2,721,439 results match your criteria cardiovascular disease


Hospital-based observational study of neurological disorders in patients recently vaccinated with COVID-19 mRNA vaccines.

J Neurol Sci 2021 Oct 13;430:120030. Epub 2021 Oct 13.

Department of Neurology, National Neuroscience Institute (Tan Tock Seng Hospital Campus), Singapore.

Purpose: We describe the spectrum of acute neurological disorders among hospitalized patients who recently had COVID-19 mRNA vaccination.

Method: We performed a prospective study at 7 acute hospitals in Singapore. Hospitalized patients who were referred for neurological complaints and had COVID-19 mRNA vaccines, BNT162b2 and mRNA-1273, in the last 6 weeks were classified into central nervous system (CNS) syndromes, cerebrovascular disorders, peripheral nervous system (PNS) disorders, autonomic nervous system (ANS) disorders and immunization stress-related responses (ISRR). Read More

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October 2021

Non-alcoholic fatty liver disease: Current therapeutic options.

Curr Opin Pharmacol 2021 Oct 20;61:98-105. Epub 2021 Oct 20.

UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, UK; Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated global prevalence of 25%. NAFLD is found in up to 80% of people with obesity and over 60% of patients with diabetes. Cardiovascular disease is the main cause of mortality, followed by extra-hepatic cancers and then liver-specific complications of cirrhosis and hepatocellular carcinoma. Read More

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October 2021

Ankle-brachial index and subsequent risk of incident and recurrent cardiovascular events in older adults: The Atherosclerosis Risk in Communities (ARIC) study.

Atherosclerosis 2021 Oct 6;336:39-47. Epub 2021 Oct 6.

Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Background And Aims: The ankle-brachial index (ABI) is a diagnostic test for screening and detecting peripheral artery disease (PAD), as well as a risk enhancer in the AHA/ACC guidelines on the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, our understanding of the association between ABI and cardiovascular risk in contemporary older populations is limited. Additionally, the prognostic value of ABI among individuals with prior ASCVD is not well understood. Read More

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October 2021

Does prior exposure to immune checkpoint inhibitors treatment affect incidence and mortality of COVID-19 among the cancer patients: The systematic review and meta-analysis.

Int Immunopharmacol 2021 Oct 11;101(Pt A):108242. Epub 2021 Oct 11.

Department of Intensive care unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) treatment among cancer patients has been shown to have antiviral effects by reactivating exhausted T cells. However, they could also trigger inflammatory storm. Therefore, prior exposure to ICIs may influence the risk of SARS-CoV2 infection and subsequent mortality. Read More

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October 2021

A highly polymorphic panel of 40-plex microhaplotypes for the Chinese Han population and its application in estimating the number of contributors in DNA mixtures.

Forensic Sci Int Genet 2021 Oct 8;56:102600. Epub 2021 Oct 8.

Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, PR China; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, PR China. Electronic address:

Microhaplotypes (MHs) have great potential in multiple forensic applications and have proven to be promising markers in complex DNA mixture analysis. In this study, we developed a multiplex panel of 40 highly polymorphic MHs for the Chinese Han population, evaluated its forensic values, and explored its application in predicting the number of contributors (NOCs) in DNA mixtures. The panel consisted of 20 newly proposed loci and 20 previously reported loci with lengths spanning less than 120 bp. Read More

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October 2021

Acute and longer-term cardiovascular conditions in the Deepwater Horizon Oil Spill Coast Guard Cohort.

Environ Int 2021 Oct 20;158:106937. Epub 2021 Oct 20.

Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address:

Introduction: In 2010, the U.S. Coast Guard (USCG) led a clean-up response to the Deepwater Horizon (DWH) oil spill. Read More

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October 2021

Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints.

Cytokine 2021 Oct 20;149:155742. Epub 2021 Oct 20.

Division of Rheumatology, University Hospital of Geneva, and Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland. Electronic address:

Interleukin (IL)-6 is produced locally in response to an inflammatory stimulus, and is able to induce systemic manifestations at distance from the site of inflammation. Its unique signaling mechanism, including classical and trans-signaling pathways, leads to a major expansion in the number of cell types responding to IL-6. This pleiotropic cytokine is a key factor in the pathogenesis of rheumatoid arthritis (RA) and is involved in many extra-articular manifestations that accompany the disease. Read More

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October 2021

Traffic-related air pollution associated pulmonary pathophysiologic changes and cardiac injury in elderly patients with COPD.

J Hazard Mater 2021 Oct 9;424(Pt B):127463. Epub 2021 Oct 9.

Department of Occupational and Environmental Health, Peking University School of Public Health, and Peking University Institute of Environmental Medicine, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University, Beijing, China. Electronic address:

Traffic-related air pollution (TRAP) has shown enormous environmental toxicity, but its cardiorespiratory health impact on chronic obstructive pulmonary disease (COPD) has been less studied. We followed a panel of 45 COPD patients with 4 repeated clinical visits across 14 months in a traffic-predominated urban area of Beijing, China, with concurrent measurements of TRAP metrics (fine particulate matter, black carbon, oxides of nitrogen and carbon monoxide). Linear mixed-effect models were performed to evaluate the associations and potential pathways linking traffic pollution to indicators of spirometry, cardiac injury, inflammation and oxidative stress. Read More

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October 2021

Elevation transposition method for superficialization of the basilic vein achieves better patency rate than tunnel transposition.

Ann Vasc Surg 2021 Oct 20. Epub 2021 Oct 20.

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, No. 5, Fuxing Street, Guishan District, Taoyuan 333, Taiwan.

Objective: To compare the tunnel transposition and elevation transposition methods used for superficialization of the basilic vein in terms of complication and patency rates.

Methods: This retrospective study included patients who underwent two-stage basilic vein transposition between August 2016 and December 2019. Patients were categorized into brachial-basilic fistula tunnel transposition (n=32) and elevation transposition (n=21) groups using medical records. Read More

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October 2021

Cylindrospermopsin impairs vascular smooth muscle cells by P53-mediated apoptosis due to ROS overproduction.

Toxicol Lett 2021 Oct 20. Epub 2021 Oct 20.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China. Electronic address:

Cylindrospermopsin (CYN) is a toxic secondary metabolite from cyanobacteria that can cause cardiovascular disease. However, the study of CYN-induced cardiovascular toxicity in vitro is very limited and the mechanism is remain to be clarified. Vascular smooth muscle cells (VMSCs) have an important function in maintaining the structural and functional integrity of the aortic wall, and are an important in vitro model for cardiovascular research. Read More

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October 2021

Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications.

Pharmacol Ther 2021 Oct 20:108025. Epub 2021 Oct 20.

Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering, Birmingham, AL 35294, USA. Electronic address:

Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer particles naturally released from the cell. While exosomes are formed as intraluminal vesicles (ILVs) of the multivesicular endosomes (MVEs) and released to extracellular space upon MVE-plasma membrane fusion, microvesicles are generated through direct outward budding of the plasma membrane. Exosomes and microvesicles have same membrane orientation, different yet overlapping sizes; their cargo contents are selectively packed and dependent on the source cell type and functional state. Read More

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October 2021

Life''s Simple 7 and the risk of stroke in Finnish men: A prospective cohort study.

Prev Med 2021 Oct 20:106858. Epub 2021 Oct 20.

Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Central Finland Health Care District, Department of Internal Medicine, Jyvaskyla, Finland.

Background: Population-wide preventive measures constitute important approaches towards reducing stroke risk and its associated burden. We sought to examine the association between American Heart Association's (AHA) Life's Simple7 (LS7) score and the risk of stroke in men.

Methods: The study is based on the prospective population-based Kuopio Ischaemic Heart Disease cohort comprising men (42-60 years) without pre-existing history of stroke at baseline (1984-1989). Read More

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October 2021

Risk factors for multiple metabolic syndrome components in obese and non-obese Japanese individuals.

Prev Med 2021 Oct 20:106855. Epub 2021 Oct 20.

Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8577, Japan. Electronic address:

Many studies have reported that even non-obese individuals have multiple metabolic syndrome (MetS) components, such as hypertension, hyperglycemia, and lipid abnormalities have a higher cardiovascular disease mortality rate and incidence. However, the risk factors for multiple MetS components in non-obese individuals have not been sufficiently clarified. This study compared risk factors, including overall lifestyle habits, for multiple MetS components possession between obese and non-obese individuals. Read More

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October 2021

Right Internal Thoracic Artery Patency Is Affected More by Target Choice Than Conduit Configuration.

Ann Thorac Surg 2021 Oct 20. Epub 2021 Oct 20.

Department of Thoracic and Cardiovascular Surgery, Lerner Research Institute.

Background: Although coronary artery bypass grafting using bilateral internal thoracic arteries (BITA) maximizes long-term survival, knowledge of the effect of different right ITA (RITA) inflow configurations on graft patency is limited. We have compared RITA occlusion among these configurations and identified its risk factors while adjusting for outflow coronary target location.

Methods: From 1/1972-1/2016, of 7,092 patients undergoing BITA grafting at a single center, 1,331 received 1 ITA to the left anterior descending coronary artery (LAD) and had ≥1 evaluable postoperative coronary angiograms: 835 (63%) in-situ, 496 free-RITA grafts (311 [63%] originating from aorta, 98 [20%] left internal thoracic artery (LITA), 76 [15%] saphenous vein graft [SVG], 11 [2%] radial graft). Read More

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October 2021

Thickened nuchal translucency in a fetus with neonatal dilated cardiomyopathy and MAP3K7 genetic variant.

Ultrasound Obstet Gynecol 2021 Oct 23. Epub 2021 Oct 23.

Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA.

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October 2021

CAD-RADS may underestimate coronary plaque progression as detected by serial CT angiography.

Eur Heart J Cardiovasc Imaging 2021 Oct 23. Epub 2021 Oct 23.

MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Városmajor st, 1122 Budapest, Hungary.

Aims: We wished to assess whether different clinical definitions of coronary artery disease (CAD) [segment stenosis and involvement score (SSS, SIS), Coronary Artery Disease-Reporting and Data System (CAD-RADS)] affect which patients are considered to progress and which risk factors affect progression.

Methods And Results: We enrolled 115 subsequent patients (60.1 ± 9. Read More

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October 2021

European Society of Cardiology Quality Indicators for Cardiovascular Disease Prevention: developed by the Working Group for Cardiovascular Disease Prevention Quality Indicators in collaboration with the European Association for Preventive Cardiology of the European Society of Cardiology.

Eur J Prev Cardiol 2021 Oct 23. Epub 2021 Oct 23.

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9LU, UK.

Aims: To develop a set of quality indicators (QIs) for the evaluation of the care and outcomes for atherosclerotic cardiovascular disease (ASCVD) prevention.

Methods And Results: The Quality Indicator Committee of the European Society of Cardiology (ESC) formed the Working Group for Cardiovascular Disease Prevention Quality Indicators in collaboration with Task Force members of the 2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice and the European Association of Preventive Cardiology (EAPC). We followed the ESC methodology for QI development, which involved (i) the identification of the key domains of care for ASCVD prevention by constructing a conceptual framework of care, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. Read More

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October 2021

Speckle-tracking-based global longitudinal and circumferential strain detect early signs of antibody-mediated rejection in heart transplant patients.

Eur Heart J Cardiovasc Imaging 2021 Oct 23. Epub 2021 Oct 23.

Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

Aims: Acute rejection is an important cause of mortality after heart transplant (HTx), but symptoms develop only when myocardial damage is already extensive. We sought to investigate if echocardiographic parameters can detect and predict an acute cellular rejection (ACR) or antibody-mediated rejection (AMR) episode in HTx patients.

Methods And Results: Data of 403 consecutive HTx recipients between 2003 and 2020 from our centre were reviewed. Read More

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October 2021

Clinicopathological features and resistance mechanism in HIP1-ALK-rearranged lung cancer: A multicenter study.

Genes Chromosomes Cancer 2021 Oct 23. Epub 2021 Oct 23.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Anaplastic lymphoma kinase (ALK)- rearranged non-small cell lung cancer (NSCLC) respond well to ALK tyrosine kinase inhibitors (TKIs), and echinoderm microtubule-associated protein-like 4 (EML4)-ALK-rearranged NSCLC account for the majority of those patients. However, few studies have evaluated ALK-TKIs treatment for patients with huntingtin-interacting protein 1 (HIP1)-ALK fusions. This retrospective study evaluated the clinicopathological characteristics, genomic features, response to ALK-TKIs, and resistance mechanisms in 11 cases with HIP1-ALK fusions from 5 Chinese centers. Read More

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October 2021

Social affiliation moderates the link between depressive symptoms and heart rate variability in healthy middle-aged and older individuals: An intensive ecologic momentary assessment study.

Psychophysiology 2021 Oct 23:e13958. Epub 2021 Oct 23.

Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.

Depressive symptoms have been associated with lower cardiac autonomic control, thus contributing to cardiovascular diseases, especially among older adults. Interpersonal factors have been found to attenuate physiologic stress responses, but little is known about whether these factors (e.g. Read More

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October 2021

Long-Term Effects of COVID-19 on Health Care Workers 1-Year Post-Discharge in Wuhan.

Infect Dis Ther 2021 Oct 23. Epub 2021 Oct 23.

Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, China.

Introduction: To assess the long-term consequences of coronavirus disease (COVID-19) among health care workers (HCWs) in China (hereafter surviving HCWs).

Methods: A total of 303 surviving HCWs were included. Lung (pulmonary function test, 6-min walk test [6MWT], chest CT), physical (St. Read More

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October 2021

Training During the COVID-19 Lockdown: Knowledge, Beliefs, and Practices of 12,526 Athletes from 142 Countries and Six Continents.

Sports Med 2021 Oct 23. Epub 2021 Oct 23.

Facultad de Ciencias del Deporte, Universidad de Extremadura, Cáceres, Spain.

Objective: Our objective was to explore the training-related knowledge, beliefs, and practices of athletes and the influence of lockdowns in response to the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: Athletes (n = 12,526, comprising 13% world class, 21% international, 36% national, 24% state, and 6% recreational) completed an online survey that was available from 17 May to 5 July 2020 and explored their training behaviors (training knowledge, beliefs/attitudes, and practices), including specific questions on their training intensity, frequency, and session duration before and during lockdown (March-June 2020).

Results: Overall, 85% of athletes wanted to "maintain training," and 79% disagreed with the statement that it is "okay to not train during lockdown," with a greater prevalence for both in higher-level athletes. Read More

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October 2021

Hydrogen sulfide plays a potential alternative for the treatment of metabolic disorders of diabetic cardiomyopathy.

Mol Cell Biochem 2021 Oct 23. Epub 2021 Oct 23.

Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, 421001, China.

Diabetic cardiomyopathy (DCM) is a cardiovascular complication that tends to occur in patients with diabetes, obesity, or insulin resistance, with a higher late mortality rate. Sustained hyperglycemia, increased free fatty acids, or insulin resistance induces metabolic disorders in cardiac tissues and cells, leading to myocardial fibrosis, left ventricular hypertrophy, diastolic and/or systolic dysfunction, and finally develop into congestive heart failure. The close connection between all signaling pathways and the complex pathogenesis of DCM cause difficulties in finding effective targets for the treatment of DCM. Read More

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October 2021

Can Sound Public Health Policies Stem the Tide of Burgeoning Epidemic of Cardiovascular Disease in South Asians?

Curr Cardiol Rep 2021 Oct 23;23(12):181. Epub 2021 Oct 23.

Department of Medicine, Aga Khan University, Karachi, Pakistan.

Purpose Of Review: To revisit the importance of prevention strategies and policies in reducing the burden of ischemic heart disease in South Asian countries.

Recent Findings: South Asia has seen rapid growth in its population with variable improvement in health indicators such as life expectancy at birth over the last three decades. Parallel to these improvements, there has been a stark rise in noncommunicable diseases (NCDs) but without a commensurate improvement in infrastructure/policies and health system interventions to address NCDs. Read More

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October 2021

Impact of calcific aortic valve disease on valve mechanics.

Biomech Model Mechanobiol 2021 Oct 23. Epub 2021 Oct 23.

Biomedical Engineering Department, Michigan Technological University, 1400 Townsend Dr, Houghton, MI, 49931, USA.

The aortic valve is a highly dynamic structure characterized by a transvalvular flow that is unsteady, pulsatile, and characterized by episodes of forward and reverse flow patterns. Calcific aortic valve disease (CAVD) resulting in compromised valve function and increased pressure overload on the ventricle potentially leading to heart failure if untreated, is the most predominant valve disease. CAVD is a multi-factorial disease involving molecular, tissue and mechanical interactions. Read More

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October 2021

Adjuvant Rituximab - exploratory trial in young people with Graves' disease.

J Clin Endocrinol Metab 2021 Oct 23. Epub 2021 Oct 23.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom.

Objective: Remission rates in young people with Graves' hyperthyroidism are <25% after two years of thionamide antithyroid drug (ATD). We explored whether rituximab, a B lymphocyte depleting agent, would increase remission rates when administered with a short course of ATD.

Design: This was an open label multi-centre single arm phase 2 trial in young people (12-20y) with Graves' hyperthyroidism. Read More

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October 2021

Letter to the Editor From Bin Zhou et al: "Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein".

J Clin Endocrinol Metab 2021 Oct 23. Epub 2021 Oct 23.

Fuwai Hospital, National Centre for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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October 2021

Pathophysiological pathways in patients with heart failure and atrial fibrillation.

Cardiovasc Res 2021 Oct 23. Epub 2021 Oct 23.

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Aims: Atrial fibrillation (AF) and heart failure (HF) are two growing epidemics that frequently co-exist. We aimed to gain insights into underlying pathophysiological pathways in HF patients with AF by comparing circulating biomarkers using pathway overrepresentation analyses.

Methods And Results: From a panel of 92 biomarkers from different pathophysiological domains available in 1,620 patients with HF, we first tested which biomarkers were dysregulated in patients with HF and AF (n = 648) compared with patients in sinus rhythm (n = 972). Read More

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October 2021

Obesity paradox in patients with chronic total occlusion of coronary artery.

Eur J Clin Invest 2021 Oct 23:e13698. Epub 2021 Oct 23.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Obesity is associated with metabolic syndrome which increases further risk of coronary artery disease and adverse cardiovascular events. Impact of body mass index (BMI) on long term outcome in patients with coronary chronic total occlusion (CTO) is less clear.

Method And Results: From January 2005 to November 2020, a total of 1301 patients with coronary angiographic confirmed CTO were enrolled in our study. Read More

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October 2021

PKM2 promotes angiotensin-II-induced cardiac remodelling by activating TGF-β/Smad2/3 and Jak2/Stat3 pathways through oxidative stress.

J Cell Mol Med 2021 Oct 23. Epub 2021 Oct 23.

Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Beijing Lab for Cardiovascular Precision Medicine, Department of Pathology, Capital Medical University, Beijing, China.

Hypertensive cardiac remodelling is a common cause of heart failure. However, the molecular mechanisms regulating cardiac remodelling remain unclear. Pyruvate kinase isozyme type M2 (PKM2) is a key regulator of the processes of glycolysis and oxidative phosphorylation, but the roles in cardiac remodelling remain unknown. Read More

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October 2021