1,929,782 results match your criteria cardiac


Risk Factors for High Blood Product Use in Patients with Stanford Type A Dissection.

Thorac Cardiovasc Surg 2022 Jan 18. Epub 2022 Jan 18.

Department of Cardiac Surgery, Heart Center, University Hospital Bonn, Bonn, Germany.

Background:  Intraoperative and postoperative bleeding associated with allogeneic blood transfusion and reoperation is still a common and feared complication in patients undergoing surgery due to acute Type A Aortic Dissection (aTAAD). The aim of our study was to identify risk factors for higher transfusion rates.

Methods:  In this retrospective single center study we evaluated pre -, intra-, and postoperative data of 121 patients with aTAAD. Read More

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January 2022

Preoperative Risk Factors and Early Outcomes of Delirium in Valvular Open-Heart Surgery.

Thorac Cardiovasc Surg 2022 Jan 18. Epub 2022 Jan 18.

Institute of Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany.

Background:  Compared with coronary artery bypass grafting surgery, data regarding postoperative delirium are scant in valvular open-heart surgery. Therefore, the goal of this retrospective study was to investigate the incidence, preoperative risk factors, and early outcomes of delirium in a large group of patients undergoing valvular open-heart surgery.

Methods:  In 13,229 patients with isolated valvular or combined valvular and bypass surgery, the incidence of postoperative delirium was assessed until discharge. Read More

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January 2022

Dexmedetomidine Can Reduce the Level of Oxidative Stress and Serum miR-10a in Patients with Lung Cancer after Surgery.

Thorac Cardiovasc Surg 2022 Jan 18. Epub 2022 Jan 18.

Department of Operating Room, The First People's Hospital of Jinan, Jinan, Shandong Province, China.

Objective:  Lung cancer is a primary cause of cancer death. This study assessed the action of dexmedetomidine (DEX) on oxidative stress (OS) and microRNA 10a (miR-10a) in patients with lung cancer.

Methods:  Patients were given 1 µg/kg DEX before anesthesia and control patients were given saline. Read More

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January 2022

Can low-dose aspirin help the RECOVERY of patients hospitalized with COVID-19?

Eur Heart J 2022 Jan 18. Epub 2022 Jan 18.

Department of Pharmacology, Catholic University School of Medicine, Largo A. Gemelli, Rome 8-00168, Italy.

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January 2022

Lupus anticoagulant test persistence over time and its associations with future thrombotic events.

Blood Adv 2022 Jan 18. Epub 2022 Jan 18.

Medical University Vienna, Vienna, Austria.

Data on lupus anticoagulant (LA) test stability in patients persistently positive for LA are limited and its implications on clinical outcomes are lacking. We investigated the rate and predictors of a negative LA test and whether experiencing a negative test affected a patient's risk of future thrombotic events or death in a prospective observational study of persistently LA positive patients. We followed 164 patients (84% women) for a median of 9. Read More

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January 2022

Reply to the Letter to the Editor "THE MICROBIOTA IN PARKINSON'S DISEASE: RANKING THE RISK OF HEART DISEASE".

Ann Nutr Metab 2022 Jan 18. Epub 2022 Jan 18.

Although it is clear that disturbance of the gut microbiota also affects brain and heart function in Parkinson's disease patients, the changes in the gut microbiota reported so far do not explain why we consider variation in the gut microbiota to be an independent risk factor for sudden death. Further studies are needed to determine whether it causes sudden death in PD. Read More

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January 2022

Multimorbidity and readmissions in older people with acute coronary syndromes.

Cardiology 2022 Jan 18. Epub 2022 Jan 18.

Aims: To examine the multimorbidity as well as the 30-day and one-year readmission rates, in a large, unselected cohort of elderly patients with acute coronary syndrome (ACS).

Methods And Results: All patients ≥70 years, hospitalized due to ACS during January 1st 2006 - December 31st 2013 and registered in the SWEDEHEART-registry were included. In-hospital multimorbidity and disease burden were determined. Read More

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January 2022

THE MICROBIOTA IN PARKINSON'S DISEASE: RANKING THE RISK OF HEART DISEASE.

Ann Nutr Metab 2022 Jan 18. Epub 2022 Jan 18.

This letter is a commenting on the article recently published in Annals of Nutrition and Metabolism entitled "Parkinson's Disease and Gut Microbiota" by Hirayama and Ohno published in your esteemed journal. In brief, the authors properly discussed the recent research on possible mechanisms of how gut dysbiosis is causally associated with the development and progression of Parkinson's Disease. However, we would like to add some thoughts that may open the debate about the relationship between gut microbiome dysbiosis and cardiac disorders, highlighting the possible role of this association with the occurrence of some cases of sudden death in Parkinson's Disease. Read More

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January 2022

Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway.

Int Immunopharmacol 2022 Jan 15;104:108488. Epub 2022 Jan 15.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, El Arish, Egypt. Electronic address:

Depression is a risk factor for Alzheimer's (AD) and cardiovascular diseases (CVD). Therefore, depression treatment restricts its deteriorating effects on mood, memory and CV system. Fluoxetine is the most widely used antidepressant drug, it has neuroprotective effect through its antioxidant/anti-inflammatory properties. Read More

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January 2022

Association between greenness and dyslipidemia in patients with coronary heart disease: A proteomic approach.

Ecotoxicol Environ Saf 2022 Jan 15;231:113199. Epub 2022 Jan 15.

Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China. Electronic address:

Background: Residential surrounding greenness may be protective of dyslipidemia are often theorized but remain poorly quantified. In particular, the underlying biological mechanisms of blood lipid changes with green spaces remain unclear.

Methods: Our observational epidemiology study included a residentially stable sample of 1035 coronary heart disease patients, and proteomics study included 16 participants. Read More

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January 2022

The effect of apnea length on vital parameters in apnea of prematurity - Hybrid observations from clinical data and simulation in a mathematical model.

Early Hum Dev 2022 Jan 11;165:105536. Epub 2022 Jan 11.

Applied Physics, Eindhoven University of Technology, Eindhoven, the Netherlands; Clinical Physics, Máxima Medical Center, Veldhoven, the Netherlands.

Apnea of prematurity (AOP) is a critical condition for preterm infants which can lead to several adverse outcomes. Despite its relevance, mechanisms underlying AOP are still unclear. In this work we aimed at improving the understanding of AOP and its physiologic responses by analyzing and comparing characteristics of real infant data and model-based simulations of AOP. Read More

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January 2022

The effect of prolonged walking on muscle fatigue and neuromuscular control in children with cerebral palsy.

Gait Posture 2022 Jan 7;93:7-13. Epub 2022 Jan 7.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement Sciences, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, Netherlands. Electronic address:

Background: Muscle fatigue of the lower limbs is considered a main contributor to the perceived fatigue in children with cerebral palsy (CP) and is expected to occur during prolonged walking. In adults without disabilities, muscle fatigue has been proposed to be associated with adaptations in complexity of neuromuscular control.

Research Question: What are the effects of prolonged walking on signs of muscle fatigue and complexity of neuromuscular control in children with CP?

Methods: Ten children with CP and fifteen typically developing (TD) children performed a standardised protocol on an instrumented treadmill consisting of three stages: six-minutes walking at preferred speed (6 MW), moderate-intensity walking (MIW, with two minutes at heart rate > 70% of predicted maximal heart rate) and four-minutes walking at preferred speed (post-MIW). Read More

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January 2022

One day at a time.

Biomed J 2022 Jan 14. Epub 2022 Jan 14.

Berlin, Germany. Electronic address:

In this issue of Biomedical Journal we get to know measures to prevent a nosocomial COVID-19 outbreak, a compound that is able to stall SARS-CoV-2 replication, and the connection between air pollution and COVID-19 cases. Another article allows an insight into the potential of treating HIV combining a conventional drug and low level laser therapy. Furthermore, the advantages of awake craniotomy are presented, the efficacy of IRES is examined, and plant extracts are on the one hand explored as a nociceptive agent and on the other hand as therapeutic approach against breast cancer. Read More

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January 2022

The best protection is early detection.

Biomed J 2022 Jan 15. Epub 2022 Jan 15.

Berlin, Germany. Electronic address:

This current special issue of the Biomedical Journal provides insights in various cancer forms, and possible ways of prognostic and predictive screening. In detail we learn about lung cancer and tissue samples from ground glass opacifications, liquid biopsy through circulating tumor cells in colon cancer, transcription factor analysis in cervical cancer, and long non-coding RNAs in breast and lung cancer. A prognosis factor in individuals with acute myeloid leukemia and a rare fungal infection are determined. Read More

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January 2022

Early development of the pulmonary vascular system: An anatomical and histochemical reinvestigation of the pulmonary venous return development in mice.

Acta Histochem 2022 Jan 15;124(2):151840. Epub 2022 Jan 15.

Department of Anatomy, School of Medicine, Iwate Medical University, Iwate 0283694, Japan.

Pulmonary venous return development establishes the fetal circulation and is critical for the formation of pulmonary circulation independent of systemic circulation at birth. Anomalous returns lead to inappropriate drainage of blood flow, sometimes resulting in neonatal cyanosis and cardiac failure. While many classical studies have discussed the anatomical features of the pulmonary venous system development, the cellular dynamics of the endothelia based on the molecular marker expression remain unknown. Read More

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January 2022

Randomized evidence on graft patency after off-pump versus on-pump coronary artery bypass grafting: An updated meta-analysis.

Int J Surg 2022 Jan 15:106212. Epub 2022 Jan 15.

Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: The debate between off-pump CABG (OPCAB) and on-pump CABG (ONCAB) has been ongoing for decades. We aimed to provide a comprehensive update of the current randomized controlled trials (RCTs) in evaluating the graft patency of OPCAB versus ONCAB.

Materials And Methods: A literature search was conducted in PubMed, EMBASE, and the Cochrane Library databases until April 30, 2021. Read More

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January 2022

Biology or Disparity? Untangling Racial Differences in Val122Ile Transthyretin Cardiac Amyloidosis.

J Card Fail 2022 Jan 15. Epub 2022 Jan 15.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

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January 2022

The V-LAP System for Remote Left Atrial Pressure Monitoring of Patients with Heart Failure: Remote Left Atrial Pressure Monitoring.

J Card Fail 2022 Jan 15. Epub 2022 Jan 15.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: Patients with heart failure (HF) are at an increased risk of hospital admissions. The aim of this report is to describe the feasibility, safety and accuracy of a novel wireless left atrial pressure (LAP) monitoring system in HF patients.

Methods: The V-LAP Left Atrium Monitoring systEm for Patients With Chronic sysTOlic & Diastolic Congestive heart Failure (VECTOR-HF) study is a prospective, multicenter, single-arm, open-label, first-in human clinical trial to assess the safety, performance and usability of the V-LAP system (Vectorious Medical Technologies, Ltd) in NYHA Class III HF patients. Read More

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January 2022

Prediction of sudden cardiac arrest in the general population: Review of traditional and emerging risk factors.

Can J Cardiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; ICES Central, Toronto, Ontario, Canada; Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada. Electronic address:

Sudden cardiac death (SCD) is the most common and devastating outcome of sudden cardiac arrest (SCA), defined as an abrupt and unexpected cessation of cardiovascular function leading to circulatory collapse. The incidence of SCD is relatively infrequent for individuals in the general population, in the range of 0.03-0. Read More

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January 2022

Exercise Training for People Living with a Fontan Circulation: An Underutilized Intervention.

Can J Cardiol 2022 Jan 15. Epub 2022 Jan 15.

Sydney Medical School, University of Sydney; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales.

Surgical repair for children born with single ventricle congenital heart disease, culminating in the Fontan operation, has resulted in dramatic improvements in survival; children born with these lesions are now typically expected to survive well into adulthood. Most, but not all, individuals with a Fontan circulation have reduced exercise capacity compared with the general population that in turn is associated with increased cardiovascular morbidity and mortality. The cause of reduced exercise capacity is multifactorial. Read More

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January 2022

Atrial Ischemia: an Underappreciated Piece of the Atrial Fibrillation Mosaic.

Heart Rhythm 2022 Jan 15. Epub 2022 Jan 15.

Beth Israel Deaconess Medical Center, Department of Medicine, Division of Cardiovascular Medicine, Harvard Medical School, Boston MA, USA.

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January 2022

Interobserver Variability Among Experienced Electrocardiogram Readers To Diagnose Acute Thrombotic Coronary Occlusion In Patients with Out of Hospital Cardiac Arrest: Impact of Metabolic Milieu and Angiographic Culprit.

Resuscitation 2022 Jan 15. Epub 2022 Jan 15.

Division of Cardiology, Department of Medicine, Hennepin Healthcare System, HCMC and University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address:

Objectives: We sought to evaluate interobserver concordance among experienced electrocardiogram (ECG) readers in predicting acute thrombotic coronary occlusion (ATCO) in the context of abnormal metabolic milieu (AMM) following resuscitated out of hospital cardiac arrest (OHCA).

Methods: OHCA patients with initial shockable rhythm who underwent invasive coronary angiography (ICA) were included. AMM was defined as one of: pH < 7. Read More

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January 2022

Deep learning of early brain imaging to predict post-arrest electroencephalography.

Resuscitation 2022 Jan 15. Epub 2022 Jan 15.

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA; Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, USA.

Introduction: Guidelines recommend use of computerized tomography (CT) and electroencephalography (EEG) in post-arrest prognostication. Strong associations between CT and EEG might obviate the need to acquire both modalities. We quantified these associations via deep learning. Read More

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January 2022

Outcomes and Revascularization Strategies of ST-Elevation Myocardial Infarction in Patients with Hypertrophic Cardiomyopathy.

Curr Probl Cardiol 2022 Jan 15:101102. Epub 2022 Jan 15.

Section of Cardiology, Baylor College of Medicine, Houston, TX.

Background: Myocardial ischemia is a known complication of HCM. Contemporary outcomes and care processes after STEMI are extensively examined; however, there are limited data on outcomes and revascularization strategies of HCM patients with STEMI.

Methods: The National Inpatient Sample 2004-2018 was queried to identify adult patients presenting with a primary diagnosis of STEMI, of whom a subset of patients with concomitant diagnosis of HCM were identified. Read More

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January 2022

Prevalence and Trends of Type 2 Diabetes Mellitus and Prediabetes among Community-Dwelling Heart Failure Patients in the United States.

Diabetes Res Clin Pract 2022 Jan 15:109191. Epub 2022 Jan 15.

Department of Nutritional Sciences, College of Family and Consumer Sciences, University of Georgia. 305 Sanford Drive, Dawson Hall, Athens, GA 30605, USA; Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia. 250 West Green Street, R.C. Wilson Pharmacy, Athens, GA 30602, USA. Electronic address:

Aims: This study estimated national prevalence and trends of diagnosed and undiagnosed type 2 diabetes mellitus (T2DM) and prediabetes among heart failure (HF) patients in the U.S.

Methods: This cross-sectional study included 527 participants aged 20+ years with a diagnosis of HF, using data from the National Health and Nutrition Examination Survey 2005-2016. Read More

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January 2022

Arsenic trioxide activates yes-associated protein by lysophosphatidic acid metabolism to selectively induce apoptosis of vascular smooth muscle cells.

Biochim Biophys Acta Mol Cell Res 2022 Jan 15:119211. Epub 2022 Jan 15.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address:

Inhibition of vascular smooth muscle cells (VSMCs) proliferation without dysregulating endothelial cells (ECs) may provide an ideal therapy for in-stent restenosis. Due to its anti-proliferation effect on VSMCs and pro-endothelium effect, arsenic trioxide (ATO) has been used in a drug-eluting stent in a recent clinical trial. However, the underlying mechanism by which ATO achieves this effect has not been determined. Read More

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January 2022

Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes.

Toxicol Appl Pharmacol 2022 Jan 15:115886. Epub 2022 Jan 15.

VistaGen Therapeutics, Inc., 343 Allerton Ave., South San Francisco, CA, 94080, United States of America. Electronic address:

Many small molecule kinase inhibitors (SMKIs), used predominately in cancer therapy, have been implicated in serious clinical cardiac adverse events, which means that traditional preclinical drug development assays were not sufficient for identifying these cardiac liabilities. To improve clinical cardiac safety predictions, the effects of SMKIs targeting many different signaling pathways were studied using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) in combined assays designed for the detection of both electrophysiological (proarrhythmic) and non-electrophysiological (non-proarrhythmic) drug-induced cardiotoxicity. Several microplate-based assays were used to quantitate cell death, apoptosis, mitochondrial damage, energy depletion, and oxidative stress as mechanism-based non-electrophysiological cardiomyocyte toxicities. Read More

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January 2022

Remote cyclic compression ameliorates myocardial infarction injury in rats via AMPK-dependent pathway.

Microvasc Res 2022 Jan 15:104313. Epub 2022 Jan 15.

School of Acupuncture and Tuina, School of Regimen and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Background: Remote ischemic conditioning (RIC) displays a cardioprotective role in acute myocardial infarction (AMI). Since interruption of blood vessel is not an essential trigger of remote cardioprotection, tissue compression may play a prominent part in the effect. The purpose of this study was to confirm the protective effect of tissue compression on AMI and the underlying mechanisms. Read More

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January 2022

RBM20 mutation is a high genetic risk factor for premature death through RNA-protein condensates.

J Mol Cell Cardiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Animal and Dairy Sciences, University of Wisconsin, Madison, WI 53706, USA. Electronic address:

Dilated cardiomyopathy (DCM) is a heritable and genetically heterogenous disease often idiopathic and a leading cause of heart failure with high morbidity and mortality. DCM caused by RNA binding motif protein 20 (RBM20) mutations is diverse and needs a more complete mechanistic understanding. RBM20 mutation S637G (S639G in mice) is linked to severe DCM and early death in human patients. Read More

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January 2022

Telehealth Management and Risk Stratification of Older Patients With Chronic Heart Failure During COVID-19 Pandemic: Prognostic Evaluation of the TeleHFCovid19-Score.

J Am Med Dir Assoc 2021 Dec 24. Epub 2021 Dec 24.

Heart Failure Clinic, Division of Geriatric Medicine and Intensive Care Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objectives: To evaluate 6-month risk stratification capacity of the newly developed TeleHFCovid19-Score for remote management of older patients with heart failure (HF) during the coronavirus disease 2019 pandemic.

Design: Monocentric observational prospective study.

Setting And Participants: Older HF outpatients remotely managed during the first pandemic wave. Read More

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December 2021