112,765 results match your criteria cardiovascular events


Increase in Nuclear Cell-Free DNA is Associated with Major Adverse Events in Adult and Pediatric Heart Transplant Recipients.

Clin Transplant 2021 Oct 14:e14509. Epub 2021 Oct 14.

Division of Pediatric Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, United States.

Background: Cell-free DNA is an emerging biomarker. While donor fraction may detect graft events in heart transplant recipients, the prognostic value of total nuclear cell-free DNA (ncfDNA) itself is largely unexplored.

Objective: Explore the relationship between ncfDNA and clinical events in heart transplant recipients. Read More

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October 2021

Oral Anticoagulation Timing in Patients with Acute Ischaemic Stroke and Atrial Fibrillation.

Thromb Haemost 2021 Oct 14. Epub 2021 Oct 14.

aGeneral Clinical Research Center, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.

Background And Purpose: Oral anticoagulants (OACs) prevent stroke recurrence and vascular embolism in patients with acute ischaemic stroke (AIS) and atrial fibrillation (AF). Current guidance recommends a "1-3-6-12 day"' rule to resume OACs after AIS, based mainly on empirical consensus. This study investigated the suitability of guideline-recommended timing for OAC initiation. Read More

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October 2021

Twelve Months of Time-restricted Eating and Resistance Training Improve Inflammatory Markers and Cardiometabolic Risk Factors.

Med Sci Sports Exerc 2021 Jul 7. Epub 2021 Jul 7.

Department of Biomedical Sciences, University of Padova, Padova, Italy Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Introduction: Recently, a modified intermittent fasting protocol was demonstrated to be able to maintain muscle mass and strength, decrease fat mass and improve some inflammation and cardiovascular risk factors in healthy resistance-trained males after 2 months. The present study sought to investigate the long-term effects on these parameters.

Methods: The experiment is a single-blind randomized study. Read More

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Timing of venous thromboembolism diagnosis in hospitalized and non-hospitalized patients with COVID-19.

Thromb Res 2021 Oct 7;207:150-157. Epub 2021 Oct 7.

Department of Cardiovascular Diseases, Division of Vascular Medicine, Rochester, MN, United States of America; Department of Internal Medicine, Division of Hematology/Oncology, Mayo Clinic, MN, United States of America. Electronic address:

Background: The reported incidence of venous thromboembolism (VTE) in COVID-19 patients varies widely depending on patient populations sampled and has been predominately studied in hospitalized patients. The goal of this study was to assess the evolving burden of COVID-19 and the timing of associated VTE events in a systems-wide cohort.

Methods: COVID-19 PCR positive hospitalized and non-hospitalized patients ≥18 years of age tested between 1/1/2020 through 12/31/2020 were retrospectively analyzed using electronic medical records from multiple states across the Mayo Clinic enterprise. Read More

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October 2021

Sleep Apnea Specific Hypoxic Burden, Symptom Subtypes and Risk of Cardiovascular Events and All-Cause Mortality.

Am J Respir Crit Care Med 2021 Oct 14. Epub 2021 Oct 14.

CHU, Pneumologie, Angers, France.

Background: Data from population-based cohorts suggest that symptom subtypes, and OSA-specific hypoxic burden (HB) could help to better identify patients with OSA at high cardiovascular (CV) risk.

Aim: We aimed to evaluate whether those new markers are associated with the risk of major adverse CV events (MACE) in clinical setting.

Methods: Data from the Pays de la Loire cohort were linked to health administrative data to identify the occurrence of MACE (a composite outcome including all-cause mortality, acute myocardial infarction, stroke, and unplanned coronary revascularization) in patients with newly diagnosed OSA and no overt CV disease. Read More

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October 2021

Circulating soluble receptor of advanced glycation end product is associated with bicuspid aortic aneurysm progression via NF-κB pathway.

Interact Cardiovasc Thorac Surg 2021 Oct 14. Epub 2021 Oct 14.

Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: Patients with bicuspid aortic valve (BAV) have a high risk of aortic dilation and adverse vascular events. Previous studies had reported soluble receptor for advanced glycation end products (sRAGE) to compete with receptor of advanced glycation end products (RAGE) for ligand binding and inhibit the activation of nuclear-factor kappa-B (NF-κB) pathway and matrix metalloproteinases (MMP) transcription. Thus, sRAGE serum levels may contribute to the clinical diagnosis and monitoring of ascending aorta aneurysm in patients with BAV. Read More

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October 2021

The association between 24-h blood pressure variability and major adverse cardiac events (MACE) in hospitalized patients with acute myocardial infarction: a retrospective cohort study.

Egypt Heart J 2021 Oct 14;73(1):88. Epub 2021 Oct 14.

Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia.

Background: Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Read More

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October 2021

[Contraception in women with obesity].

Med Sci (Paris) 2021 Oct 14;37(10):882-887. Epub 2021 Oct 14.

Endocrinologie et médecine de la reproduction, Centre de référence des maladies endocriniennes rares de la croissance et du développement, Centre de référence des pathologies gynécologiques rares, Hôpital universitaire Pitié Salpêtrière, 47-83 boulevard de l'hôpital, 75013 Paris, France.

Obese women are at high risk of unintended pregnancy. In addition, obesity is an important risk factor for venous thromboembolism events and arterial thrombosis. All of these data are to be considered in choosing a contraceptive method for obese women. Read More

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October 2021

Association between molecular markers of COVID-19 and Alzheimer's disease.

J Med Virol 2021 Oct 14. Epub 2021 Oct 14.

Programa de Pós-Graduação em Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

The COVID-19 pandemic has represented an exceptional health challenge since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has acute and chronic consequences. Acute events are mainly related to the respiratory tract; however, SARS-CoV-2 may affect cardiovascular system, kidneys, gut, and brain. Several studies have suggested patients with more severe systemic presentations are most affected by neurological symptoms, 1,2 while data from brain of postmortem patients show that SARS-CoV-2 has neuroinvasive properties. Read More

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October 2021

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds.

Eur J Prev Cardiol 2021 Oct;28(12):1376-1385

Department of Medicine, Karolinska Institutet, Sweden.

Aims: The purpose of this study was to analyse the association of leisure-time physical activity of different intensities at baseline, and cardiovascular disease incidence, cardiovascular disease mortality and all-cause mortality in a population-based sample of 60-year-old men and women with and without established metabolic syndrome, for more than 20 years of follow-up. A secondary aim was to study which cardiometabolic factors may mediate the association between physical activity and long-term outcomes.

Methods: A total of 3693 participants (53% women) underwent physical examination and laboratory tests, completed an extensive questionnaire at baseline 1997-1999 and were followed until their death or until 31 December 2017. Read More

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October 2021

Abdominal aortic calcification: from ancient friend to modern foe.

Eur J Prev Cardiol 2021 Oct;28(12):1386-1391

Department of Radiology, University Medical Center Utrecht, the Netherlands.

Background: Abdominal aortic calcifications were already ubiquitous in ancient populations from all continents. Although nowadays generally considered as an innocent end stage of stabilised atherosclerotic plaques, increasing evidence suggests that arterial calcifications contribute to cardiovascular risk. In this review we address abdominal aortic calcification from an evolutionary perspective and review the literature on histology, prevalence, risk factors, clinical outcomes and pharmacological interventions of abdominal aortic calcification. Read More

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October 2021

Physical Activity and Cardiorespiratory Fitness: Vital Signs for Cardiovascular Risk Assessment.

Curr Cardiol Rep 2021 Oct 13;23(11):172. Epub 2021 Oct 13.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9047, USA.

Purpose Of Review: Current risk prediction tools do not include physical activity (PA) or cardiorespiratory fitness (CRF), despite their robust association with adverse cardiovascular disease (CVD) events and their potential as targets for preventive interventions.

Recent Findings: PA and CRF are each associated with cardiovascular (CV) morbidity and mortality, independent of traditional risk factors. Improvement in CRF is associated with reduced risk of atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF). Read More

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October 2021

Cardiac Safety Assessment of Lazertinib: Findings From Patients With Mutation-Positive Advanced NSCLC and Preclinical Studies.

JTO Clin Res Rep 2021 Oct 8;2(10):100224. Epub 2021 Sep 8.

Yuhan R&D Institute, Yuhan Corporation, Yongin, Republic of Korea.

Introduction: Lazertinib is a potent, irreversible, brain-penetrant, mutant-selective, and wild-type-sparing third-generation EGFR tyrosine kinase inhibitor (TKI), creating a wide therapeutic index. Cardiovascular adverse events (AEs), including QT prolongation, decreased left ventricular ejection fraction (LVEF), and heart failure, have emerged as potential AEs with certain EGFR TKI therapies.

Methods: Cardiac safety of lazertinib was evaluated in TKI-tolerant adults with mutation-positive locally advanced or metastatic NSCLC receiving lazertinib (20-320 mg/d). Read More

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October 2021

Cardiac radioablation in the treatment of ventricular tachycardia.

Clin Transl Radiat Oncol 2021 Nov 12;31:71-79. Epub 2021 Feb 12.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, USA.

Cardiac radioablation with SBRT is a very promising non-invasive modality for the treatment of refractory VT and potentially other cardiac arrhythmias. Initial reports indicate that it is relatively safe and associated with excellent responses, particularly in reduction of ICD-related events, need for anti-arrhythmic medications, and resulting in significantly improved quality of life for patients. Establishment of objective criteria for candidates for cardiac radioablation will accelerate the adoption of this important radiation therapy modality in the treatment of refractory VT and other cardiac arrhythmias in the coming years. Read More

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November 2021

Cardiovascular Toxicity of Carfilzomib: The Real-World Evidence Based on the Adverse Event Reporting System Database of the FDA, the United States.

Front Cardiovasc Med 2021 27;8:735466. Epub 2021 Sep 27.

School of Medicine, Tongji University, Shanghai, China.

Carfilzomib, an effective proteasome inhibitor agent for the therapy of relapsed and refractory multiple myeloma, has been related to a significant number of cardiovascular events. However, patterns of cardiovascular complications associated with this agent remain poorly characterized in real-world settings. To gain further insight into the frequency, spectrum, clinical features, timing, and outcomes of carfilzomib-related cardiovascular toxicities. Read More

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September 2021

Serum Uric Acid and Kidney Disease Measures Independently Predict Cardiovascular and Total Mortality: The Uric Acid Right for Heart Health (URRAH) Project.

Front Cardiovasc Med 2021 27;8:713652. Epub 2021 Sep 27.

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Serum uric acid predicts the onset and progression of kidney disease, and the occurrence of cardiovascular and all-cause mortality. Nevertheless, it is unclear which is the appropriate definition of hyperuricemia in presence of chronic kidney disease (CKD). Our goal was to study the independent impact of uric acid and CKD on mortality. Read More

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September 2021

Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.

Front Med (Lausanne) 2021 27;8:705159. Epub 2021 Sep 27.

Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, Instituto de Investigacin Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.

Kidney transplantation is the best option for patients with end-stage renal disease. Despite the improvement in cardiovascular burden (leading cause of mortality among patients with chronic kidney disease), cardiovascular adverse outcomes related to the inflammatory process remain a problem. Thus, the aim of the present study was to characterize the immune profile and microvesicles of patients who underwent transplantation. Read More

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September 2021

Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function.

Theranostics 2021 9;11(19):9376-9396. Epub 2021 Sep 9.

Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates glucose levels and positively affects cardiovascular function in patients with diabetes and cardiovascular complications. Endothelial dysfunction (ED) represents the primary pathological change of multiple vascular diseases, because it causes decreased arterial plasticity, increased vascular resistance, reduced tissue perfusion and atherosclerosis. Caused by "biochemical injury", ED is also an independent predictor of cardiovascular events. Read More

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September 2021

facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: mice display increases atherosclerotic plaque stability.

Theranostics 2021 9;11(19):9358-9375. Epub 2021 Sep 9.

The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, China.

: Atherosclerosis plaque rupture (PR) is the pathological basis and chief culprit of most acute cardiovascular events and death. Given the complex and important role of macrophage apoptosis and autophagy in affecting plaque stability, an important unanswered question include is whether, and how, immunity-related GTPase family M protein (IRGM) and its mouse orthologue IRGM1 affect macrophage survival and atherosclerotic plaque stability. To investigate whether serum IRGM of ST-segment elevation myocardial infarction (STEMI) patients is related to plaque morphology, we divided 85 STEMI patients into those with and without plaque rupture (PR and non-PR, respectively) based on OCT image analysis, and quantified the patients' serum IRGM levels. Read More

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September 2021

ImageTBAD: A 3D Computed Tomography Angiography Image Dataset for Automatic Segmentation of Type-B Aortic Dissection.

Front Physiol 2021 27;12:732711. Epub 2021 Sep 27.

Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Type-B Aortic Dissection (TBAD) is one of the most serious cardiovascular events characterized by a growing yearly incidence, and the severity of disease prognosis. Currently, computed tomography angiography (CTA) has been widely adopted for the diagnosis and prognosis of TBAD. Accurate segmentation of true lumen (TL), false lumen (FL), and false lumen thrombus (FLT) in CTA are crucial for the precise quantification of anatomical features. Read More

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September 2021

Systematic Review and Meta-analyses of Effects of Phosphate-lowering Agents in Non-dialysis Chronic Kidney Disease.

J Am Soc Nephrol 2021 Oct 13. Epub 2021 Oct 13.

N Toussaint, Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia

Benefits of phosphate-lowering interventions on clinical outcomes in patients with chronic kidney disease (CKD) are unclear; systematic reviews have predominantly involved dialysis patients. This study aimed to summarize evidence from randomized controlled trials (RCTs) concerning benefits and risks of non-calcium-based phosphate-lowering treatment in non-dialysis CKD. We conducted a systematic review and meta-analyses of RCTs involving noncalcium-based phosphate-lowering therapy compared to placebo, calcium-based binders, or no study medication, in adults with CKD not on dialysis or post-transplant. Read More

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October 2021

Validating a risk assessment tool in United Kingdom and Irish paediatric cardiac catheterisation practice.

Cardiol Young 2021 Oct 14:1-8. Epub 2021 Oct 14.

The Heart Institute, Children's Hospital of Colorado, University of Colorado, Denver, CO, USA.

Background: No established risk prediction tool exists in United Kingdom and Irish Paediatric Cardiology practice for patients undergoing cardiac catheterisation. The Catheterisation RISk score for Paediatrics is used primarily in North American practice to assess risk prior to cardiac catheterisation. Validating the utility and transferability of such a tool in practice provides the opportunity to employ an already established risk assessment tool in everyday practice. Read More

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October 2021

Risk for ischemic stroke and coronary heart disease associated with migraine and migraine medication among older adults.

J Headache Pain 2021 Oct 13;22(1):124. Epub 2021 Oct 13.

Peter Munk Cardiac Centre and Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, Canada.

Background: Migraine has been associated with cardiovascular disease (CVD) events among middle-aged adults. The objective of this study was to determine the risk for ischemic stroke and coronary heart disease (CHD) events among older adults with versus without migraine.

Methods: This retrospective cohort study was conducted using data from US adults ≥66 years of age with Medicare health insurance between 2008 and 2017. Read More

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October 2021

Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis.

Circ Res 2021 Oct 14. Epub 2021 Oct 14.

Medicine, University of Minnesota, UNITED STATES.

The initial hypertrophy response to cardiac pressure overload is considered compensatory, but with sustained stress, it eventually leads to heart failure. Recently, a role for recruited macrophages (mψs) in determining the transition from compensated to decompensated hypertrophy has been established. However, whether cardiac-resident immune cells influence the early phase of hypertrophy development has not been established. Read More

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October 2021

Long-term effects of the mean hemoglobin A1c levels after percutaneous coronary intervention in patients with diabetes.

Korean J Intern Med 2021 Oct 14. Epub 2021 Oct 14.

Yeungnam University College of Medicine, Daegu, Korea.

Background/aims: The clinical benefit of strict blood glucose-lowering therapy for patients with coronary artery disease (CAD) is still debated. We aimed to evaluate the long-term outcomes of patients with diabetes who underwent percutaneous coronary intervention (PCI), according to the mean hemoglobin A1c (HbA1c) level after PCI.

Methods: We evaluated 675 diabetes patients with CAD treated with PCI. Read More

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October 2021

[Aspirin in primary prevention of cardiovascular and cerebrovascular diseases].

Dtsch Med Wochenschr 2021 Oct 13;146(20):1353-1359. Epub 2021 Oct 13.

Klinik I für Innere Medizin, Klinikum Gütersloh, Gütersloh.

Acetylsalicylic acid (aspirin) is one of the most used medications worldwide. The antithrombotic agent acts mainly through inhibition of cyclooxygenase-1 and consequently thromboxane A synthesis, causing an irreversible suppression of platelet function. Despite of its proven benefit in the treatment and secondary prevention of atherosclerotic diseases, its use for the primary prevention remains controversial due to an unclear balance between the benefits and risks of aspirin. Read More

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October 2021

Evaluation of long-term outcomes of femoropopliteal bypass surgery in patients with chronic limb-threatening ischemia in an endovascular era.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Department of Vascular Surgery, Barmherzige Brüder Hospital, Regensburg, Germany.

Objective: To investigate the long-term outcomes of femoropopliteal bypass surgery in patients with chronic limb-threatening ischemia (CLTI) and TransAtlantic Inter-Society Consensus II (TASC II), type D (TASC D) femoropopliteal disease.

Methods: A retrospective analysis was performed for all consecutive patients undergoing above-knee (AK) femoropopliteal bypass surgery at an academic vascular centre between January 2007 and March 2019. Patients with claudication (IC) and patients with CLTI were included. Read More

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October 2021

A Systematic Review and Meta-analysis on the Efficacy and Safety of Direct Oral Anticoagulants in Patients with Peripheral Artery Disease.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Division of Vascular Surgery and Endovascular Therapy, University of Colorado, Anschutz Medical Center, Aurora, CO. Electronic address:

Background-objective: PAD is a significant cause of morbidity and mortality affecting over 200 million people worldwide. Current guidelines recommend at least a single antiplatelet or anticoagulant agent in symptomatic PAD and lifelong antithrombotic treatment after a revascularization procedure. The aim of this systematic review and meta-analysis was to investigate the efficacy and safety of direct oral anticoagulants (DOACs) in patients with peripheral artery disease (PAD). Read More

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October 2021

OUTCOME ANALYSIS USING THE MODIFIED FRAILTY INDEX-5 IN PATIENTS WITH COMPLEX AORTOILIAC DISEASE.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Biomedicine - Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address:

Objectives: Vascular surgery patients commonly have several comorbidities that cumulatively lead to a frailty status. The cumulative comorbidities disproportionately increase the risk of adverse events and are also associated with worsened long-term prognosis. In recent years, several tools have been elaborated with the objective of quantifying a patient's frailty. Read More

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October 2021

Do diabetic complications influence cancer-related events in people with type 2 diabetes? A cohort approach.

Diabetes Metab 2021 Oct 10:101289. Epub 2021 Oct 10.

Institut du thorax, INSERM, CNRS, Université de Nantes, CHU Nantes, Nantes, France.

Aim: To investigate whether diabetic micro- and macrovascular complications (mMVC) influence cancer-related events in people with type 2 diabetes.

Methods: People with type 2 diabetes from the SURDIAGENE cohort were characterized (duration of diabetes, HbA1c, mMVC, history of cancer) and prospectively followed-up for death and cancer-related events (occurrence, dissemination and cancer-related death).

Results: Between 2002 and 2012, 1468 participants (58% men, mean age 64. Read More

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October 2021