588,850 results match your criteria cancer risks


Factors Correlated With Fear of Cancer Recurrence in Cancer Survivors: A Meta-analysis.

Cancer Nurs 2021 Sep 23. Epub 2021 Sep 23.

Author Affiliations: School of Nursing, China Medical University (Drs Zhang and Li); School of Nursing, Liaoning University of Traditional Chinese Medicine (Dr Sun); and Department of Gynecology, Cancer Hospital of China Medical University (Dr Qin), Shenyang; School of Nursing, Norman Bethune Health Science Center of Jilin University (Ms Liu), Changchun; and Department of Neurosurgery, The First Hospital of China Medical University Shenyang (Dr Jiang).

Background: Fear of cancer recurrence (FCR) is one of the most common and aversive psychological phenomena among cancer survivors. Understanding the independent and potentially modifiable risk factors that contribute toward FCR seen in cancer survivors would inform future interventional trials aimed at reducing this risk.

Objective: The aim of this study was to provide an evidence synthesis of factors correlated with FCR to inform the development of preventive interventions. Read More

View Article and Full-Text PDF
September 2021

Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study.

J Neurosurg 2021 Sep 24:1-7. Epub 2021 Sep 24.

17Department of Radiation Oncology, University of Southern California, Los Angeles, California.

Objective: Resection of meningiomas in direct contact with the anterior optic apparatus carries risk of injury to the visual pathway. Stereotactic radiosurgery (SRS) offers a minimally invasive alternative. However, its use is limited owing to the risk of radiation-induced optic neuropathy. Read More

View Article and Full-Text PDF
September 2021

Laryngeal disorders in people living with HIV.

Am J Otolaryngol 2021 Sep 20;43(1):103234. Epub 2021 Sep 20.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States of America.

Objectives: Several studies have shown that HIV infected individuals are at higher risk compared to the general population of developing non-AIDS defining conditions such as some types of cancer, kidney disease, liver disease and others. In this case-control study, we compared the incidence of laryngeal disorders between a treatment-seeking HIV-positive population and uninfected controls. We aimed to investigate whether there are any laryngeal disorders that are overrepresented in HIV-positive individuals. Read More

View Article and Full-Text PDF
September 2021

Osteosarcoma of the maxilla presenting as a chronic pyogenic abscess: A case report.

Int J Surg Case Rep 2021 Sep 20;87:106425. Epub 2021 Sep 20.

Solid Tumour Oncology, Barts NHS Trust London, UK.

Introduction: Osteosarcoma of the maxilla is recorded as the least common of all bone malignancies. It exhibits a clinical behavior and natural history distinct from their counterparts of the trunk and extremities. Transformation from a chronic pyogenic abscess of the maxilla is even more unusual. Read More

View Article and Full-Text PDF
September 2021

Cancer driver gene and non-coding RNA alterations as biomarkers of brain metastasis in lung cancer: A review of the literature.

Biomed Pharmacother 2021 Sep 21;143:112190. Epub 2021 Sep 21.

Zimagene Medical Genetics Laboratory, Avicenna St., Hamedan, Iran. Electronic address:

Brain metastasis (BM) is the most common event in patients with lung cancer. Despite multimodal treatments and advances in systemic therapies, development of BM remains one of the main factors associated with poor prognosis and mortality in patients with lung cancer. Therefore, better understanding of mechanisms involved in lung cancer brain metastasis (LCBM) is of great importance to suppress cancer cells and to improve the overall survival of patients. Read More

View Article and Full-Text PDF
September 2021

Gestational diabetes mellitus - A metabolic and reproductive disorder.

Biomed Pharmacother 2021 Sep 21;143:112183. Epub 2021 Sep 21.

Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, Vellore 632 014, Tamil Nadu, India. Electronic address:

Maternal health associated with Gestational Diabetes Mellitus (GDM) has been gaining significant research attention due to its severe risk and adverse health effects. GDM is the leading health disease in pregnant women. It is the most common metabolic disease and it can affect up to 25% of women during pregnancy. Read More

View Article and Full-Text PDF
September 2021

A prospective cohort evaluation of the sensitivity and specificity of the chest X-ray for the detection of lung cancer in symptomatic adults.

Eur J Radiol 2021 Sep 20;144:109953. Epub 2021 Sep 20.

Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: The accuracy of the chest x-ray (CXR) in the identification of lung cancer amongst symptomatic individuals is uncertain.

Purpose: To determine the diagnostic accuracy of the CXR for the detection of non-small cell carcinomas (NSCLC) and all primary intrathoracic malignancies.

Methods: A prospective cohort study of consecutive CXR reports obtained within a primary care open access initiative. Read More

View Article and Full-Text PDF
September 2021

14-3-3ζ promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.

Pathol Res Pract 2021 Sep 22;227:153619. Epub 2021 Sep 22.

Department of Pathology, The First People's Hospital of Zigong, shang yi hao yi zhi lu 42#, Zigong 643099, Sichuan Province, China.

Background: HER2 was a recognized oncogene that promoted the development and metastasis of breast cancer, but its positive expression rate in invasive ductal carcinoma (IDC) was much lower than that in ductal carcinoma in situ (DCIS). The correlation between the occurrence and development of breast cancer and the amplification and overexpression of HER2 gene alone was still controversial. 14-3-3ζ had a strong protein binding ability and a variety of functions, mainly through the interaction with other proteins to exert its unique biological activities. Read More

View Article and Full-Text PDF
September 2021

The effect of silica exposure on the risk of lung cancer: A dose-response meta-analysis.

Cancer Epidemiol 2021 Sep 22;75:102024. Epub 2021 Sep 22.

Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran; Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Background: The relationship between silica and the risk of developing lung cancer has been established in previous literature, but how much the level of exposure to silica can increase the risk of lung cancer is a question that has been addressed in this review.

Methods: Three electronic databases, including MEDLINE, Scopus, and Web of Science were searched for relevant literature. For the dose-response relationship between exposure to silica and developing lung cancer, we performed a meta-analysis using the random-effects model. Read More

View Article and Full-Text PDF
September 2021

Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde.

Environ Int 2021 Sep 21;158:106871. Epub 2021 Sep 21.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA.

Epigenetic aging biomarkers are associated with increased morbidity and mortality. We evaluated if occupational exposure to three established chemical carcinogens is associated with acceleration of epigenetic aging. We studied workers in China occupationally exposed to benzene, trichloroethylene (TCE) or formaldehyde by measuring personal air exposures prior to blood collection. Read More

View Article and Full-Text PDF
September 2021

Hazard identification and risk assessment of the organic, inorganic and microbial contaminants in the surface water after the high magnitude of flood event.

Environ Int 2021 Sep 21;157:106851. Epub 2021 Sep 21.

River Engineering and Urban Drainage Research Centre (REDAC), Universiti Sains Malaysia (USM), Engineering Campus, Seri Ampangan, 14300 Nibong Tebal, Penang, Malaysia. Electronic address:

The present work has been oriented to the qualitative and quantitative assessments of the aftermath effects of 2014 flood tragedy on the organic, inorganic and microbial contaminants in the floodwater, with a particular emphasis on their relative health risks and microbial infectious hazards to the flood-affected population, using average daily dose, hazard quotient, hazard index (HI), cancer risk (CR) and quantitative microbial risk assessment. Statistical comparison of the organic and inorganic contents was performed using the paired t-tests, while the predominant socio-demographic profiles and health attributes of the respondents to flood-induced health risks (HI) were verified by the chi-square test and binary logistic regression analysis. Among all, Fe, Cu, Pb, Ni, Zn, Cr, Cd, chlorpyrifos, diazinon, polycyclic aromatic hydrocarbons, estriol, 17α-ethinylestradiol, estrone, β-estradiol and bisphenol A were detected at the study area after flooding. Read More

View Article and Full-Text PDF
September 2021

American Society of Transplantation and Cellular Therapy Series: #4 - Cytomegalovirus treatment and management of resistant or refractory infections after hematopoietic cell transplantation.

Transplant Cell Ther 2021 Sep 21. Epub 2021 Sep 21.

Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update its 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A new approach was employed with the goal of better serving clinical providers by publishing each standalone topic in the infectious diseases series as a concise format of frequently asked questions (FAQ), tables, and figures. Adult and pediatric infectious diseases and HCT content experts developed and answered FAQs. Read More

View Article and Full-Text PDF
September 2021

Dietary intakes of monounsaturated fatty acids and risk of mortality from all causes, cardiovascular disease and cancer: A systematic review and dose-response meta-analysis of prospective cohort studies.

Ageing Res Rev 2021 Sep 21:101467. Epub 2021 Sep 21.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Findings on the link between dietary intakes of monounsaturated fatty acids (MUFA) and risk of mortality are conflicting. This study aimed to summarize existing literature regarding the association between MUFA intake and risk of mortality from all causes, cardiovascular diseases (CVDs), and cancer.

Methods: PubMed, Scopus, and ISI Web of Science was systematically searched up to December 2020. Read More

View Article and Full-Text PDF
September 2021

Diffusion weighted imaging for evaluation of breast lesions: Comparison between high b-value single-shot and routine readout-segmented sequences at 3 T.

Magn Reson Imaging 2021 Sep 21. Epub 2021 Sep 21.

Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen, the Netherlands; Department of Radiology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066, CX, Amsterdam, the Netherlands.

Purpose: In this study, we compare readout-segmented echo-planar imaging (rs-EPI) Diffusion Weighted Imaging (DWI) to a work-in-progress single-shot EPI with modified Inversion Recovery Background Suppression (ss-EPI-mIRBS) sequence at 3 T using a b-value of 2000 s/mm on image quality, lesion visibility and evaluation time.

Method: From September 2017 to December 2018, 23 women (one case used for training) with known breast cancer were included in this study, after providing signed informed consent. Women were scanned with the conventional rs-EPI sequence and the work-in-progress ss-EPI-mIRBS during the same examination. Read More

View Article and Full-Text PDF
September 2021

Mechanistic insights into genetic susceptibility to prostate cancer.

Cancer Lett 2021 Sep 21. Epub 2021 Sep 21.

Fudan University Shanghai Cancer Center, Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, 200032, China. Electronic address:

Prostate cancer (PCa) is the second most common cancer in men and is a highly heritable disease that affects millions of individuals worldwide. Genome-wide association studies have to date discovered nearly 270 genetic loci harboring hundreds of single nucleotide polymorphisms (SNPs) that are associated with PCa susceptibility. In contrast, the functional characterization of the mechanisms underlying PCa risk association is still growing. Read More

View Article and Full-Text PDF
September 2021

Efficacy of hydrophilic resin-based sealant: A systematic review and meta-analysis.

J Dent 2021 Sep 21:103816. Epub 2021 Sep 21.

Restorative Dentistry, Department of Oral Rehabilitation, The Medical University of South Carolina, James B. Edwards College of Dental Medicine, 173 Ashley Avenue, Charleston, SC, 29425, USA. Electronic address:

Objectives: This meta-analysis review aims to answer two questions: 1) What is the effectiveness of hydrophilic resin-based sealant (RBS) in preventing/arresting pits and fissures caries in permanent teeth, and 2) What is the retention rate of a hydrophilic RBS as compared to alternative treatments.

Data: Randomized control trials investigating the efficacy of hydrophilic RBS compared to any other (placebo) treatment for permanent teeth. Outcomes were retention rate and caries prevention/arresting. Read More

View Article and Full-Text PDF
September 2021

An international Delphi consensus for pelvic Stereotactic Ablative Radiotherapy re-irradiation.

Radiother Oncol 2021 Sep 21. Epub 2021 Sep 21.

Leeds Teaching Hospitals NHS Trust, Beckett Street, Leeds, LS9 7TF, UK; University of Leeds, Leeds, LS2 9JT, UK. Electronic address:

Introduction: Stereotactic Ablative Radiotherapy (SABR) is increasingly used to treat metastatic oligorecurrence and locoregional recurrences but limited evidence/guidance exists in the setting of pelvic re-irradiation. An international Delphi study was performed to develop statements to guide practice regarding patient selection, pre-treatment investigations, treatment planning, delivery and cumulative organs at risk (OARs) constraints.

Materials And Methods: Forty-one radiation oncologists were invited to participate in three online surveys. Read More

View Article and Full-Text PDF
September 2021

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials.

Lancet Haematol 2021 Oct;8(10):e711-e722

Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

Background: CNS relapse of acute lymphocytic leukaemia is difficult to treat. Durable remissions of relapsed or refractory B-cell acute lymphocytic leukaemia have been observed following treatment with CD19-directed chimeric antigen receptor (CAR) T cells; however, most trials have excluded patients with active CNS disease. We aimed to assess the safety and activity of CAR T-cell therapy in patients with a history of CNS relapsed or refractory B-cell acute lymphocytic leukaemia. Read More

View Article and Full-Text PDF
October 2021

Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study.

Lancet Haematol 2021 Oct;8(10):e700-e710

Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Oncode Institute, Utrecht, Netherlands; Department of Pediatric Oncology and Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands.

Background: Patients with Down syndrome and acute lymphocytic leukaemia are at an increased risk of treatment-related mortality and relapse, which is influenced by unfavourable genetic aberrations (eg, IKZF1 deletion). We aimed to investigate the potential underlying effect of Down syndrome versus the effects of adverse cancer genetics on clinical outcome.

Method: Patients (aged 1-23 years) with Down syndrome and acute lymphocytic leukaemia and matched non-Down syndrome patients with acute lymphocytic leukaemia (matched controls) from eight trials (DCOG ALL10 and ALL11, ANZCHOG ALL8, AIEOP-BFM ALL2009, UKALL2003, NOPHO ALL2008, CoALL 07-03, and CoALL 08-09) done between 2002 and 2018 across various countries (the Netherlands, the UK, Australia, Denmark, Finland, Iceland, Norway, Sweden, and Germany) were included. Read More

View Article and Full-Text PDF
October 2021

Risk stratification for Down syndrome and acute lymphocytic leukaemia: one size does not fit all.

Authors:
Karen R Rabin

Lancet Haematol 2021 Oct;8(10):e673-e675

Baylor College of Medicine, Texas Children's Cancer Center, Houston, TX 77030, USA. Electronic address:

View Article and Full-Text PDF
October 2021

Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey.

Lancet Oncol 2021 Sep 15. Epub 2021 Sep 15.

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, ON, Canada; Departments of Oncology, Queen's University, Kingston, ON, Canada; Public Health Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

Background: The WHO Essential Medicines List (EML) identifies priority medicines that are most important to public health. Over time, the EML has included an increasing number of cancer medicines. We aimed to investigate whether the cancer medicines in the EML are aligned with the priority medicines of frontline oncologists worldwide, and the extent to which these medicines are accessible in routine clinical practice. Read More

View Article and Full-Text PDF
September 2021

A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.

Am J Hum Genet 2021 Sep 18. Epub 2021 Sep 18.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

Genome-wide association studies (GWASs) have discovered 20 risk loci in the human genome where germline variants associate with risk of pancreatic ductal adenocarcinoma (PDAC) in populations of European ancestry. Here, we fine-mapped one such locus on chr16q23.1 (rs72802365, p = 2. Read More

View Article and Full-Text PDF
September 2021

Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer.

Mol Carcinog 2021 Sep 24. Epub 2021 Sep 24.

Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Cancer and the immune system share an intimate relationship. Chronic inflammation increases the risk of cancer occurrence and can also drive inflammatory mediators into the tumor microenvironment enhancing tumor growth and survival. The p38 MAPK pathway is activated both acutely and chronically by stress, inflammatory chemokines, chronic inflammatory conditions, and cancer. Read More

View Article and Full-Text PDF
September 2021

Interreader agreement in evaluation of 68Ga-PSMA PET/CT at the time of initial staging: comparison of the three evaluation criteria in the pretreatment risk groups.

Nucl Med Commun 2021 Sep 23. Epub 2021 Sep 23.

Department of Nuclear Medicine, Dokuz Eylul University Faculty of Medicine, Izmir Department of Nuclear Medicine, Başakşehir Çam ve Sakura City Hospital, Istanbul Department of Urology, Dokuz Eylul University Faculty of Medicine Department of Pathology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Objective: The aim of this study was to assess the interreader agreement in evaluation 68Ga-prostate-specific membrane antigen (PSMA) PET/CT according to three current criteria European association of nuclear medicine, PROMISE with miTNM, and PSMA-RADS in newly diagnosed prostate cancer (PC) patients.

Methods: The images of 101 patients who had been diagnosed with PC and underwent 68Ga-PSMA PET/CT at the time of initial staging were evaluated according to the three interpretation criteria by two nuclear medicine specialists. Local tumor, pelvic lymph node metastasis and distant metastasis were evaluated separately. Read More

View Article and Full-Text PDF
September 2021

What Are the Long-term Surgical Outcomes of Compressive Endoprosthetic Osseointegration of the Femur with a Minimum 10-year Follow-up Period?

Clin Orthop Relat Res 2021 Sep 24. Epub 2021 Sep 24.

Department of Orthopedic Surgery, University of California, Davis, UC Davis Medical Center, Sacramento, CA, USA.

Background: Endoprosthetic reconstruction after oncologic resection of bone tumors requires stable fixation between the prosthesis and residual host bone. Compressive osseointegration has been developed as an alternative to traditional stemmed implants to address the challenges and complications of achieving this fixation. Sufficient time has now passed from the advent of compressive implants to allow for an assessment of the intermediate-term and long-term results of this form of fixation. Read More

View Article and Full-Text PDF
September 2021

Designing and development of epitope-based vaccines against .

Crit Rev Microbiol 2021 Sep 24:1-24. Epub 2021 Sep 24.

Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

infection is the principal cause of serious diseases (e.g. gastric cancer and peptic ulcers). Read More

View Article and Full-Text PDF
September 2021

Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer.

Sci Prog 2021 Jul-Sep;104(3):368504211039590

Department of Bioregulation and Pharmacological Medicine, 12775Fukushima Medical University, Japan.

The incidence of breast cancer increases annually, and it has become common within families of breast cancer patients. Interleukin-2 activates cytotoxic T lymphocytes, which are important for cancer immunity. To identify markers of increased familial breast cancer risk, soluble interleukin-2 receptor levels and immunologic factors were investigated in familial breast cancer and non-familial breast cancer patients. Read More

View Article and Full-Text PDF
September 2021

Imaging Features at the Periphery: Hemodynamics, Pathophysiology, and Effect on LI-RADS Categorization.

Radiographics 2021 Sep 24:210019. Epub 2021 Sep 24.

From the Department of Radiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 (N.C.); University of California San Diego Health, San Diego, Calif (C.B.S., K.J.F.); Montefiore Medical Center, Bronx, NY (V.C.); University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); University of Michigan Medical School, Ann Arbor, Mich (W.R.M.); Yale School of Medicine, New Haven, Conn (S.S.A.); Memorial Sloan Kettering Cancer Center, New York, NY (R.K.G.D.); Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Northwestern University, Chicago, Ill (A.A.B.); and University of Texas MD Anderson Cancer Center, Houston, Tex (K.M.E.).

Liver lesions have different enhancement patterns at dynamic contrast-enhanced imaging. The Liver Imaging Reporting and Data System (LI-RADS) applies the enhancement kinetic of liver observations in its algorithms for imaging-based diagnosis of hepatocellular carcinoma (HCC) in at-risk populations. Therefore, careful analysis of the spatial and temporal features of these enhancement patterns is necessary to increase the accuracy of liver mass characterization. Read More

View Article and Full-Text PDF
September 2021

Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.

Cancer Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Internal Medicine, University of Pittsburgh, PA, USA.

Introduction: Preoperative autophagy inhibition with hydroxychloroquine (HCQ) in combination with gemcitabine in pancreatic adenocarcinoma (PDAC) has been shown to be safe and effective in inducing a serum biomarker response and increase resection rates in a previous phase I/II clinical trial. We aimed to analyze the long-term outcomes of preoperative HCQ with gemcitabine for this cohort.

Methods: A review of patients enrolled between July 2010 and February 2013 in the completed phase I/II single arm (two doses of fixed-dose gemcitabine (1500 mg/m ) in combination with oral hydroxychloroquine administered for 31 consecutive days until the day of surgery for high-risk pancreatic cancer) was undertaken. Read More

View Article and Full-Text PDF
September 2021

Obesity and endocrine therapy resistance in breast cancer: Mechanistic insights and perspectives.

Obes Rev 2021 Sep 24:e13358. Epub 2021 Sep 24.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy.

The incidence of obesity, a recognized risk factor for various metabolic and chronic diseases, including numerous types of cancers, has risen dramatically over the recent decades worldwide. To date, convincing research in this area has painted a complex picture about the adverse impact of high body adiposity on breast cancer onset and progression. However, an emerging but overlooked issue of clinical significance is the limited efficacy of the conventional endocrine therapies with selective estrogen receptor modulators (SERMs) or degraders (SERDs) and aromatase inhibitors (AIs) in patients affected by breast cancer and obesity. Read More

View Article and Full-Text PDF
September 2021