24,715 results match your criteria cardiac troponin


del Nido cardioplegia better preserves cardiac diastolic function but histidine-tryptophan-ketoglutarate is better for endothelial function.

Eur J Cardiothorac Surg 2022 Jan 26. Epub 2022 Jan 26.

The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, China.

Objectives: The effectiveness of myocardial protection of cardioplegia has been a matter of debate for decades. This study was designed to compare cardiac and endothelial protection of 3 clinically used cardioplegias: del Nido cardioplegia (DNC), histidine-tryptophan-ketoglutarate (HTK) and blood cardioplegia (BC) followed by HTK (BC + HTK) in a rat model of ischaemia/reperfusion (I/R).

Methods: Sixty male Wistar rats were subjected to either 120 min of global ischaemia at 4°C followed by 90 min of reperfusion (I/R) at 37°C or no I/R (control) in a Langendorff apparatus and were randomly allocated to 5 groups: control, I/R, DNC, HTK and BC + HTK. Read More

View Article and Full-Text PDF
January 2022

Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome.

Eur J Cardiothorac Surg 2022 Jan 25. Epub 2022 Jan 25.

Department of Cardiac Surgery, Virgen del Rocio Children's Hospital, University Hospitals of Seville, Seville, Spain.

Objectives: Cardiopulmonary bypass generates a systemic inflammatory response. This inflammatory response is reduced if patients are ventilated during bypass, as evidenced by lower levels of postoperative circulating inflammatory mediators. However, this does not appear to make much clinical difference in adults, at least not consistently, but, to our knowledge, has never been assessed in paediatric cardiac surgery, which is the objective of this study. Read More

View Article and Full-Text PDF
January 2022

Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.

Am Heart J Plus 2021 Dec 27;12. Epub 2021 Nov 27.

Department of Medicine, University of Florida, Gainesville, FL, USA.

Study Objective: Infarct size is a strong predictor of outcomes after ST elevation myocardial infarction (STEMI). Circulating fibrocytes are bone marrow-derived progenitor cells associated with fibrotic processes. We tested whether fibrocytes correlate with infarct size in STEMI patients treated with primary percutaneous coronary intervention (PCI). Read More

View Article and Full-Text PDF
December 2021

Immune checkpoint inhibitor-related myocarditis: an illustrative case series of applying the updated Cardiovascular Magnetic Resonance Lake Louise Criteria.

Eur Heart J Case Rep 2022 Jan 21;6(1):ytab478. Epub 2022 Jan 21.

Department of Medical Imaging, Peter Munk Cardiac Center, University Health Network, 585 University Avenue, Toronto, Ontario M5G 2N2, Canada.

Background: Immune checkpoint inhibitors (ICIs) have improved outcomes for many types of cancer. However, ICI therapies are associated with the development of myocarditis, an immune-mediated adverse event associated with a high mortality rate. Therefore, prompt diagnosis and early intervention are of outmost importance. Read More

View Article and Full-Text PDF
January 2022

The false positive troponin results: case studies of analytical interference.

Clin Med (Lond) 2022 Jan;22(1):87-88

University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Cardiac troponin I and T are particularly sensitive and specific markers for cardiomyocyte damage. Myocardial injury can occur due to a discrepancy between oxygen supply and demand (eg coronary artery occlusion and arrhythmias), other cardiac causes (eg pericarditis, myocarditis, cardiac surgery, cardioversion etc) or systemic conditions (eg sepsis, stroke and chronic renal disease). The latest European Society of Cardiology guidelines help to guide clinicians through these different causes. Read More

View Article and Full-Text PDF
January 2022

Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca mishandling and preventive role of Klotho in mice to its potential mortality prediction in human.

Transl Res 2022 Jan 22. Epub 2022 Jan 22.

Cardiorenal Translational Laboratory, Institute of Research i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; CIBER-CV, Hospital Universitario 12 de Octubre, Madrid, Spain. Electronic address:

Biomarkers of mineral bone disorders (MBD) including phosphorus, fibroblast growth factor (FGF)-23 and Klotho are strongly altered in patients with acute kidney injury (AKI) who have high cardiac outcomes and mortality rates. However, the crosslink between MBD and cardiac damage after an AKI episode still remains unclear. We tested MBD and cardiac biomarkers in an experimental AKI model after 24 or 72 hours of folic acid injection and we analyzed structural cardiac remodeling, intracellular calcium (Ca) dynamics in cardiomyocytes and cardiac rhythm. Read More

View Article and Full-Text PDF
January 2022

Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose?

Eur J Cardiothorac Surg 2022 Jan 25. Epub 2022 Jan 25.

Coronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Objectives: The diagnosis and clinical implications of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) are contentious, especially the importance of PPMI in the interpretation of trial data.

Methods: Consecutive patients admitted to a cardiothoracic critical care unit over a 6-month period following open cardiac surgery had high-sensitivity cardiac troponin I assay performed on admission and every day for 48 h, regardless of whether there was a request by the supervising clinical team. Patients were categorized as PPMI using both the Universal Definition of Myocardial Infarction (UDMI) and Society of Cardiovascular Angiography and Interventions (SCAI) criteria. Read More

View Article and Full-Text PDF
January 2022

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021.

JAMA 2022 Jan;327(4):331-340

US Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Vaccination against COVID-19 provides clear public health benefits, but vaccination also carries potential risks. The risks and outcomes of myocarditis after COVID-19 vaccination are unclear.

Objective: To describe reports of myocarditis and the reporting rates after mRNA-based COVID-19 vaccination in the US. Read More

View Article and Full-Text PDF
January 2022

Case report of acute myocarditis after administration of coronavirus disease 2019 vaccine in Japan.

Eur Heart J Case Rep 2022 Jan 5;6(1):ytab534. Epub 2022 Jan 5.

Department of Comprehensive Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, 520-2192 Otsu, Japan.

Background: The worldwide spread of coronavirus disease 2019 (COVID-19) is still not under control and vaccination in Japan started in February 2021, albeit later than in Europe and the USA. The COVID-19 vaccination frequently leads to minor adverse reactions, which may be more intense after the second dose. The number of case reports of myocarditis following COVID-19 vaccination have been recently increased. Read More

View Article and Full-Text PDF
January 2022

Exploring the association of fibrinogen and CRP with the clinical spectrum of CAD and periprocedural outcomes in patients undergoing percutaneous coronary interventions.

Ann Card Anaesth 2022 Jan-Mar;25(1):34-40

Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: The pathophysiology of an atherosclerotic plaque is mediated by the mechanisms involving thrombus formation and systemic inflammation. While C-reactive protein (CRP) levels are useful in predicting a cardiovascular event in intermediate risk population, the usefulness of routinely measuring fibrinogen in patients with acute coronary syndrome (ACS) is debatable. Also, data on the association of these markers with periprocedural outcomes in patients undergoing percutaneous coronary interventions (PCI) is scarce. Read More

View Article and Full-Text PDF
January 2022

Efficiency Comparison of Direct Reprogramming CD34 Cells into Cardiomyocytes Using Cardiomyocyte Differentiation Medium vs MicroRNA-1.

Cell Reprogram 2022 Jan 21. Epub 2022 Jan 21.

Medical Faculty of Nahdlatul Ulama Surabaya University, Surabaya, Indonesia.

The development of a direct reprogramming method to provide cell availability for regenerative therapy has led to a lot of studies. However, the search for appropriate cell sources and methods is still being carried out until now. Direct reprogramming using microRNA-1 (miR-1) is an option to obtain cardiomyocytes from other cells because miR-1 has evidence to play a role in the development of cardiac muscle cells in the embryo. Read More

View Article and Full-Text PDF
January 2022

3'-daidzein sulfonate protects myocardial cells from hypoxic-ischemic injury via the signaling pathway.

J Thorac Dis 2021 Dec;13(12):6897-6910

Department of pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Background: Myocardial infarction (MI) has a high mortality and disability rate and greatly affects human health. This study sought to explore the therapeutic effect and molecular mechanism of 3'-daidzein sulfonate (DSS) on MI.

Methods: A rat MI model was established and low and high doses of DSS were administered to the rats. Read More

View Article and Full-Text PDF
December 2021

A 15-year-old with chest pain: An unexpected etiology.

SAGE Open Med Case Rep 2022 19;10:2050313X211069026. Epub 2022 Jan 19.

The University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

A 15-year-old female with no significant past medical history presented to the emergency department with 1 day of substernal and pleuritic chest pain, chills, cough, and hematuria. She also had swelling of the face and ankles that resolved by presentation. She was found to have elevated troponin and brain natriuretic peptide during initial workup. Read More

View Article and Full-Text PDF
January 2022

Highly sensitive troponin I assay in the diagnosis of coronary artery disease in patients with suspected stable angina.

Authors:
Indra Ramasamy

World J Cardiol 2021 Dec;13(12):745-757

Department of Biochemistry, Worcester Royal Hospital, Worcester WR5 1DD, United Kingdom.

Background: Evaluation of suspected stable angina patients with probable coronary artery disease (CAD) in the community is challenging. In the United Kingdom, patients with suspected stable angina are referred by community physicians to be assessed by specialists within the hospital system in rapid access chest pain clinics (RACPC). The role of a highly sensitive troponin I (uscTnI) assay in the diagnosis of suspected CAD in a RACPC in a "real-life" setting in a non-academic hospital has not been explored. Read More

View Article and Full-Text PDF
December 2021

In Vivo Cardiotoxic Potential of Micrurus frontalis Venom.

Cardiovasc Toxicol 2022 Jan 24. Epub 2022 Jan 24.

Department of Veterinary Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

In the present study, we investigated the cardiotoxic potential of Micrurus frontalis venom. Twelve guinea pigs (Cavia porcellus) were distributed in two groups (n = 6), named control and envenomed. Control groups received 0. Read More

View Article and Full-Text PDF
January 2022

Can we predict risk for cardiac involvement in paediatric multisystem inflammatory syndrome?

Cardiol Young 2022 Jan 24:1-21. Epub 2022 Jan 24.

Basaksehir Cam and Sakura City Hospital, Department of Pediatrics, Division of Pediatric Cardiology.

Introduction: Increasing recognition of paediatric multisystem inflammatory syndrome (PIMS) is a cause of concern. This study aimed to evaluate children with PIMS and compare the clinical and laboratory features of children with and without cardiac involvement.

Material And Methods: We conducted a prospective single-center study including 57 (male 37, 65%) patients with PIMS at a tertiary care hospital between November 2020 and March 2021. Read More

View Article and Full-Text PDF
January 2022

Protective effect of glucagon-like peptide-1 mediated by ultrasound microbubbles on myocardial injury in rats with diabetic cardiomyopathy.

Bioengineered 2022 Feb;13(2):3251-3261

Department of Ultrasound, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Abbreviations: Ultrasound-targeted microbubble destruction, UTMD; glucagon-like peptide-1 receptor, GLP-1R; diabetic cardiomyopathy, DCM; Goto-Kakizaki, GK; velocity vector imaging, VVI; left ventricular end-diastolic diameter LVIDd; left ventricular end-systolic diameter, LvIDs; left ventricular end-diastolic pressure, LVEDP; fractional shortening, LVFs; left ventricular ejection fraction, LVEF; mean peak radial velocity, Vs; radial strain, Sr; radial strain rate, SRr; superoxide dismutase, SOD; malondialdehyde, MDA; glutathione peroxidase, GSH-Px; peroxisome proliferator-activated receptor-γ, PPAR-γ; nuclear transcription factor κB, NF-κB; insulin resistance, IR; total cholesterol, TC; total triglycerides, TG; creatine kinase, CK; lactate dehydrogenase, LDH; cardiac troponin I, cTnI; collagen volume fraction, CVF; Hematoxylin eosin, H&E. Read More

View Article and Full-Text PDF
February 2022

Allele-specific silencing by RNAi of R92Q and R173W mutations in cardiac troponin T.

Exp Biol Med (Maywood) 2022 Jan 22:15353702211072453. Epub 2022 Jan 22.

Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.

Autosomal dominant mutations in sarcomere proteins such as the cardiac troponin T () are the main genetic causes of human hypertrophic cardiomyopathy and dilated cardiomyopathy. Allele-specific silencing by RNA interference (ASP-RNAi) holds promise as a therapeutic strategy for downregulating a single mutant allele with minimal suppression of the corresponding wild-type allele. Here, we propose ASP-RNAi as a possible strategy to specifically knockdown mutant alleles coding for R92Q and R173W mutant TNNT2 proteins, identified in hypertrophic and dilated cardiomyopathy, respectively. Read More

View Article and Full-Text PDF
January 2022

Electrophysiological characteristics of septal perforation during left bundle branch pacing.

Heart Rhythm 2022 Jan 20. Epub 2022 Jan 20.

Geisinger Heart Institute, Geisinger Commonwealth School of Medicine, Wilkes Barre, PA, USA.

Background: Left bundle branch pacing(LBBP) provides low and stable threshold by direct capture of left bundle fibers on the left ventricular sub-endocardium. As the procedure involves the deployment of the pacing lead deep inside the septum, septal-perforation is a potential complication OBJECTIVES: The aim of our study was to analyze the morphology of intracardiac-electrograms and unipolar pacing parameters to identify septal-perforation in patients undergoing LBBP.

Methods: Patients who had undergone successful LBBP between January-2020 to November-2021 were retrospectively included in the study RESULTS: LBBP was successful in 212/219 attempted patients(96. Read More

View Article and Full-Text PDF
January 2022

Diagnostic Accuracy of High-Sensitive Troponin for the Identification of Myocardial Infarction in Patients Presenting with Acute Heart Failure.

J Emerg Med 2022 Jan 20. Epub 2022 Jan 20.

Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Background: The differentiation of myocardial infarction (MI) in the setting of acute heart failure (AHF) can be challenging because the majority of patients presenting with AHF show elevations of high-sensitive troponin (hs-Tn). Fast identification of MI is crucial to perform timely coronary angiography and to improve clinical outcome.

Objectives: The aim of the present study was to assess the diagnostic accuracy of different levels of hs-Tn for the identification of type 1 MI in patients with AHF. Read More

View Article and Full-Text PDF
January 2022

Higher intensity of 72-hour non-invasive cardiac test referral does not improve short-term outcomes among emergency department patients with chest pain.

Acad Emerg Med 2022 Jan 22. Epub 2022 Jan 22.

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

Background: It is unclear whether referral for cardiac non-invasive testing (NIT) following emergency department (ED) chest pain encounters improves short-term outcomes.

Methods: Retrospective cohort study of patients presenting with chest pain, without ST-elevation myocardial infarction or myocardial injury by serum troponin testing, between 2013-2019 to 21 EDs within an integrated health care system. We examined the association between NIT referral (within 72-hours of the ED encounter) and a primary outcome of 60-day major adverse cardiac events (MACE). Read More

View Article and Full-Text PDF
January 2022

Accuracy of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Diagnosing Acute Myocardial Infarction.

Acad Emerg Med 2022 Jan 22. Epub 2022 Jan 22.

Department of Emergency Medicine, Rush University Medical Center.

Aim: This study investigated whether prehospital advanced airway management (AAM) is associated with improved survival of out-of-hospital cardiac arrest (OHCA) compared with conventional bag-valve-mask ventilation (BVM).

Methods: We investigated the neurologically favorable survival of adult patients with OHCA who underwent BVM or AAM using the Korean Cardiac Arrest Research Consortium (KoCARC), a multicenter OHCA registry of Korea. The differences in clinical characteristics were adjusted by matching or weighting the clinical propensity for use of AAM, or by least absolute shrinkage and selection operator (LASSO). Read More

View Article and Full-Text PDF
January 2022

Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats.

Cardiovasc Toxicol 2022 Jan 22. Epub 2022 Jan 22.

Department of Histology and Embriyology, Faculty of Medicine, Firat University, Elazig, Turkey.

Epilepsy is a chronic neurological disease that affects more than 50 million people worldwide. Antiepileptic drugs (AEDs) are the mainstay of treatment for most patients with epilepsy. However, AEDs have been reported to be associated with adverse cardiac effects. Read More

View Article and Full-Text PDF
January 2022

Myocarditis and pericarditis after COVID-19 messenger RNA vaccines.

Authors:
Ran D Goldman

Can Fam Physician 2022 Jan;68(1):17-18

Question: With the approval of coronavirus disease 2019 (COVID-19) vaccine for children 5 to 11 years of age and concerns among parents in the past year following reported cases of myocarditis and pericarditis in adolescents, should my office continue to encourage all children and young adults to receive the COVID-19 messenger RNA vaccine?

Answer: Since April 2021 reports have documented cases of myocarditis and pericarditis in adolescents and young adults after messenger RNA COVID-19 vaccination, and several hundred such reports were documented in Canada. Clinical presentations were mostly mild, with rare instances of admission to the hospital, and were typically among male adolescents 16 years of age and older within several days after the second dose of the vaccine. After vaccination, children and adolescents with symptoms of chest pain, shortness of breath, or palpitations should be evaluated with a physical examination, an electrocardiogram, and measurement of cardiac troponin levels. Read More

View Article and Full-Text PDF
January 2022

What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?

Int Immunopharmacol 2022 Jan 17;105:108542. Epub 2022 Jan 17.

Erzincan Binali Yıldırım Unversıty, Faculty of Medicine, Department of Clinical Biochemistry, Erzincan, Türkiye; Inonu University, Faculty of Medicine, Department of Clinical Biochemistry, Malatya, Türkiye.

It remains important to investigate the changing and impact of routine blood values (RBVs) in order to predict mortality and follow an appropriate treatment in COVID-19 patients. In the study, the importance of RBVs in the mortality of patients with COVID-19 was investigated. The changes in the biochemical, hematological, and immunological parameters of patients who recovered (n = 4364) and died (n = 233) from COVID-19 over time and their relationship with the mortality of the disease were evaluated retrospectively. Read More

View Article and Full-Text PDF
January 2022

Unstable Angina Pectoris With Myocardial Injury Versus Myocardial Infarction in the Era of High-Sensitivity Cardiac Troponin.

Am J Cardiol 2022 Jan 18. Epub 2022 Jan 18.

Department of Medicine; Department of Emergency and Reparative Medicine, Karolinska University Hospital, Stockholm, Sweden.

It is unknown whether outcomes in patients with unstable angina pectoris (UAP) and myocardial injury are different from outcomes in patients with non-ST-segment myocardial infarction (NSTEMI) with low peak concentrations of high-sensitivity cardiac troponin T (hs-cTnT). This study aimed to compare the prognosis in patients with UAP and evidence of myocardial injury, with prognosis in patients with NSTEMI and different peak hs-cTnT concentrations. All visits to 7 different emergency departments in Sweden from December 9, 2009 to December 31, 2016 were identified (n = 5,225,075). Read More

View Article and Full-Text PDF
January 2022

Combined Role of Troponin and Natriuretic Peptides Measurements in Patients With Covid-19 (from the Cardio-COVID-Italy Multicenter Study).

Am J Cardiol 2022 Jan 18. Epub 2022 Jan 18.

Division of Cardiology, Civil Hospital, Cremona, Italy.

Data concerning the combined prognostic role of natriuretic peptide (NP) and troponin in patients with COVID-19 are lacking. The aim of the study is to evaluate the combined prognostic value of NPs and troponin in hospitalized COVID-19 patients. From March 1, 2020 to April 9, 2020, consecutive patients with COVID-19 and available data on cardiac biomarkers at admission were recruited. Read More

View Article and Full-Text PDF
January 2022

Multisystem Inflammatory-like Syndrome in a Child Following COVID-19 mRNA Vaccination.

Vaccines (Basel) 2021 Dec 30;10(1). Epub 2021 Dec 30.

Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

A 12-year-old male was presented to the hospital with acute encephalopathy, headache, vomiting, diarrhea, and elevated troponin after recent COVID-19 vaccination. Two days prior to admission and before symptom onset, he received the second dose of the Pfizer-BioNTech COVID-19 vaccine. Symptoms developed within 24 h with worsening neurologic symptoms, necessitating admission to the pediatric intensive care unit. Read More

View Article and Full-Text PDF
December 2021

Waterpipe smoke-induced hypercoagulability and cardiac injury in mice: Influence of cessation of exposure.

Biomed Pharmacother 2022 Feb 3;146:112493. Epub 2022 Jan 3.

Department of Pharmacology and Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Muscat 123, Al-Khod, Sultanate of Oman.

Waterpipe tobacco smoking has gained worldwide popularity, particularly among youths. Several clinical and experimental studies have reported that waterpipe smoking (WPS) injures the cardiovascular system. However, the impact of smoking cessation (CS) on the cardiovascular toxicity induced by WPS received scant attention. Read More

View Article and Full-Text PDF
February 2022

Eyes on amyloidosis: microvascular retinal dysfunction in cardiac amyloidosis.

ESC Heart Fail 2022 Jan 21. Epub 2022 Jan 21.

Department of Cardiology, University Hospital Zurich, University of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.

Aims: Cardiac involvement in systemic amyloidosis is a marker of particularly poor prognosis. Cardiac amyloidosis (CA) is characterized by extracellular amyloid deposits inducing heart failure and symptoms of cardiac microvascular disease. While amyloid deposition is most common in the myocardium but also seen in pericardium and endocardium, atria, and vasculature, the role of (micro-)vascular dysfunction in CA pathophysiology remains still elusive. Read More

View Article and Full-Text PDF
January 2022