Animals (Basel) 2021 Aug 19;11(8). Epub 2021 Aug 19.
Faculty of Veterinary Medicine, University of Veterinary Sciences, 612 42 Brno, Czech Republic.
The purpose of this review is to summarize current knowledge on canine and feline cystinuria from available scientific reports. Cystinuria is an inherited metabolic defect characterized by abnormal intestinal and renal amino acid transport in which cystine and the dibasic amino acids ornithine, lysine, and arginine are involved (COLA). At a normal urine pH, ornithine, lysine, and arginine are soluble, but cysteine forms a dimer, cystine, which is relatively insoluble, resulting in crystal precipitation. Read More