601,444 results match your criteria capacity


Characterization of gastric cancer stem-like molecular features, immune and pharmacogenomic landscapes.

Brief Bioinform 2021 Sep 24. Epub 2021 Sep 24.

Department of Internal Medicine, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450001, China.

Cancer stem cells (CSCs) actively reprogram their tumor microenvironment (TME) to sustain a supportive niche, which may have a dramatic impact on prognosis and immunotherapy. However, our knowledge of the landscape of the gastric cancer stem-like cell (GCSC) microenvironment needs to be further improved. A multi-step process of machine learning approaches was performed to develop and validate the prognostic and predictive potential of the GCSC-related score (GCScore). Read More

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September 2021

Improved oral delivery of insulin by PLGA nanoparticles coated with 5β-cholanic acid conjugated glycol chitosan.

Biomed Mater 2021 Sep 27. Epub 2021 Sep 27.

China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu, 210009, CHINA.

Oral insulin has been regarded as the best alternative to insulin injection in therapy of diabetes because of its convenience and painlessness. However, several obstacles in the gastrointestinal tract, such as gastric acid and enzyme, greatly reduce the bioavailability of oral insulin. Herein, we report design and preparation of poly (d, l-lactic-co-glycolic acid) nanoparticles (PLGA NPs) coated with 5β-cholanic acid modified glycol chitosan (GC-CA) ([email protected] NPs) to improve the oral delivery of insulin. Read More

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September 2021

Spatial-temporal evolution of coupling relationship between land development intensity and resources environment carrying capacity in China.

J Environ Manage 2021 Sep 24;301:113778. Epub 2021 Sep 24.

College of Public Administration, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. Electronic address:

Land development poses challenges to the sustainable use of resources and environmental health in regions. This study explores the coupling relationship and its spatial-temporal evolution trend between land development intensity and resources environment carrying capacity of 31 provinces in China from 2005 to 2017. The information entropy method, coupling degree model, and coupling coordination degree model are used to calculate the index weight, coupling degree, and coupling coordination degree. Read More

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September 2021

Remediation of petroleum-contaminated soil by ball milling and reuse as heavy metal adsorbent.

J Hazard Mater 2021 Sep 21;424(Pt A):127305. Epub 2021 Sep 21.

School of Environmental and Safety Engineering, Changzhou University, Changzhou 213164, PR China; Jiangsu Petrochemical Safety and Environmental Protection Engineering Research Center, Changzhou 213164, PR China.

A simple mechanochemical (MC) method is used to treat petroleum-contaminated soil and prepare a heavy metal adsorbent in one step. XRD, Raman, FT-IR, VSM, BET, and XPS were used to characterize the adsorbent. After MC treatment, the dissolved total petroleum hydrocarbons of the adsorbent is less than 1 mg·L, and a porous structure and carbonization phenomenon are evident. Read More

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September 2021

Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers.

Colloids Surf B Biointerfaces 2021 Sep 15;208:112119. Epub 2021 Sep 15.

Department of Polymer Science and Engineering, School of Chemical Engineering, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

Tunable multi-responsive mesoporous silica nanoparticles were prepared by post-condensation/surface modification of MCM-41 nanoparticles. Surface grafting of a poly(N,N-dimethylaminoethyl methacrylate)-based polymer containing disulfide bonds was achieved by a click reaction. Chemical modification, morphological characteristics, and textural properties of the nanoparticles were studied using multiple characterization techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, small-angle X-ray scattering, and nitrogen adsorption/desorption behavior. Read More

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September 2021

Impact of interprofessional education on the teaching and learning of higher education students: A systematic review.

Nurse Educ Pract 2021 Sep 18;56:103212. Epub 2021 Sep 18.

School of Life Sciences, Pontifical Catholic University of Paraná, No. 1155, Imaculada Conceição Street, Curitiba, Paraná 80215-901, Brazil. Electronic address:

Aim: This systematic review was to explore the potentialities and limitations of Interprofessional Education (IPE), from the perspective of undergraduate students.

Background: The increasing complexity in health increasingly demand professionals with the capacity to act in the face of new global challenges. Thus, this pedagogical approach presents itself as one of the most promising choices in facing these new obstacles. Read More

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September 2021

Gamma radiation-induced polymerization of polyacrylic acid-dolomite composite and applications for removal of cesium, cobalt, and zirconium from aqueous solutions.

Appl Radiat Isot 2021 Sep 22;178:109956. Epub 2021 Sep 22.

Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority, PO.13759, Cairo, Egypt.

Gamma-irradiation initiated polymerization was utilized to prepare polyacrylic acid dolomite P(AA/D) nanocomposites. Different analytical techniques have been applied to investigate the structure of the new materials. XRD and TEM revealed the crystalline phase with an average particle size ranging from 2 to 4 nm. Read More

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September 2021

LEFTY-PITX2 signaling pathway is critical for generation of mature and ventricular cardiac organoids in human pluripotent stem cell-derived cardiac mesoderm cells.

Biomaterials 2021 Sep 21;278:121133. Epub 2021 Sep 21.

Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:

The generation of mature ventricular cardiomyocytes (CMs) resembling adult CMs from human pluripotent stem cells (hPSCs) is necessary for disease modeling and drug discovery. To investigate the effect of self-organizing capacity on the generation of mature cardiac organoids (COs), we generated cardiac mesoderm cell-derived COs (CMC-COs) and CM-derived COs (CM-COs) and evaluated COs. CMC-COs exhibited more organized sarcomere structures and mitochondria, well-arranged t-tubule structures, and evenly distributed intercalated discs. Read More

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September 2021

Ammonium regulates redox homeostasis and photosynthetic ability to mitigate copper toxicity in wheat seedlings.

Ecotoxicol Environ Saf 2021 Sep 24;226:112825. Epub 2021 Sep 24.

Triticeae Research Institute, Sichuan Agricultural University, Wenjiang 611130, Sichuan, China.

As an essential plant micronutrient, copper (Cu) is required as a component of several enzymes, but it can be highly toxic to plants when present in excess quantities. Nitrogen (N) application can help to alleviate the phytotoxic effects of heavy metals, including Cu, and different N forms significantly affect the uptake and accumulation of heavy metals in plants. The aim of this study was to determine the effects of different N forms, i. Read More

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September 2021

Antioxidant capacity of phenolic compounds separated from tea seed oil in vitro and in vivo.

Food Chem 2021 Sep 15;371:131122. Epub 2021 Sep 15.

College of Food Science and Engineering, Yangzhou University, 225127 Yangzhou, Jiangsu Province, China. Electronic address:

Tea seed oil is rich in phenols with good antioxidant capacity. However, the antioxidant capacity evaluation of tea seed oil polyphenols is not deep enough, which mainly focusing on the evaluation of the chemical system. Thirty-nine phenols were tentatively identified by UPLC-ESI-MS/MS analysis, including flavonoids and phenolic acids. Read More

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September 2021

TASK-1 regulates mitochondrial function under hypoxia.

Biochem Biophys Res Commun 2021 Sep 21;578:163-169. Epub 2021 Sep 21.

Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:

TASK-1, TWIK-related acid-sensitive potassium channel 1, is a member of the two-pore- domain potassium channel family. It is constitutively active at resting potentials and strongly expressed in the heart. However, little is known about the role of TASK-1 channels in hypoxia. Read More

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September 2021

Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination.

EBioMedicine 2021 Sep 24;72:103589. Epub 2021 Sep 24.

Department of Internal Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam 1081 HV, the Netherlands. Electronic address:

Background: To optimise the use of available SARS-CoV-2 vaccines, some advocate delaying second vaccination for individuals infected within six months. We studied whether post-vaccination immune response is equally potent in individuals infected over six months prior to vaccination.

Methods: We tested serum IgG binding to SARS-CoV-2 spike protein and neutralising capacity in 110 healthcare workers, before and after both BNT162b2 messenger RNA (mRNA) vaccinations. Read More

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September 2021

YF/CoF co-doped 1D carbon nanofibers with dual functions of lithium polysulfudes adsorption and efficient catalytic activity as a cathode for high-performance Li-S batteries.

J Colloid Interface Sci 2021 Sep 20;607(Pt 2):922-932. Epub 2021 Sep 20.

State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes, Tiangong University, Tianjin 300387, China; School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China. Electronic address:

Lithium-sulfur (Li-S) batteries have attracted extensive attention in the field of energy storage due to their high energy density and low cost. However, conundrums such as severe polarization, poor cyclic performance originating from shuttle effect of lithium polysulfides and sluggish sulfur redox kinetics are stumbling blocks for their practical application. Herein, a novel sulfur cathode integrating sulfur and polyvinylpyrrolidone(PVP)-derived N-doped porous carbon nanofibers (PCNFs) with embedded CoF and YF nanoparticles are designed and prepared though the electrostatic blowing technology and carbonization process. Read More

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September 2021

2,3-diaminophenazine as a high-rate rechargeable aqueous zinc-ion batteries cathode.

J Colloid Interface Sci 2021 Sep 16;607(Pt 2):1262-1268. Epub 2021 Sep 16.

Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, Hubei, PR China. Electronic address:

Organic materials are attracting extensive attention as promising cathodes for rechargeable aqueous zinc-ion batteries (ZIBs). However, most of them fail to implement the requirement of batteries with combined high-rate and long-cycle performance. Herein, we report a flexible organic molecule 2,3-diaminophenazine (DAP) which exhibits ultrahigh rate performance up to 500C and high capacity retention of 80% after 10,000 cycles at 100C (25. Read More

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September 2021

Adjusting the d-band center of metallic sites in NiFe-based Bimetal-organic frameworks via tensile strain to achieve High-performance oxygen electrode catalysts for Lithium-oxygen batteries.

J Colloid Interface Sci 2021 Sep 17;607(Pt 2):1215-1225. Epub 2021 Sep 17.

College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, 1#, Dongsanlu, Erxianqiao, Chengdu, Sichuan 610059, PR China. Electronic address:

Developing effective electrocatalyst and fundamentally understanding the corresponding working mechanism are both urgently desired to overcome the current challenges facing lithium-oxygen batteries (LOBs). Herein, a series of NiFe-based bimetal-organic frameworks (NiFe-MOFs) with certain internal tensile strain are fabricated via a simple organic linker scission strategy, and served as cathode catalysts for LOBs. The introduced tensile strain broadens the inherent interatomic distances, leading to an upshifted d-band center of metallic sites and thus the enhancement of the adsorption strength of catalysts surface towards intermediates, which is contributed to rationally regulate the crystallinity of discharge product LiO. Read More

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September 2021

Large-scale defect-rich iron/nitrogen co-doped graphene-based materials as the excellent bifunctional electrocatalyst for liquid and flexible all-solid-state zinc-air batteries.

J Colloid Interface Sci 2021 Sep 15;607(Pt 2):1201-1214. Epub 2021 Sep 15.

School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.

Defect-engineering in transition-metal-doped carbon-based catalyst plays an essential role for improving the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) performance. Herein, we report a ball-milling induced defect assisted with ZnCl strategy for fabricating defect-rich iron/nitrogen co-doped graphene-based materials (Fe-N-G). The substantial mechanical shear forces and the constant corrosion to the carbon matrix by ZnCl lead to the creation of abundant defects in graphene-based materials, which facilitates doping for heteroatoms. Read More

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September 2021

11,11,12,12-tetracyano-9,10-anthraquinonedimethane as a high potential and sustainable cathode for organic potassium-ion batteries.

J Colloid Interface Sci 2021 Sep 2;607(Pt 2):1173-1179. Epub 2021 Sep 2.

Institute of Materials Science & Devices, School of Material Science and Engineering, Suzhou University of Science and Technology, Suzhou 215000, PR China; Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, PR China; Institute of Advanced Cross-field Science, College of Life Science, Qingdao University, Qingdao 200671, PR China. Electronic address:

We fabricated a potassium-ion battery by using 11,11,12,12-tetracyano-9,10-anthraquinonedimethane (TCAQ) as the cathode for the first time. Owing to the unique molecular structure and configuration of ionic liquid electrolytes, TCAQ shows a high redox potential of 2.6 V vs. Read More

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September 2021

Molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under neutral pH.

J Colloid Interface Sci 2021 Sep 11;607(Pt 2):1163-1172. Epub 2021 Sep 11.

College of Chemistry and Bioengineering, Shandong University of Science and Technology, Qingdao, Shandong 266590, China. Electronic address:

Glycoproteins play vital roles in living organisms and often serve as biomarkers for some disease. However, due to the low content of glycoprotein in biological fluids, selective detection of glycoproteins is still a challenging issue that needs to be addressed. In this study, molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under physiological pH was proposed. Read More

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September 2021

Rod-like NiCoCO·2HO in-situ formed on rGO by an interface induced engineering: Extraordinary rate and cycle performance as an anode in lithium-ion and sodium-ion half/full cells.

J Colloid Interface Sci 2021 Sep 14;607(Pt 2):1153-1162. Epub 2021 Sep 14.

College of Chemistry, Zhengzhou University, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Transition metal oxalates have attracted wide attention due to the characteristics of the conversion reaction as anode materials in lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs), However, there are huge volume expansion and sluggish circulation dynamics during the reversible Li and Na insertion/extraction process, which would lead to unsatisfactory reversible capacity and stability. In order to solve these problems, a rod-like structure NiCoCO·2HO is in-situ formed on the reduced graphene oxide layer (NiCoCO·2HO/rGO) in a glycol-water mixture medium via an interface induced engineering strategy. Benefitting from the synergistic cooperation of nano-diameter rod-like structure and high conductive rGO networks, the experimental results show that the prepared NiCoCO·2HO/rGO electrode has predominant rate performance and ultra-long cycle stability. Read More

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September 2021

Interplay of distributions of multiple guest molecules in block copolymer micelles: A dissipative particle dynamics study.

J Colloid Interface Sci 2021 Sep 13;607(Pt 2):1142-1152. Epub 2021 Sep 13.

School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao, Shandong 266580, PR China; Institute of Advanced Materials, China University of Petroleum (East China), Qingdao, Shandong 266580, PR China. Electronic address:

Hypothesis: Delivery of multiple payloads using the same micelle is of significance to achieve multifunctional or synergistic effects. The interacting distribution of different payloads in micelles is expected to influence the loading stability and capacity. It is highly desirable to explore how intermolecular interactions affect the joint distribution of multi-payloads. Read More

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September 2021

Structural, thermodynamic and functional studies of human 71 kDa heat shock cognate protein (HSPA8/hHsc70).

Biochim Biophys Acta Proteins Proteom 2021 Sep 24:140719. Epub 2021 Sep 24.

São Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP, Brazil. Electronic address:

Human 71 kDa heat shock cognate protein (HSPA8, also known as Hsc70, Hsp70-8, Hsc71, Hsp71 or Hsp73) is a constitutively expressed chaperone that is critical for cell proteostasis. In the cytosol, HSPA8 plays a pivotal role in folding and refolding, facilitates protein trafficking across membranes and targets proteins for degradation, among other functions. Here, we report an in solution study of recombinant HSPA8 (rHSPA8) using a variety of biophysical and biochemical approaches. Read More

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September 2021

Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells.

Mitochondrion 2021 Sep 24. Epub 2021 Sep 24.

Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address:

The weightlessness or microgravity, a physical factor in space, may adversely affect the health of the space travellers or astronauts. The knowledge about the effect of microgravity on human cancer cells is very limited and poorly understood. Here, we employed rotary cell culture system (RCCS) to induce simulated microgravity (SMG) and examined its effects on human promyelocytic leukemic HL-60 cells. Read More

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September 2021

Water inflow and endogenous factors drove the changes in the buffering capacity of biogenic elements in Erhai Lake, China.

Sci Total Environ 2021 Sep 14;806(Pt 1):150343. Epub 2021 Sep 14.

Guangdong-Hong Kong Joint Laboratory for Water Security, Center for Water Research, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai 519087, China; College of Water Sciences, Beijing Normal University, Beijing 100875, China; Engineering Research Center of Ministry of Education on Groundwater Pollution Control and Remediation, Beijing 100875, China.

Buffering capacity could provide a comprehensive view to recognize the response between external loads and water quality and help address the significant challenges associated with the reduction of lake pollution. However, quantification of the dynamic change in the holistic buffering capacity of biogenic elements in lakes and its driving mechanisms has not been fully understood. Taking Erhai Lake in China as an example, this study quantified the long-term (2000-2019) dynamic changes in buffering capacity and revealed key driving forces for the changes in buffering capacity. Read More

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September 2021

Salinity-dependent impacts on the effects of antiepileptic and antihistaminic drugs in Ruditapes philippinarum.

Sci Total Environ 2021 Sep 16;806(Pt 1):150369. Epub 2021 Sep 16.

Biology Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In coastal systems, pollutants as pharmaceutical drugs exert changes from the molecular to the organism level in marine bivalves. Besides pollutants, coastal systems are prone to changes in environmental parameters, as the alteration of salinity values because of Climate Change. Together, these stressors (pharmaceutical drugs and salinity changes) can exert different threats than each stressor acting individually; for example, salinity can change the physical-chemical properties of the drugs and/or the sensitivity of the organisms to them. Read More

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September 2021

Multifunctional capacity of CoMnFe-LDH/LDO activated peroxymonosulfate for p-arsanilic acid removal and inorganic arsenic immobilization: Performance and surface-bound radical mechanism.

Sci Total Environ 2021 Sep 20;806(Pt 1):150379. Epub 2021 Sep 20.

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.

Organoarsenic contaminants existing in water body threat human health and ecological environment due to insufficient bifunctional treatment technologies for organoarsenic degradation and inorganic arsenic immobilization. In order to safely and efficiently treat organoarsenic contaminants discharged into the aquatic environment, Co-Mn-Fe layered double hydroxide (CoMnFe-LDH) and Co-Mn-Fe layered double oxide (CoMnFe-LDO) were fabricated and employed as peroxymonosulfate (PMS) activator for organoarsenic degradation and inorganic arsenic immobilization, and p-arsanilic acid (p-ASA) was selected as target pollutant. Results demonstrated that the satisfactory removal of p-ASA (100. Read More

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September 2021

Good Engraftment but Quality and Donor Concerns for Cryopreserved HPC Products Collected During the COVID-19 Pandemic.

Transplant Cell Ther 2021 Sep 24. Epub 2021 Sep 24.

Department of Haematology and Bone Marrow Transplantation, St Vincent's Hospital, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia.

Background: Changes to donor availability, collection centre capacity and travel restrictions during the early phase of the COVID-19 pandemic led to routine cryopreservation of most unrelated donor products for haematopoietic transplantation prior to the recipient commencing the conditioning regimen.

Objective: We investigated the effect of this change on unrelated donor product quality and clinical outcomes.

Study Design: Product information was requested from transplant centres in Australia and New Zealand, and clinical outcome data from the Australasian Bone Marrow Transplant Recipient Registry (ABMTRR). Read More

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September 2021

Comparative analysis of erythrocyte hemolysis, plasma parameters and metabolic features in red crucian carp (Carassius auratus red var) and triploid hybrid fish following Aeromonas hydrophila challenge.

Fish Shellfish Immunol 2021 Sep 24. Epub 2021 Sep 24.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, PR China.

Aeromonas hydrophila can pose a great threat to survival of freshwater fish. In this study, A. hydrophila challenge could promote the erythrocyte hemolysis, increase free hemoglobin (FHB) level and generate malondialdehyde (MDA) production in plasma but decrease the levels of total antioxidant capacity (T-AOC), total superoxide dismutase (SOD), catalase (CAT), alkaline phosphatase (ALP) and lysozyme (LZM) of red crucian carp (RCC, 2N = 100) and triploid hybrid fish (3N fish, 3N = 150) following A. Read More

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September 2021

Invited review: Thermal effects on oxidative stress in vertebrate ectotherms.

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 24:111082. Epub 2021 Sep 24.

School of Earth, Atmospheric and Life Sciences, The University of Wollongong, 2522 Wollongong, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Heydon-Laurence Bldg A08, Science Road, Sydney, NSW 2006, Australia. Electronic address:

Human-induced climate change is occurring rapidly. Ectothermic organisms are particularly vulnerable to these temperature changes due to their reliance on environmental temperature. The extent of ectothermic thermal adaptation and plasticity in the literature is well documented; however, the role of oxidative stress in these processes needs more attention. Read More

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September 2021

AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).

Toxicol Lett 2021 Sep 24. Epub 2021 Sep 24.

Institute for Agri-Food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.

Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants. They are constantly detected in terrestrial, ocean, and atmospheric systems, and it is of particular concern that these fat-soluble xenobiotics may have a negative impact on human health. This study aimed to evaluate the toxic effect and underlying mechanism of decabromodiphenyl ether (BDE-209) on human liver in a HepG2 cell model. Read More

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September 2021

Use of Gallic acid for cancer treatment: Molecular mechanisms and improvement of efficacy by nanoformulations.

Food Chem Toxicol 2021 Sep 24:112576. Epub 2021 Sep 24.

Regional Center of Advanced Technologies and Materials, Palacky University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. Electronic address:

Cancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Read More

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September 2021