4,167 results match your criteria cancers covid-19

Impact of the COVID-19 pandemic situation on HIV care in Liège, Belgium.

HIV Res Clin Pract 2021 Jul 25:1-8. Epub 2021 Jul 25.

Department of Infectious Diseases and General Internal Medicine, Liège University Hospital, Liège, Belgium.

Background: The COVID-19 pandemic and associated containment measures dramatically affected the health care systems including the screening of human immunodeficiency virus and the management people living with HIV around the world by making the access to preventive care services and specific medical monitoring more difficult.

Objective: To study the impact of the COVID-19 pandemic on the holistic care of people living with HIV in Liège (Belgium).

Methods: In this retrospective observational study conducted in Liège University Hospital, we compared the out-patient follow-up of HIV-infected individuals as well as the number of new HIV diagnoses between 2019 and 2020 and between the different waves of the COVID-19 pandemic in 2020. Read More

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Precision medicine: Uses and challenges.

Med J Armed Forces India 2021 Jul 3;77(3):258-265. Epub 2021 Jul 3.

Professor & Head, Department of Pharmacology, Armed Forces Medical College, Pune, India.

Precision medicine has brought in many changes to the practise of medicine. The omics-based development of biomarkers and pharmaco-omics-based drug development programmes are evidences for the advancement. However, the field where it has proved to be most useful is in the development of various modalities of treatment in oncology. Read More

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Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective.

Int J Mol Sci 2021 Jul 16;22(14). Epub 2021 Jul 16.

Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.

In the past few years, Bruton's tyrosine Kinase (Btk) has emerged as new target in medicinal chemistry. Since approval of ibrutinib in 2013 for treatment of different hematological cancers (as leukemias and lymphomas), two other irreversible Btk inhibitors have been launched on the market. In the attempt to overcome irreversible Btk inhibitor limitations, reversible compounds have been developed and are currently under evaluation. Read More

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The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy.

Cancers (Basel) 2021 Jul 18;13(14). Epub 2021 Jul 18.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.

Cancer immunotherapy harnesses the immune system by targeting tumor cells that express antigens recognized by immune system cells, thus leading to tumor rejection. These tumor-associated antigens include tumor-specific shared antigens, differentiation antigens, protein products of mutated genes and rearrangements unique to tumor cells, overexpressed tissue-specific antigens, and exogenous viral proteins. However, the development of effective therapeutic approaches has proven difficult, mainly because these tumor antigens are shielded, and cells primarily express self-derived antigens. Read More

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COVID-19 Vaccine Safety in Cancer Patients: A Single Centre Experience.

Cancers (Basel) 2021 Jul 16;13(14). Epub 2021 Jul 16.

Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.

Emergency approval of vaccines against COVID-19 provides an opportunity for us to return to pre-pandemic oncology care. However, safety data in cancer patients is lacking due to their exclusion from most phase III trials. We included all patients aged less than 65 years who received a COVID-19 vaccine from 8 December 2020 to 28 February 2021 at our London tertiary oncology centre. Read More

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Cannabis Use among Cancer Survivors amid the COVID-19 Pandemic: Results from the COVID-19 Cannabis Health Study.

Cancers (Basel) 2021 Jul 13;13(14). Epub 2021 Jul 13.

School of Nursing and Health Studies, University of Miami, Coral Gables, FL 33146, USA.

Clinical indications for medicinal cannabis use include those with cancer, a subgroup advised to avoid exposure to COVID-19. This study aims to identify changes to cannabis use, methods of cannabis delivery, and coping strategies among cancer survivors since the pandemic by cancer status. Chi-squared tests were used for univariate comparisons of demographic characteristics, cannabis use patterns, COVID-19 symptoms, and coping behaviors by cancer survivor status. Read More

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Anosmia but Not Ageusia as a COVID-19-Related Symptom among Cancer Patients-First Results from the PAPESCO-19 Cohort Study.

Cancers (Basel) 2021 Jul 6;13(14). Epub 2021 Jul 6.

Department of Medical Oncology, Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.

Cancer patients may fail to distinguish COVID-19 symptoms such as anosmia, dysgeusia/ageusia, anorexia, headache, and fatigue, which are frequent after cancer treatments. We aimed to identify symptoms associated with COVID-19 and to assess the strength of their association in cancer and cancer-free populations. The multicenter cohort study PAPESCO-19 included 878 cancer patients and 940 healthcare workers (HCWs). Read More

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Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study.

Eur J Cancer 2021 Jun 30;154:246-252. Epub 2021 Jun 30.

Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy.

Background: Specific data regarding coronavirus disease 2019 (COVID-19) in patients with neuroendocrine neoplasms (NENs) are lacking. The aim of this study is to describe the characteristics of patients with NENs who tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive.

Material And Methods: This is a worldwide study collecting cases of patients with NENs along with a positive nasopharyngeal swab reverse transcriptase-polymerase chain reaction (RT-PCR) test for SARS-CoV-2 between June 1, 2020, and March 31, 2021. Read More

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Characteristics, clinical outcomes, and risk factors of SARS-COV-2 infection in adult acute myeloid leukemia patients: experience of the PETHEMA group.

Leuk Lymphoma 2021 Jul 22:1-11. Epub 2021 Jul 22.

Hematology and Hemotherapy Department, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces higher morbidity and mortality in hematological malignancies, but evidence in acute myeloid leukemia (AML) is scarce. A multicenter observational study was conducted to determine the clinical outcomes and assess the impact of therapeutic approaches in adult AML patients with SARS-CoV-2 infection in the first wave (March-May 2020). Overall, 108 patients were included: 51. Read More

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Temporal association between SARS-CoV-2 and new-onset myasthenia gravis: is it causal or coincidental?

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Neurology, Care Hospital Banjara Hills, Hyderabad, India.

Several case reports of COVID-19 in patients with myasthenia gravis (MG) have been documented. However, new-onset autoimmune MG following COVID-19 has been reported very rarely. We report one such case here. Read More

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A role for T-cell exhaustion in Long COVID-19 and severe outcomes for several categories of COVID-19 patients.

Kevin Roe

J Neurosci Res 2021 Jul 19. Epub 2021 Jul 19.

San Jose, CA, USA.

Unusual mortality rate differences and symptoms have been experienced by COVID-19 patients, and the postinfection symptoms called Long COVID-19 have also been widely experienced. A substantial percentage of COVID-19-infected individuals in specific health categories have been virtually asymptomatic, several other individuals in the same health categories have exhibited several unusual symptoms, and yet other individuals in the same health categories have fatal outcomes. It is now hypothesized that these differences in mortality rates and symptoms could be caused by a SARS-CoV-2 virus infection acting together with one or more latent pathogen infections in certain patients, through mutually beneficial induced immune cell dysfunctions, including T-cell exhaustion. Read More

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COVID-19 hospitalization and death and relationship with social determinants of health and morbidities in Espírito Santo State, Brazil: a cross-sectional study.

Epidemiol Serv Saude 2021 9;30(3):e2020919. Epub 2021 Jul 9.

Universidade Federal do Espírito Santo, Laboratório de Epidemiologia, Vitória, ES, Brasil.

Objective: To analyze the association between social determinants and morbidities for the outcomes of hospitalization, intensive care unit admission and death by COVID-19 in Espírito Santo State, Brazil.

Methods: Cross-sectional study with secondary data from confirmed cases of COVID-19, reported in the Notifiable Diseases Information System. Poisson regression was used to estimate the prevalence ratios. Read More

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Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis.

Diseases 2021 Jul 1;9(3). Epub 2021 Jul 1.

Department of Pathology, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica.

Globally, millions of persons have contracted the coronavirus disease 2019 (COVID-19) over the past several months, resulting in significant mortality. Health care systems are negatively impacted including the care of individuals with cancers and other chronic diseases such as chronic active hepatitis, cirrhosis and hepatocellular carcinoma. There are various probable pathogenic mechanisms that have been presented to account for liver injury in COVID-19 patients such as hepatotoxicity cause by therapeutic drugs, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the bile duct cells and hepatocytes, hypoxia and systemic inflammatory response. Read More

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Fine needle aspiration in COVID-19 vaccine-associated lymphadenopathy.

Swiss Med Wkly 2021 07 20;151:w20557. Epub 2021 Jul 20.

Department of Pathology and Molecular Pathology, University Hospital, University of Zurich, Switzerland.

Aims: With ongoing intensive vaccination programme against COVID-19, numerous cases of adverse reactions occur, some of which represent rare events. Enlargement of the injection site’s draining lymph nodes is increasingly reported, but is not yet widely recognised as being possibly associated with recent vaccination. As patients at risk of a severe course of COVID-19, indicated by their medical history such as a previous diagnosis of malignancy, receive priority vaccination, newly palpable lymph nodes raise concerns of disease progression. Read More

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Impact of COVID-19 on gastric cancer treatment in Japanese high-volume centers: a JCOG stomach cancer study group survey.

Surg Today 2021 Jul 20. Epub 2021 Jul 20.

Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Purposes: The spread of coronavirus disease 2019 (COVID-19) has affected socioeconomic and healthcare systems in many countries. Accordingly, many individuals may have canceled their annual health-check programs, including esophagogastroduodenoscopy, which would have resulted in lower numbers of newly diagnosed patients with gastric cancer in comparison to other times.

Methods: Questionnaires were distributed to 62 hospitals every week from May 2020 to August 2020 (total 744) through mailing lists of the Stomach Cancer Study Group of the Japan Clinical Oncology Group. Read More

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Diagnosis of Anosmia and Hyposmia: A Systematic Review.

Allergy Rhinol (Providence) 2021 Jan-Dec;12:21526567211026568. Epub 2021 Jul 5.

Indiana University School of Medicine, Indianapolis, Indiana.

Background: Anosmia and hyposmia have many etiologies, including trauma, chronic sinusitis, neoplasms, and respiratory viral infections such as rhinovirus and SARS-CoV-2. We aimed to systematically review the literature on the diagnostic evaluation of anosmia/hyposmia.

Methods: PubMed, EMBASE, and Cochrane databases were searched for articles published since January 1990 using terms combined with Medical Subject Headings (MeSH). Read More

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Pleomorphic liposarcoma of the male breast: lessons from a rare malignancy during COVID-19 pandemic.

BMJ Case Rep 2021 Jul 20;14(7). Epub 2021 Jul 20.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

A 52-year-old man presented with a recurrent right side breast lump. He had undergone excision of a lump on the right breast followed by adjuvant chemoradiotherapy 1 year ago for a diagnosis of pleomorphic liposarcoma. Imaging revealed a 47×36 mm lesion on the right side of the chest wall involving the pectoralis muscle. Read More

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Restoring NK cells functionality via cytokine activation enhances cetuximab-mediated NK-cell ADCC: A promising therapeutic tool for HCC patients.

Mol Immunol 2021 Jul 17;137:221-227. Epub 2021 Jul 17.

Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Ein-Helwan, Cairo, 11795, Egypt. Electronic address:

Natural Killer (NK) cells are considered the first line of defense against viral infections and tumors. Several factors affect NK cytotoxic activity rendering it dysfunctional and thereby impeding the ability to scavenge abnormal cells as a part of immune escaping mechanisms induced by different types of cancers. NK cells play a crucial role augmenting the activity of various types of anticancer mAb since dysfunctional NK cells are the main reason for the low response to these therapies. Read More

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Quality of Life and Psychosocial Impacts of the Different Restrictive Measures during One Year into the COVID-19 Pandemic on Patients with Cancer in Italy: An Ecological Study.

Int J Environ Res Public Health 2021 Jul 4;18(13). Epub 2021 Jul 4.

Health Education Observatory of the Hygiene Laboratory, Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.

Background: The aim of the study was to assess the perceived quality of life and the psychosocial impact of the various restrictive measures due to COVID-19 pandemic on cancer patients in Italy, as well as their perception of the relationship with doctors and caregivers.

Methods: This study compares three population-based observational studies of patients with cancer carried out in three consecutive time periods characterized by different restrictive measures using a self-administered online questionnaire.

Results: Among the basic needs, psychological and medical support appeared to be prevalent; so did the need for safe transportation to reach the treatment facilities. Read More

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Supporting cancer care clinicians to 'hold' their patients during and beyond the COVID-19 pandemic: a role for reflective ethics discussions.

Intern Med J 2021 Jul;51(7):1143-1145

Palliative Care, Austin Health, Melbourne, Victoria, Australia.

The COVID-19 pandemic has placed an overwhelming burden on healthcare delivery globally. This paper examines how COVID-19 has affected cancer care clinicians' capacity to deliver cancer care in the Australian context. We use the lens of 'holding patients' (drawing from attachment theory, psychology and from Australian Indigenous knowledge) to conceptualise cancer clinicians' processes of care and therapeutic relationships with patients. Read More

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State of the art of F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation.

Clin Transl Imaging 2021 Jul 10:1-41. Epub 2021 Jul 10.

Regional Center of Nuclear Medicine, Department of Translational Research and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy.

Aim: The diagnosis, severity and extent of a sterile inflammation or a septic infection could be challenging since there is not one single test able to achieve an accurate diagnosis. The clinical use of 18F-fluorodeoxyglucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) imaging in the assessment of inflammation and infection is increasing worldwide. The purpose of this paper is to achieve an Italian consensus document on [F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases, such as osteomyelitis (OM), prosthetic joint infections (PJI), infective endocarditis (IE), prosthetic valve endocarditis (PVE), cardiac implantable electronic device infections (CIEDI), systemic and cardiac sarcoidosis (SS/CS), diabetic foot (DF), fungal infections (FI), tuberculosis (TBC), fever and inflammation of unknown origin (FUO/IUO), pediatric infections (PI), inflammatory bowel diseases (IBD), spine infections (SI), vascular graft infections (VGI), large vessel vasculitis (LVV), retroperitoneal fibrosis (RF) and COVID-19 infections. Read More

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Impact of COVID 19 on red flag discussions for haematological malignancies within the Belfast trust.

Ulster Med J 2021 May 8;90(2):77-80. Epub 2021 Jul 8.

Consultant Haematologist, Department of Haematology, Belfast City Hospital (UK).

Introduction: During the COVID-19 pandemic, there have been suggestions that there will be a reduction in cancer diagnoses, causing a detrimental effect on patients1. We therefore conducted an analysis to assess if there has been a reduction in new haematological malignancy diagnoses within the Belfast Health and Social Care Trust (BHSCT).

Methods: We observed a significant decline in diagnostic tests used in the diagnosis of haematological malignancies. Read More

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Surgical Management of Axilla Following Neoadjuvant Endocrine Therapy.

Ann Surg Oncol 2021 Jul 17. Epub 2021 Jul 17.

Division of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Randomized clinical trials support deescalation of axillary surgery in breast cancer patients with low-volume axillary disease treated with a surgery-first approach. However, few data exist to guide axillary surgery following neoadjuvant endocrine therapy (NET). Therefore, we evaluated the extent and outcomes of axillary surgery in a contemporary cohort of NET patients, a treatment approach that has become particularly relevant during the coronavirus disease-19 (COVID-19) pandemic. Read More

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Molecular insight on the formation structure and dynamics of melatonin in an aqueous solution and at the Water-Air interface: A molecular dynamics study.

J Mol Graph Model 2021 Jul 6;108:107983. Epub 2021 Jul 6.

School of Physics, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand; SUT Center of Excellence on Advanced Functional Nanomaterials, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand. Electronic address:

Melatonin is a natural hormone that has been shown highly antioxidant effects. Consequently, it has been extensively studied for its therapeutic potential in several diseases such as insomnia, cardiovascular, Alzheimer, and certain types of cancers. Recently, it has been used to adjuvant treatment for COVID-19 patients. Read More

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COVID-19 elicits an impaired antibody response against SARS-CoV-2 in patients with haematological malignancies.

Br J Haematol 2021 Jul 16. Epub 2021 Jul 16.

Università di Torino, Azienda Ospedaliera Città della Salute e della Scienza, Alessandria, Italy.

COVID-19 is associated with high mortality in patients with haematological malignancies (HM) and rate of seroconversion is unknown. The ITA-HEMA-COV project (NCT04352556) investigated patterns of seroconversion for SARS-CoV-2 IgG in patients with HMs. A total of 237 patients, SARS-CoV-2 PCR-positive with at least one SARS-CoV-2 IgG test performed during their care, entered the analysis. Read More

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Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors.

J Immunother Cancer 2021 07;9(7)

Renal and Skin Units, Royal Marsden NHS Foundation Trust, London, UK

The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer receiving systemic anticancer therapy have introduced a multitude of clinical challenges and academic controversies. This review summarizes the current evidence, discussion points, and recommendations regarding the use of immune checkpoint inhibitors (ICIs) in patients with cancer during the SARS-CoV-2 pandemic, with a focus on patients with melanoma and renal cell carcinoma (RCC). More specifically, we summarize the theoretical concepts and available objective data regarding the relationships between ICIs and the antiviral immune response, along with recommended clinical approaches to the management of melanoma and RCC patient cohorts receiving ICIs throughout the course of the COVID-19 pandemic. Read More

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Characteristics and outcomes of over 300,000 COVID-19 individuals with history of cancer in the United States and Spain.

Cancer Epidemiol Biomarkers Prev 2021 Jul 16. Epub 2021 Jul 16.

Tennessee Valley Healthcare System, Veterans Affairs Medical Center, Nashville, TN, USA.

Background: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and COVID-19. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.

Methods: We conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, standardized to the Observational Medical Outcome Partnership common data model. Read More

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Updates on Lobular Neoplasms, Papillary, Adenomyoepithelial, and Fibroepithelial Lesions of the Breast.

Arch Pathol Lab Med 2021 Jul 16. Epub 2021 Jul 16.

The Department of Pathology and Laboratory Medicine, Loyola University, Maywood, Illinois (Uraizee, Tang).

Context.—: This review article is a result of the breast pathology lectures given at the Sixth Chinese American Pathologists Association annual diagnostic pathology course in October 2020 (held virtually due to the coronavirus disease 2019).

Objective. Read More

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Homecare Encounters: An Organizational Response to Innovative Care for Patients Undergoing Hematopoietic Stem Cell Transplantation During COVID-19.

Clin J Oncol Nurs 2021 08;25(4):457-464

Duke University.

Background: Healthcare delivery has been significantly changed because of the COVID-19 pandemic. Patients undergoing hematopoietic stem cell transplantation (HSCT) are vulnerable to infections because of their immunocompromised status. The risk of nosocomial infection may be reduced by providing care to patients at home. Read More

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