39,865 results match your criteria capable growth

On the origin and evolution of SARS-CoV-2.

Exp Mol Med 2021 Apr 16. Epub 2021 Apr 16.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global outbreak of a coronavirus disease (herein referred to as COVID-19). Other viruses in the same phylogenetic group have been responsible for previous regional outbreaks, including SARS and MERS. SARS-CoV-2 has a zoonotic origin, similar to the causative viruses of these previous outbreaks. Read More

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Physiological ecology of cyanobacteria in microbial mats and other communities.

Lucas J Stal

New Phytol 1995 Sep;131(1):1-32

Laboratory for Microbiology, University of Amsterdam, Nieuwe Achtergracht 127, NL-1018 WS Amsterdam, The Netherlands.

In this review some aspects of the physiological ecology of cyanobacteria are discussed by taking a microbial mat as an example. The majority of microbial mats are built and dominated by cyarsobacteria which are primary producers at the basis of the microbial foodweb in microbial mats. These micro-scale ecosystems are characterized by steep and fluctuating physico-chemical gradients of which those of light, oxygen and sulphide are the most conspicuous. Read More

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September 1995

Production of pectin-degrading enzymes by ericoid mycorrhizal fungi.

New Phytol 1997 Jan;135(1):151-162

Dipartimento di Biologic Vegetate delV Università di Torino and Centra di Micologia del Terreno del CNR, V.le Mattioli 25, 10125 Torino, Italy.

Production of enzymes which degrade plant cell wall macromoleculea has been studied in relatively few ericoid fungal isolates, although these polymers arc a major component of the organic litter and an important source of nutrients for these fungi. Our aims were to investigate whether the ability to degrade the wall pectic component, only reported for one isolate, is a general feature of ericoid fungi. Of about 35 isolates from different geographic regions, all were capable of growing on pectin as the sole carbon source. Read More

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January 1997

Copper-binding proteins in ectomycorrhizal fungi.

New Phytol 1997 Jan;135(1):123-131

School of Biological Sciences, Queen Mary and Westfield College, University of London, London E1 4NS, UK.

The presence of copper-binding proteins produced in response to added copper was examined in isolates of Laccaria laccata (Scop, ex Fr.) Cooke and Paxillus involutus (Batsch ex Fr.) Fr. Read More

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January 1997

Response to phosphorus supply of tropical tree seedlings: a comparison between a pioneer species Tapirira obtusa and a climax species Lecythis corrugata.

New Phytol 1996 Jan;132(1):97-102

Department of Plant Ecology and Evolutionary Biology, Utrecht University, PO Box 800,84, 3505 TB Utrecht, The Netherlands.

The highly-weathered acid sandy soils in Guyana, South America, art very low in nutrients, especially in phosphorus (P) Earlier experiments demonstrated that P was growth-limiting for some tree seedlings on these soils, but other species failed to increase their growth in response to greater P-availability. To investigate this, we measured growth and distribution (if biomass and P of tree seedlings, of a pioneer tree species, Tapirira obtusa (Benth.) Mitchell, and of a climax tree species, Lecythis corrugata Poit. Read More

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January 1996

Updated Review on the Role of Curcumin in Gastrointestinal Cancers.

Adv Exp Med Biol 2021 ;1308:55-89

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Malignant conditions of the gastrointestinal tract and accessory organs of digestion, including the oral cavity, esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus, are referred to as gastrointestinal cancers. Curcumin is a natural compound derived from turmeric with a wide range of biological activities. Several in vitro and in vivo studies have investigated the effects of curcumin on gastrointestinal cancers. Read More

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January 2021

Wastewater treatment by microalgae.

Physiol Plant 2021 Apr 16. Epub 2021 Apr 16.

Department of Chemistry, Umeå University, Umeå, Sweden.

The growth of the world's population expands the demand for fresh water, food, energy and technology, which on their turn lead to increasing amount of wastewater, produced both by domestic and industrial sources. These different wastewaters contain a huge variety of organic and inorganic compounds, which can cause tremendous environmental problems if released untreated. Traditional treatment systems are usually expensive and energy demanding and often still not capable of facing all challenges presented by the produced wastewaters. Read More

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Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations.

AAPS PharmSciTech 2021 Apr 15;22(4):135. Epub 2021 Apr 15.

Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA.

Efficient delivery of dry powder aerosols dispersed with low volumes of air is challenging. This study aims to develop an efficient dry powder inhaler (DPI) capable of delivering spray-dried Survanta-EEG powders (3-10 mg) with a low volume (3 mL) of dispersion air. A series of iterative design modifications were made to a base low air volume actuated DPI. Read More

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Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth.

ACS Pharmacol Transl Sci 2021 Apr 11;4(2):452-460. Epub 2020 Sep 11.

Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California, Davis 95616, United States.

Cortical neuron atrophy is a hallmark of depression and includes neurite retraction, dendritic spine loss, and decreased synaptic density. Psychoplastogens, small molecules capable of rapidly promoting cortical neuron growth, have been hypothesized to produce long-lasting positive effects on behavior by rectifying these deleterious structural and functional changes. Here we demonstrate that ketamine and LSD, psychoplastogens from two structurally distinct chemical classes, promote sustained growth of cortical neurons after only short periods of stimulation. Read More

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DGG-100629 inhibits lung cancer growth by suppressing the NFATc1/DDIAS/STAT3 pathway.

Exp Mol Med 2021 Apr 15. Epub 2021 Apr 15.

Personalized Genomic Medicine Research Center, KRIBB, Daejeon, 34141, Korea.

DNA damage-induced apoptosis suppressor (DDIAS) promotes the progression of lung cancer and hepatocellular carcinoma through the regulation of multiple pathways. We screened a chemical library for anticancer agent(s) capable of inhibiting DDIAS transcription. DGG-100629 was found to suppress lung cancer cell growth through the inhibition of DDIAS expression. Read More

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Quantum-dot microlasers based on whispering gallery mode resonators.

Light Sci Appl 2021 Apr 15;10(1):80. Epub 2021 Apr 15.

Nanophotonics laboratory, Alferov University, Khlopina 8/3, St. Petersburg, 194021, Russia.

The subject of this paper is microlasers with the emission spectra determined by the whispering gallery modes. Owing to the total internal reflection of light on the sidewalls, a high Q-factor is achieved until the diameter is comparable to the wavelength. The light emission predominantly occurs in the plane of the structure, which facilitates the microlaser integration with other elements. Read More

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Mycoremediation of oxytetracycline by marine fungi mycelium isolated from salmon farming areas in the south of Chile.

Food Chem Toxicol 2021 Apr 12:112198. Epub 2021 Apr 12.

Laboratorio de Química Aplicada y Sustentable, Departamento de Química, Facultad de Ciencias, Universidad del Bío-Bío, Avenida Collao, 1202, PO Box 5-C, Concepción, Chile; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA. Electronic address:

Antibiotics are extensively used for growth promotion purposes in intensive aquaculture. In Chile, the use of antibiotics in salmon farming is excessive, approximately 62 times more than is used in Norway. In the salmon industry, antibiotics such as oxytetracycline (OTC) are administered in the diet, both in the juvenile stage in freshwater and in the fattening process of salmon in marine sectors. Read More

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Selenium nanoparticle synthesis from endangered medicinal herb (Enicostema axillare).

Bioprocess Biosyst Eng 2021 Apr 15. Epub 2021 Apr 15.

Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University, Madurai, India.

Green synthesis of selenium nanoparticles (SeNPs) was achieved by a simple biological procedure using the reducing power of E. axillare leaf extract. This method is capable of producing SeNPs in a size range of around 56. Read More

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Exposure Pathways of Nontuberculous Mycobacteria Through Soil, Streams, and Groundwater, Hawai'i, USA.

Geohealth 2021 Apr 1;5(4):e2020GH000350. Epub 2021 Apr 1.

Center for Genes, Environment, and Health National Jewish Health Denver CO USA.

Although uncommon, nontuberculous mycobacterial (NTM) pulmonary infection in the Hawaiian Islands has a relatively high incidence and mortality compared to the mainland U.S. As a result, this study examines the possible geological and hydrological pathways by which NTM patients may become infected, including the environmental conditions that may favor growth and transport. Read More

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Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G.

J Cancer 2021 5;12(9):2560-2569. Epub 2021 Mar 5.

Ear, Nose and Throat (ENT) Department, Ludwig-Maximilians University of Munich, Munich, Germany.

Immunotherapy is being used for the past five years either as first line or second line treatment with great results. Chemotherapy and radiotherapy have been also used as combination to immunotherapy to further enhance this type of treatment. Intratumoral treatment has been previously proposed as a treatment option for certain non-small cell lung cancer patients. Read More

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Precipitated Fluorophore-Based Molecular Probe for Imaging of Aminopeptidase N in Living Cells and Tumors.

Anal Chem 2021 Apr 14. Epub 2021 Apr 14.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

Aminopeptidase N (APN) is capable of cleaving N-terminal amino acids from peptides with alanine in the N-terminal position and plays a key role in the growth, migration, and metastasis of cancer. However, reliable information is hard to be obtained with the current APN-responsive molecular probes because the released fluorophores are cytoplasmic soluble and thus rapidly depart from the enzymatic reaction sites and spread out all over the cytoplasm. Here, we report a precipitated fluorophore, , which is completely insoluble in water and shows strong yellow solid emission when excited with a 405 nm laser. Read More

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Electrical Impedance Spectroscopy for Microtissue Spheroid Analysis in Hanging-Drop Networks.

ACS Sens 2016 Jul;1(8):1028-1035

Department of Biosystems Science and Engineering, Bio Engineering Laboratory, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.

Electrical impedance spectroscopy (EIS) as a label free and noninvasive analysis method receives growing attention for monitoring three-dimensional tissue constructs. In this Article, we present the integration of an EIS readout function into the hanging-drop network platform, which has been designed for culturing microtissue spheroids in perfused multitissue configurations. Two pairs of microelectrodes have been implemented directly in the support of the hanging drops by using a small glass inlay inserted in the microfluidic structure. Read More

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Anticancer activity of repurposed hemostatic agent desmopressin on AVPR2-expressing human osteosarcoma.

Exp Ther Med 2021 Jun 26;21(6):566. Epub 2021 Mar 26.

Center of Molecular and Translational Oncology, National University of Quilmes, Bernal B1876BXD, Buenos Aires, Argentina.

Osteosarcoma is the most prevalent primary bone malignancy. Due to its high aggressiveness, novel treatment strategies are urgently required to improve survival of patients with osteosarcoma, especially those with advanced disease. Desmopressin (dDAVP) is a widely used blood-saving agent that has been repurposed as an adjuvant agent for cancer management due to its antiangiogenic and antimetastatic properties. Read More

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High-throughput screening identifies idasanutlin as a resensitizing drug for venetoclax-resistant neuroblastoma cells.

Mol Cancer Ther 2021 Apr 13. Epub 2021 Apr 13.

Molenaar group, Princess Máxima Center for pediatric oncology

Neuroblastoma tumors frequently overexpress the anti-apoptotic protein B cell lymphoma/leukemia 2 (BCL-2). We previously showed that treating BCL-2-dependent neuroblastoma cells with the BCL-2 inhibitor venetoclax results in apoptosis, but unfortunately partial therapy resistance is observed. The current study describes the identification of drugs capable of resensitizing venetoclax-resistant neuroblastoma cells to venetoclax. Read More

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Incorporating domain growth into hybrid methods for reaction-diffusion systems.

J R Soc Interface 2021 Apr 14;18(177):20201047. Epub 2021 Apr 14.

Centre for Mathematical Biology, Department of Mathematical Sciences, University of Bath, Claverton Down, Bath BA2 7AY, UK.

Reaction-diffusion mechanisms are a robust paradigm that can be used to represent many biological and physical phenomena over multiple spatial scales. Applications include intracellular dynamics, the migration of cells and the patterns formed by vegetation in semi-arid landscapes. Moreover, domain growth is an important process for embryonic growth and wound healing. Read More

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Gram-scale production of the sesquiterpene α-humulene with Cupriavidus necator.

Biotechnol Bioeng 2021 Apr 12. Epub 2021 Apr 12.

DECHEMA Research Institute, Frankfurt a.M., Germany.

Terpenoids have an impressive structural diversity and provide valuable substances for a variety of industrial applications. Among terpenes, the sesquiterpenes (C ) are the largest sub-class with bioactivities ranging from aroma to health promotion. In this paper, we show a gram-scale production of the sesquiterpene α-humulene in final aqueous concentrations of 2 g L with the recombinant strain Cupriavidus necator pKR-hum in a fed-batch mode on fructose as carbon source and n-dodecane as an extracting organic phase for in situ product removal. Read More

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Antibacterial and Antibiofilm Photodynamic Activities of Lysozyme-Au Nanoclusters/Rose Bengal Conjugates.

ACS Omega 2021 Apr 24;6(13):9279-9290. Epub 2021 Mar 24.

Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8689, Japan.

Antibacterial photodynamic therapy (aPDT) utilizes reactive oxygen species such as singlet oxygen (O) and free radicals via photosensitizers, which are light and light-sensitive agents, to reduce bacterial infections. It has been utilized as a treatment for dental diseases in place of antibiotic therapies. However, aPDT does not always cause the desired therapeutic effect due to the instability of organic photosensitizers and the formation of bacterial biofilms. Read More

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Adipose-Derived Stromal Cell-Sheets Sandwiched, Book-Shaped Acellular Dermal Matrix Capable of Sustained Release of Basic Fibroblast Growth Factor Promote Diabetic Wound Healing.

Front Cell Dev Biol 2021 25;9:646967. Epub 2021 Mar 25.

The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

The management of diabetic wounds is a therapeutic challenge in clinical settings. Current tissue engineering strategies for diabetic wound healing are insufficient, owing to the lack of an appropriate scaffold that can load a large number of stem cells and induce the interaction of stem cells to form granulation tissue. Herein we fabricated a book-shaped decellularized dermal matrix (BDDM), which shows a high resemblance to native dermal tissue in terms of its histology, microstructure, and ingredients, is non-cytotoxic and low-immunogenic, and allows adipose-derived stromal cell (ASC) attachment and proliferation. Read More

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Single Cell Label-Free Probing of Chromatin Dynamics During B Lymphocyte Maturation.

Front Cell Dev Biol 2021 26;9:646616. Epub 2021 Mar 26.

School of Physics and Astronomy, University of Exeter, Exeter, United Kingdom.

Large-scale intracellular signaling during developmental growth or in response to environmental alterations are largely orchestrated by chromatin within the cell nuclei. Chemical and conformational modifications of the chromatin architecture are critical steps in the regulation of differential gene expression and ultimately cell fate determination. Therefore, establishing chemical properties of the nucleus could provide key markers for phenotypic characterization of cellular processes on a scale of individual cells. Read More

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Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Meyer.

J Ginseng Res 2021 Mar 7;45(2):218-227. Epub 2020 Jan 7.

Department of Oriental Medicinal Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea.

Background: is one of the most important medicinal plants and is usually harvested after 5 to 6 years of cultivation in Korea. Heavy metal (HM) exposure is a type of abiotic stress that can induce oxidative stress and decrease the quality of the ginseng crop. Siderophore-producing rhizobacteria (SPR) may be capable of bioremediating HM contamination. Read More

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Recent progress toward clinical translation of tissue engineered heart valves.

Can J Cardiol 2021 Apr 8. Epub 2021 Apr 8.

Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada, M5G 1M1; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 3G9; Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 3G8. Electronic address:

Surgical replacement remains the primary option to treat the rapidly growing number of patients with severe valvular heart disease. While current valve replacements - mechanical, bioprosthetic, and cryopreserved homografts - enhance survival and quality of life for many patients, the ideal prosthetic heart valve that is abundantly available, immunocompatible, and capable of growth, self-repair, and life-long performance has yet to be developed. These features are essential for pediatric patients with congenital defects, children and young adult rheumatic fever patients, and active adult patients with valve disease. Read More

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GILT in tumor cells improves T cell-mediated anti-tumor immune surveillance.

Immunol Lett 2021 Apr 7;234:1-12. Epub 2021 Apr 7.

Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China. Electronic address:

The lysosomal thiol reductase GILT catalyzes the reduction of disulfide bonds of protein antigens, facilitating antigen-presenting cells (APCs) to present antigen to T cells. However, whether GILT expression in tumor cells can be associated with improved T cell-mediated anti-tumor responses remains unknown. Here, we identify that GILT is able to facilitate anti-tumor immune surveillance via promoting MHC class I mediated-antigen presentation in colon carcinoma. Read More

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Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses.

Sci Immunol 2021 Apr;6(58)

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

Although radiotherapy has been used for over a century to locally control tumor growth, alone it rarely induces an abscopal response or systemic antitumor immunity capable of inhibiting distal tumors outside of the irradiation field. Results from recent studies suggest that combining immune checkpoint blockades to radiotherapy may enhance abscopal activity. However, the treatment conditions and underlying immune mechanisms that consistently drive an abscopal response during radiation therapy combinations remain unknown. Read More

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Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis.

Semin Cancer Biol 2021 Apr 6. Epub 2021 Apr 6.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

Arsenic exposure in contaminated drinking water is a global health issue, as more than 200 million people are affected globally. Arsenic has been known to cause skin, liver, lung, bladder and prostate cancers. Accordingly, it has been categorized as a group I human carcinogen by the International Agency for Research on Cancer (IARC). Read More

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Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery.

J Neurosci Methods 2021 Apr 6:109180. Epub 2021 Apr 6.

Cognition Therapeutics Inc., Pittsburgh, PA, 15203, United States. Electronic address:

Background: Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use of larger format microtiter plates while preserving culture quality.

New Method: Here we describe a method and quality control procedures for growing embryonic day 18 rat hippocampal/cortical neuronal cultures in 384-well microtiter plates for three weeks in vitro. Read More

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