24,985 results match your criteria cannabis

Commentary on Shi et al: Prenatal cannabis use and infant health - the search for clarity and consistency.

Sunah S Hwang

Addiction 2021 May 4. Epub 2021 May 4.

Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

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LC-MS/MS-based profiling of bioactive metabolites of endophytic bacteria from Cannabis sativa and their anti-Phytophthora activity.

Antonie Van Leeuwenhoek 2021 May 4. Epub 2021 May 4.

Department of Plant Pathology, Mid-Florida Research and Education Center, University of Florida/Institute of Food and Agricultural Sciences, 2725 Binion Rd, Apopka, FL, 32703, USA.

Protection of crop plants from phytopathogens through endophytic bacteria is a newly emerged area of biocontrol. In this study, endophytic bacteria were isolated from the rhizosphere of Cannabis sativa. Based on initial antimicrobial screening, three (03) bacteria Serratia marcescens MOSEL-w2, Enterobacter cloacae MOSEL-w7, and Paenibacillus MOSEL-w13 were selected. Read More

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CANNUSE, a database of traditional Cannabis uses-an opportunity for new research.

Database (Oxford) 2021 May;2021

Institut Botànic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), Passeig del Migdia s/n, Barcelona, Catalonia 08038, Spain.

Cannabis is one of the most versatile genera in terms of plant uses and has been exploited by humans for millennia due to its medicinal properties, strong fibres, nutritious seeds and psychoactive resin. Nowadays, Cannabis is the centre of many scientific studies, which mainly focus on its chemical composition and medicinal properties. Unfortunately, while new applications of this plant are continuously being developed, some of its traditional uses are becoming rare and even disappearing altogether. Read More

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Cannabis use, self-perceived risk, perceived peer approval and parental attitudes among youth at clinical high-risk for psychosis.

Early Interv Psychiatry 2021 May 3. Epub 2021 May 3.

Department of Psychology, Northwestern University, Evanston, Illinois, USA.

Aim: Cannabis use is associated with greater likelihood of psychosis. The relationship between attitudes about cannabis and use has not been examined in youth at clinical high-risk (CHR) for psychosis. Additionally, the shifting legal landscape can provide a valuable context for evaluating use and related attitudes. Read More

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Complementary and alternative medicine in children with diffuse intrinsic pontine glioma-A SIOPE DIPG Network and Registry study.

Pediatr Blood Cancer 2021 May 4:e29061. Epub 2021 May 4.

Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction: Diffuse intrinsic pontine glioma (DIPG) is a rare and aggressive childhood brainstem malignancy with a 2-year survival rate of <10%. This international survey study aims to evaluate the use of complementary and alternative medicine (CAM) in this patient population.

Methods: Parents and physicians of patients with DIPG were asked to participate in a retrospective online survey regarding CAM use during time of illness. Read More

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Maladaptive behaviours in adolescence and their associations with personality traits, emotion dysregulation and other clinical features in a sample of Italian students: a cross-sectional study.

Borderline Personal Disord Emot Dysregul 2021 May 4;8(1):14. Epub 2021 May 4.

Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, I-25125, Brescia, Italy.

Background: Emotion Dysregulation (ED), childhood trauma and personality are linked to the occurrence of maladaptive behaviours in adolescence which, in turn, may be related to increased risk for psychopathology in the life course. We sought to explore the relationship among the occurrence of different clusters of maladaptive behaviours and ED, clinical features (i.e. Read More

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Subjective symptoms and serum methadone concentrations: what should guide dose adjustments in methadone maintenance treatment? A naturalistic cohort study from Norway.

Subst Abuse Treat Prev Policy 2021 May 3;16(1):39. Epub 2021 May 3.

Institute of Clinical Medicine, UiT - Norway's Arctic University, Tromsø, Norway.

Background: There is little evidence-based guidance on how to optimize methadone dosages among patients with opioid addiction undergoing methadone maintenance treatment (MMT). This study aims to investigate whether self-perceived opioid withdrawal symptoms, adverse effects, and self-reported substance use in patients on MMT are related to serum methadone concentrations and the role that these variables could play in clinical decisions on dose adjustments.

Methods: This naturalistic prospective cohort study included clinical and laboratory measurements from 83 patients undergoing MMT in outpatient clinics in Bergen, Norway, from May 2017 to January 2020. Read More

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Development of individuals' own and perceptions of peers' substance use from early adolescence to adulthood.

Addict Behav 2021 Apr 20;120:106958. Epub 2021 Apr 20.

Center for Child and Family Policy, Duke University, Durham, NC, USA.

This study evaluated how individuals' own substance use and their perception of peers' substance use predict each other across development from early adolescence to middle adulthood. Participants were from two longitudinal studies: Fast Track (FT; N = 463) and Child Development Project (CDP; N = 585). Participants reported on their own and peers' substance use during early and middle adolescence and early adulthood, and their own substance use in middle adulthood. Read More

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Current controversies in medical cannabis: recent developments in human clinical applications and potential therapeutics.

Neuropharmacology 2021 Apr 30:108586. Epub 2021 Apr 30.

Drug Science, London, UK; , Imperial College London, Du Cane Road, London, W12 0NN, UK. Electronic address:

Knowledge about the therapeutic potential of medical cannabis has greatly improved over the past decade, with an ever-increasing range of developments in human clinical applications. A growing body of scientific evidence supports the use of medical cannabis products for some therapeutic indications, whilst for others, the evidence base remains disputed. For this narrative review, we incorporate areas where the current evidence base is substantial, such as intractable childhood epilepsy and multiple sclerosis, as well as areas where the evidence is still controversial, such as PTSD and anxiety. Read More

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Adolescents' Substance Use and Physical Activity Before and During the COVID-19 Pandemic.

JAMA Pediatr 2021 May 3. Epub 2021 May 3.

Division of Adolescent Medicine, Department of Pediatrics, Stanford University, Stanford, California.

Importance: Stay-at-home policies related to the COVID-19 pandemic could disrupt adolescents' substance use and physical activity.

Objective: To compare adolescents' substance use and physical activity behaviors before and after stay-at-home restrictions.

Design, Setting, And Participants: Ongoing prospective cohort study of tobacco use behaviors among ninth- and tenth-grade students enrolled at 8 public high schools in Northern California from March 2019 to February 2020 and followed up from September 2019 to September 2020. Read More

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Use of medical cannabis by patients with fibromyalgia in Canada after cannabis legalisation: a cross-sectional study.

Clin Exp Rheumatol 2021 Apr 29. Epub 2021 Apr 29.

Department Internal Medicine I, Klinikum Saarbrücken, and Department of Psychosomatic Medicine and Psychotherapy, Technische Universität München, Germany.

Objectives: Medications have only small to moderate effects on symptoms in fibromyalgia (FM). Cannabinoids, including medical cannabis (MC) may have potential to fill this gap. Since recreational legalisation of cannabis in Canada, patients have easier access and may be self-medicating with cannabis. Read More

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A multicenter observational study on the distribution of orthopaedic fracture types across 17 low- and middle-income countries.

OTA Int 2019 Sep 9;2(3):e026. Epub 2019 Apr 9.

Division of Orthopedic Surgery, Centre for Evidence-Based Orthopedics.

Objectives: To describe the regional distribution of fractures sustained by women and health care system characteristics across 17 low- and middle-income countries (LMICs).

Methods: The INternational ORthopaedic MUlticentre Study in fracture care (INORMUS) is an observational study collecting data on patients in LMICs who sustained a fracture or musculoskeletal injury. As a planned analysis for the INORMUS study, we explored differences in fracture locations and demographics reported among 9878 female patients who sustained a fracture within 17 LMICs in 5 regions (China, Africa, India, Other Asia, and Latin America). Read More

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September 2019

Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22.

Biomol Ther (Seoul) 2021 May 3. Epub 2021 May 3.

Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. Read More

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Phytocannabinomics: Untargeted metabolomics as a tool for cannabis chemovar differentiation.

Talanta 2021 Aug 20;230:122313. Epub 2021 Mar 20.

Department of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy; CNR NANOTEC, Campus Ecotekne, University of Salento, Via Monteroni, 73100, Lecce, Italy.

Cannabis sativa is traditionally classified according to five chemotypes based on the concentration of the main phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG). However, cannabis chemovars and varieties very often present similar concentrations of such phytocannabinoids but different chemical profiles, which is unavoidably translated into different pharmacological effects when used for therapeutic purposes. For this reason, a more refined approach is needed for chemovar distinction, which is described in this study and named phytocannabinomics. Read More

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First report of causing root rot in (L.) in California.

Plant Dis 2021 May 2. Epub 2021 May 2.

Dark Heart Nursery, Oakland, California, United States;

In June of 2020 we observed greenhouse grown in Sonoma County, CA and Monterey County, CA showing stress symptoms: stunting, leaf chlorosis, and leaf senescence, when moved to flower production conditions. We uprooted symptomatic and healthy plants and observed disease symptoms only in symptomatic plants: reduced root mass, reduced root hair density, and necrosis. Roots and growth substrate samples were taken from infected and healthy plants for further analysis. Read More

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A high-quality reference genome of wild Cannabis sativa.

Hortic Res 2020 May 2;7(1):73. Epub 2020 May 2.

Institute of Forensic Science, Ministry of Public Security, No. 17 South Muxidi Lane, Xicheng District, Beijing, 100038, China.

Cannabis sativa is a well-known plant species that has great economic and ecological significance. An incomplete genome of cloned C. sativa was obtained by using SOAPdenovo software in 2011. Read More

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Cannabis use disorder, anger, and violence in Iraq/Afghanistan-era veterans.

J Psychiatr Res 2021 Apr 22;138:375-379. Epub 2021 Apr 22.

Durham VA Health Care System, Durham, NC, USA; Duke University Medical Center, Durham, NC, USA; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, USA; VA Center for Health Services Research in Primary Care, Durham, NC, USA.

An association has been found between cannabis use disorder (CUD) and violence in several clinical populations, including veterans with posttraumatic stress disorder (PTSD), and there is evidence that CUD has been increasing among veterans since September 11, 2001. There is also evidence that some veterans may be attempting to self-medicate psychological problems including PTSD and aggression with cannabis, despite the lack of safety and efficacy data supporting this use. To date, however, the association between CUD and aggression has yet to be examined in a large, non-clinic sample of veterans. Read More

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Opioid use in medical cannabis authorization adult patients from 2013 to 2018: Alberta, Canada.

BMC Public Health 2021 May 1;21(1):843. Epub 2021 May 1.

School of Public Health, 2-040 Li Ka Shing Centre for Health Research Innovation, University of Alberta, 11203-87 Avenue, Edmonton, AB, T6G 2E1, Canada.

Background: The opioid overdose epidemic in Canada and the United States has become a public health crisis - with exponential increases in opioid-related morbidity and mortality. Recently, there has been an increasing body of evidence focusing on the opioid-sparing effects of medical cannabis use (reduction of opioid use and reliance), and medical cannabis as a potential alternative treatment for chronic pain. The objective of this study is to assess the effect of medical cannabis authorization on opioid use (oral morphine equivalent; OME) between 2013 and 2018 in Alberta, Canada. Read More

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Sensory gating in tobacco-naïve cannabis users is unaffected by acute nicotine administration.

Psychopharmacology (Berl) 2021 May 1. Epub 2021 May 1.

Department of Psychology, Saint Mary's University, Halifax, NS, Canada.

Objectives: Long-term cannabis use has been associated with the appearance of psychotic symptoms and schizophrenia-like cognitive impairments; however these studies may be confounded by concomitant use of tobacco by cannabis users. We aimed to determine if previously observed cannabis-associated deficits in sensory gating would be seen in cannabis users with no history of tobacco use, as evidenced by changes in the P50, N100, and P200 event-related potentials. A secondary objective of this study was to examine the effects of acute nicotine administration on cannabis users with no tobacco use history. Read More

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Medical cannabis in pediatric oncology: a survey of patients and caregivers.

Support Care Cancer 2021 May 1. Epub 2021 May 1.

Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: There are minimal data regarding the safety and efficacy of cannabis used as an anti-cancer agent or for symptom management in pediatric oncology. We aimed to characterize the prevalence and factors associated with the use of cannabis for the treatment of cancer and management of cancer-related symptoms in children during or after cancer treatment.

Methods: An anonymous 40 question paper survey was offered to patients/caregivers of children with cancer attending a pediatric oncology clinic in a provincially mandated cancer agency between October 2019 and March 2020. Read More

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Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.

Mol Psychiatry 2021 Apr 30. Epub 2021 Apr 30.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.

Cannabis and cannabinoid drugs are central agents that are used widely recreationally and are employed broadly for treating psychiatric conditions. Cannabinoids primarily act by stimulating presynaptic CB1 receptors (CB1Rs), the most abundant G-protein-coupled receptors in brain. CB1R activation decreases neurotransmitter release by inhibiting presynaptic Ca channels and induces long-term plasticity by decreasing cellular cAMP levels. Read More

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A mixed-methods study to inform the clarity and accuracy of cannabis-use and cannabis-tobacco co-use survey measures.

Drug Alcohol Depend 2021 Apr 21;224:108697. Epub 2021 Apr 21.

Center for Tobacco Control Research and Education and Division of General Internal Medicine, Department of Medicine, University of California San Francisco, 530 Parnassus Ave. Ste 366, San Francisco, CA, 94143, United States. Electronic address:

Background: Legalization of medical and recreational cannabis in US states has been accompanied by increases in availability, acceptability, and diversity in methods of cannabis use, as well as an increase in devices and methods for cannabis-tobacco co-use. Updated and specific survey measures of cannabis and cannabis-tobacco co-use are needed.

Methods: We employed a mixed-methods approach to identify sources of specification and measurement error in cannabis and cannabis-tobacco co-use measures. Read More

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Young Aboriginal people in Australia who have never used marijuana in the 'Next Generation Youth Well-being study': A strengths-based approach.

Int J Drug Policy 2021 Apr 27;95:103258. Epub 2021 Apr 27.

Curtin Medical School, Curtin University, Western Australia 6102, Australia.

Background: Being young is a period of experimentation which can lead to increased vulnerability to poor health choices and outcomes. Aboriginal and Torres Strait Islander (Aboriginal) people have a long and strong history of resilience; however, a deficit approach is often taken with messages of poor health and low socioeconomic status. This study takes a strengths-based approach and examines the demographic factors and behaviours associated with never using marijuana among young Aboriginal people in Australia. Read More

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Medicinal cannabis: new challenges for the anesthesiologist.

Braz J Anesthesiol 2021 Apr 27. Epub 2021 Apr 27.

Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, São Paulo, SP, Brazil; Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, São Paulo, SP, Brazil. Electronic address:

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Periodontal status in cannabis smokers. A systematic review.

J Int Acad Periodontol 2021 Apr;23(2):150-166

Federal University of Rio Grande do Sul, Brazil.

Aims: To assess the periodontal status in cannabis smokers in comparison with non-cannabis smokers.

Materials And Methods: Electronic databases were searched as well as hand searches performed. Eligible studies followed the Population Exposure Comparison Outcome Study (PECOS) structure: P: dentate humans, E: cannabis smoking, C: non-cannabis smoking, O: Primary outcomes: periodontitis case definition, clinical attachment loss, probing depth; Secondary outcomes: bleeding on probing/ gingival inflammation, plaque index and calculus; S: observational studies. Read More

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CANreduce 2.0 Adherence-Focused Guidance for Internet Self-Help Among Cannabis Users: Three-Arm Randomized Controlled Trial.

J Med Internet Res 2021 Apr 30;23(4):e27463. Epub 2021 Apr 30.

Swiss Research Institute for Public Health and Addiciton, University of Zurich, Zürich, Switzerland.

Background: Despite increasing demand for treatment among cannabis users in many countries, most users are not in treatment. Internet-based self-help offers an alternative for those hesitant to seek face-to-face therapy, though low effectiveness and adherence issues often arise.

Objective: Through adherence-focused guidance enhancement, we aimed to increase adherence to and the effectiveness of internet-based self-help among cannabis users. Read More

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Predictors of medicinal cannabis users' willingness to utilise a new prescription Medicinal Cannabis Scheme in New Zealand.

N Z Med J 2021 Apr 30;134(1534):66-75. Epub 2021 Apr 30.

Technical Officer, SHORE & Whāriki Research Centre, Massey University, New Zealand.

Aim: To investigate medicinal cannabis users' intentions to transition to the new prescription Medicinal Cannabis Scheme (MCS) in New Zealand.

Method: An online survey of 3,634 past-year medicinal cannabis users completed prior to implementation of the MCS in New Zealand in April 2020. Logistic regression models were fitted to identify predictors of intended future engagement with the MCS. Read More

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Are researchers getting the terms used to denote different types of recreational cannabis right?-a user perspective.

J Cannabis Res 2021 Apr 29;3(1):12. Epub 2021 Apr 29.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Background: While current cannabis research has advanced our understanding into the effects of its individual components, there is a pressing need to identify simple terminology that is understood in the same way by researchers and users of cannabis. Current categorisation in research focuses on the two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD); and two different species of cannabis: indica and sativa. Recreational cannabis has also been categorised by researchers as 'skunk' or 'hash'. Read More

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Cannabis use, sedentary behavior, and physical activity in a nationally representative sample of US adults.

Harm Reduct J 2021 Apr 29;18(1):48. Epub 2021 Apr 29.

Department of Psychology, Chapman University, 1 University Drive, Orange, CA, 92866, USA.

Background: Prior research examining the relationship between cannabis use, sedentary behavior, and physical activity has generated conflicting findings, potentially due to biases in the self-reported measures used to assess physical activity. This study aimed to more precisely explore the relationship between cannabis use and sedentary behavior/physical activity using objective measures.

Methods: Data were obtained from the 2005-2006 National Health and Nutrition Examination Survey. Read More

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Plant-Origin Stabilizer as an Alternative of Natural Additive to Polymers Used in Packaging Materials.

Int J Mol Sci 2021 Apr 13;22(8). Epub 2021 Apr 13.

Institute of Polymer and Dye Technology, Faculty of Chemistry, Lodz University of Technology, Stefanowskiego 12/16, 90-924 Lodz, Poland.

Over the past 25 years, cannabis plants have gained major popularity in the research community. This study aimed to evaluate the antioxidant capacity and stabilization efficiency of cannabidiol (CBD) extract in two different polymers: polylactide (PLA) and ethylene-norbornene copolymer (Topas) that are used in packaging materials more often. The research technology included weathering in a special chamber, surface free energy and color change measurements, surface morphology and Fourier-transform infrared spectroscopy (FTIR) analysis, thermogravimetry, and determination of the oxidation induction time or temperature (OIT) values, based on which the effectiveness of the cannabidiol extract could be estimated. Read More

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