41,847 results match your criteria cardiac lesions


Pulsed field ablation selectively spares the oesophagus during pulmonary vein isolation for atrial fibrillation.

Europace 2021 May 7. Epub 2021 May 7.

IHU LIRYC-CHU Bordeaux, Univ. Bordeaux, Inserm U1045, Avenue du Haut Lévêque, 33604 Pessac, France.

Aims: Extra-atrial injury can cause complications after catheter ablation for atrial fibrillation (AF). Pulsed field ablation (PFA) has generated preclinical data suggesting that it selectively targets the myocardium. We sought to characterize extra-atrial injuries after pulmonary vein isolation (PVI) between PFA and thermal ablation methods. Read More

View Article and Full-Text PDF

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Front Cardiovasc Med 2021 20;8:655869. Epub 2021 Apr 20.

Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An improved understanding of the mechanisms that regulate VSMC phenotypic changes may provide insights that suggest new therapeutic targets in treatment of cardiovascular disease (CVD). Read More

View Article and Full-Text PDF

Remarkable Response to Cisplatin Doublet Chemotherapy in Pulmonary Metastasis With Left Atrial Extension From a Nasopharyngeal Cancer.

Cureus 2021 Mar 9;13(3):e13793. Epub 2021 Mar 9.

Pathology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung City, TWN.

A 60-year-old male patient whose nasopharyngeal carcinoma was brought to complete remission with induction chemotherapy composing of cisplatin plus fluorouracil and subsequent radiotherapy with intent of cure eight years ago presented with dyspnea due to left side massive pleural effusion with pleural seedings, left lower lobe huge space occupying lesion, and left atrial tumor extending from the intrapulmonary lesion through left inferior pulmonary veins. Pleural biopsy revealed a picture of nonkeratinizing squamous cell carcinoma positive for Epstein-Barr virus-encoded small RNAs in situ hybridization, leading to a diagnosis of late pulmonary metastases from the antecedent nasopharyngeal carcinoma. Systemic chemotherapy with initial cisplatin plus paclitaxel and subsequent cisplatin plus gemcitabine brought remarkable resolution to the malignant cardiac and intrathoracic lesions. Read More

View Article and Full-Text PDF

COVID-19 in Children with Congenital Heart Diseases: A Multicenter Case Series from Iran.

Case Rep Pediatr 2021 17;2021:6690695. Epub 2021 Apr 17.

Department of Pediatrics and Hand Hygiene and Infection Control Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Promptly discovering and counteracting COVID-19 is critical as it could have catastrophic effects. As an asymptomatic group, children are highly susceptible to be misdiagnosed, especially those suffering from underlying diseases. Furthermore, discriminating the direct effects of the virus from those of the underlying diseases can pose a dilemma to physicians. Read More

View Article and Full-Text PDF

Role of Indices Incorporating Power, Force and Time in AF Ablation: A Systematic Review of Literature.

Heart Lung Circ 2021 May 3. Epub 2021 May 3.

Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia; Lyell McEwin Hospital, Adelaide, SA, Australia. Electronic address:

Introduction: Successful pulmonary vein isolation (PVI) for atrial fibrillation (AF) depends on the formation of durable transmural lesions. Recently, novel indices have emerged to guide lesion delivery. The aim of the systematic review of literature was to determine AF recurrence following ablation guided by indices incorporating force, power and time, and compare acute procedural outcomes and 12-month AF recurrence with ablation guided by contact force (CF) guided only. Read More

View Article and Full-Text PDF

Toward Eliminating Perinatal Comfort Care for Prenatally Diagnosed Severe Congenital Heart Defects: A Vision.

Mayo Clin Proc 2021 May;96(5):1276-1287

Division of Maternal-Fetal Medicine, Mayo Clinic, Rochester, MN.

Over the past 40 years, the medical and surgical management of congenital heart disease has advanced considerably. However, substantial room for improvement remains for certain lesions that have high rates of morbidity and mortality. Although most congenital cardiac conditions are well tolerated during fetal development, certain abnormalities progress in severity over the course of gestation and impair the development of other organs, such as the lungs or airways. Read More

View Article and Full-Text PDF

Circumflex aorta: An uncharted territory.

Asian Cardiovasc Thorac Ann 2021 May 6:2184923211015092. Epub 2021 May 6.

Department of Cardiac Surgery, National Heart Institute, Kuala Lumpur, Malaysia.

Background: Vascular rings are aortic arch anomalies with a spectrum of manifestations ranging from asymptomatic lesions detected incidentally to an acute presentation secondary to tracheo-esophageal compression. Circumflex retro-esophageal aortic arch is an extreme form of true vascular ring. It remains an uncharted territory to many surgeons. Read More

View Article and Full-Text PDF

Intramuscular hemangioma in the zygomaticus minor muscle: a case report and literature review.

Arch Craniofac Surg 2021 Apr 20;22(2):115-118. Epub 2021 Apr 20.

TN Plastic and Reconstructive Surgery Clinic, Seoul, Korea.

Intramuscular hemangioma is a rare vascular benign proliferation that can occur within any muscle, particularly in the trunk and extremities. In the head and neck region, the masseter muscle is most commonly involved, followed by the periorbital and sternocleidomastoid muscles. Diagnosing intramuscular hemangioma is challenging because there are no characteristic symptoms; instead, magnetic resonance imaging is the best imaging modality to diagnose these lesions. Read More

View Article and Full-Text PDF

Discordant congenital heart defects in monochorionic twins: Risk factors and proposed pathophysiology.

PLoS One 2021 6;16(5):e0251160. Epub 2021 May 6.

David Geffen School of Medicine, UCLA, Los Angeles, California, United States of America.

A six-fold increase in congenital heart defects (CHD) exists among monochorionic (MC) twins compared to singleton or dichorionic twin pregnancies. Though MC twins share an identical genotype, discordant phenotypes related to CHD and other malformations have been described, with reported rates of concordance for various congenital anomalies at less than 20%. Our objective was to characterize the frequency and spectrum of CHD in a contemporary cohort of MC twins, coupled with genetic and clinical variables to provide insight into risk factors and pathophysiology of discordant CHD in MC twins. Read More

View Article and Full-Text PDF

Long-term impact of high-sensitivity C-reactive protein in patients with intermittent claudication due to peripheral artery disease following endovascular treatment.

Heart Vessels 2021 May 6. Epub 2021 May 6.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Little is known about the prognostic impact of high-sensitivity C-reactive protein (hs-CRP) levels on causes of death during long-term follow-up. We, therefore, investigated the associations between hs-CRP and clinical outcomes in the patients with intermittent claudication. Three hundred thirty-five consecutive patients (mean age, 72 ± 8 years, 82% men) undergoing first intervention for de novo iliac and/or femoropopliteal artery lesions from 2009 to 2020 were studied. Read More

View Article and Full-Text PDF

Yellow Fever as Cause of Death of Titi Monkeys ( Spp.).

Vet Pathol 2021 May 6:3009858211009781. Epub 2021 May 6.

Universidade de São Paulo, São Paulo, Brazil.

From 2016 to 2018, an epidemic wave of yellow fever (YF) occurred in Brazil, affecting a large number of Platyrrhini monkeys. Titi monkeys ( spp.) were severely affected yet pathological characterizations are lacking. Read More

View Article and Full-Text PDF

Integrating Ethnobotany, Phytochemistry, and Pharmacology of and : What Predictions can be Made for the European Smoketree?

Front Pharmacol 2021 19;12:662852. Epub 2021 Apr 19.

Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

The smoketree () is a historically known medicinal plant from Southeast Europe. Its ethnomedicinal use in skin and mucosal lesions is commonly accepted across countries. Other utilizations reported locally include fever reduction, cardiac diseases, hypertension, urinary diseases, cough, asthma, hemorrhoids, diabetes, numbness of arm, liver disease, and cancer. Read More

View Article and Full-Text PDF

[Roles of growth factors on vascular remodeling in pulmonary hypertension].

Nihon Yakurigaku Zasshi 2021 ;156(3):161-165

Department of Physiology, Aichi Medical University.

Pulmonary hypertension (PH) is defined as mean pulmonary arterial pressure at rest ≥25 mmHg. Pulmonary arterial hypertension (PAH) is classified as group 1 of PH and is a progressive and fatal disease of the pulmonary artery. The pathogenesis is sustained pulmonary vasoconstriction and pulmonary vascular remodeling, which cause progressive elevations in pulmonary vascular resistance and pulmonary arterial pressure. Read More

View Article and Full-Text PDF
January 2021

Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source.

J Atheroscler Thromb 2021 May 1. Epub 2021 May 1.

Department of Neurology, Tokyo Women's Medical University School of Medicine.

Aim: Embolic stroke of undetermined source (ESUS) is a clinical construct introduced to describe cryptogenic stroke cases with ambiguous diagnoses. Cardiac causes are recognized as a major cause of ESUS, Patent foramen ovale (PFO) being among them. We aimed to investigate the relationship between infarct patterns and PFO in patients with ESUS. Read More

View Article and Full-Text PDF

Quality of life and healthcare utilisation improvements after atrial fibrillation ablation.

Heart 2021 May 5. Epub 2021 May 5.

Department of Cardiology, AZ Sint-Jan AV, Bruges, WVL, Belgium.

Objective: Pulmonary vein isolation (PVI) guided by a standardised CLOSE (contiguous optimised lesions) protocol has been shown to increase clinical success after catheter ablation for paroxysmal atrial fibrillation (PAF). This study analysed healthcare utilisation and quality of life (QOL) outcomes from a large multicentre prospective study, measured association between QOL and atrial fibrillation (AF) burden and identified factors associated with lack of QOL improvement.

Methods: CLOSE-guided ablation was performed in 329 consecutive patients (age 61. Read More

View Article and Full-Text PDF

Native contrast visualization and tissue characterization of myocardial radiofrequency ablation and acetic acid chemoablation lesions at 0.55 T.

J Cardiovasc Magn Reson 2021 May 6;23(1):50. Epub 2021 May 6.

Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Purpose: Low-field (0.55 T) high-performance cardiovascular magnetic resonance (CMR) is an attractive platform for CMR-guided intervention as device heating is reduced around 7.5-fold compared to 1. Read More

View Article and Full-Text PDF

Circulating T regulatory cells in patients with psoriasis with and without atherosclerosis: A pilot comparative study before and after photochemotherapy.

Photodermatol Photoimmunol Photomed 2021 May 5. Epub 2021 May 5.

Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, PO box, 11562.

Evidence is accumulating proving the role of T regulatory cells (Tregs) in both psoriasis and atherosclerosis pathogenesis and treatment. Psoralen-ultraviolet A (PUVA) remains a standard line of therapy for psoriasis, particularly darker phototypes, whenever the risk-benefit ratio is waived carefully. Despite the well-known therapeutic effect of UV phototherapy on psoriasis cutaneous lesions, it is still unclear if its immunomodulatory function can positively impact cardiac comorbidities in patients with psoriasis, such as atherosclerosis. Read More

View Article and Full-Text PDF

Pre-eclampsia and late fetal growth restriction.

Minerva Obstet Gynecol 2021 May 5. Epub 2021 May 5.

Division of Obstetrics and Gynaecology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy -

There is a strong but complex relationship between fetal growth restriction and pre-eclampsia. According to the International Society for the Study of Hypertension in Pregnancy the co-existence of gestational hypertension and fetal growth restriction identifies pre-eclampsia with no need for other signs of maternal organ impairment. While early-onset fetal growth restriction and pre-eclampsia are often strictly associated, such association becomes looser in the late preterm and term periods. Read More

View Article and Full-Text PDF

LncRNA AFAP1-AS1 regulates proliferation and apoptosis of endometriosis through activating STAT3/TGF-β/Smad signaling via miR-424-5p.

J Obstet Gynaecol Res 2021 May 4. Epub 2021 May 4.

Reproductive Center, The First People's Hospital of Yueyang, Yueyang, China.

Aim: Endometriosis is a common gynecological disorder characterized by chronic pelvic pain and infertility, which negatively affects women's health worldwide. AFAP1-AS1 has been implicated in endometriosis lesions recently, but its mechanism of endometriosis progression remains unclear.

Methods: Endometrial stromal cells (ESCs) were used to identify the role of AFAP1-AS1 in endometriosis. Read More

View Article and Full-Text PDF

Cranial Mandibular Fibrosis Syndrome in Adult Farmed Rainbow Trout .

Pathogens 2021 Apr 30;10(5). Epub 2021 Apr 30.

International Centre of Excellence for Aquatic Animal Health, Cefas Weymouth Laboratory, Weymouth, Dorset DT4 8UB, UK.

An unusual condition affecting market size rainbow trout was investigated. This condition was prevalent for several years at low levels but affected a large proportion of stock during 2018 and 2019. Chronic fibrosis affecting cranial tissues and the jaw was observed in samples collected in 2018. Read More

View Article and Full-Text PDF

Antegrade versus Retrograde Techniques for Chronic Total Occlusions (CTO): A Review and Comparison of Techniques and Outcomes.

Expert Rev Cardiovasc Ther 2021 May 4. Epub 2021 May 4.

Division of Cardiology, Henry Ford Hospital, Detroit, MI.

: As the field of chronic total occlusion percutaneous coronary intervention has evolved, technical approaches have evolved and been refined.: In this review, we discuss the major techniques utilized in modern CTO PCI including antegrade wiring, antegrade dissection re-entry, retrograde wiring, and retrograde dissection re-entry. Retrograde techniques have been extensively studied in comparison to antegrade techniques. Read More

View Article and Full-Text PDF

Safety and efficacy of new-generation coronary bioresorbable scaffolds: a systematic review.

Minerva Cardiol Angiol 2021 May 4. Epub 2021 May 4.

UO Cardiologia, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy -

Introduction: The concept of bioresorbable scaffolds (BRS) born with the aim to reduce the rate of late and very late cardiac events related to drug-eluting stents. However, first-generation BRS failed to prove their short-term safety and efficacy. Based on data derived from early investigations, new-generation BRS have been developed and tested in preliminary studies. Read More

View Article and Full-Text PDF

Tricuspid valve in congenital heart disease: multimodality imaging and electrophysiological considerations.

Minerva Cardiol Angiol 2021 May 4. Epub 2021 May 4.

Department of Women's and Children's Health, University of Padua, Padua, Italy -

The tricuspid valve (TV) has been neglected for many years. Only recently, new studies demonstrated the prognostic role of the tricuspid valve lesions. In addition to that, new interventional approaches offer the possibility to non-invasively treat tricuspid valve disease. Read More

View Article and Full-Text PDF

Clinical Diagnosis of Central Vertigo in Patients With Dizziness in Emergency Practice.

Neurologist 2021 May 5;26(3):75-79. Epub 2021 May 5.

Department of Otorhinolaryngology, Dokkyo Medical University Saitama Medical Center, Saitama.

Background: Life-threatening diseases should be promptly identified to provide appropriate medical care for emergency outpatients experiencing dizziness. However, dizziness is associated with various medical conditions; thus, a definitive diagnosis is challenging. To accurately diagnose vertigo in an emergency outpatient, we conducted a survey on the need to identify vertigo patients in the current outpatient departments. Read More

View Article and Full-Text PDF

Transaxillary Approach for Surgical Repair of Simple Congenital Cardiac Lesions: Pitfalls, and Complications.

World J Pediatr Congenit Heart Surg 2021 May;12(3):337-343

Department of Pediatric Cardiology, 29286Amrita Institute of Medical Sciences and Research Centre, Edappally, Kochi, India.

Background: In the treatment of simple congenital cardiac lesions, percutaneous and cosmetic surgical approaches have steadily gained prominence. Surgically, right vertical axillary approach is sparsely used despite superior cosmesis and less pain and blood product usage. Knowledge of potential pitfalls could lead to its more widespread acceptance. Read More

View Article and Full-Text PDF

A Prospective, observational, Italian multi-center registry of self-aPposing® cOronary Stents in patients presenting with ST-segment Elevation Myocardial InfarcTION: The iPOSITION registry.

Cardiol J 2021 May 4. Epub 2021 May 4.

Interventional Cardiology Unit, "SS. Annunziata" Hospital, Chieti, Italy.

Background: Primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI) can be challenging for high thrombus burden and catecholamine-induced vasoconstriction. The Xposition-S stent was designed to prevent stent undersizing and minimize strut malapposition. We evaluated 1-year clinical outcomes of a nitinol, self-apposing®, sirolimus-eluting stent, pre-mounted on a novel balloon delivery system, in de novo lesions of patients presenting with STEMI undergoing pPCI. Read More

View Article and Full-Text PDF

Reconsideration of the diagnostic criteria required for PCV2 reproductive disease.

Vet J 2021 Jun 23;272:105660. Epub 2021 Mar 23.

University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, Veterinaerplatz 1, 1210 Vienna, Austria.

Porcine circovirus type 2 (PCV2) causes a variety of clinical conditions including PCV2-associated reproductive disease (PCV2-RD) characterized by late term abortions and mummifications. The generally accepted diagnostic triad includes the presence of reproductive disorders, the histopathological finding of myocarditis, and detection of moderate to high viral loads within the heart tissue. A new threshold of 10 PCV2 genome equivalents (GE)/g heart tissue is suggested to fulfil the third criterion using the diagnostic settings of quantitative real time PCR and in situ hybridization of 30 fetal heart tissues. Read More

View Article and Full-Text PDF

Variation in management of paediatric isolated bicuspid aortic valve: current practice survey.

Cardiol Young 2021 May 4:1-7. Epub 2021 May 4.

Department of Pediatrics, Division of Pediatric Cardiology, University of Wisconsin, Madison, WI, USA.

Background: Prior to the recent release of appropriate use criteria for imaging valvulopathies in children, follow-up of valvular lesions, including isolated bicuspid aortic valve, was not standardised. We describe current follow up, treatment, and intervention strategies for isolated bicuspid aortic valve with varying degrees of stenosis, regurgitation, and dilation in children up to 18 years old and compare them with newly released appropriate use criteria.

Methods: Online survey was sent to members of the American Academy of Pediatrics Section on Cardiology and Cardiac Surgery and PediHeartNet. Read More

View Article and Full-Text PDF

Intravascular Lithotripsy for Treatment of Calcified Coronary Lesions: Patient-Level Pooled Analysis of the Disrupt CAD Studies.

JACC Cardiovasc Interv 2021 Apr 20. Epub 2021 Apr 20.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

Aims: The clinical outcomes of intravascular lithotripsy (IVL) to optimize target lesion preparation in severely calcified de novo coronary stenoses have been examined in four prospective studies (Disrupt CAD I, II, III, and IV). The aim of this pooled analysis was to assess the cumulative safety and effectiveness of coronary IVL.

Methods: Patient data were pooled from the Disrupt CAD studies which shared uniform study criteria, endpoint definitions and adjudication, and procedural follow-up. Read More

View Article and Full-Text PDF

Food-induced anaphylaxis in children up to 3-years-old - preliminary study.

Allergol Immunopathol (Madr) 2021 1;49(3):56-64. Epub 2021 May 1.

Department of Pediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.

Introduction And Objectives: The aim of this study was to determine the frequency of food-induced anaphylaxis, analyze the symptoms, and triggering factors in a group of youngest children. Also, the study aims to estimate the frequency of anaphylaxis episodes in children in the Kuyavian-Pomeranian Voivodeship region.

Methods: Retrospective analysis of medical records of 29 children aged 0-3 years that presented symptoms of food-induced anaphylaxis. Read More

View Article and Full-Text PDF