244,390 results match your criteria cardiac mortality


Outcomes of anterior vs. posterior approach to single-level lumbar spinal fusion with interbody device: An analysis of the nationwide inpatient sample.

Clin Neurol Neurosurg 2021 Nov 29;212:107061. Epub 2021 Nov 29.

Desert Regional Medical Center, Palm Springs, California, United States. Electronic address:

Background: Interbody devices have revolutionized lumbar spinal fusion surgery by improving mechanical stability and maximizing fusion potential. Several approaches for interbody fusion exist with two of the most common being anterior lumbar interbody fusion (ALIF) and posterior lumbar interbody fusion (PLIF). This study aims to compare patient data, hospital outcomes, and post-operative complications between an anterior vs. Read More

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November 2021

Exercise-Based Cardiac Rehabilitation: Secondary Data Analyses of Mortality and Working Capacity in Germany, 2010-2017.

Sports Med Open 2021 Dec 4;7(1):88. Epub 2021 Dec 4.

Department of Applied Health Sciences, University of Applied Sciences for Health, Bochum, Germany.

Background: Exercise-based cardiac rehabilitation is safe and implemented in international cardiac rehabilitation guidelines. Evidence for long-term health effects is scarce and rare for health care service research.

Objective: The aim of this study is to evaluate the effectiveness of exercise-based phase III cardiac rehabilitation programs in improving mortality and working capacity outcomes. Read More

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December 2021

Association of clinical and social factors with risk of fracture in children with atopic dermatitis.

Pediatr Allergy Immunol 2021 Dec 4. Epub 2021 Dec 4.

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Background: Children with atopic dermatitis (AD) have multiple risk factors for accidental fractures, injuries that can lead to significant morbidity and mortality. However, little is known about the factors that mediate the relationship between AD and fracture in children.

Objective: Our purpose was to examine the association of AD with fracture and to identify potential mediating factors. Read More

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December 2021

Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment.

Sci Rep 2021 Dec 3;11(1):23414. Epub 2021 Dec 3.

Stony Brook Medicine, Stony Brook, NY, USA.

The goal of the present work was to examine clinical risk factors for mortality in 1375 COVID + patients admitted to a hospital in Suffolk County, NY. Data were collated by the hospital epidemiological service for patients admitted from 3/7/2020 to 9/1/2020. Time until final discharge or death was the outcome. Read More

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December 2021

The heart & mind trial: intervention with cognitive-behavioural therapy in patients with cardiac disease and anxiety: randomised controlled trial protocol.

BMJ Open 2021 Dec 3;11(12):e057085. Epub 2021 Dec 3.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, 2200, Denmark.

Introduction: Patients with cardiac disease often experience anxiety (prevalence about 20%-25%) and have a doubled mortality risk when suffering from anxiety compared with patients without anxiety. This calls for interventions aiming to reduce anxiety.

Methods And Analysis: The Heart & Mind Trial consists of three parts: (1) screening of all hospitalised and outpatient cardiac patients with arrhythmia, heart failure or ischaemic heart disease at four university hospitals in Denmark using the Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A); Patients scoring ≥8 is invited to participate; (2) Assessment of the type of anxiety by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders and (3) Randomised clinical superiority trial with blinded outcome assessment, with 1:1 randomisation to cognitive-behavioural therapy (CBT) performed by a CBT-trained cardiac nurse plus usual care or, usual care alone. Read More

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December 2021

Global prevalence of dyslipidaemia in adult populations: a systematic review protocol.

BMJ Open 2021 Dec 3;11(12):e049662. Epub 2021 Dec 3.

School of Medicine, Taylor's University, Subang Jaya, Malaysia.

Introduction: Dyslipidaemia is one of the established risk factors for cardiovascular disease. Evidence from large-scale trials showed that effective treatment of dyslipidaemia can reduce all-cause and coronary mortality. To date, there is no published systematic review on the worldwide prevalence of dyslipidaemia in adults. Read More

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December 2021

Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES.

Diabetes Care 2021 Dec 3. Epub 2021 Dec 3.

Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China

Objective: Despite that periodical monitoring of cobalamin (vitamin B12) in metformin-treated patients with diabetes is recommended, cobalamin-associated mortality benefits or risks remain unclear. We investigated the association between cobalamin intake and related biomarkers and mortality risk in adults with diabetes using metformin or not.

Research Design And Methods: This study included 3,277 adults with type 2 diabetes from The National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2015. Read More

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December 2021

Impact of health literacy in patients with cardiovascular diseases: A systematic review and meta-analysis.

Patient Educ Couns 2021 Nov 27. Epub 2021 Nov 27.

Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe, Japan; Cardiovascular stroke Renal Project (CRP), Kobe, Japan. Electronic address:

Objective: To clarify the impacts of health literacy on mortality, readmission, and quality of life (QOL) in the secondary or tertiary prevention of cardiovascular diseases (CVD) through a meta-analysis.

Methods: Six electronic databases were searched on June 11, 2020. Observational studies involving patients with CVD, health literacy as an exposure factor and mortality, readmission, or QOL as outcomes were included in this study. Read More

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November 2021

The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States.

Mayo Clin Proc 2021 Dec 1. Epub 2021 Dec 1.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences, Keele University, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Objective: To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation.

Methods: All de novo CIED implantations in the United States National Inpatient Sample between 2015 and 2018 were retrospectively analyzed, stratified by CCI score (0=no comorbidity burden, 1=mild, 2=moderate, ≥3=severe). Multivariable logistic regression models were performed to examine the association between unit CCI score (scale) and in-hospital outcomes (major adverse cerebrovascular and cardiovascular events [MACCE]: composite of all-cause mortality, acute ischemic stroke, thoracic and cardiac complications, and device-related complications; and MACCE individual components). Read More

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December 2021

Characteristics and outcomes of octogenarians with revascularized critical limb ischemia: Impact of altered cardiac function for early mortality.

J Med Vasc 2021 Oct-Dec;46(5-6):224-231. Epub 2021 Nov 5.

Vascular medicine department, groupe hospitalier Paris Saint-Joseph, Paris, France.

Objective: Patients with critical limb ischemia (CLI) present with advanced age and end-stage organ damage, in particular heart failure. The aim of the present study is to describe clinical and biological characteristics in octogenarian patients with CLI compared to their younger counterparts and to determine the peri-procedural risk and early mortality after endovascular procedure.

Methods: From November 2013 to May 2019, 315 consecutive patients were retrospectively included. Read More

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November 2021

Individualised or liberal red blood cell transfusion after cardiac surgery: a randomised controlled trial.

Br J Anaesth 2021 Nov 30. Epub 2021 Nov 30.

Department of Anesthesiology and Critical Care Medicine, Amiens Picardy University Hospital, Amiens, France.

Background: Current practice guidelines for red blood cell (RBC) transfusion in ICUs are based on haemoglobin threshold, without consideration of oxygen delivery or consumption. We aimed to evaluate an individual physiological threshold-guided by central venous oxygen saturation ScvO.

Methods: In a randomised study in two French academic hospitals, 164 patients who were admitted to ICU after cardiac surgery with postoperative haemoglobin <9 g dl were randomised to receive a transfusion with one unit of RBCs (haemoglobin group) or transfusion only if the ScvO was <70% (individualised group). Read More

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November 2021

Targeted temperature management in cardiac surgery: a systematic review and meta-analysis on postoperative cognitive outcomes.

Br J Anaesth 2021 Nov 30. Epub 2021 Nov 30.

Department of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.

Background: Postoperative cognitive decline occurs commonly after cardiac surgery. The available literature is inconclusive on the role of intraoperative causal or protective factors.

Methods: We systematically reviewed studies evaluating delayed neurocognitive recovery (DNR), postoperative neurocognitive disorder (NCD), stroke, and the mortality rates among patients undergoing hypothermic or normothermic cardiopulmonary bypass (CPB). Read More

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November 2021

Changing spectrum of infective endocarditis in India: An 11-year experience from an academic hospital in North India.

Indian Heart J 2021 Nov-Dec;73(6):711-717. Epub 2021 Sep 16.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Objective: Several studies have demonstrated a shift in the spectrum of infective endocarditis (IE) in the developed world. We aimed to investigate whether demographic and microbiologic characteristics of IE have changed in India.

Design: A retrospective analysis of patients with in north India between 2010 and 2020. Read More

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September 2021

Therapeutic adherence in hypertension: Current evidence and expert opinion from India.

Indian Heart J 2021 Nov-Dec;73(6):667-673. Epub 2021 Sep 15.

Department of Neurology, Max Superspecialty Hospital, Saket, New Delhi, India. Electronic address:

Hypertension (HTN) is a globally prevalent non-communicable disease contributing significantly to cardiovascular (CV) morbidity and mortality. In achieving control of HTN, therapeutic adherence plays a crucial role. Studies from India identify varying rates of adherence to antihypertensive medications. Read More

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September 2021

The fatter, the better in old age: the current understanding of a difficult relationship.

Curr Opin Clin Nutr Metab Care 2021 Dec 1. Epub 2021 Dec 1.

Heart Institute (InCor), University of São Paulo Medical School, São Paulo/SP, Brazil Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland Department of Cardiology and Pneumology, University of Göttingen Medical Center (UMG) German Centre for Cardiovascular Research (DZHK) Partner Site, Göttingen, Germany.

Purpose Of Review: Obesity has shown a protective effect on mortality in older adults, also known as the obesity paradox, but there are still controversies about this relationship.

Recent Findings: Recent studies have shown a J or U-shaped relationship between BMI and mortality, wherein an optimal range is described between 22 and 37 kg/m2 depending on the condition. Many mechanisms can explain this protective effect of higher BMI, fat/muscle mass storage, more aggressive treatment in obese individuals, loss of bone mineral content and selection bias. Read More

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December 2021

Renin-angiotensin System Blocker in COVID-19. A Single Center Study.

J Cardiovasc Pharmacol 2021 Dec 1. Epub 2021 Dec 1.

Department of Medicine, University of Miami/JFK Medical Center Palm Beach Regional GME Consortium, Atlantis, Florida. Department of Cardiology, University of Miami/JFK Medical Center Palm Beach Regional GME Consortium, Atlantis, Florida.

Early during the Covid-19 pandemic, concerns were raised regarding potential adverse outcomes in patients taking ACEIs/ARBs. These concerns were based on animal studies showing increased ACE-2 expression in mice treated with ACEI/ARB. This is a single-center retrospective cohort study of 289 patients diagnosed with 2019 Novel Coronavirus (SARS-CoV-2) hospitalized between March of 2020 and June of 2020. Read More

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December 2021

Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer.

Transl Oncol 2021 Nov 30;15(1):101294. Epub 2021 Nov 30.

State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Tuanbo New Town West District, Poyang Lake Road, Jinghai District, Tianjin 301617, China; Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China. Electronic address:

Fibrosis and cancer is described by some epidemiological studies as chronic stages of different disease conditions typically characterized by uncontrolled accumulation of extra-cellular matrix (ECM), thereby leading to inflammation of tissues and organ (lungs, heart, liver and kidney) dysfunction. It is highly prevalent, and contributes to increased mortality rate worldwide. Currently, the therapeutical approaches involving selected medications (bemcentinib, pirfenidone and nintedanib) obtained synthetically, and used in clinical practices for fibrosis and cancer management and treatment has shown to be unsatisfactorily, especially during progressive stages of the disease. Read More

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November 2021

Attitudes among healthcare professionals towards cardiopulmonary resuscitation during COVID-19.

Am J Emerg Med 2021 Nov 15;52:34-42. Epub 2021 Nov 15.

Department of Emergency Medicine, The George Washington University, School of Medicine and Health Sciences, Washington, DC, United States. Electronic address:

Background: Out-of-hospital cardiac arrests (OHCAs) are a leading cause of mortality in the United States. The ongoing COVID-19 pandemic has dramatically altered the landscape of response to OHCAs, particularly with regard to providing cardiopulmonary resuscitation (CPR). We aimed to describe, characterize, and address the attitudes and concerns of healthcare workers towards CPR of OHCA patients during the COVID-19 pandemic. Read More

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November 2021

Beta-Blocker Use and Outcomes in Nursing Home Residents with Heart Failure with Reduced Ejection Fraction.

Am J Med 2021 Nov 30. Epub 2021 Nov 30.

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

Background: Beta-blockers improve clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF). Less is known about their role in older nursing home residents with HFrEF.

Methods: From the combined OPTIMIZE-HF and Alabama Heart Failure Project datasets, we assembled a propensity score-matched balanced cohort of 6494 hospitalized patients ≥65 years with HFrEF (ejection fraction ≤40%). Read More

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November 2021

Initiation of Anti-Hypertensive Drugs and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction.

Am J Med 2021 Nov 30. Epub 2021 Nov 30.

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

Background: In patients with heart failure with reduced ejection fraction (HFrEF) and hypertension, systolic blood pressure is recommended to be maintained below 130 mmHg, although this has not been shown to be associated with improved outcomes. We examined the association of anti-hypertensive drug initiation and outcomes in patients with HFrEF.

Methods: In the Medicare-linked OPTIMIZE-HF, 7966 patients with HFrEF (ejection fraction ≤40%) without renal failure were not receiving anti-hypertensive drugs before hospitalization, of whom 692 received discharge prescriptions for those drugs (thiazides and calcium channel blockers). Read More

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November 2021

Effect of changes in cerebral oximeter values during cardiac surgery on the incidence of postoperative neurocognitive deficits (POND): A retrospective study based on propensity score-matched analysis.

PLoS One 2021 3;16(12):e0260945. Epub 2021 Dec 3.

Department of Anaesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: The occurrence of postoperative neurocognitive deficits(POND)after major cardiac surgery is associated with an increase in perioperative mortality and morbidity. Oxidative stress caused by oxygen can affect neuronal damage, which can lead to POND. Whether the intraoperative rSO2 value reflects oxidative stress and the associated incidence of POND is unknown. Read More

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December 2021

Preoperative evaluation in thoracic surgery: limits of the patient's functional operability and consequence for perioperative anaesthesiologic management.

Curr Opin Anaesthesiol 2021 Dec 1. Epub 2021 Dec 1.

Institute of Anaesthesiology, Heart and Diabetes Centre NRW, Bad Oeynhausen, Ruhr University Bochum Institute of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Purpose Of Review: Preoperative evaluation of older and more morbid patients in thoracic surgery is getting more advanced. In this context, early risk stratification has a crucial role for adequate informed decision-making, and thus for generating favourable effects of clinical outcome.

Recent Findings: Recent findings confirm that many risk factors impair mortality and morbidity beyond classical medical findings like results of lung function tests and values of the revised cardiac risk index. Read More

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December 2021

Psychosocial Impact of Congenital Heart Diseases on Patients and Their Families: A Parent's Perspective.

World J Pediatr Congenit Heart Surg 2021 Dec 3:21501351211044127. Epub 2021 Dec 3.

27178Department of Cardiothoracic Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Background: Currently, over 90% of children with congenital heart disease (CHD) survive into adulthood. As a consequence the psychosocial impact on children and their families has become an important outcome measure. Therefore, the goal of this study was to assess the psychosocial impact from a parent's perspective and to identify possible predictors. Read More

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December 2021

Scalable and reversible axonal neuromodulation of the sympathetic chain for cardiac control.

Am J Physiol Heart Circ Physiol 2021 Dec 3. Epub 2021 Dec 3.

Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA; UCLA Molecular, Cellular and Integrative Physiology Program, Los Angeles, CA, Los Angeles, TN, United States.

Maladaptation of the sympathetic nervous system contributes to the progression of cardiovascular disease and risk for sudden cardiac death, the leading cause of mortality worldwide. Axonal modulation therapy (AMT) directed at the paravertebral chain blocks sympathetic efferent outflow to the heart, and may be a promising strategy to mitigate excess disease-associated sympathoexcitation. The present work evaluates AMT, directed at the sympathetic chain, in blocking sympathoexcitation using a porcine model. Read More

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December 2021

Hospital admissions in infants with down syndrome: a record-linked population-based cohort study in Wales.

J Intellect Disabil Res 2021 Dec 3. Epub 2021 Dec 3.

Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.

Background: Despite recent advances, mortality in children with Down syndrome remains five times higher than in the general population. This study aims to describe the burden, patterns and causes of hospital admissions in infants with Down syndrome, and compare this with infants without Down syndrome in a population-based cohort.

Methods: This study used data from the Wales Electronic Cohort for Children, a cohort of all children born in Wales between 1990 and 2012. Read More

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December 2021

Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.

J Pathol 2021 Dec 3. Epub 2021 Dec 3.

Dept. Experimental Immunology, Amsterdam University Medical Centers (UMC) and Amsterdam Infection and Immunity Institute, University of Amsterdam, Amsterdam, The Netherlands.

COVID-19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID-19 patients, we found extensive accumulation of the tryptophan degradation products 3-hydroxy anthranilic acid and quinolinic acid in lungs, heart, and brain. This was not related to the expression of the tryptophan-catabolizing indoleamine 2,3-dioxygenase (IDO)-1, but rather to that of its isoform IDO-2, which otherwise is expressed rarely. Read More

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December 2021

The association of admission random blood glucose concentration and body-mass index with mortality in COVID-19 patients.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):7144-7150

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.

Objective: This study aimed to investigate the association between hyperglycemia and body mass index (BMI), along with other associated comorbidities in hospitalized COVID-19 patients among the Indonesian population.

Patients And Methods: This was a retrospective study conducted at Hasan Sadikin Hospital, Bandung between March 1, 2020, and August 30, 2020. Data were analyzed using the chi-square test for categorical data and unpaired t-test and Mann-Whitney alternative test for numerical data using SPSS version 24. Read More

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November 2021

Metabolic syndrome and male lower urinary tract symptoms.

Panminerva Med 2021 Dec 3. Epub 2021 Dec 3.

Department of Urology, Inselspital University Hospital Berne, Berne, Switzerland.

Historically, urologists regarded prostate enlargement as the sole cause for male bladder problems. Nocturia, hesitancy, weak stream, and post void dribbling are classical symptoms that seemed to correlate solely to an enlarged prostate (benign prostate enlargement BPE resulting from benign prostatic hyperplasia BPH leading to bladder outlet obstruction BOO due to benign prostatic obstruction BPO). Over time, subdivision of symptoms into storage, voiding and post-voiding symptoms raised awareness of the urinary tract fine-tuning associated with urine storage and voiding, and led to the umbrella term "lower urinary tract symptoms (LUTS)", which respects bladder and prostate function. Read More

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December 2021

Impact of the new UNOS donor heart allocation system on waitlist outcomes and early post-transplant mortality among adults with congenital heart disease.

Am J Transplant 2021 Dec 3. Epub 2021 Dec 3.

Johns Hopkins University, USA.

Adults with congenital heart disease (ACHD) experience worse waitlist outcomes and higher early post-transplant mortality compared to non-ACHD patients. On October 18, 2018; the UNOS donor heart allocation system was redesigned giving unique listing status to ACHD patients. The impact of this change on outcomes in transplant-listed patients is unstudied. Read More

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December 2021

Communication of personalised disease risk by general practitioners to motivate smoking cessation in England: A cost-effectiveness and research prioritisation study.

Addiction 2021 Dec 2. Epub 2021 Dec 2.

National Heart & Lung Institute, Imperial College London, UK.

Background And Aims: Communication of personalised disease risk can motivate smoking cessation. We assessed whether routine implementation of this intervention by general practitioners (GPs) in England is cost-effective or whether we need further research to better establish its effectiveness.

Design: Cost-effectiveness analysis (CEA) with value of information (VoI) analysis from the UK National Health Service perspective, using GP communication of personalised disease risk on smoking cessation versus usual care. Read More

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December 2021