153,218 results match your criteria capacity female

[Perioperative Medicine in Visceral Surgery in the Elderly Patient from an Anaesthesiological Perspective].

Zentralbl Chir 2021 Jun 21;146(3):296-305. Epub 2021 Jun 21.

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Bonn, Deutschland.

Demographic change is leading to an increasing number of old patients both in our society and in hospitals. With increasing age, not only the number of pre-existing conditions increases, but also the postoperative complication rate and mortality. Ultimately, however, it is not age that is decisive, but the condition of the patient and his or her capacity to face the physical and mental challenges of a surgical procedure. Read More

View Article and Full-Text PDF

Effects of sex differences on breath-hold diving performance.

Respir Physiol Neurobiol 2021 Jun 18:103721. Epub 2021 Jun 18.

Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa-city, Saitama, 359-1192, Japan.

Purpose: The present study aimed to measure diving response, CO sensitivity and forced vital capacity in male and female breath-hold divers (BHDs), and to determine their effect on breath-hold diving performance.

Methods: This study included 8 non-divers (NDs, 4 males and 4 females) and 15 BHDs (7 males and 8 females). For NDs, diving response was measured during breath-holding with facial immersion, whereas for BHDs CO sensitivity was also measured. Read More

View Article and Full-Text PDF

Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats.

Am J Physiol Renal Physiol 2021 06 21. Epub 2021 Jun 21.

Department of Biomedical Engineering, Duke University, Durham, NC, United States.

The spontaneously hypertensive rat (SHR), a genetic model of high blood pressure, has also been studied as a potential model of overactive bladder (OAB). In vivo studies confirmed the presence of surrogate markers of OAB, including detrusor overactivity (DO), increased urinary frequency, decreased bladder capacity and voided volume, and afferent hypersensitivity to bladder irritation. However, these observations were during awake cystometry (CMG) using implanted bladder catheters tethered to an infusion pump and artificially filled. Read More

View Article and Full-Text PDF

Irisin, Fibroplast Growth Factor-21, and Follistatin Responses to Endurance Rowing Training Session in Female Rowers.

Front Physiol 2021 4;12:689696. Epub 2021 Jun 4.

Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.

This study examined selected myokine responses to an endurance rowing training session, and whether metabolic demands of the acute aerobic rowing exercise together with training volume, aerobic capacity, and body composition variables affect potential exercise-induced changes in the myokine levels in female rowers. Fifteen national level female rowers [18.3 ± 1. Read More

View Article and Full-Text PDF

The neuroprotective role of morroniside against spinal cord injury in female rats.

Neurochem Int 2021 Jun 17:105105. Epub 2021 Jun 17.

Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, 287 Chang Huai Road, Bengbu, 233004, PR China; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, 233004, PR China. Electronic address:

Spinal cord injury (SCI) is a disabling condition that often leads to permanent neurological deficits without an effective treatment. Reactive oxygen species (ROS) produced during oxidative stress play a vital role in the pathogenesis following SCI. The antioxidant morroniside is the main active component of the Chinese medicine Cornus officinalis. Read More

View Article and Full-Text PDF

Chitosan nanoparticles alleviated endocrine disruption, oxidative damage, and genotoxicity of Bisphenol-A- intoxicated female African catfish.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 17;248:109104. Epub 2021 Jun 17.

Department of Zoology, Faculty of women for Arts, Science & Education, Ain Shams University, Cairo 11757, Egypt.

Bisphenol-A (BPA) is widely used in production of plastic products. It can reach the ecosystems affecting aquatic organisms most likely fishes. The purpose of this study was to study the toxic effects of BPA on the biochemical variables and oxidative stress in female African catfish, Clarias gariepinus and to estimate the protective role of chitosan nanoparticles (CSNPs) against BPA toxicity. Read More

View Article and Full-Text PDF

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study.

BMJ Open 2021 06 18;11(6):e042376. Epub 2021 Jun 18.

Universidad Autónoma del Estado de México, Toluca, México, Mexico.

Objectives: To assess the association between the Human Development Index (HDI) and covariates on the mortality-to-incidence ratio (MIR) of lips and oral cavity cancer (LOCC) in Mexico.

Design: Ecological study.

Setting: Data from 32 Mexican states for year 2019. Read More

View Article and Full-Text PDF

Predictors of Poor Functional Status in Adult Fontan Patients Living at Moderate Altitude.

Pediatr Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Pediatrics, Section of Cardiology, University of Colorado School of Medicine, Aurora, USA.

Patients who have undergone Fontan palliation have reduced exercise tolerance measured by maximal oxygen consumption (VO max). Declining exercise capacity is associated with increased morbidity and mortality. The impact of hemodynamics and other variables on this population's functional status is not well understood. Read More

View Article and Full-Text PDF

Marketing Healthy Food in an African City: Consumer Motivations for Adopting Orange-Fleshed Sweet Potato in Maputo, Mozambique.

Roland Brouwer

Food Nutr Bull 2021 Jun 18:3795721211021266. Epub 2021 Jun 18.

54718International Potato Center, Lima, Peru.

Since the late 1990s, the International Potato Center has promoted orange-fleshed sweet potato (OFSP) cultivars in Mozambique as a healthy food, emphasizing its capacity to reduce the prevalence of vitamin A deficiency among mothers and young children. This article seeks to reveal why consumers in Maputo, the capital city of Mozambique, adopt or reject OFSP looking at the role of food systems and consumer characteristics in access and acceptance of healthy food and at the positioning OFSP on the market in terms of lifestyle and need satisfaction.The results of 255 street interviews confirm that OFSP is widely known. Read More

View Article and Full-Text PDF

Mycophenolic Acid Exposure Optimization Based on Vitamin D Status in Children with Systemic Lupus Erythematosus: A Single-Center Retrospective Study.

Rheumatol Ther 2021 Jun 17. Epub 2021 Jun 17.

Department of Clinical Pharmacy, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, 201102, China.

Introduction: Systemic lupus erythematosus (SLE) can affect bone metabolism and homeostasis of serum electrolytes that are associated with abnormal levels of vitamin D. Mycophenolate mofetil (MMF) is a commonly used immunosuppressant with the active metabolite mycophenolic acid (MPA). The area under the plasma concentration-time curve (AUC) of MPA is often monitored during the treatment to assess the exposure levels. Read More

View Article and Full-Text PDF

Maternal Piwi Regulates Primordial Germ Cell Development to Ensure the Fertility of Female Progeny in Drosophila.

Genetics 2021 Jun 17. Epub 2021 Jun 17.

Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06519, USA.

In many animals, germline development is initiated by proteins and RNAs that are expressed maternally. PIWI proteins and their associated small noncoding PIWI-interacting RNAs (piRNAs), which guide PIWI to target RNAs by base-pairing, are among the maternal components deposited into the germline of the Drosophila early embryo. Piwi has been extensively studied in the adult ovary and testis, where it is required for transposon suppression, germline stem cell self-renewal, and fertility. Read More

View Article and Full-Text PDF

Fungal Prosthetic Joint Infection Following Total Knee Arthroplasty: A Case Report.

J Orthop Case Rep 2021 Feb;11(2):95-98

Department of Orthopaedic Surgery, University of Jordan and Jordan University Hospital, Aljubeiha, Amman, Jordan.

Introduction: Prosthetic joint infection (PJI) is a rare complication of total knee replacement (TKR), yet it is a serious and debilitating condition. Bacterial infection accounts for the majority of cases and fungal infection is estimated to cause 1% of all prosthesis infection.

Case Report: This case presents a 60years female, who presented to our outpatient orthopedic clinic complaining of right knee pain, swelling, and hotness. Read More

View Article and Full-Text PDF
February 2021

The correlation between quadriceps muscle strength and endurance and exercise performance in patients with COPD.

J Appl Physiol (1985) 2021 06 17. Epub 2021 Jun 17.

Department of Research and Development, Ciro, Horn, The Netherlandsgrid.491136.8.

Purpose To determine the association between quadriceps muscle strength (QMS) and endurance (QME) and exercise capacity in COPD patients after stratification for sex and resting lung function (LF). Methods Data were collected in 3246 COPD patients (60% men, 64±9 years), including measures of exercise capacity (peak aerobic capacity (peakVO)), six-minute walk distance (6MWD)) and isokinetic QMS and QME. Patients were stratified for sex, forced expiratory volume in 1 s (>50/≤50% predicted), single breath carbon monoxide diffusing capacity (>50/≤50% predicted) and residual volume (>140/≤140% predicted). Read More

View Article and Full-Text PDF

Efficacy And Tolerability Of Oral Iron Chelator, Deferasirox.

J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):207-212

Fauji Foundation Hospital, Rawalpindi, Pakistan.

Background: Thalassemia major is the severe form of β thalassemia characterized by severe anaemia, hepatosplenomegaly and facioskeletal changes due to increased haemolysis of defective red blood cells. In iron overload states, high levels of iron exceed the iron-carrying capacity of transferrin within the plasma, leading to the formation of nontransferrin-bound iron form. These nontransferrin-bound iron forms can be taken up into cells, including liver, heart, and endocrine cells leading to organ damage. Read More

View Article and Full-Text PDF

Novel diagnostic and therapeutic approaches to pulmonary hypertension due to the unilateral absence of a pulmonary artery.

ESC Heart Fail 2021 Jun 16. Epub 2021 Jun 16.

Department of Cardiovascular Medicine, Kyorin University Hospital, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

We report the case of a 64-year-old female diagnosed with severe pulmonary hypertension due to the unilateral absence of a pulmonary artery. The four-dimensional computed tomography scan is a useful modality for revealing detailed anatomical findings for differential diagnoses and surgical decision-making. The patient had severe pulmonary hypertension with a mean pulmonary artery pressure (PAP) of 74 mmHg and was treated with triple upfront combination therapy, leading to significant improvement in pulmonary haemodynamics (to 27 mmHg in mean PAP) and functional capacity (WHO functional class, from III to II; 6-min walk distance, from 211 to 276 m). Read More

View Article and Full-Text PDF

Predictors of Diffusing Capacity in Children With Sickle Cell Disease: A Longitudinal Study.

Front Pediatr 2021 31;9:678174. Epub 2021 May 31.

Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Gas exchange abnormalities in Sickle Cell Disease (SCD) may represent cardiopulmonary deterioration. Identifying predictors of these abnormalities in children with SCD (C-SCD) may help us understand disease progression and develop informed management decisions. To identify pulmonary function tests (PFT) estimates and biomarkers of disease severity that are associated with and predict abnormal diffusing capacity (DLCO) in C-SCD. Read More

View Article and Full-Text PDF

Are rhetorical commitments to adolescents reflected in planning documents? An exploratory content analysis of adolescent sexual and reproductive health in Global Financing Facility country plans.

Reprod Health 2021 Jun 17;18(Suppl 1):124. Epub 2021 Jun 17.

World Bank, 1818 H Street, NW, Washington, DC, 20433, USA.

Background: The Global Financing Facility (GFF) offers an opportunity to close the financing gap that holds back gains in women, children's and adolescent health. However, very little work exists examining GFF practice, particularly for adolescent health. As momentum builds for the GFF, we examine initial GFF planning documents to inform future national and multi-lateral efforts to advance adolescent sexual and reproductive health. Read More

View Article and Full-Text PDF

Female genital mutilation/cutting (FGM/C) coding capacities in Swiss university hospitals using the International Classification of Diseases (ICD).

BMC Public Health 2021 Jun 16;21(1):1151. Epub 2021 Jun 16.

Division of Gynaecology, Department of the Woman, the Child and the Adolescent, Geneva University Hospitals, 30 Bld de la Cluse, 1211, Geneva, Switzerland.

Background: The real prevalence and incidence of women living with or at risk of female genital mutilation/cutting (FGM/C) is unknown in Switzerland and many parts of Europe, as there are no representative surveys similar to DHS or MICS for European countries. Indirect estimates are commonly used to estimate the number of women with FGM/C in high-income countries, but may not reflect the actual FGM/C prevalence among migrants. Direct measures may provide more accurate estimates that could guide policy- and clinical decision-making. Read More

View Article and Full-Text PDF

Reproductive toxicity and underlying mechanisms of di(2-ethylhexyl) phthalate in nematode Caenorhabditis elegans.

J Environ Sci (China) 2021 Jul 6;105:1-10. Epub 2021 Jan 6.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. Electronic address:

DEHP (di(2-ethylhexyl) phthalate) is an endocrine disruptor commonly found in plastic products that has been associated with reproduction alterations, but the effect of DEHP on toxicity is still widely unknown. Using DEHP concentrations of 10, 1, and 0.1 mg/L, we showed that DEHP reduced the reproductive capacity of Caenorhabditis elegans after 72 hr. Read More

View Article and Full-Text PDF

Substrate-Specific Respiration of Isolated Skeletal Muscle Mitochondria after 1 h of Moderate Cycling in Sedentary Adults.

Med Sci Sports Exerc 2021 Jul;53(7):1375-1384

School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR.

Introduction: Skeletal muscle mitochondria have dynamic shifts in oxidative metabolism to meet energy demands of aerobic exercise. Specific complexes oxidize lipid and nonlipid substrates. It is unclear if aerobic exercise stimulates intrinsic oxidative metabolism of mitochondria or varies between substrates. Read More

View Article and Full-Text PDF

Landscape and selection of vaccine epitopes in SARS-CoV-2.

Genome Med 2021 06 14;13(1):101. Epub 2021 Jun 14.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB# 7295, Chapel Hill, NC, 27599-7295, USA.

Background: Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4 T cell, and CD8 T cell stimulation. The rationale for this design was to drive both humoral and cellular immunity with high specificity while avoiding undesired effects such as antibody-dependent enhancement (ADE).

Methods: We explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein source, concurrent human/murine coverage, and population coverage. Read More

View Article and Full-Text PDF

Stratifying Sepsis in Uganda Using Rapid Pathogen Diagnostics and Clinical Data: A Prospective Cohort Study.

Am J Trop Med Hyg 2021 Jun 14. Epub 2021 Jun 14.

1Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, New York, New York.

The global burden of sepsis is concentrated in sub-Saharan Africa, where extensive pathogen diversity and limited laboratory capacity challenge targeted antimicrobial management of life-threatening infections. In this context, established and emerging rapid pathogen diagnostics may stratify sepsis patients into subgroups with prognostic and therapeutic relevance. In a prospective cohort of adults (age ≥18 years) hospitalized with suspected sepsis in Uganda, we stratified patients using rapid diagnostics for HIV, tuberculosis (TB), malaria, and influenza, and compared clinical characteristics and 30-day outcomes across these pathogen-driven subgroups. Read More

View Article and Full-Text PDF

Patterns of discordance of physical functioning in older persons; different associations for apathy and depression? Results from the NESDO-study.

Aging Ment Health 2021 Jun 14:1-9. Epub 2021 Jun 14.

Department of Epidemiology & Biostatistics, Medical Faculty Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: Discordance between self-reported functional limitations and performance-based physical functioning may have a negative impact in functional independence in older adults. We longitudinally examined baseline apathy- and depressive symptomatology as associates of discordance.

Method: 469 participants from the multi-site cohort study NESDO were included. Read More

View Article and Full-Text PDF

Endurance Is Improved in Female Rats After Living High-Training High Despite Alterations in Skeletal Muscle.

Front Sports Act Living 2021 28;3:663857. Epub 2021 May 28.

Département des Environnements Opérationnels, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.

Altitude camps are used during the preparation of endurance athletes to improve performance based on the stimulation of erythropoiesis by living at high altitude. In addition to such whole-body adaptations, studies have suggested that high-altitude training increases mitochondrial mass, but this has been challenged by later studies. Here, we hypothesized that living and training at high altitude (LHTH) improves mitochondrial efficiency and/or substrate utilization. Read More

View Article and Full-Text PDF

Sex Differences in the Immune System Become Evident in the Perinatal Period in the Four Core Genotypes Mouse.

Front Endocrinol (Lausanne) 2021 27;12:582614. Epub 2021 May 27.

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United States.

We have used the four core genotypes (FCG) mouse model, which allows a distinction between effects of gonadal secretions and chromosomal complement, to determine when sex differences in the immune system first appear and what influences their development. Using splenic T cell number as a measure that could be applied to neonates with as yet immature immune responses, we found no differences among the four genotypes at postnatal day 1, but by day 7, clear sex differences were observed. These sex differences were unexpectedly independent of chromosomal complement and similar in degree to gonadectomized FCG adults: both neonatal and gonadectomized adult females (XX and XY) showed 2-fold the number of CD4+ and 7-fold the number of CD8+ T cells their male (XX and XY) counterparts. Read More

View Article and Full-Text PDF

Seminal exosomes - An important biological marker for various disorders and syndrome in human reproduction.

Saudi J Biol Sci 2021 Jun 17;28(6):3607-3615. Epub 2021 Mar 17.

Unit of Biochemistry, Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia.

Background: Exosomes are nano-sized membrane vesicles, secreted by different types of cells into the body's biological fluids. They are found in abundance in semen as compared to other fluids. Exosomes contain a cargo of lipid molecules, proteins, phospholipids, cholesterol, mRNAs, and miRNAs. Read More

View Article and Full-Text PDF

The Postnatal Leptin Surge Supports Immune Cell Function in Rats.

Immunol Invest 2021 Jun 14:1-17. Epub 2021 Jun 14.

Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology). Faculty of Biology, Complutense University of Madrid, Madrid, Spain.

: Leptin plays an important role in the regulation of the immune response. There is a physiological surge of leptin in rodents during the neonatal period, which has mainly been studied in the context of brain development. However, little is known about the effects of this neonatal leptin surge on immunity. Read More

View Article and Full-Text PDF

Noncanonical functions of glucocorticoids: A novel role for glucocorticoids in performing multiple beneficial functions in endometrial stem cells.

Cell Death Dis 2021 Jun 12;12(6):612. Epub 2021 Jun 12.

Department of Biomedical Science, Jungwon University, Goesan-gun, Chungcheongbuk-do, Republic of Korea.

Chronic stress has a negative impact on many fertility-related functions; thus, the recent decline in female fertility seems to be at least partially associated with increased stress. The secretion of glucocorticoids is a typical endocrine response to chronic stress and indirectly reduces uterine receptivity through the hypothalamus-pituitary-gonadal (HPG) axis. However, in addition to its well-known canonical role, the direct effects of chronic stress-induced glucocorticoids on various uterine functions and their underlying molecular mechanisms are complex and have not yet been revealed. Read More

View Article and Full-Text PDF

Change of physical activity parameters of hip and pelvic fracture patients during inpatient rehabilitation and after discharge: analysis of global and in-depth parameters.

Eur Rev Aging Phys Act 2021 Jun 12;18(1). Epub 2021 Jun 12.

Department of Clinical Gerontology, Robert-Bosch-Hospital, Auerbachstr. 110, 70376, Stuttgart, Germany.

Background: A growing number of older adults suffer hip and pelvic fractures leading to hospital admission. They often result in reduced physical activity (PA) and impaired mobility. PA can be objectively measured with body-worn sensors. Read More

View Article and Full-Text PDF

Is physical capacity correlated with health-related quality of life in patients with adolescent idiopathic scoliosis?

Ann Palliat Med 2021 Jun 4. Epub 2021 Jun 4.

Department of Physical Medicine and Rehabilitation, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: There have been no report about the association between physical capacity and healthrelated quality of life in patients with adolescent idiopathic structural scoliosis (AIS). This study aims to investigate the correlation between dynamic cardiopulmonary capacity and quality of life in AIS patients.

Methods: This retrospective study involved 63 patients. Read More

View Article and Full-Text PDF