5,610 results match your criteria carcinoma parotid

Computed tomography-guided transfacial buccal space core biopsy of deep head and neck space lesions: our experience.

Br J Oral Maxillofac Surg 2021 Apr 21. Epub 2021 Apr 21.

Departments of Clinical Radiology, Queen Alexandra Hospital, Portsmouth, UK.

Deep head and neck space lesions can present a number of diagnostic challenges due to their deep anatomical position and difficult access for diagnostic tissue sampling. We describe a series of percutaneous 'transfacial' buccal space computed tomography (CT)-guided core biopsies of these lesions and subsequent histological findings. Six patients underwent CT-guided core biopsy of deep parotid, parapharyngeal, or masticator space lesions over a 30-month period. Read More

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DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.

Head Neck Pathol 2021 Jul 19. Epub 2021 Jul 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen (UKER), Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

DICER1, a member of the ribonuclease III family, is involved in the biogenesis of microRNAs and, hence, it influences gene expression regulation. DICER1 germline (associated with the inherited DICER1 syndrome) or somatic mutations have been linked to tumorigenesis in histogenetically diverse benign and malignant neoplasms in different organs including pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, nasal chondromesenchymal hamartoma, poorly differentiated thyroid carcinoma, thyroblastoma, intracranial sarcoma and gonadal Sertoli-Leydig cell tumors in addition to others. Moreover, rare botryoid (giant) fibroepithelial polyps may harbor this mutation. Read More

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A nomogram for predicting late radiation-induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era.

Aging (Albany NY) 2021 Jul 19;13(undefined). Epub 2021 Jul 19.

Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Background: Dry mouth sensation cannot be improved completely even though parotids are spared correctly. Our purpose is to develop a nomogram to predict the moderate-to-severe late radiation xerostomia for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) in intensity modulated radiation therapy (IMRT) / volumetric modulated arc radiotherapy (VMAT) era.

Methods: A dataset of 311 patients was retrospectively collected between January 2010 and February 2013. Read More

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Multiple Warthin Tumors With Epithelial-Myoepithelial Carcinoma of the Ipsilateral Parotid Gland: A Case Report.

Ear Nose Throat J 2021 Jul 19:1455613211028086. Epub 2021 Jul 19.

School and Hospital of Stomatology, 159344Jilin University, Changchun, China.

Multiple primary tumors of the parotid gland refer to the occurrence of 2 or more primary tumors in the ipsilateral or bilateral parotid gland metachronously or synchronously, which do not originate from postoperative recurrence or metastasis. Multiple primary tumors of the parotid gland, especially synchronous benign and malignant tumors, are extremely uncommon. A rare case of multiple Warthin tumors with epithelial-myoepithelial carcinoma of the ipsilateral parotid gland is reported as follows. Read More

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Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node.

Cancer Treat Res Commun 2021 Jul 11;28:100435. Epub 2021 Jul 11.

Department of Otolaryngology / Head & Neck Surgery, Hadassah Hebrew-University Medical Center, Jerusalem, Israel. Electronic address:

Introduction: Heterotopia is the presence of a particular tissue / tumor at a non-physiological / ectopic site. The study primary goals: To review the current data investigating heterotopic, normal appearing, and diseased salivary gland tumors, in lymph nodes. To describe the meticulous pathological investigation and multidisciplinary decision-making process of a heterotopic carcinoma ex pleomorphic adenoma arising in an intra-parotid lymph node. Read More

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Synchronous occurrence of IgG4-related sialadenitis and ductal carcinoma of the parotid gland: a case report.

Gland Surg 2021 Jun;10(6):2069-2075

Department of Surgery, School of Medicine, University of Seville, Seville, Spain.

Immunoglobulin G4-related disease (IgG4-RD) is a rare chronic systemic inflammatory pathology that poses a diagnostic challenge since it can simulate malignancy when it affects a salivary gland as a mass-like lesion. Here, the authors report an unusual clinical case of a 42-year-old man who presented with a painless, slow-growing swelling located in the right parotid gland with a 12-month evolution. Based on imaging tests and open biopsy, a diagnosis of chronic parotitis was presumed and oral methylprednisolone was prescribed. Read More

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Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Giulio Cantù

Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214

Former Director of Otorhinolaryngology and Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milano, Italy.

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Intraparotid Recurrence of Papillary Thyroid Carcinoma After Thyroidectomy Coincident With Declining Thyroglobulin Levels: A Case Report and Review of the Literature.

Ear Nose Throat J 2021 Jul 14:1455613211033124. Epub 2021 Jul 14.

King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia.

Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignancy. Intraparotid recurrence of PTC is, however, rare. Most parotid malignancies are either primary or metastatic from cancer outside the head and neck. Read More

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A Diagnostically Challenging Parotid Gland Tumor With Hybrid Features.

Cureus 2021 Jun 2;13(6):e15383. Epub 2021 Jun 2.

Internal Medicine, Jersey Shore University Medical Center/Saint Francis Medical Center Program, Trenton, USA.

Salivary gland tumors are relatively uncommon with most being benign. When diagnosed the most common benign and malignant tumors are pleomorphic adenoma and mucoepidermoid carcinoma (MEC), respectively. However, not uncommonly, it is difficult to differentiate between the histopathological entities, leading to a diagnostic dilemma that can impact a patient's treatment and prognosis. Read More

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Pretherapeutic Predictive Factors for Histological High-Grade Parotid Gland Carcinoma.

Laryngoscope 2021 Jul 10. Epub 2021 Jul 10.

Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.

Objective: The histological grade of parotid gland carcinoma (PGC) is an important prognostic factor; however, the diagnosis prior to treatment has been challenging to make. This study aimed to investigate whether the pretreatment clinical findings, including hematological inflammatory, nutritional, and immune markers, could predict the histological grade of PGC.

Study Design: Retrospective study. Read More

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Correlation of lesional uptake parameters and ratios with miPSMA score and estimating normal physiological concentration: an exploratory analysis in mCRPC patients with Ga-PSMA-11 PET-CT.

J Nucl Med Technol 2021 Jul 9. Epub 2021 Jul 9.

Radiation Medicine Centre (BARC), India.

The employment of prostate-specific membrane antigen (PSMA)-based PET-CT imaging has grown rapidly over the recent years. The aim of the present study was to estimate the lesional uptake across the different levels of molecular imaging PSMA (miPSMA) expression score along with normal physiological concentration of Ga-PSMA-11 in a cohort of mCRPC patients including their temporal variation on delayed imaging. Fifty patients of mCRPC who were being evaluated for Lu-PSMA PRLT, and underwent Ga-PSMA-11 PET-CT for evaluation of disease status, were retrospectively evaluated. Read More

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Differentiation of Benign and Malignant Parotid Gland Tumors with MRI and Diffusion Weighted Imaging.

Medeni Med J 2021 18;36(2):138-145. Epub 2021 Jun 18.

Istanbul Medeniyet University Faculty of Medicine, Goztepe Training and Research Hospital, Department of Radiology, Istanbul, Turkey.

Objective: This study investigated the effectivity of Magnetic Resonance Imaging (MRI) findings and Apparent Diffusion Coefficient (ADC) value in evaluating parotid gland tumors (PGTs), and aimed to reduce the biopsy procedure before surgery.

Methods: This retrospective study included 54 PGTs of 42 patients' (24 female, 18 male, mean age; 51.4±15. Read More

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Uncommon Metastasizing Site of Adrenocortical Carcinoma.

Cureus 2021 May 27;13(5):e15267. Epub 2021 May 27.

Surgical Oncology, All India Institute of Medical Sciences, Patna, IND.

Adrenocortical carcinoma (ACC) is a very rare tumor having a poor prognosis. Approximately 25% of these cases may present with metastases at the time of diagnosis. Common sites of metastasis are lung, liver, and lymph nodes. Read More

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Epithelial-Myoepithelial Carcinoma of the Submandibular Gland: Case Report.

J Nippon Med Sch 2021 ;88(3):238-241

Department of Otorhinolaryngology, Shanghai Tenth People's Hospital, Tongji University.

Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor that occurs mostly in the parotid gland. We report a case of EMC of the submandibular gland in a young man. The patient was aware of a slow-growing mass in the right submandibular gland for 1 year. Read More

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January 2021

Endocrine Mucin Producing Sweat Gland Carcinoma with Metastasis to Parotid Gland: Not as Indolent as Perceived?

Head Neck Pathol 2021 Jun 28. Epub 2021 Jun 28.

Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Endocrine mucin-producing sweat gland carcinoma (EMPSCG) is a rare, low-grade cutaneous adnexal neoplasm with evidence of neuroendocrine differentiation, predominantly involving the eyelids of elderly. It has a striking resemblance to solid papillary carcinoma of breast which similarly displays neuroendocrine features. EMPSGC is considered a precursor of cutaneous mucinous carcinoma, and the term "mucinous carcinoma" is also recommended for hybrid lesions which reveal an invasive mucinous component associated with EMPSGC. Read More

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Synchronous Resection of Parotid Metastasis With Esophagectomy: A Case Report.

In Vivo 2021 Jul-Aug;35(4):2337-2340

Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: Preoperative diagnosis of parotid tumor is mainly performed via imaging and cytology to avoid both facial nerve injury and tumor seeding. Synchronous resection of solitary parotid metastasis with esophagectomy for esophageal squamous cell carcinoma is rarely performed.

Case Report: This is a case report of a 58-year-old male patient with a left preauricular tumor, which was cytologically diagnosed as squamous cell carcinoma. Read More

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[Performance of the magnetic resonance imaging in parotid gland tumor histopathology].

Pan Afr Med J 2021 4;39:10. Epub 2021 May 4.

Département d´Oto-rhino-laryngologie, Hôpital Tahar Sfar Mahdia, Mahdia, Tunisia.

Introduction: salivary gland tumors mainly occur in the parotid gland. These tumors are rare but are characterized by histological heterogeneity, thus posing diagnostic challenges. Magnetic resonance imaging (MRI) is currently the most reliable imaging test for the evaluation of these tumors. Read More

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[Impact of neck dissection in N2-3 oropharyngeal squamous cell carcinomas treated with definitive chemoradiotherapy: An observational real-life study].

Cancer Radiother 2021 Jun 23. Epub 2021 Jun 23.

Service d'oncologie-radiothérapie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université de Paris, 75015 Paris, France. Electronic address:

Purpose: The purpose of this study was to assess the efficacy in terms of neck failure of an initial neck dissection before definitive chemoradiotherapy in N2-3 oropharyngeal squamous cell carcinomas, as well as the dosimetric impact and the acute and delayed morbidity of this approach.

Materials And Methods: All patients consecutively treated between 2009 and 2018 with definitive chemoradiotherapy using intensity-modulated conformal radiotherapy (IMRT) for a histologically proven N2-3 oropharyngeal squamous cell carcinomas were retrospectively included. The therapeutic approach consisted of induction chemotherapy, followed by cisplatine-based chemoradiotherapy preceded or not by neck dissection. Read More

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Regional disease in head and neck cutaneous squamous cell carcinoma: the role of primary tumor characteristics and number of nodal metastases.

Eur Arch Otorhinolaryngol 2021 Jun 25. Epub 2021 Jun 25.

Section of Otorhinolaryngology, Head and Neck Surgery, ASST Spedali Civili Di Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.

Purpose: To identify potential risk factors impacting on overall survival (OS) of patients affected by lymph node metastasis from cutaneous squamous cell carcinoma (cSCC) of the head and neck (HN), with special emphasis on primary tumor characteristics and pattern of nodal recurrence (intraparotid and/or cervical).

Methods: A bi-institutional retrospective study on consecutive patients affected by cervical and/or intraparotid NM from HN cSCC and surgically treated with curative intent from May 2010 to January 2020 was conducted. OS was considered the outcome of interest. Read More

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Basal Cell Adenoma of the Parotid Gland.

Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436

Department of ENT, Indira Gandhi Medical College and Research Institute, Pondicherry, India.

Basal Cell Adenoma (BCA) known as monomorphic adenoma is a rare type of benign epithelial salivary neoplasm that mostly occurs in the parotid gland. Clinically BCA appears as a firm, mobile, slow-growing mass and is usually diagnosed during the histopathological examination of the resected surgical specimen. Histological differential diagnosis ranges from benign to malignant neoplasms such as pleomorphic adenoma, basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma. Read More

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Differentiating low and high grade mucoepidermoid carcinoma of the salivary glands using CT radiomics.

Gland Surg 2021 May;10(5):1646-1654

Department of Radiology, The University of Chicago, Chicago IL, USA.

Background: The purpose of this study is to determine if Haralick texture analysis on CT imaging of mucoepidermoid carcinomas (MEC) can differentiate low-grade and high-grade tumors.

Methods: A retrospective review of 18 patients with MEC of the salivary glands, corresponding CT imaging and pathology report was performed. Tumors were manually segmented and image analysis was performed to calculate radiomic features. Read More

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Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.

Dentomaxillofac Radiol 2021 Jun 23:20200485. Epub 2021 Jun 23.

Department of radiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Objectives: To describe the CT and MR imaging characteristics of primary carcinoma ex pleomorphic adenoma (Ca-ex-PA) in major salivary glands and present more information for recognizing this malignancy.

Methods: 212 patients with primary Ca-ex-PA in major salivary glands (169 in the parotid gland, 36 in the submandibular gland, 7 in the sublingual gland) underwent CT and MR imaging (plain and contrast-enhanced scans) prior to surgical management and histopathological examination. The CT and MR imaging findings of this condition were retrospectively reviewed and correlated with their pathological types: non-invasive carcinoma (Type I, 37 cases), minimally invasive carcinoma (Type II, 18 cases), and widely invasive carcinoma (TypeIII, 157 cases). Read More

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High Rates of Ultraviolet-Signature Mutations in Squamous Cell Carcinomas of the Parotid Gland and Prognostic Implications.

Head Neck Pathol 2021 Jun 23. Epub 2021 Jun 23.

Department of Pathology (Anatomic Pathology), The University of Chicago Medicine, Chicago, USA.

In the absence of clear pathologic differences, clinical history may differentiate potential primary parotid squamous cell carcinomas (SCC) from metastases. The presence of an ultraviolet (UV) signature can distinguish between tumors of cutaneous and non-cutaneous origin. This study aimed to investigate rates of UV signature mutations in squamous cell carcinomas of the parotid gland as well as differences in clinical features between tumors of cutaneous and non-cutaneous origin. Read More

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A Study to Assess the Dosimetric Impact of the Anatomical Changes Occurring in the Parotid Glands and Tumour Volume during Intensity Modulated Radiotherapy using Simultaneous Integrated Boost (IMRT-SIB) in Head and Neck Squamous Cell Cancers.

Cancer Med 2021 Jun 22. Epub 2021 Jun 22.

Toxicology and Experimental Medicine Division, CSIR-Central Drug Research Institute, Lucknow, India.

Background: Anatomical variations in head and neck cancer during IMRT leads to volume shrinkage, results in dosimetric variations in tumour and normal tissue including parotid glands, with a risk of radiation toxicities.

Methods: 30 patients with a stage II-IV head and neck squamous cell carcinoma (HNSCC) were treated with definitive IMRT-SIB and concomitant chemotherapy. Volumetric and dosimetric variations were evaluated during the period of IMRT by recalculating and obtaining dose-volume histograms of re-contoured target volumes and parotid glands on repeat CT scans taken multiple times during treatment (CT1, CT2, CT3 and CT4). Read More

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Glandular metastases from renal cell carcinoma show poor clinical responses to immune checkpoint inhibition but durable responses to angiogenesis inhibitors.

BMJ Case Rep 2021 Jun 22;14(6). Epub 2021 Jun 22.

Department of Medicine, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

While half of the metastatic clear cell renal cell carcinomas (ccRCCs) involve the lungs, metastatic lesions have been described in various other organs, including glandular tissues such as the pancreas. Recent evidence suggests that ccRCC lesions affecting the pancreas are poorly responsive to immune checkpoint inhibition (ICI) but show superior responses to tyrosine kinase inhibitors (TKIs) targeting the vascular endothelial growth factor (VEGF) signalling pathway. However, this has yet to be explored in ccRCC spreading to other glandular tissues. Read More

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Primary acinic cell carcinoma of mandible, report of a case and literature review.

Int J Surg Case Rep 2021 Jul 9;84:106065. Epub 2021 Jun 9.

School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction And Importance: Acinic cell carcinoma (ACC) is a rare low-grade salivary gland malignancy that accounts for approximately 17% of all salivary gland malignancies. The most common site affected by ACC is the parotid gland followed by the submandibular glands, minor salivary glands, and sublingual glands. Also, it could hardly be observed in unusual sites such as the jaw bones. Read More

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Effect of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy on parotid gland function and quality of life in patients with nasopharyngeal carcinoma.

Am J Transl Res 2021 15;13(5):5272-5279. Epub 2021 May 15.

Department of Otolaryngology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Linhai, Zhejiang Province, China.

Objective: To investigate the effects of three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) on parotid gland function and quality of life in patients with nasopharyngeal carcinoma (NPC).

Methods: Ninety-six patients with NPC diagnosed and treated in our hospital were divided into two groups using a random number table. The control group was treated with three-dimensional conformal radiotherapy and the research group was treated with intensity-modulated radiotherapy. Read More

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First bite syndrome treated with onabotulinumtoxin A injections.

J Am Dent Assoc 2021 Jun 15. Epub 2021 Jun 15.

Background And Overview: First bite syndrome (FBS) is an orofacial pain condition characterized by moderate to severe unilateral facial pain associated with the first bite or taste of food. It is important that dentists and physicians be aware of patient history and examination findings commonly associated with FBS, as well as treatment options available for managing this condition.

Case Description: Described here is a case of FBS arising in a 43-year-old man after partial parotidectomy for the treatment of a mucoepidermoid carcinoma. Read More

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Parotid mammary analogue secretory carcinoma: A case report and review of literature.

World J Clin Cases 2021 Jun;9(16):4052-4062

Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun 130021, Jilin Province, China.

Background: Mammary analogue secretory carcinoma (MASC) is a rare low-grade malignant salivary gland tumor. The morphological and immunohistochemical features of MASC closely resemble those of breast secretory carcinoma. The key characteristics of the lesion are a lack of pain and slow growth. Read More

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Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression.

Head Neck Pathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology, University of New Mexico School of Medicine, University of New Mexico, MSC08 4640, Albuquerque, NM, 87131, USA.

Myoepithelial carcinoma (MECA) is a rare salivary gland (SG) neoplasm (0.1-0.45% of all SG tumors) that often presents with bland cytomorphology and can be misclassified as cellular pleomorphic adenoma (PA) or myoepithelioma. Read More

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