Appl Immunohistochem Mol Morphol 2021 May 12. Epub 2021 May 12.
Department of Periodontology, School of dentistry, Shahid Beheshti University of Medical Sciences Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex Department of Pathology, Amir Alam Hospital, Tehran University of Medical Sciences Department of Oral and Maxillofacial Pathology, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
Objectives: Cancer stem cells are a small group of highly tumorigenic cells with the trend of self-renewal, tumor progression, metastasis, recurrence, and therapeutic resistance. SOX2 is an important cancer stem cell marker that is involved in tumorigenesis and correlated with aggressive features in various types of malignancies. The present study was aimed to investigate the expression of this biomarker in neoplastic tissues of oral squamous cell carcinoma (OSCC) to determine whether it has the potential to predict the outcomes and survival of the affected patients. Read More