1,883,034 results match your criteria cardiac dysfunction

Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis.

Acute Crit Care 2021 Jul 26. Epub 2021 Jul 26.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.

Background: Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC. Read More

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Non-asthmatic eosinophilic bronchitis is characterized by proximal airway eosinophilic inflammation as compared with classic asthma and cough variant asthma.

Clin Exp Allergy 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University.

Non-asthmatic eosinophilic bronchitis (NAEB) is a common cause of chronic cough . NAEB involves eosinophilic airway inflammation, which manifests as sputum eosinophilia similar to that in cough variant asthma (CVA), in which cough presents as the sole manifestation, or in classic asthma (CA) which is characterized by wheezing, dyspnea and cough . However, NAEB lacks the airway hyperresponsiveness associated with asthma. Read More

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Multiple functions of pyruvate kinase M2 in various cell types.

J Cell Physiol 2021 Jul 26. Epub 2021 Jul 26.

Department of Biochemistry, College of Medicine, Hallym University, Chuncheon, Republic of Korea.

Glucose metabolism is a mechanism by which energy is produced in form of adenosine triphosphate (ATP) by mitochondria and precursor metabolites are supplied to enable the ultimate enrichment of mature metabolites in the cell. Recently, glycolytic enzymes have been shown to have unconventional but important functions. Among these enzymes, pyruvate kinase M2 (PKM2) plays several roles including having conventional metabolic enzyme activity, and also being a transcriptional regulator and a protein kinase. Read More

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Altered central and peripheral hemodynamics during rhythmic handgrip exercise in young adults with SARS-CoV-2.

Exp Physiol 2021 Jul 26. Epub 2021 Jul 26.

Department of Health & Exercise Science, Appalachian State University, Boone, NC.

New Findings: What is the central question of this study? This study sought to investigate whether central and peripheral hemodynamics during handgrip exercise were different in young adults 3-4 weeks following infection with of SARS-CoV-2 compared with young healthy adults. What is the main finding and its importance? The main findings are that exercising heart rate was higher while brachial artery blood flow and vascular conductance were lower in the SARS-CoV-2 compared with the control group. These findings provide evidence for peripheral impairments to exercise among adults with SARS-CoV-2, which may contribute to exercise limitations. Read More

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MicroRNAs as Biomarkers for Personalized Anti-platelet Therapy.

Thromb Haemost 2021 Jul 26. Epub 2021 Jul 26.

Atherothrombosis and Vascular Biology, Baker Heart Research Institute - BHRI, Melbourne, Australia.

No Abstract. Read More

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Management of Children with the Trisomy 18 and Trisomy 13 Syndromes: Is there a Shift in the Paradigm of Care?

John C Carey

Am J Perinatol 2021 Jul 26. Epub 2021 Jul 26.

Department of Pediatrics, Division of Medical Genetics, University of Utah Health, Salt Lake City, Utah.

Objective:  The conventional view toward the management of infants with the trisomy 18 and trisomy 13 syndromes has been to recommend pure comfort care and the avoidance of technological interventions. This commentary aims to address the recently raised question about whether there has been a shift in the paradigm of the management of infants with the two conditions.

Study Design:  The study design includes narrative review of the literature. Read More

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Diagnostic Performance of Office versus Ambulatory Blood Pressure in Kidney Transplant Recipients.

Am J Nephrol 2021 Jul 26:1-11. Epub 2021 Jul 26.

Clinic of Nephrology and Renal Transplantation, Laiko General Hospital, Medical School of Athens, National and Kapodistrian University, Athens, Greece.

Introduction: Hypertension is the most prominent risk factor in kidney transplant recipients (KTRs). No study so far assessed in parallel the prevalence, control, and phenotypes of blood pressure (BP) or the accuracy of currently recommended office BP diagnostic thresholds in diagnosing elevated ambulatory BP in KTRs.

Methods: 205 stable KTRs underwent office BP measurements and 24-h ambulatory BP monitoring (ABPM). Read More

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Effects of High-Intensity Interval Training on the Vascular and Autonomic Components of the Baroreflex at Rest in Adolescents.

Pediatr Exerc Sci 2021 Jul 26:1-7. Epub 2021 Jul 26.

University of Exeter.

Purpose: In a sample of healthy adolescents, the authors aimed to investigate the effects of high-intensity interval exercise (HIIE) training and detraining on baroreflex sensitivity (BRS) and it's vascular and autonomic components at rest.

Methods: Nineteen volunteers were randomly allocated to (1) 4 weeks HIIE training performed 3 times per week or (2) a control condition with no intervention for the same duration as HIIE training. PRE, POST, and following 2 weeks of detraining resting supine heart rate and blood pressure were measured, and a cross-spectral method (integrated gain [gain in low frequency]) was used to determine BRS gain. Read More

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Caffeine Mouth Rinse Does Not Improve Time to Exhaustion in Male Trained Cyclists.

Int J Sport Nutr Exerc Metab 2021 Jul 26:1-8. Epub 2021 Jul 26.

University of Brasília.

This study investigated the effects of caffeine mouth rinse on cycling time to exhaustion (TTE) and physiological responses in trained cyclists. In a double-blinded randomized counterbalanced cross-over design, 10 recreationally trained male cyclists (mean ± SD: 32 ± 3 years, 72.8 ± 5. Read More

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Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2).

J Stroke Cerebrovasc Dis 2021 Jul 23;30(9):105940. Epub 2021 Jul 23.

Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Asymptomatic carotid artery stenosis (ACS) has a low risk of stroke. To achieve an advantage over noninterventional best medical treatment (BMT), carotid endarterectomy (CEA) or carotid artery stenting (CAS) must be performed with the lowest possible risk of stroke. Therefore, an analysis of risk-elevating factors is essential. Read More

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Different distillation stages Baijiu classification by temperature-programmed headspace-gas chromatography-ion mobility spectrometry and gas chromatography-olfactometry-mass spectrometry combined with chemometric strategies.

Food Chem 2021 Jun 21;365:130430. Epub 2021 Jun 21.

Beijing Key Laboratory of Quality and Safety, Beijing Technology and Business University, Beijing 100048, China; Key Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, China.

Liquid-liquid microextraction (LLME) combined with gas chromatography-olfactometry-mass spectrometry (GC-O-MS) was used to detect the variations in volatile compounds during the distillation process (head, heart, and tail) of raw Baijiu produced by different layers of fermented grains; 47 aroma compounds were sniffed and identified. Moreover, temperature-programmed headspace gas chromatography-ion mobility spectrometry (TP-HS-GC-IMS) was applied to characterize the Baijiu distillation process for the first time. The 3D fingerprint spectrum clearly showed a variation in volatile compounds from different distillation stages, and most compounds showed a downward trend. Read More

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Sediment quality assessment combining chemical and biological (non)target analysis.

Aquat Toxicol 2021 Jun 8;238:105883. Epub 2021 Jun 8.

Risk Assessment Research Center, Korea Institute of Ocean Science and Technology, Geoje 53201, Republic of Korea; Department of Ocean Science, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:

Aquatic sediments act as a storage for diverse mixtures of organic and inorganic contaminants. Nevertheless, most evaluations of contaminated sediments have been limited to the assessment of concentrations of target compounds and lethal effects on some test species. To identify the organic contaminants causing sub-lethal effects of contaminated sediment, this study combined chemical and biological (non)target analysis involving comprehensive two-dimensional gas chromatography coupled with a time-of-flight Mass Spectrometer (GCxGC/ToF-MS) analysis, embryonic malformation and high-throughput sequencing (RNA-seq) analysis on developing flounder. Read More

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Age and gender differences in physical heart failure symptom clusters.

Heart Lung 2021 Jul 23;50(6):832-837. Epub 2021 Jul 23.

Department of Adult Nursing, College of Nursing and Health Sciences, University of Massachusetts Dartmouth, 285 Old Westport Rd. North Dartmouth 02747, MA, United States.

Background: Gender differences exist in structure and function of the heart resulting in HF symptom variation. Previous HF symptom cluster research described symptom clusters that were linked to functional status, mortality, quality of life and rehospitalization. Age and gender differences between cluster groups were described in one study. Read More

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Readmission and reoperation after laryngeal dilation in children: NSQIP-P analysis.

Int J Pediatr Otorhinolaryngol 2021 Jul 12;149:110838. Epub 2021 Jul 12.

Department of Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine & Biomedical Sciences at the University at Buffalo, Buffalo, NY, USA. Electronic address:

Objective: To identify specific comorbidities and their relationship to complications in children who underwent laryngeal dilation, specifically comparing children with tracheostomy versus no tracheostomy as well as differences in outcomes between age groups.

Methods: Retrospective study analyzing data collected in the American College of Surgeons National Surgical Improvement - Pediatric Database (2015-2018). Patients were selected using Current Procedural Terminology code 31528. Read More

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Postoperative evaluation of left ventricular global strain using cardiac computed tomography in pediatric patients with congenital heart disease: A comparison with echocardiography.

Eur J Radiol 2021 Jul 21;142:109868. Epub 2021 Jul 21.

Diagnostic Imaging Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai 200127, PR China. Electronic address:

Purpose: We explored the feasibility and reproducibility of cardiac computed tomography (CCT)-derived left ventricular (LV) global strain in postoperative children
with congenital heart disease (CHD) and compared its correlation and agreement with transthoracic echocardiography (TTE).

Methods: Fifty-one patients (28 males, 23 females) were included who underwent clinically indicated retrospective electrocardiography-triggered CCT. and all patients underwent additional TTE on the same day. Read More

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ABC-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores.

Int J Infect Dis 2021 Jul 23. Epub 2021 Jul 23.

Infectious Diseases Physician, Hospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213 - Bonsucesso, Belo Horizonte, Brazil. Electronic address:

Objectives: The majority of available scores to assess mortality risk of coronavirus disease 19 (COVID-19) patients in the emergency department have high risk of bias. Therefore, our aim was to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients, and to compare this score with other existing ones.

Methods: Consecutive patients (≥18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Read More

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The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19.

Vascul Pharmacol 2021 Jul 23:106899. Epub 2021 Jul 23.

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address:

A new virus strain detected in late 2019 and not previously described in humans is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes corona virus disease (COVID-19). While potential therapeutic approaches for COVID-19 are being investigated, significant initiatives are being made to create protective drugs and study various antiviral agents to cure the infection. However, an effective treatment strategy against COVID-19 is worrisome inadequate. Read More

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J Am Soc Echocardiogr 2021 Jul 23. Epub 2021 Jul 23.

Department of Medicine and Surgery, University Milano-Bicocca, Milano, Italy; Department of cardiac, neural and metabolic sciences, Istituto Auxologico Italiano, IRCCS, Milano, Italy.

Introduction: Pulmonary capillary wedge pressure (PCWP) plays a pivotal role in cardiac disease diagnosis and management. Right heart catheterization (RHC) invasively provides accurate PCWP measurement, but it is impractical for widespread use in all patients. The left atrial expansion index (LAEI), measured by transthoracic echocardiography (TTE), describes the relative LA volume increase during the LA reservoir phase. Read More

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Variations in mitral valve leaflet and scallop anatomy on 3-dimensional transesophageal echocardiography.

J Am Soc Echocardiogr 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiology, Westchester Medical Center, New York Medical College, Valhalla, NY. Electronic address:

Background: Textbook depictions of the mitral valve often illustrate the valve being comprised of a single non-scalloped anterior leaflet, with the posterior leaflet having three symmetric and evenly spaced scallops. However, common variations in this anatomy have been noted in autopsy series for decades. Improved cardiac imaging with 3-dimensional transesophageal echocardiography (3D TEE) now affords the ability to detect variations in scallop anatomy in vivo. Read More

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Symptoms and Suffering at End of Life for Children with Complex Chronic Conditions.

J Pain Symptom Manage 2021 Jul 23. Epub 2021 Jul 23.

Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

Context: Children with cancer and cardiac disease suffer with high symptom burden at end of life (EOL). Little is known about the EOL experience for children with other complex chronic conditions (CCCs).

Objectives: To evaluate symptoms and suffering at EOL for children with noncancer, noncardiac CCCs as well as parental distress related to child suffering. Read More

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Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects.

Reprod Toxicol 2021 Jul 23. Epub 2021 Jul 23.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address:

Accumulating studies have been focused on the independent effects of air pollutants and ambient heat exposure on congenital heart defects (CHDs) but with inconsistent results, and their interactive effect remains unclear. A case-control study including 921 cases and 9210 controls was conducted in Changsha, China in warm season in 2015-2018. The gravidas were assigned monthly averages of daily air pollutants and daily maximum temperature using the nearest monitoring station method and city-wide average method, respectively, during the first trimester of pregnancy. Read More

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Gut inference: A computational modelling approach.

Biol Psychol 2021 Jul 23:108152. Epub 2021 Jul 23.

Laureate Institute for Brain Research, Tulsa, OK, United States; Oxley College of Health Sciences, University of Tulsa, Tulsa, OK, United States. Electronic address:

Neurocomputational theories have hypothesized that Bayesian inference underlies interoception, which has become a topic of recent experimental work in heartbeat perception. To extend this approach beyond cardiac interoception, we describe the application of a Bayesian computational model to a recently developed gastrointestinal interoception task completed by 40 healthy individuals undergoing simultaneous electroencephalogram (EEG) and peripheral physiological recording. We first present results that support the validity of this modelling approach. Read More

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LncRNA HCP5 in hBMSC-derived exosomes alleviates myocardial ischemia reperfusion injury by sponging miR-497 to activate IGF1/PI3K/AKT pathway.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu Province, PR China. Electronic address:

Ischemia/reperfusion (I/R) injury is an inevitable process during heart transplant and suppressing I/R injury could greatly improve the survival rate of recipients. Mesenchymal stem cells (MSCs) have positive effects on I/R. We aimed to investigate the mechanisms underlying the protective roles of MSCs in I/R. Read More

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Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment elevation myocardial infarction.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: To compare effectiveness and safety of clopidogrel, prasugrel, and ticagrelor among all-comers with ST-segment Elevation Myocardial Infarction (STEMI) and extend the knowledge from randomized clinical trials.

Methods: All consecutive patients with STEMI admitted to Copenhagen University Hospital, Rigshospitalet, from 2009 to 2016 were identified via the Eastern Danish Heart Registry. By individual linkage to Danish nationwide registries, claimed drugs and end points were obtained. Read More

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Cardiopulmonary exercise testing in COVID-19 patients at 3 months follow-up.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Cardiology Unit, DICATOV - Cardiothoracic and Vascular Department, IRCCS San Martino Hospital, Genoa, Italy; Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy. Electronic address:

Background: Long-term effects of Coronavirus Disease of 2019 (COVID-19) and their sustainability are of the utmost relevance. We aimed to determine: 1) functional capacity of COVID-19 survivors by cardiopulmonary exercise testing (CPET); 2) characteristics associated with cardiopulmonary exercise testing (CPET) performance; 3) safety and tolerability of CPET.

Methods: We prospectively enrolled consecutive patients with laboratory-confirmed COVID-19 discharged alive at Azienda Sanitaria Locale-3, Genoa. Read More

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Interplay between inflammation and microvascular obstruction in ST-elevation myocardial infarction: The importance of velocity.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.

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Pre-procedural ATI score (age-thrombus burden-index of microcirculatory resistance) predicts long-term clinical outcomes in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University Hospitals, Oxford, UK; Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

Background: The ATI (Age-Thrombus burden-Index of Microvascular Resistance [IMR]) score was developed to predict suboptimal myocardial reperfusion in patients with ST-Elevation Myocardial Infarction (STEMI). When applied in the early phases of revascularization (e.g. Read More

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Prenatal methylmercury exposure is associated with decrease heart rate variability in children.

Environ Res 2021 Jul 23:111744. Epub 2021 Jul 23.

Department of Paediatrics, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong. Electronic address:

Background: Although several epidemiological studies have suggested mercury (Hg) might be associated with cardiotoxicity, the impact of Hg exposure on cardiac autonomic activity and blood pressure in children has not been investigated at Hg exposure levels equivalent to the Environmental Protection Agency (EPA) reference dose.

Objective: To investigate the association between low dose prenatal and recent methylmercury (MeHg) exposures and cardiac autonomic function and blood pressure with adjustment for factors such as fish consumption among children from a high fish consumption coastal city.

Methods: Children aged 7-8 years were recruited from the birth cohort of our previous study. Read More

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Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development.

Dev Biol 2021 Jul 23. Epub 2021 Jul 23.

Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01650, United States. Electronic address:

Platelet derived growth factor beta and its receptor, Pdgfrb, play essential roles in the development of vascular mural cells, including pericytes and vascular smooth muscle cells. To determine if this role was conserved in zebrafish, we analyzed pdgfb and pdgfrb mutant lines. Similar to mouse, pdgfb and pdgfrb mutant zebrafish lack brain pericytes and exhibit anatomically selective loss of vascular smooth muscle coverage. Read More

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