27,402 results match your criteria cardiac protection

Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts.

Pharmacol Res 2021 Sep 12:105883. Epub 2021 Sep 12.

Department of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada; Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada; Multi-Organ Transplant Program, Western University, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada; Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada. Electronic address:

Carbon monoxide (CO) was historically regarded solely as a poisonous gas that binds to hemoglobin and reduces oxygen-carrying capacity of blood at high concentrations. However, recent findings show that it is endogenously produced in mammalian cells as a by-product of heme degradation by heme oxygenase, and has received a significant attention as a medical gas that influences a myriad of physiological and pathological processes. At low physiological concentrations, CO exhibits several therapeutic properties including antioxidant, anti-inflammatory, anti-apoptotic, anti-fibrotic, anti-thrombotic, anti-proliferative and vasodilatory properties, making it a candidate molecule that could protect organs in various pathological conditions including cold ischemia-reperfusion injury (IRI) in kidney and heart transplantation. Read More

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September 2021

Reply to Schmitz et al.

Am J Physiol Heart Circ Physiol 2021 Oct;321(4):H665-H666

Genetics and Genomics Group, Sanford Research, Sioux Falls, South Dakota.

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October 2021

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.

Redox Biol 2021 Sep 8;46:102127. Epub 2021 Sep 8.

Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia; Victor Chang Cardiac Research Institute, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia; School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia. Electronic address:

Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of pathologies. What drives CoQ deficiency in many of these pathologies is unknown, just as there currently is no effective therapeutic strategy to overcome CoQ deficiency in humans. Read More

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September 2021

Endothelial Mineralocorticoid Receptor Ablation Confers Protection Towards Endothelial Dysfunction in Experimental Diabetes in Mice.

Acta Physiol (Oxf) 2021 Sep 14:e13731. Epub 2021 Sep 14.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense C, Denmark.

Aim: With diabetes comes significant risk of macrovascular and microvascular complications. Circulating aldosterone levels increase in patients with diabetes. Aldosterone can directly affect vascular function via activation of the mineralocorticoid receptor (MR). Read More

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September 2021

Cardiorespiratory Fitness as Protection Against the Development of Memory Intrusions: a Prospective Trauma Analogue Study.

Biol Psychol 2021 Sep 10:108189. Epub 2021 Sep 10.

Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

Intrusive and distressing memories are at the core of post-traumatic stress disorder (PTSD). Since cardiorespiratory fitness (CRF) has been linked with improved mental health, emotion regulation, and memory function, CRF may, by promoting these capabilities, protect against the development of intrusions after trauma. We investigated the CRF-intrusion relationship and its potential mediators in 115 healthy individuals, using a trauma film to induce intrusions. Read More

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September 2021

Isoflurane not at the expense of postoperative nausea and vomiting in cardiac anesthesia - an observational study.

Curr Med Res Opin 2021 Sep 13. Epub 2021 Sep 13.

Department of Anesthesiology, Intensive Care and Pain Medicine, Medical Faculty of Ruhr-University Bochum, BG-Universitätsklinikum Bergmannsheil gGmbH Bochum, Bürkle-de-la-Camp Platz 1, 44789 Bochum, Germany.

Objectives: Inhalative anesthesia is of common use, but is generally known to potentiate postoperative nausea and vomiting (PONV). With an internal change of anesthesia regimen from total intravenous anesthesia (TIVA) to isoflurane (in terms of myocardial protection) in cardiac anesthesia a higher incidence of PONV was to be expected. Therefore, we evaluated the incidence of PONV after the simultaneous implementation of PONV prophylaxis. Read More

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September 2021

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021.

Front Cardiovasc Med 2021 25;8:734514. Epub 2021 Aug 25.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research. Read More

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Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitors: Delving Into the Potential Benefits of Cardiorenal Protection Beyond the Treatment of Type-2 Diabetes Mellitus.

Cureus 2021 Aug 4;13(8):e16868. Epub 2021 Aug 4.

Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Diabetes mellitus is a leading cause of morbidity and mortality and a significant risk factor for the early onset of chronic kidney disease and heart disease. Hyperglycemia and insulin resistance are key factors that play a role in the pathogenesis of type 2 diabetes. Renal glucose reabsorption is a critical component of glycemic regulation. Read More

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Heat strain in chemical protective clothing in hot-humid environment: Effects of clothing thermal properties.

J Cent South Univ 2021 Sep 6:1-12. Epub 2021 Sep 6.

State Key Laboratory of NBC Protection for Civilian, Beijing, 100191 China.

Heat strain experienced by individuals wearing chemical protective clothing (CPC) is severe and dangerous especially in hot-humid environment. The development of material science and interdisciplinary studies including ergonomics, physiology and heat transfer is urgently required for the reduction of heat strain. The aim of this paper was to study the relationship among clothing thermal properties, physiological responses and environmental conditions. Read More

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September 2021

Clemastine Fumarate Attenuates Myocardial Ischemia Reperfusion Injury Through Inhibition of Mast Cell Degranulation.

Front Pharmacol 2021 27;12:704852. Epub 2021 Aug 27.

Shandong Provincial Medicine and Health Key Laboratory of Clinical Anesthesia, School of Anesthesiology, Weifang Medical University, Weifang, China.

Mast cell (MC) activation is associated with myocardial ischemia reperfusion injury (MIRI). Suppression of MC degranulation might be a target of anti-MIRI. This study aimed to determine whether clemastine fumarate (CLE) could attenuate MIRI by inhibiting MC degranulation. Read More

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Georgian Med News 2021 Jul-Aug(316-317):22-26

1Heart Institute Ministry of Health of Ukraine, Kiev; 2Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine.

The aim of our study was to compare the levels of myocardial damage markers and the state of the oxygen budget in patients with mitral valve insufficiency during its surgical correction, depending on the method of cardioprotection. We examined 85 patients with mitral valve insufficiency who underwent mitral valve replacement (MVR) surgery and anesthetic management according to the traditional method, the difference was only in the method of cardioprotection. In the I group (n=40) crystalloid cardioplegia (Bernsteinder's solution) was used, in the II group (n=45) - electrical fibrillation of the heart and intermittent clamping of the aorta. Read More

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September 2021

Inotropes in Patients with Advanced Heart Failure: Not Only Palliative Care.

Heart Fail Clin 2021 Oct 22;17(4):587-598. Epub 2021 Jul 22.

Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, Via Leonardo Bianchi 1, Naples 80100, Italy.

Patients with advanced heart failure suffer from severe and persistent symptoms, often not responding disease-modifying drugs, a marked limitation of functional capacity and poor quality of life that can ameliorate with inotropic drugs therapy. In small studies, pulsed infusions of classical inotropes (ie, dobutamine and milrinone) are associated with improvement in hemodynamic parameters and quality of life in patients with advanced heart failure. However, because of the adverse effects of these drugs, serious safety issues have been raised. Read More

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October 2021

Chicken bone marrow mesenchymal stem cells improve lung and distal organ injury.

Sci Rep 2021 Sep 10;11(1):17937. Epub 2021 Sep 10.

Department of Animal Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 2 Yuanmingyuan Road, Beijing, 100193, People's Republic of China.

Mesenchymal stem cells (MSCs) are associated with pulmonary protection and longevity. We separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs can improve lipopolysaccharide (LPS)-induced lung and distal organ injury; and explored the underlying mechanisms. Ninety-six male ICR (6 weeks old) mice were randomly divided into three groups: Sham, LPS, and LPS + MSC groups. Read More

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September 2021

Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?

Curr Opin Pharmacol 2021 Sep 7;60:291-297. Epub 2021 Sep 7.

Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Nicotinamide adenine dinucleotide (NAD) is essential for cellular physiological processes, directly or indirectly affecting metabolism and gene expression. The decline of NAD levels in the heart is accompanied by aging, causing cardiac pathological remodeling and dysfunction. Niacinamide mononucleotide (NMN) has emerged as a precursor to alleviate age-related cardiac pathophysiological changes by improving cardiac NAD homeostasis. Read More

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September 2021

Cancer and cardiovascular disease: The impact of cardiac rehabilitation and cardiorespiratory fitness on survival.

Int J Cardiol 2021 Sep 8. Epub 2021 Sep 8.

TotalCardiology Research Network, Calgary, AB, Canada; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA. Electronic address:

Background: Cancer survivors are at increased risk for cardiovascular disease (CVD)-related morbidity and mortality. Exercise-based cardiac rehabilitation (CR) programs improve CVD risk factors, including cardiorespiratory fitness (CRF). The purpose of this study was to investigate: (1) the association between CR completion and survival, and (2) whether CRF improvements translate to increased survival among patients with comorbid cancer and CVD. Read More

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September 2021

Dexmedetomidine protects the heart against ischemia reperfusion injury via regulation of the bradykinin receptors.

Eur J Pharmacol 2021 Sep 7:174493. Epub 2021 Sep 7.

Department of Physiology, Naval Medical University (Second Military Medical University), Shanghai, 200433, China. Electronic address:

Background: Dexmedetomidine (DEX) has been reported to protect the heart against ischemia reperfusion (I/R) injury. However, the exact mechanisms are still not fully understood.

Methods And Results: A rat cardiac I/R injury model was induced by ligation of the left anterior descending coronary artery for 1 h and subsequent reperfusion for 2 h, and DEX was administered intravenously 30 min before ischemia. Read More

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September 2021

Comparison of combinations of irradiation techniques and jaw conditions in intensity-modulated radiotherapy for lung cancer.

J Appl Clin Med Phys 2021 Sep 10. Epub 2021 Sep 10.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Purpose: To assist in the selection of a suitable combination of an irradiation technique and jaw condition in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT) for lung cancer treatment plans.

Materials And Methods: Thirty patients with lung cancer who underwent radiotherapy were enrolled retrospectively. They were categorized as having central lung cancer, peripheral lung cancer with mediastinal lymph node metastasis (peripheral E lung cancer), and peripheral lung cancer without mediastinal lymph node metastasis (peripheral N lung cancer). Read More

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September 2021

Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis the cAMP/PKA/RhoA Signaling Pathway.

Front Pharmacol 2021 24;12:723922. Epub 2021 Aug 24.

The Key Laboratory of Upper Airway Dysfunction-Related Cardiovascular Diseases, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, China.

Endothelial barrier dysfunction plays a key role in atherosclerosis progression. The primary pathology of obstructive sleep apnea-hypopnea syndrome is chronic intermittent hypoxia (IH), which induces reactive oxygen species (ROS) overproduction, endothelial barrier injury, and atherosclerosis. Salidroside, a typical pharmacological constituent of Rhodiola genus, has documented antioxidative, and cardiovascular protective effects. Read More

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Divergent incubation temperature effects on thermal sensitivity of hatchling performance in two different latitudinal populations of an invasive turtle.

J Therm Biol 2021 Aug 17;100:103079. Epub 2021 Aug 17.

Key Laboratory of Hangzhou City for Ecosystem Protection and Restoration, School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China. Electronic address:

The incubation temperature for embryonic development affects several aspects of hatchling performance, but its impact on the thermal sensitivity of performance attributes remains poorly investigated. In the present study, Trachemys scripta elegans hatchlings from two different latitudinal populations were collected to assess the effects of different incubation temperatures on the locomotor (swimming speed) and physiological (heart rate) performances, and the thermal sensitivity of these two attributes. The incubation temperature significantly affected the examined physiological traits. Read More

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Exercise heat acclimation causes human responses and safety performance improvements.

J Therm Biol 2021 Aug 28;100:103042. Epub 2021 Jun 28.

School of Environmental Science and Engineering, Tianjin University, Tianjin, 300072, China; Tianjin Key Laboratory of Built Environment and Energy Application, Tianjin University, Tianjin, 300072, China.

Heat acclimation (HA) is a widely recognized physiological phenomenon of human body in hot environments. HA has many benefits, such aspreventing hyperthermia responses, and is an efficient way to improve human responses to hyperthermal environments. However, it is not known whether HA is dependent on the environmental conditions. Read More

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High-Sensitivity C-Reactive Protein Modifies the Cardiovascular Risk of Lipoprotein(a): Multi-Ethnic Study of Atherosclerosis.

J Am Coll Cardiol 2021 Sep;78(11):1083-1094

Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA. Electronic address:

Background: Little is known about the relationship between lipoprotein (a) [Lp(a)] and high-sensitivity C-reactive protein (hsCRP) and their joint association with atherosclerotic cardiovascular disease (ASCVD).

Objectives: The purpose of this study was to assess whether Lp(a)-associated ASCVD risk is modified by hsCRP in the context of primary prevention.

Methods: The current study included 4,679 participants from the MESA (Multi-Ethnic Study of Atherosclerosis) Apolipoprotein ancillary data set. Read More

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September 2021

Management of patients explanted for implantable cardioverter defibrillator infections: Bridge therapy with external temporary ICD.

Pacing Clin Electrophysiol 2021 Sep 9. Epub 2021 Sep 9.

Division of Cardiology, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.

Aims And Methods: In case of cardiacimplantable electronicdevice (CIED)-related infections, it is mandatory to completely remove the device and administer prolonged antibiotic therapy. The management of patients explanted for an implantable defibrillator (ICD) infection is complex especially in patients needing anti-bradycardia pacing or tachyarrhythmia protection. We tested the efficacy and safety of a conventional ICD externally connected to a transvenous dual-coil lead as bridging therapy before the reimplant, comparing outcomes with a historical cohort of patients (N = 113) treated with temporary transvenous pacing. Read More

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September 2021

GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects.

Front Endocrinol (Lausanne) 2021 23;12:721135. Epub 2021 Aug 23.

Department of Pharmacology, Shanxi Medical University, Taiyuan, China.

Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet β cells, promotion of islet β cell proliferation and minimal side effects. Studies have found that GLP-1R is widely distributed on pancreatic and other tissues and has multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving heart function, suppressing appetite, delaying gastric emptying, regulating blood lipid metabolism and reducing fat deposition. Read More

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Effects of low-frequency noise from wind turbines on heart rate variability in healthy individuals.

Sci Rep 2021 Sep 8;11(1):17817. Epub 2021 Sep 8.

Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan.

Wind turbines generate low-frequency noise (LFN, 20-200 Hz), which poses health risks to nearby residents. This study aimed to assess heart rate variability (HRV) responses to LFN exposure and to evaluate the LFN exposure (dB, L) inside households located near wind turbines. Thirty subjects living within a 500 m radius of wind turbines were recruited. Read More

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September 2021

In defence of our model for just healthcare systems: why an explicit philosophy is needed in addition to the law, and how Scanlon helps derive just policies.

J Med Ethics 2021 Sep 8. Epub 2021 Sep 8.

The Healthcare Improvement Studies (THIS) Institute, University of Cambridge School of Clinical Medicine, Cambridge, UK.

In a recent response to our paper on developing a philosophical framework to guide the design and delivery of a just health service, Sarela raises several objections. We feel that although Sarela makes points which are worthy of discussion, his critique does not undermine either the need for, or the worth of, our proposed model. First, the law does not negate the need for ethics in determining just healthcare policy. Read More

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September 2021

Leu IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling.

Environ Toxicol 2021 Sep 8. Epub 2021 Sep 8.

Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

The insulin-like growth factor II receptor (IGF-IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like Gαq or Gαs. Increased expression of the ligand IGF II and IGF-IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium-calmodulin (CaM)-dependent kinase II (CaMKII)-histone deacetylase 4 (HDAC4). The dried stigma of Crocus sativus L. Read More

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September 2021

Activation of cardiac Nmnat/NAD+/SIR2 pathways mediates endurance exercise resistance to lipotoxic cardiomyopathy in aging Drosophila.

J Exp Biol 2021 Sep 15;224(18). Epub 2021 Sep 15.

Ludong University, City Yantai 264025, Shandong Province, China.

Endurance exercise is an important way to resist and treat high-fat diet (HFD)-induced lipotoxic cardiomyopathy, but the underlying molecular mechanisms are poorly understood. Here, we used Drosophila to identify whether cardiac Nmnat/NAD+/SIR2 pathway activation mediates endurance exercise-induced resistance to lipotoxic cardiomyopathy. The results showed that endurance exercise activated the cardiac Nmnat/NAD+/SIR2/FOXO pathway and the Nmnat/NAD+/SIR2/PGC-1α pathway, including up-regulating cardiac Nmnat, SIR2, FOXO and PGC-1α expression, superoxide dismutase (SOD) activity and NAD+ levels, and it prevented HFD-induced or cardiac Nmnat knockdown-induced cardiac lipid accumulation, malondialdehyde (MDA) content and fibrillation increase, and fractional shortening decrease. Read More

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September 2021

Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction.

Pharm Biol 2021 Dec;59(1):1191-1202

Fujian Key Laboratory of Integrative Medicine on Geriatric, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Context: Huoxin pill (HXP) is a commonly used TCM prescription for treatment of cardiovascular diseases. However, its mechanism in protecting against myocardial infarction (MI) remains unknown.

Objective: We performed a network pharmacology analysis to explore the bioactive ingredients, therapeutic effects, and mechanisms of HXP in protecting against MI. Read More

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December 2021

Meta-analyses of maternal exposure to atmospheric particulate matter and risk of congenital anomalies in offspring.

Environ Sci Pollut Res Int 2021 Sep 7. Epub 2021 Sep 7.

Fujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.

Congenital anomalies are the main causes of infant death and disability. Previous studies have suggested that maternal exposure to particulate matter is related to congenital malformation. However, the conclusions of this study remain controversial. Read More

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September 2021