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Effect of dietary Xiao-Chaihu-Decoction on growth performance, immune response, detoxification and intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei).

Fish Shellfish Immunol 2021 May 6. Epub 2021 May 6.

The Key Laboratory of Mariculture, Ocean University of China, Ministry of Education, Qingdao, Shandong, 266003, China.

Xiao-Chaihu-Decoction (XCHD), a classical traditional Chinese medicine with diverse biological activities, is widely applied to prevent and treat many human diseases. Effects of dietary XCHD on growth performance, immune response, detoxification system, intestinal microbiota and resistance against aflatoxin B1(AFB) of Litopenaeus vannamei was studied. Four isonitrogenous and isolipidic diets were formulated to contain 0, 1, 2, and 5 g/kg (control, XCHD1, XCHD2 and XCHD3) of XCHD, respectively. Read More

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Protective effects of a standardized extract of on pancreas and liver in streptozotocin-induced diabetic rats.

Res Pharm Sci 2021 Feb 30;16(1):71-78. Epub 2020 Dec 30.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.

Background And Purpose: Previous studies have shown the antioxidant, anti-inflammatory, immunomodulatory, and hypolipidemic activities of . The aim of the present study was to evaluate the protective effects of hydroalcoholic extract of rhizomes on streptozotocin-induced diabetic rats.

Experimental Approach: Twenty-four male Wistar rats were randomly assigned into four groups including a normal control group, diabetic control group, diabetic groups treated for 4 weeks with 100 and 200 mg/kg/day of the extract (IGE). Read More

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February 2021

Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

Poult Sci 2021 Mar 26;100(6):101172. Epub 2021 Mar 26.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

The present study was designed to assess the impact of dietary supplementation of lemongrass essential oil (LGEO) on growth performance, carcass traits, liver and kidney function, immunity, antioxidant indices and caecal microbiota of growing quail. A total of 200 Japanese quails at 1-week-old were haphazardly allotted to 5 groups of 40 chicks in five replicates (8 per replicate). The first group was the control group, while LGEO was added at levels of 150, 300, 450, and 600 mg/kg diet in the 2nd, 3rd, 4th and 5th groups, respectively. Read More

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Preventive effect of Bacillus mojavensis levan against carbon tetrachloride and cisplatin toxicity: in vivo study.

Environ Sci Pollut Res Int 2021 May 5. Epub 2021 May 5.

Laboratory of Plants Improvement and Valorization of Agroressources, National School of Engineering of Sfax (ENIS), University of Sfax, 3038, Sfax, Tunisia.

This study is the first to investigate the hepato- and nephron-preventive effect of levan from Bacillus mojavensis (BM-levan) against toxicity induced by carbon tetrachloride (CCl) and cisplatin. Thirty-six male albino rats weighing between 230 and 250 g were used for this experiment. The groups received multiples doses of BM-levan and were compared to the untreated group. Read More

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Machine Learning Approaches to Identify Factors Associated with Women's Vasomotor Symptoms Using General Hospital Data.

J Korean Med Sci 2021 May 3;36(17):e122. Epub 2021 May 3.

Department of Obstetrics & Gynecology, Korea University College of Medicine, Seoul, Korea.

Background: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine learning.

Methods: Data on 3,298 women, aged 40-80 years, who attended their general health check-up from January 2010 to December 2012 were obtained from Korea University Anam Hospital in Seoul, Korea. Five machine learning methods were applied and compared for the prediction of VMS, measured by the Menopause Rating Scale. Read More

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Aflatoxicosis in Pekin duckling and the effects of treatments with lycopene and silymarin.

Vet World 2021 Mar 29;14(3):788-793. Epub 2021 Mar 29.

Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Egypt.

Background And Aim: Aflatoxins (AFs) are potent toxic metabolites produced from species. Whose existence in poultry ration leads to drastic economic losses, notably in duck, as the most susceptible poultry species. This study aimed to determine tissue residues of AFs, alterations in selected clinical chemistry variables in serum, mainly during the exposure period, and lycopene and silymarin's possible roles as herbal treatments against aflatoxicosis in Pekin duckling. Read More

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Isolation, Identification and Function of AR and Its Effects on the Growth and Health of Weaned Pigs.

Animals (Basel) 2021 Apr 20;11(4). Epub 2021 Apr 20.

Fermentation Engineering Department, Hunan Institute of Microbiology, Changsha 410009, China.

This study isolates and identifies () AR, and studies its effect on the growth and health of weaned pigs. A strain from solid wine koji is isolated and identified using 26S rDNA analysis, and its culture conditions are optimized. Heat tolerance, bile salt tolerance, artificial gastric, and intestinal juice tolerance are evaluated. Read More

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Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness.

Cancer Metab 2021 Apr 28;9(1):18. Epub 2021 Apr 28.

Laboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, 01246-903, Brazil.

Background: Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. Metabolic reprogramming currently is recognized as one of the hallmarks of cancer. Read More

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One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency.

Genet Med 2021 Apr 19. Epub 2021 Apr 19.

Sanofi, Bridgewater, NJ, USA.

Purpose: To assess olipudase alfa enzyme replacement therapy for non-central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) in children.

Methods: This phase 1/2, international, multicenter, open-label trial (ASCEND-Peds/NCT02292654) administered intravenous olipudase alfa every 2 weeks with intrapatient dose escalation to 3 mg/kg. Primary outcome was safety through week 64. Read More

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Swietenine potentiates the antihyperglycemic and antioxidant activity of Metformin in Streptozotocin induced diabetic rats.

Biomed Pharmacother 2021 Apr 13;139:111576. Epub 2021 Apr 13.

Pharmaceutical Chemistry Department, School of Pharmacy, International Medical University, 126 Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation (IRDI), International Medical University, 126 Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia. Electronic address:

Diabetes mellitus or type-2 diabetes, commonly referred as diabetes, is a metabolic disorder that results in high blood sugar level. Despite the availability of several antidiabetic drugs in the market, they still do not adequately regulate blood sugar levels. Thus, in general people prefer to use herbal supplements/medicines along with antidiabetic drugs to control blood sugar levels. Read More

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Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin Is Essential for Effective Splenic Clearance of Pneumococcus.

J Immunol 2021 May 15;206(9):2135-2145. Epub 2021 Apr 15.

Division of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO; and

Asplenia imparts susceptibility to life-threatening sepsis with encapsulated bacteria, such as the pneumococcus. However, the cellular components within the splenic environment that guard against pneumococcal bacteremia have not been defined. The actin-bundling protein L-plastin (LPL) is essential for the generation of marginal zone B cells and for anti-pneumococcal host defense, as revealed by a mouse model of genetic LPL deficiency. Read More

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Improving the reproductive, immunity and health status of rabbit does using honey bee venom.

J Anim Physiol Anim Nutr (Berl) 2021 Apr 15. Epub 2021 Apr 15.

Department of Poultry Production, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt.

The aim of the present study was to investigate the long-term effect of using bee venom (BV) on the reproductive performance, immune, and health status of rabbit does and its effect on their litters. Sixty mature does, from Spanish V-line rabbit stock, were randomly assigned to four homogeneous groups with 15 does each. The 1 , 2 and 3 groups were injected twice weekly under the neck skin with 0. Read More

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Editorial: Nutritional Buffering Strategies to Improve Exercise Capacity and Performance.

Front Nutr 2021 25;8:669102. Epub 2021 Mar 25.

College of Health Solutions, Arizona State University, Tempe, AZ, United States.

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Protective Effects of Mill. Fruit on Carbon Tetrachloride-induced Hepatotoxicity Mediated through Mitochondria and Restoration of Cellular Energy Content.

Iran J Pharm Res 2020 ;19(4):354-364

Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Quince ( Mill.) is one of the medicinal plant with a broad range of pharmacological activities such as hepatoprotective effect. The present study was conducted to evaluate the effect of aqueous extract of Mill. Read More

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January 2020

White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects.

Drug Des Devel Ther 2021 31;15:1441-1457. Epub 2021 Mar 31.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, 400067, People's Republic of China.

Aim: White tip silver needle, a slightly fermented white tea, is abundant in flavonoids, and it has great significance in terms of D-galactose/lipopolysaccharide-induced aging in mice.

Methods: We analyzed the antioxidant capacity of white tip silver needle flavonoids (WTSNF) in vitro, assessed the effects of WTSNF on organ indexes, pathological changes, liver function indexes, biochemical indicators, molecular biological indicators, and genes related to oxidation and inflammation.

Results: Ultra-high performance liquid chromatography-tandem mass spectrometry results showed that WTSNF contained baicalin, kaempferol, kaempferide, quercetin, isorhamnetin, lespenephryl, and rutin. Read More

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Increased levels of ferritin on admission predicts intensive care unit mortality in patients with COVID-19.

Med Clin (Engl Ed) 2021 Apr 1;156(7):324-331. Epub 2021 Apr 1.

Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.

Background: The aim of this study was to evaluate hyperferritinemia could be a predicting factor of mortality in hospitalized patients with coronavirus disease-2019 (COVID-19).

Methods: A total of 100 hospitalized patients with COVID-19 in intensive care unit (ICU) were enrolled and classified into moderate ( = 17), severe ( = 40) and critical groups ( = 43). Clinical information and laboratory results were collected and the concentrations of ferritin were compared among different groups. Read More

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Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats.

Pak J Pharm Sci 2020 Sep;33(5):2131-2142

Department of Food Science and Technology, National Pingtung University of Science and Technology, Neipu, Pingtung County, Taiwan.

The hepatoprotective effects of a water extract formula (WEF) derived from three selected TCM herbs (i.e. Corn silk (Maydis stigma), lotus leaf (Nelumbo nucifera Gaertn) and dandelion (Taraxacum officinale)) were apprised by the antioxidant activities and by the decay of carbon tetrachloride (CCl)-induced rats. Read More

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September 2020

Flavonoid-rich fraction of leaves alleviates hepatotoxicity induced by carbon tetrachloride in Wistar rats.

Drug Chem Toxicol 2021 Apr 7:1-17. Epub 2021 Apr 7.

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Federal Republic of Nigeria.

P. Beauv. (Icacinaceae) is a good source of natural antioxidants, having the potential to protect against oxidative stress-related diseases and complications. Read More

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Physiological and immune responses to long road transportation in Andaman local pigs.

Trop Anim Health Prod 2021 Apr 5;53(2):247. Epub 2021 Apr 5.

Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, 744101, India.

Transportation of farm animals is a routine management practice. During transportation, animals experience physiological and psychological stress which has negative consequences on health and welfare of animals. Effect of transportation on pig health and welfare in island ecosystem is not properly known. Read More

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Potential Protective Role of Cyrtopodion Scabrum in Antioxidant Parameters in Serum and Liver of Rats with 5-FU-Induced Oxidative Damage.

Arch Razi Inst 2021 Mar 1;76(1):95-105. Epub 2021 Mar 1.

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Chemotherapy is the main approach for the treatment of cancer; however, it often causes unpleasant oxidative damages. Therefore, the development of an effective alternative/complementary therapy with improved tumor suppression efficiency and lower adverse effects is highly required. Recently, it has been shown that Cyrtopodion scabrum extract (CsE) is an effective and selective tumor suppressor medicine. Read More

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Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD .

Mol Ther Nucleic Acids 2021 Jun 1;24:253-263. Epub 2021 Mar 1.

Centre de Recherche du CHU, Québec-Université Laval, Québec, QC G1V 4G2, Canada.

The amyloid precursor protein () is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer's disease. Genomic analysis of an Icelandic population that did not show symptoms of Alzheimer's at an advanced age led to the discovery of the A673T mutation. Read More

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Impact of high dietary energy on obesity and oxidative stress in domestic pigeons.

Vet Med Sci 2021 Apr 3. Epub 2021 Apr 3.

Department of Clinical Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Obesity is associated with increased risk of oxidative stress in humans and laboratory animals but information regarding obesity-induced oxidative stress in birds is lacking. Therefore, this study aimed to investigate the influence of high-energy diets (HED) on obesity and oxidative stress in domestic pigeons. Forty-five adult clinically healthy-domestic male pigeons were randomly assigned to three equal dietary groups including low (2,850 kcal/kg), medium (3,150 kcal/kg) and high (3,450 kcal/kg) energy diets (named low energy diet, medium-energy diet and HED, respectively). Read More

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Synthesis of OmpA Oral Nanoparticles and Evaluation of Immune Functions against the Major Etiologic Agent of Cow Mastitis.

Vaccines (Basel) 2021 Mar 23;9(3). Epub 2021 Mar 23.

College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.

is a major etiologic agent of cow mastitis, a condition that results in huge economic losses. There is a lack of an oral vaccine for cow mastitis. Previous studies have confirmed that the outer membrane protein A (OmpA) of is immunogenic and can be used for vaccine design. Read More

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Comprehensive Phenolic and Free Amino Acid Analysis of Rosemary Infusions: Influence on the Antioxidant Potential.

Antioxidants (Basel) 2021 Mar 23;10(3). Epub 2021 Mar 23.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, R. J. Viterbo Ferreira, 4050-313 Porto, Portugal.

The phenolics profile, free amino acids composition, and antioxidant potential of rosemary infusions were studied. Forty-four compounds belonging to nine different groups (hydroxybenzoic acids, hydroxycinnamic acids, flavan-3-ols, flavanones, flavones, phenolic diterpenes, hydroxybenzaldehydes, coumarins, and pyranochromanones) were identified by UHPLC-ESI-Q-TOF-MS. Of these, seven were firstly described in rosemary infusions: a rosmanol derivative, two dihydroxycoumarin hexosides, a hydroxybenzaldehyde, a dihydroxybenzoic acid hexoside, coumaric acid hexoside, and isocalolongic acid. Read More

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Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues.

Int J Mol Sci 2021 Mar 6;22(5). Epub 2021 Mar 6.

Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.

A homo-dimeric enzyme, thymidylate synthase (TS), has been a long-standing molecular target in chemotherapy. To further elucidate properties and interactions with ligands of wild-type mouse thymidylate synthase (mTS) and its two single mutants, H190A and W103G, spectroscopic and theoretical investigations have been employed. In these mutants, histidine at position 190 and tryptophan at position 103 are substituted with alanine and glycine, respectively. Read More

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Is a Four-Week Ketogenic Diet an Effective Nutritional Strategy in CrossFit-Trained Female and Male Athletes?

Nutrients 2021 Mar 6;13(3). Epub 2021 Mar 6.

Department of Physiology and Biochemistry, Poznan University of Physical Education, 61-871 Poznań, Poland.

This single-arm interventional study examined the effect of a 4-week ketogenic diet (KD) on aerobic capacity and discipline-specific performance in female ( = 11) and male ( = 11) CrossFit-trained athletes. The participants performed incremental cycling (ICT) and Fight Gone Bad (FGB) tests after consuming a customary diet and a KD. Pre- and post-ICT exercise blood samples were also analysed. Read More

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Ameliorative effect of N-acetylcysteine against glyphosate-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies.

Environ Sci Pollut Res Int 2021 Apr 2. Epub 2021 Apr 2.

Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Glyphosate (GLP) is the most commonly used herbicide that presents many hazards to the environment and living organisms. The present study aimed to explore hepatotoxic properties of GLP on adult albino rats, and the ability of N-acetylcysteine (NAC) to ameliorate these toxic effects. Thirty mature male albino rats were distributed into 3 groups (10 rats/group): Group I (C) a negative control, Group II (GLP) orally administered Roundup 0. Read More

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Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress.

J Pharm Pharmacol 2021 Mar;73(3):322-331

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China.

Objectives: Improper usage of acetaminophen (APAP) leads to morbidity and also mortality secondary to liver damage. Ginseng could suppress APAP-induced hepatotoxicity and ginsenoside Rg3 is a kind of major component in ginseng against liver damage. Herein, we intended to estimate the beneficial function and molecular mechanism of Rg3 on APAP-caused hepatotoxicity and identified hepatoprotection. Read More

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Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats.

BMC Complement Med Ther 2021 Mar 30;21(1):104. Epub 2021 Mar 30.

Department of Biomedical Science, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia.

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the Western world, and it's likely to parallel the increasing prevalence of type 2 diabetes, obesity, and other components of metabolic syndrome. However, optimal treatment for NAFLD has not been established yet. Therefore, this study investigated the hepatoprotective effect of silymarin on fructose-induced nonalcoholic fatty liver disease in rats. Read More

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Selection for feed efficiency elicits different postprandial plasma metabolite profiles in response to poor hygiene of housing conditions in growing pigs.

PLoS One 2021 29;16(3):e0246216. Epub 2021 Mar 29.

PEGASE, INRAE, Institut Agro, Saint Gilles, France.

This study was conducted to compare postprandial plasma concentrations of insulin, energy-related metabolites, and amino acids measured after a 6-week challenge consisting of exposure to good or poor hygiene of housing conditions of 24 growing pigs divergently selected for low-RFI (LRFI) and high-RFI (HRFI). Blood indicators of immune responses were assessed from samples collected before 0 (W0), and 3 (W3), and 6 weeks (W6) after pigs transfer to their respective hygiene of housing conditions. Plasma haptoglobin concentrations and blood neutrophil granulocyte numbers were greater in poor than in good hygiene of housing conditions at W3. Read More

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