Am J Surg Pathol 2021 Jul 29. Epub 2021 Jul 29.
Institute of Pathology, Comprehensive Cancer Center (CCC) Erlangen-EMN Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen DERMPATH Muenchen Institute of Pathology, Ludwig Maximilians University, Munich, Germany Department of Pathology, Charles University, Faculty of Medicine in Plzen Bioptic Laboratory Ltd, Plzen, Czech Republic Department of Pathology, University Hospital Montpellier, Montpellier, France.
Most of salivary gland neoplasms (benign and malignant) are characterized by recurrent gene fusions. Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal rearrangements involving PLAG1 mapped to 8q12 and HMGA2 mapped to 12q13-15 in most cases. Multiple fusion partners have been identified including CTNNB1, FGFR1, LIFR, CHCHD7 and TCEA for PLAG1 fusions and NFIB, WIF1 and FHIT for HMGA2 fusions. Read More