3,619,099 results match your criteria cancers

NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

School of Stomatology, Wenzhou Medical University, Wenzhou 110013, China.

NudC domain containing 1 (NUDCD1) is an oncoprotein frequently activated or upregulated in various human cancers, but its role in pancreatic cancer (PC) remains unknown. Thus, we aimed to determine the function and mechanism of NUDCD1 in PC. We employed Western blot and quantitative real-time polymerase chain reaction to assess NUDCD1 expression in cells and PC tissues. Read More

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PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1.

Neoplasia 2021 Jul 26;23(9):912-928. Epub 2021 Jul 26.

Department of Pathophysiology, Zhengzhou University, Zhengzhou, China.

Protein Disulfide Isomerase Family A Member 6 (PDIA6) is an endoplasmic reticulum protein that is capable of catalyzing protein folding and disulfide bond formation. Abnormally elevated expression of PDIA6 has been reported to predict poor outcomes in various cancers. Herein, gain-of- and loss-of-function experiments were performed to investigate how PDIA6 participated in the carcinogenesis of pancreatic cancer (PC). Read More

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MSDS-UNet: A multi-scale deeply supervised 3D U-Net for automatic segmentation of lung tumor in CT.

Comput Med Imaging Graph 2021 Jul 24;92:101957. Epub 2021 Jul 24.

Amii, University of Alberta, Edmonton, Alberta, Canada.

Lung cancer is one of the most common and deadly malignant cancers. Accurate lung tumor segmentation from CT is therefore very important for correct diagnosis and treatment planning. The automated lung tumor segmentation is challenging due to the high variance in appearance and shape of the targeting tumors. Read More

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Reduction in healthcare services during the COVID-19 pandemic: Patient screening based on symptoms is an effective strategy for avoiding delayed laryngeal cancer diagnosis.

Am J Otolaryngol 2021 Jul 24;42(6):103162. Epub 2021 Jul 24.

Otolaryngology Unit, Azienda USL-IRCCS di Reggio Emilia, Italy.

Objective: Restriction in healthcare services during the COVID-19 pandemic caused delays in the diagnosis and treatment of several diseases. To overcome the risk of missed diagnosis of head and neck cancers, before deleting the scheduled appointments, we have introduced a selection of the patients by examining the clinical presenting issue and previous medical history. The aim of this study is to show the effects of the abovementioned strategy on the diagnosis and management of laryngeal cancer. Read More

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Salivary High-Risk Human Papillomavirus DNA as a Biomarker for Human Papillomavirus-Driven Head and Neck Cancers.

J Mol Diagn 2021 Jul 26. Epub 2021 Jul 26.

Saliva & Liquid Biopsy Translational Laboratory, School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Queensland, Australia; Translational Research Institute, Queensland, Australia. Electronic address:

High-risk human papillomavirus (HR-HPV) infection is one of the major risk factors for head and neck cancers (HNC). Despite the rising incidence, biomarkers for detection, prognostication and disease monitoring of HPV-driven HNC (HPV-HNC) are lacking. To evaluate the capacity of salivary HR-HPV DNA as a biomarker for HPV-HNC, salivary HR-HPV status of 491 primary HNC patients and 10 recurrent HNC patients was investigated at diagnosis using qPCR and MassARRAY. Read More

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Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing.

J Mol Diagn 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States. Electronic address:

Alterations in the BCOR gene, including internal tandem duplications (ITDs) of exon 15 have emerged as important oncogenic changes which define several diagnostic entities. In pediatric cancers, BCOR ITDs have recurrently been described in clear cell sarcoma of kidney (CCSK), primitive myxoid mesenchymal tumor of infancy (PMMTI) and CNS high-grade neuroepithelial tumor with BCOR ITD in exon 15 (HGNET-BCOR ITDex15). In adults, BCOR ITDs are also reported in endometrial and other sarcomas. Read More

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Identification of tissue of origin and guided therapeutic applications in cancers of unknown primary using deep learning and RNA sequencing (TransCUPtomics).

J Mol Diagn 2021 Jul 26. Epub 2021 Jul 26.

INSERM U830, Équipe Labellisée Ligue Nationale Contre le Cancer, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France; Department of Medical Oncology, Institut Curie Hospital, Paris, France. Electronic address:

Cancers of unknown primary (CUP) are metastatic cancers for which the primary tumor is not found despite thorough diagnostic investigations. Multiple molecular assays have been proposed to identify the tissue of origin (TOO) and inform clinical care, however none has been able to combine accuracy, interpretability and easy access for routine use. We developed a classifier tool based on the training of a variational autoencoder (VAE) to predict tissue of origin based on RNA-seq data. Read More

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Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

Biochim Biophys Acta Rev Cancer 2021 Jul 26:188596. Epub 2021 Jul 26.

UMR CNRS 7276, INSERM U1262, CRIBL, Université Limoges, Limoges, France. Electronic address:

Although CD95L (also known as FasL) is still predominantly considered as a death ligand that induces apoptosis in infected and transformed cells, substantial evidence indicate that it can also trigger non-apoptotic signaling pathways whose pathophysiological roles remain to be fully elucidated. The transmembrane ligand CD95L belongs to the tumor necrosis factor (TNF) superfamily. After cleavage by metalloprotease, its soluble form (s-CD95L) fails to trigger the apoptotic program but instead induces signaling pathways promoting the aggressiveness of certain inflammatory disorders such as autoimmune diseases and cancers. Read More

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Outcomes of cardiac diffuse large B-cell lymphoma (DLBCL) in the rituximab era.

Int J Cardiol 2021 Jul 26. Epub 2021 Jul 26.

Harrington Heart and Vascular Institute, University Hospitals, Cleveland, OH, United States of America; School of Medicine, Case Western Reserve University, Cleveland, OH, United States of America. Electronic address:

Background Cardiac diffuse large B-cell lymphoma (cDLBCL) are extremely rare. Introduction of rituximab has significantly improved survival in non-cardiac DLBCL, but there is limited data regarding outcomes of cDLBC. We sought to evaluate the outcomes of cDLBCL in both pre- and rituximab eras. Read More

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Clinical translation of immunomodulatory therapeutics.

Adv Drug Deliv Rev 2021 Jul 26:113896. Epub 2021 Jul 26.

Rice University, Department of Bioengineering, Houston TX. Electronic address:

Immunomodulatory therapeutics represent a unique class of drug products that have tremendous potential to allow for rebalance ing of a malfunctioning immune systems and are quickly becoming one of the fastest growing areas in the pharmaceutical industry. However, many challenges related to precision dosing, off-target effects, and manufacturing hurdles will need to be addressed before we see widespread adoption of these therapies in the clinic. For these drugs to become mainstream medicines, they must provide more therapeutic benefit than the currently used treatments without causing severe toxicities. Read More

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Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.

Eur J Pharmacol 2021 Jul 26:174370. Epub 2021 Jul 26.

Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, Fujian Province, China. Electronic address:

Colorectal cancer (CRC) is the most fatal gastrointestinal tumor and it is urge to explore powerful drugs for the treatment. Diosgenin (DSG) as a new steroidal had been reported exerts anti-tumor activity in multiple cancers, including CRC. However, the potential mechanism of DSG suppresses CRC remains further to be revealed. Read More

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1,3-Butadiene, styrene and selected outcomes among synthetic rubber polymer workers: Updated exposure-response analyses.

Chem Biol Interact 2021 Jul 26:109600. Epub 2021 Jul 26.

Department of Epidemiology, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, 35233, USA. Electronic address:

Objective: - To evaluate exposure-response relationships between 1,3-butadiene and styrene and selected diseases among synthetic rubber polymer workers.

Methods: - 21,087 workers (16,579 men; 4508 women) were followed from 1943 through 2009 to determine mortality outcomes. Cox regression models estimated rate ratios (RRs) and 95% confidence intervals (CIs) by quartile of cumulative exposure to butadiene or styrene and exposure-response trends for cancers of the bladder, lung, kidney, esophagus and pancreas, and for all nonmalignant respiratory disease (NMRD), chronic obstructive pulmonary disease (COPD) and pneumonia. Read More

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Dramatic response to alectinib in a patient with ALK-rearranged squamous cell lung cancer.

Thorac Cancer 2021 Jul 29. Epub 2021 Jul 29.

Division of Respiratory Medicine, Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.

Lung cancers with anaplastic lymphoma kinase (ALK) rearrangements are highly sensitive to treatment with ALK tyrosine kinase inhibitors (TKIs). Due to the very low rate of patients with squamous cell carcinoma enrolled in clinical trials, the efficacy of ALK inhibitors in patients with ALK-rearranged squamous cell carcinoma in the lung remains unclear. Herein, we present the case of a 70-year-old female patient with squamous cell lung cancer harboring the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene. Read More

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The safety and efficacy of cold vs. hot snare polypectomy including colorectal polyps ≥1 cm in size.

Dig Endosc 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Cold snare polypectomy (CSP; polypectomy without electrocautery) has rapidly spread worldwide during the past decade in what has been called a Cold Revolution. We performed a PubMed literature search for studies investigating CSP outcomes for colorectal polyps. Five randomized controlled trials (RCTs) assessed the complete resection rates (CRRs). Read More

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Cancer patterns in nasopharyngeal carcinoma multiplex families over 15 years.

Cancer 2021 Jul 29. Epub 2021 Jul 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Background: Genetic and environmental factors are important determinants of nasopharyngeal carcinoma (NPC). NPC is associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC, but evidence has been mixed for elevated rates of cancers other than NPC. Read More

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Short- and longer-term cancer risks with biologic and targeted synthetic disease modifying antirheumatic drugs as used against rheumatoid arthritis in clinical practice.

Rheumatology (Oxford) 2021 Jul 29. Epub 2021 Jul 29.

Dept of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Objective: To estimate the occurrence and relative risks of first ever incident non-cutaneous cancer overall and by 16 sites in patients with RA treated with biologic and targeted synthetic DMARDs (b/tsDMARDs), by time since treatment start, attained age, and time on active treatment.

Methods: Observational nationwide and population-based cohort study of patients with RA(n = 69 308), treated with TNF inhibitors (TNFi; adalimumab, certolizumab, etanercept, golimumab, infliximab) or other b/tsDMARDs (abatacept, rituximab, baricitinib, tofacitinib and tocilizumab) compared with RA patients not treated with b/tsDMARDs, and matched general population referents (n = 109 532), 2001-2018. Study based on prospectively collected data from the Swedish Rheumatology Quality Register and from other registers, linked to the national Cancer Register. Read More

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The 3'tsRNAs are aminoacylated: Implications for their biogenesis.

PLoS Genet 2021 Jul 29;17(7):e1009675. Epub 2021 Jul 29.

Department of Pediatrics, Stanford University, Stanford, California, United States of America.

Emerging evidence indicates that tRNA-derived small RNAs (tsRNAs) are involved in fine-tuning gene expression and become dysregulated in various cancers. We recently showed that the 22nt LeuCAG tsRNA from the 3´ end of tRNALeu is required for efficient translation of a ribosomal protein mRNA and ribosome biogenesis. Inactivation of this 3´tsRNA induced apoptosis in rapidly dividing cells and suppressed the growth of a patient-derived orthotopic hepatocellular carcinoma in mice. Read More

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Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.

PLoS Med 2021 Jul 29;18(7):e1003706. Epub 2021 Jul 29.

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), and height with cancer risk.

Methods And Findings: Single nucleotide polymorphisms (SNPs) were used as instrumental variables for BMI (312 SNPs), FMI (577 SNPs), FFMI (577 SNPs), and height (293 SNPs). Read More

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Wnt Family Member 9b (Wnt9b) Is a New Sensitive and Specific Marker for Breast Cancer.

Am J Surg Pathol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI.

Confirming the tumor origin is often a diagnostic challenge in pathology and carries significant therapeutic impacts. Cytokeratin 7, estrogen receptor, and GATA binding protein 3 (GATA3) are well-established diagnostic markers frequently used to support a tumor's breast origin. However, their specificities still have room to improve. Read More

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HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology.

Am J Surg Pathol 2021 Jul 29. Epub 2021 Jul 29.

Institute of Pathology, Comprehensive Cancer Center (CCC) Erlangen-EMN Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen DERMPATH Muenchen Institute of Pathology, Ludwig Maximilians University, Munich, Germany Department of Pathology, Charles University, Faculty of Medicine in Plzen Bioptic Laboratory Ltd, Plzen, Czech Republic Department of Pathology, University Hospital Montpellier, Montpellier, France.

Most of salivary gland neoplasms (benign and malignant) are characterized by recurrent gene fusions. Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal rearrangements involving PLAG1 mapped to 8q12 and HMGA2 mapped to 12q13-15 in most cases. Multiple fusion partners have been identified including CTNNB1, FGFR1, LIFR, CHCHD7 and TCEA for PLAG1 fusions and NFIB, WIF1 and FHIT for HMGA2 fusions. Read More

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Brain tumor classification using fine-tuned GoogLeNet features and machine learning algorithms: IoMT enabled CAD system.

IEEE J Biomed Health Inform 2021 Jul 29;PP. Epub 2021 Jul 29.

In the healthcare research community, Internet of Medical Things (IoMT) is transforming the healthcare system into the world of the future internet. In IoMT enabled Computer aided diagnosis (CAD) system, the Health-related information is stored via the internet, and supportive data is provided to the patients. The development of various smart devices is interconnected via the internet, which helps the patient to communicate with a medical expert using IoMT based remote healthcare system for various life threatening diseases, e. Read More

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Role of multiparametric MRI in long-term surveillance following focal laser ablation of prostate cancer.

Br J Radiol 2021 Jul 29:20210414. Epub 2021 Jul 29.

Joint Department of Medical Imaging, University of Toronto, University Health Network - Mount Sinai Hospital - Women's College Hospital, Toronto, ON, Canada.

Objective: Determine the multiparametric magnetic resonance imaging (mpMRI) appearance of the prostate following focal laser ablation (FLA) for PCa and to identify imaging characteristics associated with recurrent disease.

Methods: Retrospective analysis of patients who underwent FLA for low-intermediate risk PCa between 2010 and 2014 was performed. Early (median 4 months) and late mpMRI (median 49 months) follow-up were qualitatively assessed for -weighted, dynamic contrast enhanced (DCE) and diffusion weighted imaging (DWI) appearances and also compared to corresponding PSA values and biopsy results. Read More

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Identification of Thieno[3,2-]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.

J Med Chem 2021 Jul 29. Epub 2021 Jul 29.

Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-]pyrimidine derivatives. An intensive structure-activity relationship (SAR) study led to the identification of as a lead. Read More

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Conformational Features of Ras: Key Hydrogen-Bonding Interactions of Gln61 in the Intermediate State during GTP Hydrolysis.

J Phys Chem B 2021 Jul 29. Epub 2021 Jul 29.

Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Key Laboratory of Computational Physical Sciences, Departments of Chemistry, Fudan University, Shanghai 200433, China.

The Ras protein is one of the most important drug targets for battling cancers. To effectively design novel drugs of Ras, we characterize here its conformational ensembles for the hydrolysis intermediate state RasGDP·Pi and the product state RasGDP by extensive replica-exchange molecular dynamics simulations. Several substates for RasGDP·Pi have been identified, while structural analyses have revealed an unrecognized hydrogen-bonding network that stabilizes the hydrolysis intermediate state. Read More

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The Synergistic Anticancer Traits of Graphene Oxide Plus Doxorubicin Against BT474 and MCF7 Breast Cancer Stem Cells In Vitro.

Appl Biochem Biotechnol 2021 Jul 29. Epub 2021 Jul 29.

Department of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Breast cancer is among the leading causes of death due to cancers around the globe. Current therapeutic approaches towards healing of breast cancer have been associated with poor outcomes. Graphene and its derivatives have a two-dimensional flat structure, which is characterized by the ability to carry drugs and modify the surface, low cytotoxicity, and high biocompatibility. Read More

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FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells.

Hum Cell 2021 Jul 29. Epub 2021 Jul 29.

Department of General Surgery, Hanchuan People's Hospital, Hanchuan, 431600, Hubei Province, China.

Long noncoding RNA (lncRNA) FOXC2-AS1 has been reported to act as an oncogene in multiple human cancers. However, the clinical significance, functional role and underlying mechanism of FOXC2-AS1 in gastric cancer (GC) remains largely unknown. Here, we found that FOXC2-AS1 expression was significantly elevated in GC tissues and cells, and overexpression of FOXC2-AS1 indicated advanced TNM stage and shorter overall survival in GC patients. Read More

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MicroRNAs as biomarkers and perspectives in the therapy of pancreatic cancer.

Mol Cell Biochem 2021 Jul 29. Epub 2021 Jul 29.

Department of Laboratory Medicine, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang People's Hospital), Kangning Middle Road, Shifeng Street, Tiantai County, Taizhou, 317200, Zhejiang Province, People's Republic of China.

Pancreatic cancer is considered as one of the most aggressive tumor types, representing over 45,750 mortality cases annually in the USA solely. The aggressive nature and late identification of pancreatic cancer, combined with the restrictions of existing chemotherapeutics, present the mandatory need for the advancement of novel treatment systems. Ongoing reports have shown an important role of microRNAs (miRNAs) in the initiation, migration, and metastasis of malignancies. Read More

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[Idiopathic orbital inflammation].

Wolfgang E Lieb

Ophthalmologe 2021 Jul 29. Epub 2021 Jul 29.

ViDia Christliche Kliniken Karlsruhe, St. Vincentius-Kliniken, Steinhäuserstr. 18, 76135, Karlsruhe, Deutschland.

Background: Orbital inflammatory disease encompasses a spectrum of disorders. Idiopathic orbital inflammation (IOI) is often a diagnosis of exclusion, which needs to be differentiated from infections, systemic inflammatory disease, and neoplasms. IOI includes anterior inflammation with dacryoadenitis, myositis, perineuritis of the optic nerve, periscleritis, diffuse sclerosing inflammation, and orbital apex inflammation. Read More

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Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma.

Histochem Cell Biol 2021 Jul 29. Epub 2021 Jul 29.

Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.

Although the expression of the putative cannabinoid receptor GPR55 has been shown to be involved in the growth of various tumours and is increased in a number of cancers, its expression has not been examined in patients with endometrial cancer (EC). Quantitative RT-PCR (for mRNA levels) and immunohistochemistry (for protein levels) were used to measure GPR55 expression in patients with Type 1 and Type 2 EC and correlated against cannabinoid receptor (CB1 and CB2) protein levels using non-cancerous endometrium as the control tissue. The data indicated that GPR55 transcript and GPR55 protein levels were significantly (p < 0. Read More

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