Can J Cardiol 2021 Apr 8. Epub 2021 Apr 8.
Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada, M5G 1M1; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 3G9; Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 3G8. Electronic address:
Surgical replacement remains the primary option to treat the rapidly growing number of patients with severe valvular heart disease. While current valve replacements - mechanical, bioprosthetic, and cryopreserved homografts - enhance survival and quality of life for many patients, the ideal prosthetic heart valve that is abundantly available, immunocompatible, and capable of growth, self-repair, and life-long performance has yet to be developed. These features are essential for pediatric patients with congenital defects, children and young adult rheumatic fever patients, and active adult patients with valve disease. Read More