeletal Troponin I Assay in Patients with Idiopathic Inflammatory Myopathies.

J Appl Lab Med 2020 03;5(2):320-331

Department of Biochemistry/Biotechnology, University of Turku, Turku, Finland.

Background: The current biomarkers for diagnosis and monitoring of injured and diseased skeletal muscles, such as creatine kinase (CK), have limited tissue specificity and incapability to differentiate between pathological and physiological changes. Thus, new biomarkers with improved diagnostic accuracy are needed. Our aim was to develop and validate a novel assay for skeletal troponin I (skTnI), and to assess its clinical performance in patients with idiopathic inflammatory myopathies (IIM). Read More

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Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy.

Authors:
Jan Wesström

Arch Gynecol Obstet 2020 05 8;301(5):1127-1131. Epub 2020 Apr 8.

Department of Obstetrics and Gynecology, Center for Clinical Research Dalarna, Falun Hospital, Falun, Sweden.

Purpose: To evaluate the efficacy and safety for mother and child of using intravenous iron isomaltoside (IV-IIM) during pregnancy.

Methods: Using an appointment register, we retrospectively identified all pregnant women who received a single dose of 1000 or 1500 mg IV-IIM in the maternity ward of Falu Hospital and subsequently gave birth between August 6, 2013 and July 31, 2018. Women who received IV-IIM (case group) were individually matched with pregnant women who did not receive IV-IIM (control group) by delivery date, maternal age (± 2 years), and parity. Read More

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Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014.

Autoimmun Rev 2020 Jun 29;19(6):102531. Epub 2020 Mar 29.

Centre National de Référence des Maladies Auto-Immunes et Systémiques Rares, Est/Sud-Ouest (RESO), France; Service de rhumatologie, Centre Hospitalier Universitaire de Strasbourg, 1 avenue Molière, 67098 Strasbourg, France; Immuno-rhumatologie moléculaire, INSERM UMR-S 1109, Strasbourg, France. Electronic address:

Aim: To describe changes in the 2001-2014 mortality of 6 autoimmune systemic diseases (AISDs), namely Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathies (IIM), Sjögren's Syndrome (SS), Mixed Connective Tissue Disease (MCTD) and ANCA-associated vasculitis (AAV) at the country-, continent-, and world-levels.

Methods: Mortality data were retrieved from the World Health Organization (WHO) mortality database for each disease, based on ICD-10 codes. We computed age-standardized mortality rate (ASMR) as the estimated number of deaths per million inhabitants and its 95% confidence interval (95%CI). Read More

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