15,549 results match your criteria capsaicin


Gut Microbiota Mediates the Preventive Effects of Dietary Capsaicin Against Depression-Like Behavior Induced by Lipopolysaccharide in Mice.

Front Cell Infect Microbiol 2021 27;11:627608. Epub 2021 Apr 27.

Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.

Capsaicin (CAP) is an active ingredient in chili pepper that is frequently consumed. It exerts various pharmacological activities, and also has potential effects on mental illness. However, its mechanism of antidepressant effects is still unclear. Read More

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Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation.

Front Pharmacol 2021 27;12:659015. Epub 2021 Apr 27.

Institute of Cardiovascular Diseases, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital of Nanchang University, Nanchang, China.

The myocardium is susceptible to lipopolysaccharide (LPS)-induced damage in sepsis, and cardiac dysfunction is a leading cause of mortality in patients with sepsis. The changes in cardiomyocyte autophagy in sepsis and the effects and mechanism of action of capsaicin (Cap) remain unclear. The potential pathway of 14-3-3γ-dependent autophagy and the effects and mechanisms of Cap were studied in LPS-induced injury to primary cultured neonatal rat cardiomyocytes. Read More

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A preliminary prospective observational study of the effectiveness of high-concentration capsaicin cutaneous patch in the management of chronic post-surgical neuropathic pain.

Ir J Med Sci 2021 May 13. Epub 2021 May 13.

Department of Anaesthesiology and Pain Medicine, St. James's Hospital, Dublin, Ireland.

Introduction: Chronic post-surgical neuropathic pain is difficult to treat. Topically applied analgesics provide an alternative to systemic therapy in localised neuropathic pain syndromes. The aim of this study was to prospectively assess whether 8% capsaicin is effective in surgically induced neuropathic pain. Read More

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PEER systematic review of randomized controlled trials: Management of chronic neuropathic pain in primary care.

Can Fam Physician 2021 May;67(5):e130-e140

Nurse in Edmonton and Clinical Evidence Expert for the College of Family Physicians of Canada.

Objective: To determine the proportion of patients with neuropathic pain who achieve a clinically meaningful improvement in their pain with the use of different pharmacologic and nonpharmacologic treatments.

Data Sources: MEDLINE, EMBASE, the Cochrane Library, and a gray literature search.

Study Selection: Randomized controlled trials that reported a responder analysis of adults with neuropathic pain-specifically diabetic neuropathy, postherpetic neuralgia, or trigeminal neuralgia-treated with any of the following 8 treatments: exercise, acupuncture, serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), topical rubefacients, opioids, anticonvulsant medications, and topical lidocaine. Read More

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Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling.

Mol Brain 2021 May 10;14(1):79. Epub 2021 May 10.

Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Astrocytes are critical regulators of neuronal function in the central nervous system (CNS). We have previously shown that astrocytes in the spinal dorsal horn (SDH) have increased intracellular Ca levels following intraplantar injection of the noxious irritant, formalin. However, the underlying mechanisms remain unknown. Read More

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Time-resolved fluorescent lateral flow strip for easy and rapid quality control of edible oil.

Food Chem 2021 Apr 6;357:129739. Epub 2021 Apr 6.

School Food and Biological Engineering, Hefei University of Technology, China. Electronic address:

Gutter oil is strictly prohibited from being reprocessed back to the catering and food industry. Extensive attention has been paid to rapid screening of gutter oil to guarantee the safety of edible oil. Capsaicin, a special component of condiments, has been adopted as the marker of gutter oil. Read More

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Divergent metabolic responses to sex and reproduction in the sea cucumber Apostichopus japonicus.

Comp Biochem Physiol Part D Genomics Proteomics 2021 May 6;39:100845. Epub 2021 May 6.

Liaoning Key Lab of Germplasm Improvement and Fine Seed Breeding of Marine Aquatic Animals, Liaoning Ocean and Fisheries Science Research Institute, Dalian, Liaoning 116023, PR China. Electronic address:

The sea cucumber Apostichopus japonicus is an economically important marine organism, and its aquaculture has rapidly developed in China. The very large market demand puts forward higher requirements for the economically efficient breeding of sea cucumbers. Sex and the associated reproductive processes have been reported to affect the physiological characteristics of sea cucumbers. Read More

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Plant Metabolites Drive Different Responses in Caterpillars of Two Closely Related Species.

Front Physiol 2021 21;12:662978. Epub 2021 Apr 21.

The Institute of Chemical Ecology and College of Plant Protection, Henan Agricultural University, Zhengzhou, China.

The host acceptances of insects can be determined largely by detecting plant metabolites using insect taste. In the present study, we investigated the gustatory sensitivity and feeding behaviors of two closely related caterpillars, the generalist (Hübner) and the specialist (Guenée), to different plant metabolites by using the single sensillum recording technique and the dual-choice assay, aiming to explore the contribution of plant metabolites to the difference of diet breadth between the two species. The results depicted that the feeding patterns of caterpillars for both plant primary and secondary metabolites were significantly different between the two species. Read More

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Effects of ethephon on ethephon residue and quality properties of chili pepper during pre-harvest ripening.

J Food Sci Technol 2021 Jun 18;58(6):2098-2108. Epub 2020 Aug 18.

College of Food Science, Southwest University, 2 Tiansheng Road, Beibei, Chongqing, 400715 People's Republic of China.

The application of ethephon was investigated to examine its effects on both ethephon residue and quality properties of chili peppers during pre-harvest ripening with the goal of facilitating maximum commercial harvest along with improving color and flavor. A single ethephon treatment significantly increased * and * values and capsanthin concentration, while decreased total chlorophyll contents. Moreover, ethephon treatment induced significant promotion of capsaicin synthesis and reduction of soluble sugar content. Read More

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Dose Escalation and Safety of Capsaicin for Cerebral Perfusion Augmentation: A Pilot Study.

Stroke 2021 May 10:STROKEAHA120032773. Epub 2021 May 10.

Instituto Mexicano del Seguro Social HGZ 2, Aguascalientes, Mexico (J.M.M.-R., C.A.M.-G., M.G.V.-B.).

Background And Purpose: Sphenopalatine ganglion (SPG) electrical stimulation has been studied in the setting of acute ischemic stroke to enhance collateral flow. Capsaicin poses an alternative to chemically stimulate the sphenopalatine ganglion. Therefore, the objective of this study was to determine the safety and effect of increasing doses of capsaicin upon serial transcranial Doppler markers of cerebral blood flow. Read More

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Nano-sized carriers for capsaicinoids with topic analgesic and anti-inflammatory effects.

J Biotechnol 2021 May 5;333:77-85. Epub 2021 May 5.

Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Eugenio Garza Sada 2501 Sur, C.P., 64849, Monterrey, N.L., Mexico. Electronic address:

Capsaicinoids confer the pungency in chili peppers and are proven to contain many beneficial traits, among them analgesic and anti-inflammatory properties. Capsaicinoids produce a burning sensation when administered and have other secondary effects given their pungency. This is why many drug delivery vehicles have been tested to prove their efficacy in reducing the secondary effects of these compounds while still having its primary beneficial effects. Read More

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Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum.

Cell Calcium 2021 Apr 30;97:102417. Epub 2021 Apr 30.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Background: The roles of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and subfamily A, member 1 (TRPA1) in mechanisms of gastrointestinal motility are complex. This study aimed to clarify the effects of several TRPV1 and TRPA1 ligands on the electrical potentials generated by pacemaker cells in the mouse-isolated ileum.

Method: The pacemaker potentials of ileal segments of mice were recorded extracellularly using a 60-channel microelectrode array. Read More

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TLC-ESI-MS as a QuEChERS approach to detection of capsaicin present in different matrices.

Nat Prod Res 2021 May 7:1-5. Epub 2021 May 7.

Chemical Engineering Section, Laboratory of Organic Bioprocesses, Military Engineering Institute (IME), Rio de Janeiro, Brazil.

Pepper is one of the most consumed spices in the world. Its main compound is capsaicin, a widely studied biomarker that has pharmacological activities due to its anti-inflammatory and analgesic capacity. Topical formulations such as patches based on capsaicin have been developed as an option in relieving pain and reducing swelling. Read More

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p70S6K on astrocytes protects dopamine neurons from 1-methyl-4-phenylpyridinium neurotoxicity.

Glia 2021 May 6. Epub 2021 May 6.

Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, South Korea.

Our recent finding has demonstrated that astrocytes confer neuroprotection by endogenously producing ciliary neurotrophic factor (CNTF) via transient receptor potential vanilloid 1 (TRPV1) in Parkinson's disease (PD). In this study, the possible molecular target for TRPV1-mediated CNTF production and its neuroprotective effects on dopamine neurons were further investigated. For comparison, glial cell-line derived neurotrophic factor (GDNF) was also examined. Read More

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Sweet pepper and its principle constituent capsiate: functional properties and health benefits.

Crit Rev Food Sci Nutr 2021 May 6:1-25. Epub 2021 May 6.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Capsiate is a non-pungent analogue of capsaicin. It belongs to the family of capsinoids which are esters of vanillyl alcohol with fatty acids while capsaicin belongs to the family of capsaicinoids that are amides of vanillylamine with a variety of branched-chain fatty acids. While capsaicin is extensively reported for plethora of pharmacological actions, capsiate remains much less explored. Read More

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Electroanalytical overview: the pungency of chile and chilli products determined the sensing of capsaicinoids.

Analyst 2021 May;146(9):2769-2783

Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK.

When you bite into a chile pepper or eat food containing chile (chilli), one might feel heat, or other associated feelings, some good such as the release of endorphins, and some bad. The heat, or pungency, and related feelings from eating chile peppers are the result of their chemical composition, i.e. Read More

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Quinoa (Chenopodium quinoa Willd.) Seeds Increase Intestinal Protein Uptake.

Mol Nutr Food Res 2021 May 3:e2100102. Epub 2021 May 3.

National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.

Scope: Within the last decade, quinoa seeds have gained much popularity as a new food and have recently been proposed as an appropriate food for early introduction in infants. Quinoa contains high levels of saponins, which are known for their adjuvant activity and effect on the intestinal barrier function. The aim of this study was to investigate the impact of quinoa on intestinal permeability and inflammation in comparison with the positive controls; cholera toxin (CT) and capsaicin. Read More

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Activation of TRPV1 by Capsaicin or Heat Drives Changes in 2-Acyl Glycerols and -Acyl Ethanolamines in a Time, Dose, and Temperature Dependent Manner.

Front Cell Dev Biol 2021 16;9:611952. Epub 2021 Apr 16.

Bradshaw Laboratory of Lipid Neuroscience, Indiana University Bloomington, Bloomington, IN, United States.

Endocannabinoids (eCBs) and transient receptor potential (TRP) channels are associated with thermoregulation; however, there are many gaps in the understanding of how these signaling systems work together in responding to changes in temperature. TRPV1, a calcium-permeable ion channel, is activated by capsaicin, elevated temperature, the eCB Anandamide, and over 15 additional endogenous lipids. There is also evidence for signaling crosstalk between TRPV1 and the eCB receptor, CB. Read More

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[Involvement of Pirt /TRPV1 signaling in acupuncture-induced reduction of visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats].

Zhen Ci Yan Jiu 2021 Apr;46(4):278-83

School of Acupuncture-moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Objective: To observe the effect of electroacupuncture (EA) on the expression of Pirt (a regulator of TRPV1) in the dorsal root ganglia (DRG) and transient receptor potential vanilloid 1 (TRPV1, a molecular sensor of noxious heat and capsaicin) in the colonic mucosa in rats suffering from diarrhea-predominant irritable bowel syndrome (IBS-D), so as to explore its mechanisms underlying alleviation of visceral hypersensitivity of IBS-D.

Methods: Forty SD rats (half male and half female) were randomly assigned to control, model, EA, and medication groups by lottery, with 10 rats in each group. The IBS-D model was established by chronic unpredictable mild stress (CUMS) and gavage of senna soaking fluid. Read More

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Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice.

Sci Rep 2021 Apr 29;11(1):9224. Epub 2021 Apr 29.

Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 890-8544, Japan.

Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. Read More

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Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper ( L.) Fruits and Their Modulation by Nitric Oxide (NO).

Int J Mol Sci 2021 Apr 25;22(9). Epub 2021 Apr 25.

Group of Antioxidant, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC, 18008 Granada, Spain.

Plant species are precursors of a wide variety of secondary metabolites that, besides being useful for themselves, can also be used by humans for their consumption and economic benefit. Pepper ( L.) fruit is not only a common food and spice source, it also stands out for containing high amounts of antioxidants (such as vitamins C and A), polyphenols and capsaicinoids. Read More

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Two New -Alkanoyl-5-Hydroxytryptamides with Relevant Antinociceptive Activity.

Biomedicines 2021 Apr 22;9(5). Epub 2021 Apr 22.

Laboratório de Farmacologia da Dor e da Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

In this work, we describe a new route for the synthesis and the antinociceptive effects of two new -alkanoyl-5-hydroxytryptamides (named C-5HT and C-5HT). The antinociceptive activities were evaluated using well-known models of thermal-induced (reaction to a heated plate, the hot plate model) or chemical-induced (licking response to paw injection of formalin, capsaicin, or glutamate) nociception. The mechanism of action for C-5HT and C-5HT was evaluated using naloxone (opioid receptor antagonist, 1 mg/kg), atropine (muscarinic receptor antagonist, 1 mg/kg), AM251 (cannabinoid CB1 receptor antagonist, 1 mg/kg), or ondansetron (5-HT3 serotoninergic receptor antagonist, 0. Read More

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Vitamin B and Zinc Supplements and Capsaicin Oral Rinse Treatment Options for Burning Mouth Syndrome.

Medicina (Kaunas) 2021 Apr 17;57(4). Epub 2021 Apr 17.

RSU Institute of Stomatology, Department of Oral Medicine, Rīga Stradiņš University, LV-1007 Riga, Latvia.

: Burning mouth syndrome (BMS) is an enigmatic, idiopathic, chronic, often painful clinical entity, where patients experience oral burning without clear clinical changes on the oral mucosa. There are yet to be well established standardized and validated definitions, diagnostic criteria or classifications for burning mouth syndrome. The aim of this study is to determine whether vitamin B complex and zinc supplements or 0. Read More

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Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of .

Biomolecules 2021 Apr 17;11(4). Epub 2021 Apr 17.

Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.

is a "super-food" and has attracted researchers' attention due to its anti-inflammatory, antioxidant, and analgesic properties. Herein, we investigated the antinociceptive effects of in different rodent behavior models of inflammatory pain. Male Swiss mice were treated with (3-300 mg/kg, p. Read More

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