18,460 results match your criteria canine intestinal

Effects of time on differential leucocyte counts and biochemical parameters of ovariohysterectomy, gastrotomy and intestinal resection and anastomosis in Nigerian indigenous dogs.

Vet Anim Sci 2021 Dec 30;14:100203. Epub 2021 Aug 30.

Department of Veterinary Surgery and Diagnostic Imaging, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.

Differential leucocytes counts and some biochemical parameters could be affected over time by surgical procedures leading to kidney failure. Hence this study evaluates the effects of ovariohysterectomy (OVH), gastrotomy (GAT) and intestinal resection and anastomosis (ITR) on differential leucocyte counts and some biochemical parameters in Nigerian dogs. Twelve dogs of both sexes weighing 10. Read More

View Article and Full-Text PDF
December 2021

[Prospects for the correction of intestinal microbiota in the prevention and treatment of asthma in children].

Vopr Pitan 2021 22;90(4):74-83. Epub 2021 Jul 22.

I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University), 119991, Moscow, Russian Federation.

The issues of therapy and prevention of asthma in children do not lose their relevance. The increase in the prevalence of allergic diseases and asthma is associated, among other things, with a relative deficit in the microbial load and changes in the microbiota due to improved hygiene and living conditions. The microbiota plays an important role in the formation and functioning of the immune system. Read More

View Article and Full-Text PDF

Analysis of the gut microbiome in dogs and cats.

Vet Clin Pathol 2021 Sep 12. Epub 2021 Sep 12.

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

The gut microbiome is an important immune and metabolic organ. Intestinal bacteria produce various metabolites that influence the health of the intestine and other organ systems, including kidney, brain, and heart. Changes in the microbiome in diseased states are termed dysbiosis. Read More

View Article and Full-Text PDF
September 2021

Successful treatment of pleural and peritoneal larval mesocestoidosis with fenbendazole in two dogs.

Vet Parasitol Reg Stud Reports 2021 Jul 24;25:100603. Epub 2021 Jun 24.

Università di Parma, Dip. Scienze Medico-Veterinarie, Parassitologia e Malattie Parassitarie, Italy.

Mesocestoides spp. are common intestinal tapeworms of dogs and cats. The presence of numerous larval stages in the pleural or peritoneal cavities causes larval mesocestoidosis, that is a potentially life-threatening disease in massive infection. Read More

View Article and Full-Text PDF

The effects of raw-meat diets on the gastrointestinal microbiota of the cat and dog: a review.

N Z Vet J 2021 Sep 19:1-9. Epub 2021 Sep 19.

Smart Foods, AgResearch Limited, Palmerston North, New Zealand.

The aim of this review is to summarise the available literature on the effects of consuming raw, red meat diets on the gastrointestinal microbiome of the cat and dog. In recent years, feeding raw meat diets to cats and dogs has increased, in part associated with trends in human nutrition for "natural" and "species-appropriate" diets. These diets range from home-prepared unprocessed, nutritionally incomplete diets to complete and balanced diets with sterilisation steps in their manufacturing process. Read More

View Article and Full-Text PDF
September 2021

Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission.

Geroscience 2021 Aug 30. Epub 2021 Aug 30.

Vascular Cognitive Impairment and Neurodegeneration Program, Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

The current COVID-19 pandemic, caused by the highly contagious respiratory pathogen SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has already claimed close to three million lives. SARS-CoV-2 is a zoonotic disease: it emerged from a bat reservoir and it can infect a number of agricultural and companion animal species. SARS-CoV-2 can cause respiratory and intestinal infections, and potentially systemic multi-organ disease, in both humans and animals. Read More

View Article and Full-Text PDF

Prevalence of Anti-Toxocara canis Antibodies in Dogs Detected with Recombinant Cathepsin L-1 and TES-26 Antigens in Three States of India.

Acta Parasitol 2021 Aug 28. Epub 2021 Aug 28.

Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Wayanad, Kerala, India.

Purpose: Toxocara canis is a common intestinal nematode parasite of dogs with recognized zoonotic potential in tropical countries. The purpose of this study was to determine the seroprevalence of anti-T. canis antibodies in two target dog populations: household and community-owned, distributed over three distinct geographical regions of India. Read More

View Article and Full-Text PDF

In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets.

Pharmaceutics 2021 Aug 13;13(8). Epub 2021 Aug 13.

Global Research & Development, Lonza, Bend, OR 97703, USA.

Amorphous solid dispersion (ASD) dosage forms can improve the oral bioavailability of poorly water-soluble drugs, enabling the commercialization of new chemical entities and improving the efficacy and patient compliance of existing drugs. However, the development of robust, high-performing ASD dosage forms can be challenging, often requiring multiple formulation iterations, long timelines, and high cost. In a previous study, acalabrutinib/hydroxypropyl methylcellulose acetate succinate (HPMCAS)-H grade ASD tablets were shown to overcome the pH effect of commercially marketed Calquence in beagle dogs. Read More

View Article and Full-Text PDF

Fulvestrant-3-Boronic Acid (ZB716) Demonstrates Oral Bioavailability and Favorable Pharmacokinetic Profile in Preclinical ADME Studies.

Pharmaceuticals (Basel) 2021 Jul 26;14(8). Epub 2021 Jul 26.

RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.

Fulvestrant-3-boronic acid (ZB716), an oral selective estrogen receptor degrader (SERD) under clinical development, has been investigated in ADME studies to characterize its absorption, metabolism, and pharmacokinetics. ZB716 was found to have high plasma protein binding in human and animal plasma, and low intestinal mucosal permeability. ZB716 had high clearance in hepatocytes of all species tested. Read More

View Article and Full-Text PDF

Cystinuria in Dogs and Cats: What Do We Know after Almost 200 Years?

Animals (Basel) 2021 Aug 19;11(8). Epub 2021 Aug 19.

Faculty of Veterinary Medicine, University of Veterinary Sciences, 612 42 Brno, Czech Republic.

The purpose of this review is to summarize current knowledge on canine and feline cystinuria from available scientific reports. Cystinuria is an inherited metabolic defect characterized by abnormal intestinal and renal amino acid transport in which cystine and the dibasic amino acids ornithine, lysine, and arginine are involved (COLA). At a normal urine pH, ornithine, lysine, and arginine are soluble, but cysteine forms a dimer, cystine, which is relatively insoluble, resulting in crystal precipitation. Read More

View Article and Full-Text PDF

Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans.

Animals (Basel) 2021 Aug 9;11(8). Epub 2021 Aug 9.

Lipids and Atherosclerosis Unit, Internal Medicine Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain.

Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet and its relationship with the intestinal microbiota. Read More

View Article and Full-Text PDF

Nonsurgical reduction of prolapsed colocolic intussusception in 2 puppies.

J Vet Emerg Crit Care (San Antonio) 2021 Sep 24;31(5):656-660. Epub 2021 Aug 24.

Anderson Moores Veterinary Specialists, Winchester, UK.

Objective: To describe the nonsurgical management of prolapsed colocolic intussusception in 2 puppies.

Case Summary: Two 3-month-old male intact puppies (Pug and Labrador Retriever) developed intussusceptions that had prolapsed from the anus after they had suffered from tenesmus with soft feces or diarrhea. Reduction of the prolapsed tissue was performed and colocolic intussusception was diagnosed ultrasonographically in 1 dog. Read More

View Article and Full-Text PDF
September 2021

Inclusion of small intestinal absorption and simulated mucosal surfaces further improve the Mucosal Simulator of the Canine Intestinal Microbial Ecosystem (M-SCIME™).

Res Vet Sci 2021 Aug 8;140:100-108. Epub 2021 Aug 8.

ProDigest bv, Technologiepark 82, 9052 Ghent, Belgium; Center of Microbial Ecology and Technology (CMET), Ghent University, Coupure Links 653, 9000 Ghent, Belgium. Electronic address:

While a large set of in vitro models are available to study the effects of specific food ingredients (e.g. pre- and probiotics) on the human gut microbiome, the availability of such models for companion animals is limited. Read More

View Article and Full-Text PDF

Overview of Coronaviruses in Veterinary Medicine.

Susan R Compton

Comp Med 2021 Aug 19. Epub 2021 Aug 19.

Coronaviruses infect humans and a wide range of animals, causing predominantly respiratory and intestinal infections. Thisreview provides background on the taxonomy of coronaviruses, the functions of viral proteins, and the life cycle of coronaviruses.In addition, the review focuses on coronaviral diseases in several agriculturally important, companion, and laboratoryanimal species (cats, cattle, chickens, dogs, mice, rats and swine) and briefly reviews human coronaviruses and their origins. Read More

View Article and Full-Text PDF

L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies.

J Pharmacol Toxicol Methods 2021 Aug 17:107110. Epub 2021 Aug 17.

Merck KGaA, Chemical and Preclinical Safety, Darmstadt, Germany.

Introduction: Gastrointestinal (GI) toxicity is still an issue within drug development, especially for novel oncology drugs. The identification of GI mucosal damage at an early stage with high sensitivity and specificity across preclinical species and humans remains difficult. To date, in preclinical studies, no qualified mechanistic, diagnostic or prognostic biomarkers exist for GI mucosal toxicity. Read More

View Article and Full-Text PDF

Hierarchical modelling of immunoglobulin coated bacteria in dogs with chronic enteropathy shows reduction in coating with disease remission but marked inter-individual and treatment-response variability.

PLoS One 2021 19;16(8):e0255012. Epub 2021 Aug 19.

Department of Veterinary Clinical Sciences, Melbourne Veterinary School, The University of Melbourne, Werribee, Victoria, Australia.

Chronic enteropathies are a common problem in dogs, but many aspects of the pathogenesis remain unknown, making the therapeutic approach challenging in some cases. Environmental factors are intimately related to the development and perpetuation of gastrointestinal disease and the gut microbiome has been identified as a contributing factor. Previous studies have identified dysbiosis and reduced bacterial diversity in the gastrointestinal microbiota of dogs with chronic enteropathies. Read More

View Article and Full-Text PDF

[Study on metabolic dynamics,metabolic enzyme phenotype and species difference of hepatic and intestinal microsome of psoralidin].

Zhongguo Zhong Yao Za Zhi 2021 Jul;46(13):3410-3421

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of China,Jinan University Guangzhou 510632,China College of Pharmacy,Jinan University Guangzhou 510632,China.

This study aims to investigate metabolic activities of psoralidin in human liver microsomes( HLM) and intestinal microsomes( HIM),and to identify cytochrome P450 enzymes( CYPs) and UDP-glucuronosyl transferases( UGTs) involved in psoralidin metabolism as well as species differences in the in vitro metabolism of psoralen. First,after incubation serial of psoralidin solutions with nicotinamide adenine dinucleotide phosphate( NADPH) or uridine 5'-diphosphate-glucuronic acid( UDPGA)-supplemented HLM or HIM,two oxidic products( M1 and M2) and two conjugated glucuronides( G1 and G2) were produced in HLM-mediated incubation system,while only M1 and G1 were detected in HIM-supplemented system. The CLintfor M1 in HLM and HIM were 104. Read More

View Article and Full-Text PDF

Canine bocavirus-2 infection and its possible association with encephalopathy in domestic dogs.

PLoS One 2021 12;16(8):e0255425. Epub 2021 Aug 12.

Faculty of Veterinary Science, Department of Pathology, Chulalongkorn University, Bangkok, Thailand.

Canine bocaviruses (CBoVs) have been recognized as pathogens associated with intestinal diseases. Hematogenous spreading caused by CBoV has been documented and may potentiate the virus entry across the blood-brain barrier to initiate a brain infection. This study focused attention on CBoV detection in cases of encepahlopathy and attempted to determine its viral localization. Read More

View Article and Full-Text PDF

Parvoviral enteritis and salmonellosis in raccoons with sudden death.

J Vet Diagn Invest 2021 Aug 12:10406387211038766. Epub 2021 Aug 12.

Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.

Eight of 9 juvenile raccoons at a rehabilitation center died without obvious prior clinical signs. Gross changes were unremarkable except for mildly distended intestines. Microscopically, crypt loss, distension, necrosis, and regeneration with intranuclear viral inclusions were observed in the small intestine, with marked lymphoid depletion and necrosis in Peyer patches and mesenteric lymph nodes. Read More

View Article and Full-Text PDF

Intraoperative surgeon probe inspection compared to leak testing for detecting gaps in canine jejunal continuous anastomoses: A cadaveric study.

Vet Surg 2021 Aug 10. Epub 2021 Aug 10.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Objective: To compare the detection of gaps in jejunal continuous anastomoses by probing (PT) versus leak testing (LT).

Study Design: Experimental study.

Animals: Normal jejunal segments (n = 24) from two fresh canine cadavers. Read More

View Article and Full-Text PDF

Mechanical strength and gastric residence time of expandable fibrous dosage forms.

Int J Pharm 2021 Aug 4:120792. Epub 2021 Aug 4.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; These authors contributed equally to this work.

The expandable, gastroretentive dosage forms are promising for precise control of drug concentration in blood. So far, however, short gastric retention times and safety considerations have precluded their use. In this work, to mitigate the above limitations, expandable fibrous dosage forms were investigated for mechanical strength and gastric retention time in dogs. Read More

View Article and Full-Text PDF

[Hepatic distress syndrome in surgery: concept, pathogenesis, prevention and correction].

Khirurgiia (Mosk) 2021 (8):20-27

Ogarev National Research Mordovia State University, Saransk, Russia.

Objective: To establish the universality and regularity of hepatic disorders, their role in pathogenesis of homeostasis impairment and determine scientific base for a new syndrome - hepatic distress syndrome in surgery.

Material And Methods: Chronic experiments on outbred dogs were carried out. Acute peritonitis was simulated in the first group (=15), acute destructive pancreatitis in the second group (=15), acute obstructive intestinal obstruction in the third group (15). Read More

View Article and Full-Text PDF

LAMP Assay for the Detection of   Eggs Isolated from Canine Faeces by a Cost-Effective NaOH-Based DNA Extraction Method.

Pathogens 2021 Jul 5;10(7). Epub 2021 Jul 5.

Institute of Parasitology, Vetsuisse and Medical Faculty, University of Zurich, 8057 Zurich, Switzerland.

The detection of in infected canids and the environment is pivotal for a better understanding of the epidemiology of alveolar echinococcosis in endemic areas. Necropsy/sedimentation and counting technique remain the gold standard for the detection of canid infection. PCR-based detection methods have shown high sensitivity and specificity, but they have been hardly used in large scale prevalence studies. Read More

View Article and Full-Text PDF

Isolation and immunophenotyping by flow cytometry of canine peripheral blood and intraepithelial and lamina propria duodenal T lymphocytes.

Vet Immunol Immunopathol 2021 Sep 28;239:110305. Epub 2021 Jul 28.

Department of Animal Medicine and Surgery, College of Veterinary Medicine, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.

The gut associated lymphoid tissue (GALT) effector sites play a crucial role on the pathogenesis of many immune-mediated gastrointestinal diseases. The lymphocytes at these effector sites are principally T cells which present important morphological, phenotypical and functional differences. Flow cytometry (FC) is one of the most commonly used techniques to characterize intestinal lymphocytes in human and animal models. Read More

View Article and Full-Text PDF
September 2021

Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses - Yet it is of major concern.

Int J Parasitol Drugs Drug Resist 2021 Jul 25;17:36-45. Epub 2021 Jul 25.

Institute of Parasitology, University of Zurich, Switzerland.

Anthelmintic resistance (AR) has thus far only rarely been reported for intestinal helminths of dogs and cats, in contrast to parasites of livestock and horses. We highlight possible reasons for this striking and important discrepancy, including ecological, biological and genetic factors and/or intervention regimens of key intestinal helminths concerning both host groups. In view of the current knowledge related to the genetics, mechanisms and principles of AR development, we point at issues which in our view contribute to a comparatively lower risk of AR development in intestinal helminths of dogs and cats. Read More

View Article and Full-Text PDF

Molecular characterization of Cryptosporidium spp. in dogs and cats in the city of Rio de Janeiro, Brazil, reveals potentially zoonotic species and genotype.

PLoS One 2021 3;16(8):e0255087. Epub 2021 Aug 3.

Instituto Oswaldo Cruz-Laboratório de Estudos Integrados em Protozoologia, Rio de Janeiro, Brazil.

Intestinal cryptosporidiosis is a diarrheal disease caused by protists of genus Cryptosporidium that infect a wide variety of hosts, primarily vertebrates. Due to the close contact between humans and their companion animals, especially dogs and cats, there is concern about the potential for zoonotic transmission of this enteric protozoan parasite by infected animals. This study aimed to perform a microscopic and molecular diagnosis of Cryptosporidium spp. Read More

View Article and Full-Text PDF

Full Genomic Sequences of H5N1 Highly Pathogenic Avian Influenza Virus in Human Autopsy Specimens Reveal Genetic Variability and Adaptive Changes for Growth in MDCK Cell Cultures.

Biomed Res Int 2021 22;2021:3890681. Epub 2021 Jul 22.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand.

The entire H5N1 highly pathogenic avian influenza viral genomes were identified in the frozen autopsy specimens: the trachea, lung, colon, and intestinal feces from a patient who died of the disease in 2006. Phylogenetic analysis of the viral genomes showed that these viruses belonged to clade 1 and were the reassortants generated from the reassortment of the viruses within the same clade. The sequencing data from the autopsy specimens revealed at least 8 quasispecies of the H5N1 viruses across all 4 specimen types. Read More

View Article and Full-Text PDF
September 2021

Microencapsulated phytogenic in dog feed modulates immune responses, oxidative status and reduces bacterial (Salmonella and Escherichia coli) counts in feces.

Microb Pathog 2021 Oct 29;159:105113. Epub 2021 Jul 29.

Departamento de Zootecnia, UDESC, Chapecó, SC, Brazil. Electronic address:

Improving the health and immunity of pets is a concern of the guardians, while maintaining the health of the animals directly impacts the owners' health and public health. The objective of this study was to produce a dog feed containing a microencapsulated phytogenic blend, as well as determine the impact of the additive on animal health and its intestinal microbiota. The composition included microencapsulated thymol, carvacrol, and cinnamaldehyde, at 300 mg/kg of feed. Read More

View Article and Full-Text PDF
October 2021

Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses.

J Complement Integr Med 2021 Jul 29. Epub 2021 Jul 29.

Department of physiology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.

Objectives: To investigate effect of beta adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses.

Methods: Experiments were carried out on 35 fasted male anaesthetized dogs weighing between 9 and 16 kg. The animals were divided into 7 (5 dogs per group) groups. Read More

View Article and Full-Text PDF

Changes in the fecal microbiota in dogs with acute hemorrhagic diarrhea during an outbreak in Norway.

J Vet Intern Med 2021 Jul 21. Epub 2021 Jul 21.

Faculty of Veterinary Medicine, Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.

Background: A severe form of acute hemorrhagic diarrhea syndrome (AHDS) occurred in dogs in the Oslo region of Norway during autumn 2019.

Objectives: To characterize the fecal microbiota of dogs with AHDS during the outbreak and compare it to that of healthy dogs from the same period and before the outbreak.

Animals: Dogs with AHDS (n = 50), dogs with nonhemorrhagic diarrhea (n = 3), and healthy dogs (n = 11) were sampled during the outbreak. Read More

View Article and Full-Text PDF