66,022 results match your criteria cardiac biomarkers


Sepsis and the microcirculation: the impact on outcomes.

Curr Opin Anaesthesiol 2022 Jan 25. Epub 2022 Jan 25.

Department of Anesthesiology, Virginia Commonwealth University Health System, Richmond, Virginia, USA.

Purpose Of Review: Advances in the treatment of septic shock have historically focused on resuscitation endpoints, mainly mean arterial pressure and cardiac output. As the definitions of sepsis and septic shock have shifted to focus on the diversity of causes of dysregulated host-response we have seen an emerging phenotype where tissue hypoxia persists despite adequate macrocirculatory parameters. Interest in the topic of microcirculation is re-emerging as validated bedside techniques for hemodynamic monitoring, such as video microscopes, are becoming available. Read More

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January 2022

Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension.

Am J Respir Crit Care Med 2022 Jan 26. Epub 2022 Jan 26.

Imperial College London, London, United Kingdom of Great Britain and Northern Ireland;

Rationale: N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker of cardiac origin, is used to risk stratify patients with pulmonary arterial hypertension (PAH). Its limitations include poor sensitivity to early vascular pathology. Other biomarkers of vascular or systemic origin may also be useful in the management of PAH. Read More

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January 2022

Coding and regulatory variants are associated with serum protein levels and disease.

Nat Commun 2022 Jan 25;13(1):481. Epub 2022 Jan 25.

Icelandic Heart Association, Holtasmari 1, IS-201 Kopavogur, Kopavogur, Iceland.

Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current study, 54,469 low-frequency and common exome-array variants were compared to 4782 protein measurements in the serum of 5343 individuals from the AGES Reykjavik cohort. Read More

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January 2022

Cardiac oxidative stress: a potential tool for risk stratification in cardiac sarcoidosis.

Heart 2022 Jan 25. Epub 2022 Jan 25.

School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

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January 2022

Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis.

Heart 2022 Jan 25. Epub 2022 Jan 25.

Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Objective: Sudden cardiac death (SCD) is the major cause of death in cardiac sarcoidosis (CS). We aimed to identify the prognostic markers for sustained ventricular tachycardia (sVT) and SCD in patients with CS.

Methods: We performed a prospective observational cohort study for patients with CS diagnosed according to the Japanese or Heart Rhythm Society guidelines between June 2008 and March 2020 in our hospital. Read More

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January 2022

Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events.

Biomarkers 2022 Jan 26:1-17. Epub 2022 Jan 26.

Erasmus MC, University Medical Center Rotterdam, Department of Cardiology, the Netherlands.

Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent ACS or cardiac death. We used the BIOMArCS case-cohort, consisting of 187 patients who underwent serial blood sampling during one year follow-up post-ACS. Read More

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January 2022

Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca mishandling and preventive role of Klotho in mice to its potential mortality prediction in human.

Transl Res 2022 Jan 22. Epub 2022 Jan 22.

Cardiorenal Translational Laboratory, Institute of Research i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; CIBER-CV, Hospital Universitario 12 de Octubre, Madrid, Spain. Electronic address:

Biomarkers of mineral bone disorders (MBD) including phosphorus, fibroblast growth factor (FGF)-23 and Klotho are strongly altered in patients with acute kidney injury (AKI) who have high cardiac outcomes and mortality rates. However, the crosslink between MBD and cardiac damage after an AKI episode still remains unclear. We tested MBD and cardiac biomarkers in an experimental AKI model after 24 or 72 hours of folic acid injection and we analyzed structural cardiac remodeling, intracellular calcium (Ca) dynamics in cardiomyocytes and cardiac rhythm. Read More

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January 2022

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.

Alzheimers Dement 2022 Jan 25. Epub 2022 Jan 25.

Rosa & Co LLC, San Carlos, California, USA.

Introduction: The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood.

Methods: We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers and Lifestyle [AIBL] flagship study, n = 1087; the Alzheimer's Disease Neuroimaging Initiative [ADNI] 1 study, n = 819; and the Busselton Health Study [BHS], n = 4384), and we defined associations between APOE ε2 and ε4 and 569 plasma/serum lipid species. Read More

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January 2022

Neural oscillations track recovery of consciousness in acute traumatic brain injury patients.

Hum Brain Mapp 2022 Jan 25. Epub 2022 Jan 25.

Department of Psychology, University of California Los Angeles, Los Angeles, California, USA.

Electroencephalography (EEG), easily deployed at the bedside, is an attractive modality for deriving quantitative biomarkers of prognosis and differential diagnosis in severe brain injury and disorders of consciousness (DOC). Prior work by Schiff has identified four dynamic regimes of progressive recovery of consciousness defined by the presence or absence of thalamically-driven EEG oscillations. These four predefined categories (ABCD model) relate, on a theoretical level, to thalamocortical integrity and, on an empirical level, to behavioral outcome in patients with cardiac arrest coma etiologies. Read More

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January 2022

NT-proBNP and D-Dimer in acute decompensated heart failure: assessment of diagnostic accuracy and correlation with echocardiographic parameters.

Acta Cardiol 2022 Jan 25:1-6. Epub 2022 Jan 25.

Department of Cardiothoracic Surgery, University of Alabama School of Medicine, Birmingham, AL, USA.

Purpose: Abnormalities in coagulation and inflammation exist in heart failure. This study compares the diagnostic accuracy of NT-proBNP and D-Dimer and the correlation of these biomarkers with echocardiographic parameters in acute decompensated heart failure.

Methods: A retrospective cross-sectional/observational study was performed using 162 patients with acute decompensated heart failure and 253 age-matched controls. Read More

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January 2022

Assessment of stress response attenuation with caudal morphine using a surrogate marker during pediatric cardiac surgery.

Ann Card Anaesth 2022 Jan-Mar;25(1):61-66

Department of Studies and Research, Oman Medical Specialty Board, Muscat, Oman.

Background: Measurement of biomarkers representing sympathetic tone and the surgical stress response are helpful for objective comparison of anesthetic protocols.

Aims: The primary aim was to compare changes in chromogranin A levels following pump pediatric cardiac surgery between children who received bolus caudal morphine and those who received a conventional intravenous narcotic-based anesthesia regime. The secondary objectives were to compare hemodynamic responses to skin incision and the magnitude of the rise in blood sugar values between the groups. Read More

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January 2022

Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study.

Heart Lung 2022 Jan 10;52:136-145. Epub 2022 Jan 10.

Assistant professor in nursing, Department of Nursing, Maragheh University of Medical Sciences, Maragheh, Iran. Electronic address:

Background: COVID-19 causes fatal cardiac damages. Despite many overwhelming meta-analysis related to cardiac complications following COVID-19 disease, no umbrella meta-analysis study has been conducted.

Objectives: We aimed to report the summarized pooled incidences of cardiac complications in the overall, critically ill, and deceased patients, compare the cardiac complications between the severe/non-severe or deceased/non-deceased patients, and also compare poor outcomes between patients with/without acute myocardial injury (AMI). Read More

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January 2022

Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40-Year Study of Men.

J Am Heart Assoc 2022 Jan 24:e022006. Epub 2022 Jan 24.

Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health Boston MA.

Background Anxiety is linked to elevated risk of cardiometabolic disease onset, but the underlying mechanisms remain unclear. We examined the prospective association of 2 anxiety facets, neuroticism and worry, with cardiometabolic risk (CMR) trajectories for 4 decades. Methods and Results The sample comprised 1561 men from an ongoing adult male cohort. Read More

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January 2022

The platelet-lymphocyte ratio is a promising predictor of early postoperative acute kidney injury following cardiac surgery: a case-control study.

Ann Transl Med 2021 Dec;9(24):1751

School of Medicine, South China University of Technology, Guangzhou, China.

Background: Acute kidney injury (AKI) is a common complication following cardiac surgery. This study explored the correlation between hematological biomarkers and the occurrence of postoperative AKI following cardiac surgery.

Methods: This was a retrospective case-control, single-center study. Read More

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December 2021

Integrative Analysis of Bulk and Single-Cell RNA Sequencing Data Reveals Cell Types Involved in Heart Failure.

Front Bioeng Biotechnol 2021 5;9:779225. Epub 2022 Jan 5.

Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Owing to the high mortality rates of heart failure (HF), a more detailed description of the HF becomes extremely urgent. Since the pathogenesis of HF remain elusive, a thorough identification of the genetic factors will provide novel insights into the molecular basis of this cardiac dysfunction. In our research, we performed publicly available transcriptome profiling datasets, including non-failure (NF), dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) hearts tissues. Read More

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January 2022

Molecular signaling pathways in right ventricular impairment of adult patients after tetralogy of Fallot repair.

Cardiovasc Diagn Ther 2021 Dec;11(6):1295-1309

Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany.

Background: Right ventricular impairment (RVI) secondary to altered hemodynamics contributes to morbidity and mortality in adult patients after tetralogy of Fallot (TOF) repair. The goal of this study was to describe signaling pathways contributing to right ventricular (RV) remodeling by analyzing over lifetime alterations of RV gene expression in affected patients.

Methods: RV tissue was collected at the time of cardiac surgery in 13 patients with a diagnosis of TOF. Read More

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December 2021

ELABELA acts as a protective biomarker in patients with atrial fibrillation.

J Thorac Dis 2021 Dec;13(12):6876-6884

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Atrial fibrillation (AF) is the most common type of clinical arrhythmia. An early diagnosis can be beneficial in the prevention of complications, such as heart failure (HF) and stroke. In this study, we revealed that ELABELA (ELA) acts as a protective factor in patients with arrhythmia and could serve as a prognostic marker for AF and its associated complication of HF. Read More

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December 2021

Potential biomarkers of acute myocardial infarction based on co-expression network analysis.

Exp Ther Med 2022 Feb 21;23(2):162. Epub 2021 Dec 21.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.

Acute myocardial infarction (AMI) is a common cause of death in numerous countries. Understanding the molecular mechanisms of the disease and analyzing potential biomarkers of AMI is crucial. However, specific diagnostic biomarkers have thus far not been fully established and candidate regulatory targets for AMI remain to be determined. Read More

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February 2022

Diagnosis and Management of Cirrhotic Cardiomyopathy.

J Clin Exp Hepatol 2022 Jan-Feb;12(1):186-199. Epub 2021 Aug 21.

Department of Hepatology, Postgraduate Institute of Medical Education and Research, 60012, Chandigarh, India.

Background: Cirrhotic cardiomyopathy refers to the structural and functional changes in the heart leading to either impaired systolic, diastolic, electrocardiographic, and neurohormonal changes associated with cirrhosis and portal hypertension. Cirrhotic cardiomyopathy is present in 50% of patients with cirrhosis and is clinically seen as impaired contractility, diastolic dysfunction, hyperdynamic circulation, and electromechanical desynchrony such as QT prolongation. In this review, we will discuss the cardiac physiology principles underlying cirrhotic cardiomyopathy, imaging techniques such as cardiac magnetic resonance imaging and scintigraphy, cardiac biomarkers, and newer echocardiographic techniques such as tissue Doppler imaging and speckle tracking, and emerging treatments to improve outcomes. Read More

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The regulation of PBXs and their emerging role in cancer.

J Cell Mol Med 2022 Jan 23. Epub 2022 Jan 23.

Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, China.

Pre-B-cell leukaemia transcription factor (PBX) proteins are a subfamily of evolutionarily conserved, atypical homeodomain transcription factors that belong to the superfamily of three amino acid loop extension (TALE) homeodomain proteins. Members of the PBX family play crucial roles in regulating multiple pathophysiological processes, such as the development of organs, congenital cardiac defects and carcinogenesis. The dysregulation of PBXs has been shown to be closely associated with many diseases, particularly cancer. Read More

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January 2022

Plasma levels of miRNA-1-3p are associated with subclinical atrial fibrillation in patients with cryptogenic stroke.

Rev Esp Cardiol (Engl Ed) 2022 Jan 20. Epub 2022 Jan 20.

Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Parc de Salut Mar, Barcelona, Spain; Servicio de Cardiología, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.

Introduction And Objectives: Identifying biomarkers of subclinical atrial fibrillation (AF) is of most interest in patients with cryptogenic stroke (CrS). We sought to evaluate the circulating microRNA (miRNA) profile of patients with CrS and AF compared with those in persistent sinus rhythm.

Methods: Among 64 consecutive patients with CrS under continuous monitoring by a predischarge insertable monitor, 18 patients (9 with AF and 9 in persistent sinus rhythm) were selected for high-throughput determination of 754 miRNAs. Read More

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January 2022

Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol.

Neurol Res Pract 2022 Jan 24;4(1). Epub 2022 Jan 24.

Department of Neurology, Yale University School of Medicine, New Haven, CT, 06520, USA.

Background: Nearly one in three unconscious cardiac arrest survivors experience post-anoxic status epilepticus (PASE). Historically, PASE has been deemed untreatable resulting in its exclusion from status epilepticus clinical trials. However, emerging reports of survivors achieving functional independence following early and aggressive treatment of PASE challenged this widespread therapeutic nihilism. Read More

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January 2022

Exploring a new method for the assessment of metal exposure by analysis of exhaled breath of welders.

Int Arch Occup Environ Health 2022 Jan 23. Epub 2022 Jan 23.

Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 414, 405 30, Gothenburg, Sweden.

Purpose: Air monitoring has been the accepted exposure assessment of toxic metals from, e.g., welding, but a method characterizing the actual dose delivered to the lungs would be preferable. Read More

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January 2022

Esmolol TO Treat The Hemodynamic Effects of Septic Shock: A Randomized Controlled Trial.

Shock 2021 Dec 27. Epub 2021 Dec 27.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts Department of Medicine, Division of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts Department of Medicine, Division of Critical Care Medicine, Montefiore Medical Center, Bronx, New York Department of Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Introduction: Septic shock is often characterized by tachycardia and a hyperdynamic hemodynamic profile. Use of the beta antagonist esmolol has been proposed as a therapy to lower heart rate, thereby improving diastolic filling time and improving cardiac output, resulting in a reduction in vasopressor support.

Methods: We conducted a two-center, open-label, randomized, Phase II trial comparing esmolol to placebo in septic shock patients with tachycardia. Read More

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December 2021

Circulating serum microRNAs including senescent miR-31-5p are associated with incident fragility fractures in older postmenopausal women with type 2 diabetes mellitus.

Bone 2022 Jan 20:116308. Epub 2022 Jan 20.

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Fragility fractures are an important hallmark of aging and an increasingly recognized complication of Type 2 diabetes (T2D). T2D individuals have been found to exhibit an increased fracture risk despite elevated bone mineral density (BMD) by dual X-ray absorptiometry (DXA). However, BMD and FRAX-scores tend to underestimate fracture risk in T2D. Read More

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January 2022

Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma -a systematic review and meta-analysis.

Transl Res 2022 Jan 20. Epub 2022 Jan 20.

Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Szigeti út 12, Hungary; János Szentágothai Research Center, University of Pécs, 7624 Pécs, Szigeti út 12, Hungary; Center for Translational Medicine, Semmelweis University, 1085 Budapest, Üllői út 26, Hungary; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, 1085 Budapest, Baross út 22-24, Hungary. Electronic address:

Extensive research is focused on the role of liquid biopsy in pancreatic cancer since reliable diagnostic and follow-up biomarkers represent an unmet need for this highly lethal malignancy. We performed a systematic review and meta-analysis on the prognostic value of exosomal biomarkers in pancreatic ductal adenocarcinoma (PDAC). MEDLINE, Embase, Scopus, Web of Science, and CENTRAL were systematically searched on the 18th of January, 2021 for studies reporting on the differences in overall (OS) and progression-free survival (PFS) in PDAC patients with positive versus negative exosomal biomarkers isolated from blood. Read More

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January 2022

Validation of ICD-10-AM Coding for Myocardial Infarction Subtype in Hospitalisation Data.

Heart Lung Circ 2022 Jan 19. Epub 2022 Jan 19.

School of Population and Global Health, The University of Western Australia, Perth, WA, Australia.

Background: International Classification of Disease (ICD) codes are central for identifying myocardial infarction (MI) in administrative hospitalisation data, however validation of MI subtype codes is limited. We measured the sensitivity and specificity of ICD-10-AM (Australian Modification) codes for ST-elevation MI (STEMI) and non-STEMI (NSTEMI).

Methods: A sample of MI admissions was obtained from a dataset containing all MI hospitalisations in Western Australia (WA) for 2003, 2008 and 2013. Read More

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January 2022

Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study.

Lancet 2022 Jan;399(10322):359-371

Departments of Medicine and Pediatrics, University of North Carolina, Chapel Hill, NC, USA.

Background: For young children with peanut allergy, dietary avoidance is the current standard of care. We aimed to assess whether peanut oral immunotherapy can induce desensitisation (an increased allergic reaction threshold while on therapy) or remission (a state of non-responsiveness after discontinuation of immunotherapy) in this population.

Methods: We did a randomised, double-blind, placebo-controlled study in five US academic medical centres. Read More

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January 2022

Characteristics of Zn Content and Localization, Cu-Zn SOD, and MT Levels in the Tissues of Marginally Zn-Deficient Mice.

Biol Trace Elem Res 2022 Jan 22. Epub 2022 Jan 22.

Department of Preventive Medicine, School of Public Health, Wuhan University, Wuhan, 430071, People's Republic of China.

Zinc (Zn) is an important trace element in the human body, and Zn deficiency affects the Zn content of major tissues. Marginal Zn deficiency is more common than severe Zn deficiency in humans. The objective of the present study was to compare the content and distribution of Zn and the change in the copper (Cu)-Zn superoxide dismutase (SOD) and metallothionein (MT) levels of soft tissues. Read More

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January 2022

Disturbed lipid and amino acid metabolisms in COVID-19 patients.

J Mol Med (Berl) 2022 Jan 22. Epub 2022 Jan 22.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20251, Hamburg, Germany.

The Coronavirus disease 2019 (COVID-19) pandemic is overwhelming the healthcare systems. Identification of systemic reactions underlying COVID-19 will lead to new biomarkers and therapeutic targets for monitoring and early intervention in this viral infection. We performed targeted metabolomics covering up to 630 metabolites within several key metabolic pathways in plasma samples of 20 hospitalized COVID-19 patients and 37 matched controls. Read More

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January 2022