7,772 results match your criteria capsaicin treatment

Redox-sensitive TRP channels: A promising pharmacological target in chemotherapy-induced peripheral neuropathy.

Expert Opin Ther Targets 2021 Jul 22. Epub 2021 Jul 22.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali)- 160062, Punjab, India.

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) and its related pain is a major side effect of certain chemotherapeutic agents used in cancer treatment. Available analgesics are mostly symptomatic, and on prolonged treatment, patients become refractive to them. Hence, the development of improved therapeutics that act on novel therapeutic targets is necessary. Read More

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Combined anti-hepatocellular carcinoma therapy inhibit drug-resistance and metastasis via targeting "substance P-hepatic stellate cells-hepatocellular carcinoma" axis.

Biomaterials 2021 Jul 9;276:121003. Epub 2021 Jul 9.

School of Bioscience and Technology, Weifang Medical University, PR China. Electronic address:

Peripheral nerves have emerged as the important components in tumor microenvironment (TME), which could activate hepatic stellate cells (HSCs) by secreting substance P (SP), leading to hepatocellular carcinoma (HCC) invasion and metastasis. Herein, we proposed a novel anti-HCC concept of blocking "SP-HSCs-HCC" axis for omnidirectional inhibition of HCC development. To pursue this aim, the novel CAP/GA-sHA-DOX NPs were developed for targeted co-delivery of capsaicin (CAP) and doxorubicin (DOX) using glycyrrhetinic acid (GA) modified sulfated-HA (sHA) as nanocarriers. Read More

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Effects of natural capsicum extract on growth performance, nutrient utilization, antioxidant status, immune function, and meat quality in broilers.

Poult Sci 2021 Jun 4;100(9):101301. Epub 2021 Jun 4.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address:

This research was conducted to determine the effects of natural capsaicin extract (NCE) as an alternative to the antibiotic (chlortetracycline, CTC) on growth performance, antioxidant capacity, immune function, and meat quality of broiler chickens. A total of 168 one-day-old Arbor Acre male broiler chickens with an average weight of 46.4 ± 0. Read More

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Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure.

Am J Physiol Heart Circ Physiol 2021 Jul 16. Epub 2021 Jul 16.

Department of Anesthesiology, grid.266813.8University of Nebraska Medical Center, Omaha, NE, United States.

An exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Read More

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Natural capsicum extract replacing chlortetracycline enhances performance via improving digestive enzyme activities, antioxidant capacity, anti-inflammatory function, and gut health in weaned pigs.

Anim Nutr 2021 Jun 4;7(2):305-314. Epub 2021 Mar 4.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.

The objective of this study was to investigate the effects of natural capsicum extract (NCE, containing 2% natural capsaicin, the rest is carrier) replacing chlortetracycline (CTC) on performance, digestive enzyme activities, antioxidant capacity, inflammatory cytokines, and gut health in weaned pigs. A total of 108 weaned pigs (Duroc × [Landrace × Yorkshire], initial body weight = 8.68 ± 1. Read More

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Efficacy of topical capsaicin for cannabinoid hyperemesis syndrome in a pediatric and adult emergency department.

Am J Emerg Med 2021 Jun 29;49:343-351. Epub 2021 Jun 29.

University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

Introduction: Cannabinoid hyperemesis syndrome (CHS) is a clinical diagnosis characterized by symptoms of recurrent nausea, vomiting, and severe abdominal pain in the setting of chronic cannabis use. Symptoms of CHS are frequently unresponsive to standard antiemetic therapy. Topical capsaicin applied to the abdomen has been cited as a potential effective agent for CHS however robust evidence is lacking. Read More

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Population Coding of Capsaicin Concentration by Sensory Neurons Revealed Using Ca Imaging of Dorsal Root Ganglia Explants from Adult pirt-GCaMP3 Mouse.

Cell Physiol Biochem 2021 Jul;55(4):428-448

International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Ireland.

Background/aims: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration [CAPS] remain obscure. Prolonged (up to 1h.) exposure to CAPS is used clinically to desensitise sensory fibres for treatment of neuropathic pain, but its signalling has typically been studied in cultures of dissociated sensory neurons employing low cell numbers and very short exposure times. Read More

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Noopept Attenuates Diabetes-Mediated Neuropathic Pain and Oxidative Hippocampal Neurotoxicity via Inhibition of TRPV1 Channel in Rats.

Mol Neurobiol 2021 Jul 9. Epub 2021 Jul 9.

Department of Pathology, Faculty of Medicine, Inonu University, Malatya, Turkey.

Neuropathic pain and oxidative neurotoxicity are two adverse main actions of diabetes mellitus (DM). The expression levels of calcium ion (Ca) permeable TRPV1 channels are high in the dorsal root ganglion (DRGs) and hippocampus (HIPPO). TRPV1 is activated by capsaicin and reactive free oxygen radicals (fROS) to mediate peripheral neuropathy and neurotoxicity. Read More

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The Treatment of Painful Diabetic Neuropathy.

Curr Diabetes Rev 2021 Jul 6. Epub 2021 Jul 6.

Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield. United Kingdom.

Painful diabetic peripheral neuropathy (painful-DPN) is a highly prevalent and disabling condition, affecting up to one-third of patients with diabetes. This condition can have a profound impact, resulting in a low quality of life, disruption of employment, impaired sleep, and poor mental health with an excess of depression and anxiety. The management of painful-DPN poses a great challenge. Read More

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Capsaicin affects macrophage anti-inflammatory activity via the MAPK and NF-κB signaling pathways.

Int J Vitam Nutr Res 2021 Jul 8. Epub 2021 Jul 8.

Department of Food Science and Engineering, Jinzhou Medical University, Jinzhou, China.

Capsaicin, the main constituent in chili, is an extremely spicy vanillin alkaloid and is found in several species in China. Traditionally, it has been used to treat inflammatory diseases such as allergic rhinitis, neuralgia after shingles, refractory female urethral syndrome, spontaneous recalcitrant anal pruritus, and solid tumors. Constant stimulation of the body by inflammatory factors can lead to chronic inflammation. Read More

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Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1).

Front Mol Neurosci 2021 18;14:643483. Epub 2021 Jun 18.

Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon, South Korea.

Riboflavin, also known as vitamin B, isfound in foods and is used as a dietary supplement. Its deficiency (also called ariboflavinosis) results in some skin lesions and inflammations, such as stomatitis, cheilosis, oily scaly skin rashes, and itchy, watery eyes. Various therapeutic effects of riboflavin, such as anticancer, antioxidant, anti-inflammatory, and anti-nociceptive effects, are well known. Read More

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Pharmacological, Pharmacokinetic, Pharmacodynamic and Physicochemical Characterization of FE 205030: A Potent, Fast Acting, Injectable CGRP Receptor Antagonist for the Treatment of Acute Episodic Migraine.

J Pharm Sci 2021 Jul 1. Epub 2021 Jul 1.

Ferring Research Institute, Ferring Pharmaceuticals, 4245 Sorrento Valley Blvd, San Diego, CA 92121.

The neuropeptide calcitonin gene-related peptide (CGRP) is known to play a central role in the underlying pathophysiology of migraine. In comparison to the effective triptan class of antimigraine treatments, the CGRP antagonists possess a comparable efficacy but a superior cardiovascular safety profile in patients. This paper describes the development of selective and potent peptidic CGRP antagonist, FE 205030, that has a fast onset of action and an optimal half-life (subcutaneous T ∼ 60 min, and t ∼ 4. Read More

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Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals.

Evid Based Complement Alternat Med 2021 9;2021:9995903. Epub 2021 Jun 9.

Faculties of Medicine and Arts and Sciences, Arab American University, P.O. Box 240, Jenin, State of Palestine.

Ever-growing research efforts are demonstrating the potential of medicinal plants and their phytochemicals to prevent and manage obesity, either individually or synergistically. Multiple combinations of phytochemicals can result in a synergistic activity that increases their beneficial effects at molecular, cellular, metabolic, and temporal levels, offering advantages over chemically synthesized drug-based treatments. Herbs and their derived compounds have the potential for controlling appetite, inhibiting pancreatic lipase activity, stimulating thermogenesis and lipid metabolism, increasing satiety, promoting lipolysis, regulating adipogenesis, and inducing apoptosis in adipocytes. Read More

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Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus.

Molecules 2021 Jun 28;26(13). Epub 2021 Jun 28.

Department of Medicine, Johns Hopkins University School of Medicine, Ross Research Building, 720 Rutland Ave, Baltimore, MD 21205, USA.

Heartburn and non-cardiac chest pain are the predominant symptoms in many esophageal disorders, such as gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), functional heartburn and chest pain, and eosinophilic esophagitis (EoE). At present, neuronal mechanisms underlying the process of interoceptive signals in the esophagus are still less clear. Noxious stimuli can activate a subpopulation of primary afferent neurons at their nerve terminals in the esophagus. Read More

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Stimulation of myogenesis by ascorbic acid and capsaicin.

Biochem Biophys Res Commun 2021 Jun 28;568:83-88. Epub 2021 Jun 28.

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan. Electronic address:

Myogenesis is a complex process regulated by several factors. This study evaluated the functional interaction between vitamin C and a high dose of capsaicin (a potential endoplasmic reticulum (ER) stress inducer) on myogenesis. After the induction of differentiation, treatment with ascorbic acid or ascorbic acid phosphate (AsAp) alone had minimal effects on myogenesis in C2C12 cells. Read More

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Limosilactobacillus reuteri DSM-17938 for preventing cough in adults with mild allergic asthma: A double-blind randomized placebo-controlled cross-over study.

Clin Exp Allergy 2021 Jun 30. Epub 2021 Jun 30.

Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Cough is a common troublesome symptom in asthma which is neuronally mediated. Limosilactobacillus reuteri DSM-17938 (L. reuteri DSM-17938) is a probiotic shown to be effective in pre-clinical models at suppressing neuronal responses to capsaicin, a transient receptor potential vanilloid agonist (TRPV1). Read More

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Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis.

Biomaterials 2021 Jun 23;275:120984. Epub 2021 Jun 23.

Musculoskeletal Research Laboratory of Department of Orthopaedics & Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, The Chinese University of Hong Kong, Hong Kong SAR, China; CHUK Hong Kong - Shenzhen Innovation and Technology Institute (Futian), China. Electronic address:

Critical size bone defects are frequently caused by accidental trauma, oncologic surgery, and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of critical size bone defects. However, DO is usually a lengthy treatment, therefore accompanied with increased risks of complications such as infections and delayed union. Read More

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The efficacy and safety profile of capsaicin 8% patch versus 5% Lidocaine patch in patients with diabetic peripheral neuropathic pain: a randomized, placebo-controlled study of south Asian male patients.

J Diabetes Metab Disord 2021 Jun 19;20(1):271-278. Epub 2021 Jan 19.

College of Health and Human Sciences, Charles Darwin University, Darwin, Northern territory 0810 Australia.

Aims: Diabetic peripheral neuropathy affects up to 60% of individuals and often leads to foot ulceration and eventual amputation. When oral therapy has failed to achieve pain relief, the first line local treatment is the 5% lidocaine-medicated plaster which provides local relief. Capsaicin 8% patch is considered a promising topical treatment for diabetic peripheral neuropathy. Read More

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An update on targets for treating osteoarthritis pain: NGF and TRPV1.

Curr Treatm Opt Rheumatol 2020 Sep 6;6(3):129-145. Epub 2020 May 6.

Division of Rheumatology, Rush University Medical Center, Chicago, IL.

Purpose Of Review: a)Osteoarthritis (OA) is the most common form of arthritis, and pain is the primary symptom of the disease, yet analgesic options for treating OA pain remain limited. In this review, we aimed to give an update on the current clinical and preclinical studies targeting two pathways that are being investigated for treating OA pain: the nerve growth factor (NGF) pathway and the transient receptor potential vanilloid-1 (TRPV1) pathway.

Recent Findings: b)Antibodies against NGF, small molecule inhibitors of TrkA, TRPV1 agonists, and TRPV1 antagonists are all in different stages of clinical and pre-clinical testing for the treatment of OA pain. Read More

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September 2020

Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy.

J Pharmacol Toxicol Methods 2021 Jun 25;112:107090. Epub 2021 Jun 25.

Departamento de Fisiologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará, 1720, Uberlândia Zip Code 38405-320, Minas Gerais, Brazil. Electronic address:

Previous data indicate that the diabetogenic substance streptozotocin might act in nociceptive neurons changing the sensory signal, regardless of hyperglycemia. In the present article the effects of streptozotocin were compared with another diabetogenic drug, alloxan, for diabetes induction in rats. A possible direct effect of these drugs was tested by means of in vivo experiments and in vitro assays using cultured primary nociceptive neurons. Read More

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Signaling Targets Related to Antiobesity Effects of Capsaicin: A Scoping Review.

Adv Nutr 2021 Jun 25. Epub 2021 Jun 25.

Instituto de Ciências Biológicas, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The search for new antiobesogenic agents is increasing because of the current obesity pandemic. Capsaicin (Caps), an exogenous agonist of the vanilloid receptor of transient potential type 1 (TRPV1), has shown promising results in the treatment of obesity. This scoping review aims to verify the pathways mediating the effects of Caps in obesity and the different methods adopted to identify these pathways. Read More

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Gastrointestinal Distension by Pectin-Containing Carbonated Solution Suppresses Food Intake and Enhances Glucose Tolerance GLP-1 Secretion and Vagal Afferent Activation.

Front Endocrinol (Lausanne) 2021 8;12:676869. Epub 2021 Jun 8.

Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.

Diet-induced gastrointestinal distension is known to evoke satiation and suppress postprandial hyperglycemia; however, the underlying mechanisms remain poorly understood. This study explored how gastrointestinal distension regulates energy homeostasis by using inflating stomach formulation (ISF), the carbonated solution containing pectin that forms stable gel bubbles under acidic condition in the stomach. Here we show that, in mice, oral administration of ISF induced distension of stomach and proximal intestine temporarily, stimulated intestinal glucagon-like peptide-1 (GLP-1) secretion, and activated vagal afferents and brainstem. Read More

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Deoxycholic Acid Activates and Sensitizes Vagal Nociceptive Afferent C-fibers in Guinea Pig Esophagus.

Am J Physiol Gastrointest Liver Physiol 2021 06 23. Epub 2021 Jun 23.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Bile acid reflux in the esophagus plays a role in the pathogenesis of certain esophageal disorders where it can induce esophageal pain and heartburn. The present study aimed to determine whether bile acid, deoxycholic acid (DCA), directly activates and sensitizes esophageal vagal nociceptive afferent C-fiber subtypes. DCA-elicited effects on vagal nodose and jugular neurons were studied by calcium imaging. Read More

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Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study.

J Int Soc Sports Nutr 2021 Jun 21;18(1):50. Epub 2021 Jun 21.

Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), "Ministro Petrônio Portella" Campus, PI, 64049-550, Teresina, Brazil.

Background: Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflammatory response and performance in untrained men.

Methods: Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design. Read More

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Capsaicin stability and bio-accessibility affected by complexation with high-amylose corn starch (HACS).

Food Funct 2021 Jun 17. Epub 2021 Jun 17.

Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.

Delivery of pungent bioactives such as capsaicin from hot peppers is a scientific, technological and sensorial challenge. While capsaicin intake is positively related to various bowel diseases, its high pungency and instability upon digestion generate a problem in its delivery to the target organ. Helical V-amylose architectures have been shown to be a possible nano-sized delivery vehicle for such hydrophobic bioactives. Read More

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Scalp dysesthesia and lichen simplex chronicus: diagnostic and therapeutic update with literature review.

Clin Exp Dermatol 2021 Jun 17. Epub 2021 Jun 17.

Dermatology Unit - IRCCS Policlinico di Sant'Orsola - Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Alma Mater, Studiorum University of Bologna, Bologna, Italy.

Scalp dysesthesia and lichen simplex chronicus, conditions that can be associated, are both challenging and frustrating for the patient and the physician. The etiology is not well elucidated and treatment options are limited. Pathogenetic factors, diagnostic methods and therapeutic options in the management of scalp dysesthesia are reviewed according to the literature: dissociation, cervical spine disease and muscle tension seem to be the most important pathogenetic factors. Read More

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Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity.

Food Sci Nutr 2021 Jun 4;9(6):2823-2835. Epub 2021 May 4.

INDIGO Biosciences, Inc. State College PA USA.

Obesity is a significant public health concern, and finding safe and effective means for combating this condition is needed. This study investigates the safety and efficacy of supplementation of a blend of capsaicinoids on weight gain, fat mass, and blood chemistry in a high-fat diet (HFD) model of obesity in mice and on adipocyte differentiation and gene expression in 3T3-L1 preadipocytes. High-fat diet (HFD)-fed mice were treated with a proprietary capsaicinoid concentrate (Capsimax; OmniActive Health Technologies Ltd. Read More

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High-throughput screening of TRPV1 ligands in the light of the Bioluminescence Resonance Energy Transfer technique.

Mol Pharmacol 2021 Jun 14. Epub 2021 Jun 14.

IMS laboratory / CNRS UMR 5218, Bordeaux University, France

Ion channels are attractive drug targets for many therapeutic applications. However, high-throughput screening (HTS) of drug candidates is difficult and remains very expensive. We thus assessed the suitability of the Bioluminescence Resonance Energy Transfer (BRET) technique as a new HTS method for ion-channel studies by taking advantage of our recently characterized intra- and intermolecular BRET probes targeting the TRPV1 ion channel. Read More

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Improving NKCC1 Function Increases the Excitability of DRG Neurons Exacerbating Pain Induced After TRPV1 Activation of Primary Sensory Neurons.

Front Cell Neurosci 2021 25;15:665596. Epub 2021 May 25.

The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Physiology, Shihezi University Medical College, Shihezi, China.

Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action. Male Sprague-Dawley rats were randomly divided into control, capsaicin, and inhibitor groups. The expression and distribution of TRPV1 and NKCC1 in rat DRG were observed by immunofluorescence. Read More

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Trends and characteristics associated with dietary triggers and psychological distress in patients with irritable bowel syndrome: a cross-sectional study.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3752-3761

Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.

Objective: Diet, visceral sensitivity, and psychological distress play an important role in Irritable Bowel Syndrome (IBS). This study focused on the relation between IBS severity, foods, visceral sensitivity, and anxiety/depression.

Patients And Methods: Patients with IBS were investigated through (1) IBS-symptoms severity score (SSS), (2) self-reported food intolerance, (3) visceral sensitivity index (VSI), and (4) Hospital Anxiety and Depression Scale (HADS). Read More

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