10,131 results match your criteria cardiac anomaly

Complications associated with myocardial bridging in four children without underlying cardiac disease: a case series.

Paediatr Int Child Health 2021 Jun 11:1-7. Epub 2021 Jun 11.

Department of Life Sciences and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Myocardial bridging is largely considered to be a benign, symptomless congenital anomaly of the coronary arteries in which the intramyocardial coronary course is partially 'tunnelled' and leads to vessel compression during ventricular systole. There are few data regarding children. To report on myocardial bridging observed in children seeking medical help in the paediatric emergency room. Read More

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First trimester sonographic diagnosis of limb-body wall defect associating both cephalic and thoraco-abdominal defects - a case report and literature update.

Med Ultrason 2021 May 30. Epub 2021 May 30.

1st Department of Obstetrics and Gynecology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

We present the first trimester prenatal ultrasonography and pathological assessment of a case diagnosed with limb-body wall complex (LBWC) presenting both exenchephaly and a complex thoraco-abdominal wall defect. Ectopia cordis is demonstrated with a movie showing the heart beating outside the body of the fetus after its expulsion. Also, we discuss the pathogenesis and possible etiology of LBWC and associated malformations and we provide an update of the literature of this very rare anomaly. Read More

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Cardiogenic shock in the context of newly diagnosed anomalous origin of the right coronary artery originating from the pulmonary artery: a case report.

Eur Heart J Case Rep 2021 Mar 31;5(3):ytab030. Epub 2021 Mar 31.

Department of Medicine, Division of Cardiology, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada.

Background: Anomalous right coronary artery (RCA) from the pulmonary artery (ARCAPA) is a rare congenital heart abnormality with varying clinical presentations, for which multiple imaging modalities are often required for diagnosis.

Case Summary: We present a case of a 76-year-old female presenting with 2 weeks of palpitations and shortness of breath who was found to be in rapid atrial fibrillation (AF) with congestive heart failure. Despite initial medical management, the patient developed cardiogenic shock with anuric renal failure. Read More

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Is arterial switch operation possible with neonatology-focused intensive care unit modality.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):136-142. Epub 2021 Apr 26.

Department of Pediatric Cardiology, Health Sciences University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Background: In this study, we aimed to examine the feasibility of arterial switch operation and its perioperative management with neonatology-focused intensive care modality in a region of Turkey where the birth rate and the number of asylum seekers who had to leave their country due to regional conflicts are high.

Methods: Between December 2017 and June 2020, a total of 57 patients (48 males, 9 females; median age: 12.2 days; range, 2 to 50 days) who were diagnosed with transposition of the great arteries in our clinic and underwent arterial switch operation were retrospectively analyzed. Read More

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Transposition of the great arteries with total anomalous pulmonary venous connection in a 1½year-old child: Pulmonary arterial hypertension - An advantage.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):235-238. Epub 2021 Feb 16.

Sri Sathya Sai Sanjeevani International Paediatric Cardiac Centre, Raipur, Chhattisgarh, India.

Transposition of the great arteries with total anomalous pulmonary venous connection is a rare anomaly with varied management approach depending on the time of presentation; the management of cases which present early is usually by anatomical surgical approach while late presentation is by physiologic approach. This is due to early left ventricular mass regression as a result of the absence of volume and pressure load to the left ventricle (LV). We report a late presentation (at 1½ years of age) that had a successful anatomic surgical correction because the LV was "prepared" by both pressure and volume load from pulmonary arterial hypertension and large ostium secundum atrial septal defect. Read More

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February 2021

A comprehensive study of congenital unilateral absence of branch pulmonary artery associated with other congenital heart defects and ipsilateral non-unifocalizable major aorto-pulmonary collateral arteries: A single-center retrospective study.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):139-145. Epub 2021 Apr 10.

RXDX Healthcare and Teleradiology Solutions, Bengaluru, Karnataka, India.

Introduction: Congenital unilateral absence of pulmonary artery (UAPA) is a rare congenital anomaly with the complete absence of intrapericardial segment of one of the branch pulmonary arteries. Sixty percent are associated with other congenital heart defects (CHD) that often need correction.

Aim: To analyze the data of patients with UAPA and ipsilateral non-unifocalizable major aortopulmonary collateral arteries (MAPCAs) associated with other CHD to identify the commonly associated CHD, their management strategies and outcomes. Read More

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CT evaluation of unrepaired/incidental congenital cardiovascular diseases in adults.

Diagn Interv Imaging 2021 Apr 21;102(4):213-224. Epub 2020 Oct 21.

Department of Radiological Sciences, Thoracic and Diagnostic Cardiovascular Imaging, David Geffen School of Medicine, 90095 Los Angeles, CA, USA.

Congenital heart disease (CHD) affects approximately one million people in the USA with the number increasing by 5% each year. Patients are usually both diagnosed and treated in infancy, however many of them may have subclinical CHD that remains undiagnosed until late adulthood. Patients with complex CHD tend to be symptomatic and are diagnosed at a younger age than those with a single defect. Read More

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is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.

Elife 2021 Jun 8;10. Epub 2021 Jun 8.

Shanghai Pediatric Congenital Heart Disease Institute and Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Chromosome 4q deletion is one of the most frequently detected genomic imbalance events in congenital heart disease (CHD) patients. However, a portion of CHD-associated 4q deletions without known CHD genes suggests unknown CHD genes within these intervals. Here, we have shown that knockdown of , a 4q interval gene, disrupted sarcomeric integrity of cardiomyocytes and caused reduced cardiomyocyte number in human embryonic stem cell differentiation model. Read More

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Characterization of hemodynamic patterns in human fetuses with cyanotic congenital heart disease using MRI.

Ultrasound Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Division of Paediatric Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada.

Objectives: To characterize the distribution of blood flow and oxygen transport in human fetuses with congenital heart disease (CHD) subtypes that present with neonatal cyanosis using magnetic resonance imaging (MRI).

Methods: Blood flow was measured in the major vessels of 152 late gestation human fetuses with CHD and 40 gestational age-matched normal fetuses using cine phase contrast MRI. Oxygen saturation (SaO2) was measured in the major vessels of 57 fetuses with CHD and 40 controls. Read More

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Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: A retrospective study.

J Vet Intern Med 2021 Jun 7. Epub 2021 Jun 7.

Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Belgium.

Background: Hypochloremia is a strong negative prognostic factor in humans with congestive heart failure (CHF), but the implications of electrolyte abnormalities in small animals with acute CHF are unclear.

Objectives: To document electrolyte abnormalities present upon admission of small animals with acute CHF, and to assess the relationship between electrolyte concentrations and diuretic dose, duration of hospitalization and survival time.

Animals: Forty-six dogs and 34 cats with first onset of acute CHF. Read More

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Absent pulmonary valve with tricuspid atresia/stenosis: literature review with new three long-term cases.

Heart Vessels 2021 Jun 5. Epub 2021 Jun 5.

Department of Pediatric Cardiology, Osaka City General Hospital, Osaka, Japan.

Absent pulmonary valve (APV) syndrome with tricuspid atresia or tricuspid stenosis (TA/TS) is an extremely rare malformation recently reported as a variant of APV with intact ventricular septum (VS). The condition, however, has univentricular physiology and unique structural and clinical features. The purpose of this study was to update the current knowledge about this condition by describing long-term outcomes of three new cases and reviewing the available literatures. Read More

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Congenital Malformation Risk According to Hemoglobin A1c Values in a Contemporary Cohort with Pregestational Diabetes.

Am J Perinatol 2021 Jun 4. Epub 2021 Jun 4.

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.

Objective:  The study aimed to evaluate the association between hemoglobin A1c values and likelihood of fetal anomalies in women with pregestational diabetes.

Study Design:  Women with pregestational diabetes who delivered at a single institution that serves a nonreferred population from May 1, 2009 to December 31, 2018 were ascertained. Hemoglobin A1c values were obtained at the first prenatal visit. Read More

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Should isolated aberrant right subclavian artery be ignored in the antenatal period? A management dilemma

Turk J Obstet Gynecol 2021 06;18(2):103-108

Biruni University Faculty of Medicine, Department of Perinatology, İstanbul, Turkey

Objective: To investigate the frequency and types of chromosomal abnormalities in fetuses with the aberrant right subclavian artery (ARSA) and to evaluate its association with other ultrasonographic findings.

Materials And Methods: In all, 11,666 fetal anatomic surveys were performed between March 2014 and March 2020. The cases diagnosed as ARSA were examined. Read More

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Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant.

Am J Med Genet A 2021 Jun 3. Epub 2021 Jun 3.

Unidade de Genética, Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Noonan syndrome (NS) is a Mendelian phenotype, member of a group of disorders sharing neurocardiofaciocutaneous involvement, known as RASopathies, caused by germline variants in genes coding for components of the RAS/MAPK signaling pathway. Recently, a novel gene of the RAS family (MRAS) was reported to be associated with NS in five children, all of them presenting, among the cardinal features of NS, the same cardiac finding, hypertrophic cardiomyopathy (HCM). We report on a 2-month-old infant boy also presenting this cardiac anomaly that evolved to a fatal outcome after a surgical myectomy. Read More

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Cephalic/cardiac neural crest cell and moyamoya disease.

Neuroradiol J 2021 Jun 2:19714009211021780. Epub 2021 Jun 2.

Department of Neurointervention, Osaka City General Hospital, Japan.

Background: The neural crest is a transient structure present in early embryogenesis. Cephalic neural crest cells migrate into the pharyngeal arches and the frontonasal process that becomes the forehead and midfacial structures. They also contribute to forming the media of the arteries of the circle of Willis and their branches. Read More

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BeSafe B2.0 Smart Multisensory Platform for Safety in Workplaces.

Sensors (Basel) 2021 May 12;21(10). Epub 2021 May 12.

BISITE Research Group, University of Salamanca, Calle Espejo s/n. Edificio Multiusos I+D+i, 37007 Salamanca, Spain.

Wearable technologies are becoming a profitable means of monitoring a person's health state, such as heart rate and physical activity. The use of the smartwatch is becoming consolidated, not only as a novelty but also as a very useful tool for daily use. In addition, other devices, such as helmets or belts, are beneficial for monitoring workers and the early detection of any anomaly. Read More

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Respiratory Trajectory after Invasive Interventions for Patent Ductus Arteriosus of Preterm Infants.

Children (Basel) 2021 May 15;8(5). Epub 2021 May 15.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.

Invasive interventions have been conducted in preterm infants with significant patent ductus arteriosus (PDA) when medical treatment has failed, and methods of invasive intervention have been reported. Surgical ligation via lateral thoracotomy has been a well-established procedure for decades. Recently, transcatheter occlusion has been safely and feasibly applied to the premature population. Read More

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Cross-sectional analysis and trend of vertebral and associated anomalies in Chinese congenital scoliosis population: a retrospective study of one thousand, two hundred and eighty nine surgical cases from 2010 to 2019.

Int Orthop 2021 Jun 1. Epub 2021 Jun 1.

Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) & Chinese Academy of Medical Sciences (CAMS), 1st Shuaifuyuan Hutong, Beijing, 100730, People's Republic of China.

Purpose: The objective of this article is to report associated anomaly incidences of a large CS cohort and analyze interrelationships among vertebral anomaly types and associated abnormalities.

Methods: We retrospectively searched and extracted medical records of 1289 CS inpatients surgically treated in our institute from January 2010 to December 2019. All patients have taken spine X-ray, CT, MRI, echocardiogram, urogenital ultrasound, and systemic physical examination. Read More

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Commentary on a Neonate with Hypocalcemia and Cardiac Anomaly.

Monica H Wojcik

Clin Chem 2021 Jun;67(6):827-828

Divisions of Newborn Medicine and Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

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Commentary on a Neonate with Hypocalcemia and Cardiac Anomaly.

Clin Chem 2021 Jun;67(6):827

Department of Pathology, Oregon Health & Science University, Mailcode HRC-9, Portland.

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A Neonate with Hypocalcemia and Cardiac Anomaly.

Clin Chem 2021 Jun;67(6):823-826

Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia.

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Surgical treatment of Ebstein anomaly in pediatric patients: A 10-year single-center study.

J Card Surg 2021 May 30. Epub 2021 May 30.

Department of Pediatric Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.

Objective: We report the early and long-term results of the strategies and surgical methods used in our center to treat pediatric patients who underwent surgical intervention to correct Ebstein anomaly (EA) in our center.

Materials And Methods: In our study, a consecutive sample of 29 patients who underwent surgery for EA between February 2011 and February 2020 in our center were evaluated retrospectively.

Results: The 29 patients underwent a total of 40 operations. Read More

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Surgical repair of discontinuous right pulmonary artery utilising an autologous main pulmonary artery flap: a case report and literature review.

Cardiol Young 2021 May 31:1-3. Epub 2021 May 31.

Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, USA.

This is a case of an infant with unilateral discontinuous right pulmonary artery. Cardiac catheterisation with pulmonary wedge injection diagnosed the anomaly and aided in surgical planning. The patient underwent semi-autologous surgical repair utilising an autologous main pulmonary artery flap. Read More

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Prenatal histological, cellular, and molecular anomalies in Trisomy 21 lung.

J Pathol 2021 May 29. Epub 2021 May 29.

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Down Syndrome (DS), also known as Trisomy 21 (T21), is the most common human chromosomal anomaly. Although DS can affect many organ systems, lung and heart disease are the leading causes of death. An abundance of existing data suggests lung abnormalities originate postnatally in DS. Read More

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Tracheal trifurcation: new cases and review of the literature.

Pediatr Radiol 2021 May 28. Epub 2021 May 28.

Advanced Cardiovascular Imaging Unit-Department of Imaging, Bambino Gesù Children's Hospital, IRCCS, Rome, RM, Italy.

Background: Tracheal trifurcation is an uncommon and often unknown type of anomalous tracheobronchial arborization, characterized by three main bronchi originating at the level of the carina. Diagnosis is important due to its clinical implications.

Objective: To highlight the anatomical, clinical and diagnostic aspects of tracheal trifurcation by reporting our experience and reviewing the literature. Read More

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Considerations in the Surgical Management of Unicuspid Aortic Stenosis.

Pediatr Cardiol 2021 Jun 28;42(5):993-1001. Epub 2021 May 28.

Divisions of Cardiothoracic Surgery, University of Illinois College of Medicine at Chicago, 840 S Wood St Suite 417(MC 958), Chicago, IL, 60612, USA.

Unicuspid aortic valve (UAV) stenosis is a rare condition accounting for 5% of non-rheumatic aortic stenosis. The diagnosis can be difficult to make prior to surgical intervention and transesophageal echocardiography has been demonstrated to be more accurate in making the diagnosis compared to transthoracic echocardiography. The presence of a posteriorly located aortic orifice on the short-axis views, with one or two visible raphe anteriorly; the absence of commissures (acommissural); or the presence of a lone commissure (unicommissural) between the left and noncoronary, or the left and right cusps suggests the diagnosis. Read More

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Anomalous Origin of the Coronary Artery from the Pulmonary Artery in Children and Adults: A Pictorial Review of Cardiac Imaging Findings.

Hyun Woo Goo

Korean J Radiol 2021 May 20. Epub 2021 May 20.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Anomalous origin of the coronary artery from the pulmonary artery is a rare and potentially fatal congenital heart defect. Up to 90% of infants with an anomaly involving the left coronary artery die within the first year of life if left untreated. Patients who survive beyond infancy are at risk of sudden cardiac death. Read More

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Anomalous right pulmonary artery from aorta, surgical approach case report and literature review.

J Card Surg 2021 May 28. Epub 2021 May 28.

Prince Sultan Cardiac Center-Qassim, Buraydah, Saudi Arabia.

Background: Anomalous origin of one pulmonary artery from the aorta is a rare congenital anomaly affecting the right pulmonary artery more than the left. These patients are at risk for the early development of significant pulmonary hypertension. Early surgical treatment has been proven safe with excellent results. Read More

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Fetal toxicity associated with statins: A systematic review and meta-analysis.

Atherosclerosis 2021 May 16;327:59-67. Epub 2021 May 16.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background And Aims: Statins are the drugs of choice for decreasing elevated low-density lipoprotein cholesterol. Based mostly on animal studies and case reports, they are forbidden to pregnant women and in the preconception period because of their possible teratogenic effects, for which causality has never been proven. The aim of this study was to systematically review the existing studies and to perform a meta-analysis on this topic. Read More

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Semantic Anomaly Detection in Medical Time Series.

Stud Health Technol Inform 2021 May;278:118-125

Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital.

The main goal of this project was to define and evaluate a new unsupervised deep learning approach that can differentiate between normal and anomalous intervals of signals like the electrical activity of the heart (ECG). Denoising autoencoders based on recurrent neural networks with gated recurrent units were used for the semantic encoding of such time frames. A subsequent cluster analysis conducted in the code space served as the decision mechanism labelling samples as anomalies or normal intervals, respectively. Read More

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