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Efficacy and safety of heterologous booster vaccination with Ad26.COV2.S after BNT162b2 mRNA COVID-19 vaccine in haemato-oncological patients with no antibody response.

Br J Haematol 2021 Dec 6. Epub 2021 Dec 6.

Department of Internal Medicine II, Feldkirch Academic Teaching Hospital, Feldkirch, Austria.

Patients with haemato-oncological malignancies are one of the high-risk groups for a severe course in case of COVID-19 infections. Furthermore, vaccination results in significantly lower response rates in haematological malignancies and lower antibody levels in patients with solid cancer. We investigated efficacy and safety of a heterologous booster vaccination with Ad26. Read More

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December 2021

[Testicular Cancer Screening in Men Aged 16 Years and Older: IQWiG ThemenCheck Health Technology Assessment Report on Medical, Economic, Social, Ethical, Legal and Organisational Aspects].

Gesundheitswesen 2021 Dec 6. Epub 2021 Dec 6.

Dept. of Public Health, Health Services Research and Health Technology Assessment, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall i.T, Österreich.

Background: Testicular cancer occurs mainly in young men between 25 and 45 years and is the most common cancer at this age. Possible testicular cancer early detection measures, clinical palpation and scrotal ultrasound (CUS) or testicular self-examination (TSE) in asymptomatic men aged 16 years and older, could perhaps avoid deaths and aggressive late therapies. Therefore, we investigated whether these measures have an additional benefit compared to the current situation. Read More

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December 2021

Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.

Pathol Res Pract 2021 Nov 24;229:153705. Epub 2021 Nov 24.

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

The dynamic balance between ubiquitination and deubiquitination is a key mechanism that regulates protein degradation and maintains cell protein homeostasis. Ubiquitin-specific peptidase 13 (USP13), a deubiquitinase (DUB), regulates various physiological and pathological processes, including cancer. A previous study reported that high USP13 mRNA expression confers poor prognosis in gastric cancer (GC). Read More

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November 2021

Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells.

Biochem Biophys Res Commun 2021 Nov 27;587:126-130. Epub 2021 Nov 27.

School of Fundamental Sciences, Massey University, Palmerston North, 4442, New Zealand. Electronic address:

Plasma membrane tension is known to regulate many cell functions, such as motility and membrane trafficking. Membrane tether pulling is an effective method for measuring the apparent membrane tension of cells and exploring membrane-cytoskeleton interactions. In this article, the mechanical properties of HP1α-depleted MCF7 breast cancer cells are explored in comparison to controls, by pulling membrane tethers using optical tweezers. Read More

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November 2021

Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience.

Phys Med 2021 Dec 3;92:62-68. Epub 2021 Dec 3.

Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.

Aim: The primary aim of this study is to provide preliminary indications for safe constraints of rectum and bladder in patients re-irradiated with stereotactic body RT (SBRT).

Methods: Data from patients treated for prostate cancer (PCa) and intraprostatic relapse, from 1998 to 2016, were retrospectively collected. First RT course was delivered with 3D conformal RT techniques, SBRT or volumetric modulated arc therapy (VMAT). Read More

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December 2021

An automated radiosynthesis of [F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.

Appl Radiat Isot 2021 Nov 18;180:110032. Epub 2021 Nov 18.

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA; Emily Couric Clinical Cancer Center, University of Virginia, Charlottesville, VA, USA. Electronic address:

[F]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [F]DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology. Read More

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November 2021

Impact of demographic and perioperative risk factors on complication rates in skin-sparing/nipple-sparing mastectomy with implant-based reconstruction using titanized polypropylene mesh (TiLOOP® Bra).

Surg Oncol 2021 Nov 16;40:101675. Epub 2021 Nov 16.

Breast Cancer Center, St.- Franziskus Hospital Münster, Germany and Clinic for Gynecology and Obstetrics, Center of Breast Disease, University of Cologne, Cologne, Germany.

Background: Skin/nipple-sparing mastectomies (SSM/NSSM) have been reported to have acceptable complication rates and good aesthetic outcomes with high patient satisfaction. However, in this relatively young and rapidly expanding field of reconstructive plastic surgery, differences in perioperative management are noted between breast centers. Prospective studies of complication rates using a titanized polypropylene mesh (TiLOOP® Bra) are currently lacking. Read More

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November 2021

Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.

Eur J Med Chem 2021 Nov 27;228:114008. Epub 2021 Nov 27.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.

Ligustrazine is the principle bioactive alkaloid in the widely-used Chinese herb Chuan Xiong rhizome. Herein, a series of novel derivatives has been designed as human carbonic anhydrases inhibitors (hCAIs) starting from the natural product Ligustrazine inserted as a tail instead of the 4-fluorophenyl tail of SLC-0111, a front-runner selective hCA IX inhibitor currently in clinical trials as antitumor/antimetastatic agent. Other derivatives were designed via incorporation of different linkers, of amide and ester type, or incorporation of different zinc anchoring groups such as secondary sulfamoyl and carboxylic acid functionalities. Read More

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November 2021

Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells.

Eur J Med Chem 2021 Nov 29;228:114029. Epub 2021 Nov 29.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Xianlin Road 163, Nanjing, 210023, China; Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road 1, Nanjing, 210046, China. Electronic address:

Achieving selective release of chemical anticancer agents and improving therapeutic efficacy has always been a hot spot in the field of cancer research, yet how to achieve this remains a great challenge. In this work, we constructed a novel chemical anticancer agent (named MCLOP) by introducing naphthalimide into the skeleton of methylene blue (MB). Under the stimulation by cellular hypochlorous acid (HClO) and visible light, selective release of active naphthalimide can be achieved within breast cancer cell lines, the release process of which can be tracked visually using near-infrared fluorescence of MB (685 nm). Read More

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November 2021

Laparoscopic resection of a high grade serous ovarian cancer that recurred at the vaginal stump with extensive pelvic adhesions after complete surgical staging.

J Minim Invasive Gynecol 2021 Dec 3. Epub 2021 Dec 3.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China. Electronic address:

Objective: To show laparoscopic resection of a high grade serous ovarian cancer that recurred at the vaginal stump with extensive pelvic adhesions after complete surgical staging.

Design: Stepwise demonstration of the procedure with narrated video footage Setting: University hospital Interventions: We reported a case of a 62-year-old woman with a history of complete surgical staging of high grade serous ovarian cancer staged IIB, which consisted of hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymph node dissection, and omentectomy, about 18 months before this admission. She received six courses of carboplatin/paclitaxel combination therapy after complete surgical staging and achieved complete remission. Read More

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December 2021

Proton pump inhibitors interfere with the anti-tumor potency of RC48ADC.

Toxicol In Vitro 2021 Dec 3:105292. Epub 2021 Dec 3.

R & D Center, MabPlex International Co., Ltd, Yantai 264006, Shandong, China. Electronic address:

Antibody-drug conjugates (ADCs) are a promising modality for cancers, but the interaction between them and proton pump inhibitors (PPIs), the common adjuvant drugs for cancer treatment, has not been understood. Here, the interactions between PPIs and RC48ADC, a novel HER2-targeting ADC, were quantified in vitro. CCK-8 assay showed that RC48ADC displayed a significant inhibitory effect on the proliferation of SK-BR-3, NCI-N87 and SK-OV-3 cells with the IC values of 4. Read More

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December 2021

FC-BBR/IND-induced glucose oxidase nanodrugs for targeted combination therapy.

Int J Pharm 2021 Dec 3:121349. Epub 2021 Dec 3.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macao SAR, China.

Targeted therapy from cells to mitochondria can improve the bioavailability and therapeutic effects of drugs. Combination therapy by combining two or more therapeutic methods comes to be seen a hopeful strategy to overcome the emergence of resistance. Ferrocene (FC) derivatives of the sandwich structure can not only directly inhibit the proliferation of cancer cells but also catalyze the Fenton reaction to enhance chemodynamic therapy. Read More

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December 2021

Design and Synthesis of a Star-Like Polymeric Micelle Modified with AS1411 Aptamer for Targeted Delivery of Camptothecin for Cancer Therapy.

Int J Pharm 2021 Dec 3:121346. Epub 2021 Dec 3.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Improving of tumor targeting and decreasing side effects at normal cells of antitumor drugs are necessary to promote the cancer chemotherapy efficacy. Herein, we have synthesized a novel 21-arm star like diblock polymer of β-cyclodextrin-{poly(ε-caprolactone)-poly(2-aminoethylmethacrylate)} which decorated with nucleolin aptamer (AS1411). The diblock polymer was prepared by combined ROP with electron transfer atom transfer radical polymerization (ARGET ATRP) methods followed camptothecin (CPT) encapsulation with high entrapment efficiency (65%). Read More

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December 2021

Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.

Life Sci 2021 Dec 3:120192. Epub 2021 Dec 3.

Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Aims: The number of cancer survivors with cardiovascular disease is increasing. However, the effect of cancer on body fluid regulation remains to be clarified. In this study, we evaluated body osmolyte and water imbalance in rats with hepatocellular carcinoma. Read More

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December 2021

Pollution characteristics and risk assessment of air multi-pollutants from typical e-waste dismantling activities.

Environ Pollut 2021 Dec 3:118630. Epub 2021 Dec 3.

College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 101408, China; Yanshan Earth Critical Zone and Surface Fluxes Research Station, University of Chinese Academy of Sciences, Beijing, 101408, China.

This study investigated the characteristics of air multi-pollutants emitted during typical electronic waste (e-waste) dismantling processes and assessed their risks to the environment and human health. Concentrations of total volatile organic compounds (TVOCs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) in a typical e-waste dismantling workshop were 137 μg/m, 135 ng/m and 42 ng/m, respectively, which were lower than those without emission control measures. The partial removal of pollutants due to the emission control measures also decreased the ozone formation potential and non-cancer risk of volatile organic compounds (VOCs). Read More

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December 2021

Remote Clinical Consultations in Restorative Dentistry - A Survey.

J Dent 2021 Dec 3:103914. Epub 2021 Dec 3.

MPerio FDSRCS Consultant in Restorative Dentistry Addenbrookes, Cambridge University Hospitals.

Objectives: To assess the patient experience of Remote Clinical Consultations (RCCs) for head and neck cancer and cleft lip and palate patients undergoing specialist restorative dentistry treatment in the context of a secondary care service.

Methods: An online survey was designed; all ninety three patients were invited to participate in its completion following a video or telephone remote clinical consultation with one restorative consultant in * (Name of hospital removed) between August 2020 and April 2021. The video consultations were carried out via NHS England's Attend Anywhere platform. Read More

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December 2021

Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): updated outcomes from a randomised, multicentre, open-label, phase 3 study.

Lancet Oncol 2021 Dec 3. Epub 2021 Dec 3.

National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Background: Despite recent advances in therapeutic options, there remains an unmet need for treating patients with relapsed or refractory multiple myeloma, especially in those previously exposed or refractory to lenalidomide. This updated efficacy and safety analysis from the phase 3 CANDOR study compared carfilzomib, daratumumab, and dexamethasone (KdD) with carfilzomib and dexamethasone (Kd) in patients with relapsed or refractory multiple myeloma.

Methods: In this updated analysis of the randomised, multicentre, open-label, phase 3 CANDOR study, patients (aged ≥18 years) with relapsed or refractory multiple myeloma, at least a partial response to between one and three previous therapies, and Eastern Cooperative Oncology Group performance status of 0-2, were recruited from 102 medical centres globally and randomly assigned (2:1) by interactive voice or web response software to receive KdD or Kd. Read More

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December 2021

VID22 counteracts G-quadruplex-induced genome instability.

Nucleic Acids Res 2021 Dec 6. Epub 2021 Dec 6.

Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.

Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer cells. To uncover new genes and cellular pathways affecting endogenous DNA damage and genome integrity, we exploited a Synthetic Genetic Array (SGA)-based screen in yeast. Among the positive genes, we identified VID22, reported to be involved in DNA double-strand break repair. Read More

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December 2021

Mortality among rough sleepers, squatters, residents of homeless shelters or hotels and sofa-surfers: a pooled analysis of UK birth cohorts.

Int J Epidemiol 2021 Dec 6. Epub 2021 Dec 6.

Department of Epidemiology and Public Health, University College London, London, UK.

Background: Homelessness encompasses a wide spectrum of experience. Rough sleepers and people attending homeless shelters have been found to be at an increased risk of mortality. It is unclear whether risks are also elevated in those squatting, living temporarily in low-cost hotels or 'sofa-surfing' with friends or family members. Read More

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December 2021

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells.

Nucleic Acids Res 2021 Dec 6. Epub 2021 Dec 6.

Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

Cockayne syndrome group B (CSB) protein has been implicated in the repair of a variety of DNA lesions that induce replication stress. However, little is known about its role at stalled replication forks. Here, we report that CSB is recruited to stalled forks in a manner dependent upon its T1031 phosphorylation by CDK. Read More

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December 2021

Patient-reported diagnostic intervals to colorectal cancer diagnosis in the Midland region of New Zealand: a prospective cohort study.

Fam Pract 2021 Dec 6. Epub 2021 Dec 6.

Medical Research Centre, University of Waikato, Hamilton, New Zealand.

Background And Objectives: New Zealand (NZ) has high rates of colorectal cancer (CRC) but low rates of early detection. The majority of CRC is diagnosed through general practice, where lengthy diagnostic intervals are common. We investigated factors contributing to diagnostic delay in a cohort of patients newly diagnosed with CRC. Read More

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December 2021

Superior vena cava graft infection in thoracic surgery: a retrospective study of the French EPITHOR database.

Interact Cardiovasc Thorac Surg 2021 Dec 6. Epub 2021 Dec 6.

Department of Thoracic and Endocrine Surgery, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France.

Objectives: To report our experience on the management of superior vena cava graft infection..

Methods: Between 2001 and 2018, patients with superior vena cava synthetic graft or patch reconstruction after resection of intrathoracic tumours or benign disease were selected retrospectively from the French EPITHOR database and participating thoracic centres. Read More

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December 2021

Long-term impacts of coal mine fire-emitted PM2.5 on hospitalisation: a longitudinal analysis of the Hazelwood Health Study.

Int J Epidemiol 2021 Dec 6. Epub 2021 Dec 6.

School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Background: Little is known about the long-term health impacts of exposures to landscape fire smoke. We aimed to evaluate the association between exposure to coal mine fire-related particulate matter 2.5 μm or less in diameter (PM2. Read More

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December 2021

Galaxy Is a Suitable Bioinformatics Platform for the Molecular Diagnosis of Human Genetic Disorders Using High-Throughput Sequencing Data Analysis. Five Years of Experience in a Clinical Laboratory.

Clin Chem 2021 Dec 6. Epub 2021 Dec 6.

Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, DMU15, AP-HP.Université Paris-Saclay, Hôpital Bicêtre, Le Kremlin Bicêtre, France.

Background: To date, the usage of Galaxy, an open-source bioinformatics platform, has been reported primarily in research. We report 5 years' experience (2015 to 2020) with Galaxy in our hospital, as part of the "Assistance Publique-Hôpitaux de Paris" (AP-HP), to demonstrate its suitability for high-throughput sequencing (HTS) data analysis in a clinical laboratory setting.

Methods: Our Galaxy instance has been running since July 2015 and is used daily to study inherited diseases, cancer, and microbiology. Read More

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December 2021

Reference Samples to Compare Next-Generation Sequencing Test Performance for Oncology Therapeutics and Diagnostics.

Am J Clin Pathol 2021 Dec 6. Epub 2021 Dec 6.

Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.

Objectives: Diversity of laboratory-developed tests (LDTs) using next-generation sequencing (NGS) raises concerns about their accuracy for selection of targeted therapies. A working group developed a pilot study of traceable reference samples to measure NGS LDT performance among a cohort of clinical laboratories.

Methods: Human cell lines were engineered via CRISPR/Cas9 and prepared as formalin-fixed, paraffin-embedded cell pellets ("wet" samples) to assess the entire NGS test cycle. Read More

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December 2021

Erlotinib combined with bevacizumab and chemotherapy in first line osimertinib-resistant NSCLC patient with leptomeningeal metastasis: A case report.

Medicine (Baltimore) 2021 Nov;100(44):e27727

Department of Oncology, Donge People's Hospital, Donge, China.

Rationale: Leptomeningeal metastasis (LM) is a fatal complication of advanced non-small cell lung cancer (NSCLC) with a poor prognosis. Osimertinib is a promising option for NSCLC with LM harboring epidermal growth factor receptor (EGFR) mutation. However, therapeutic approaches remain a challenge for osimertinib resistant NSCLCs with LM. Read More

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November 2021

Rebound of platelet count in a patient with type 2 calreticulin-mutant essential thrombocythemia in the postpartum period: A case report.

Medicine (Baltimore) 2021 Nov;100(44):e27725

National Center for Cancer Care and Research, Department of Oncology, Hematology and BMT Section, Hamad Medical Corporation, Doha, Qatar.

Introduction: Essential thrombocythemia (ET) is an uncommon myeloproliferative neoplasm. It is more common in females; 20% of them are below 40 years old. The optimal management of ET during pregnancy and postpartum periods is still not well established. Read More

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November 2021

Ruxolitinib (a JAK2 inhibitor) as an emerging therapy for refractory pruritis in a patient with low-risk polycythemia vera: A case report.

Medicine (Baltimore) 2021 Nov;100(44):e27722

Department of Oncology, Hematology and BMT Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

Introduction: Polycythemia vera (PV) is a Philadelphia-negative myeloproliferative neoplasm (MPN) characterized by the overproduction of red blood cells. The presence of JAK2 mutation is detected in up to 99% of patients with PV. Pruritis is commonly encountered in patients with PV and is considered the most troublesome symptom. Read More

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November 2021

Effects of Shenmai injection combined with platinum-containing first-line chemotherapy on quality of life, immune function and prognosis of patients with nonsmall cell lung cancer: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Nov;100(44):e27524

Qujing No. 1 Hospital, Qujing, Yunnan Province, China.

Background: Lung cancer is the leading cause of death among cancer patients worldwide. Close to 85% of lung cancer pathology types are nonsmall cell lung cancer (NSCLC). With advances in medicine, the survival rate of early-stage NSCLC has improved. Read More

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November 2021

Nurse-led exercise and cognitive-behavioral care against nurse-led usual care between and after chemotherapy cycles in Han Chinese women of ovarian cancer with moderate to severe levels of cancer-related fatigue: A retrospective analysis of the effectiveness.

Medicine (Baltimore) 2021 Nov;100(44):e27317

Department of Nursing, Shanghai Fourth People's Hospital, No. 1279 Sanmen Road, Hongkou District, Shanghai, China.

Abstract: Women with ovarian cancer are reported to fatigue over time. Moderate to severe levels of cancer-related fatigue is fluent in Han Chinese patients with cancer. Comprehensive Cancer Network guidelines are recommending exercise and cognitive behavioral therapy to reduce cancer-related fatigue. Read More

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November 2021