242,783 results match your criteria cancer presence


Disconnected pancreatic duct syndrome and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: A systematic review and meta-analysis.

Dig Endosc 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Disconnected pancreatic duct syndrome (DPDS) frequently occurs in patients with acute necrotizing pancreatitis and resultant pancreatic fluid collection (PFC). We performed a systematic review and meta-analysis to evaluate outcomes of endoscopic ultrasound-guided treatment of PFCs according to the presence of DPDS.

Methods: Using PubMed, Embase, and the Cochrane database, we identified clinical studies published until January 2021 with data comparing outcomes of endoscopic ultrasound-guided drainage of PFCs between DPDS and non-DPDS patients. Read More

View Article and Full-Text PDF
September 2021

Palindromic-assisted self-annealing transcription amplification for reliable genotyping of epidermal growth factor receptor exon mutations.

Biosens Bioelectron 2021 Sep 13;194:113633. Epub 2021 Sep 13.

Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing, 400044, PR China. Electronic address:

Reliable discrimination of specific epidermal growth factor receptor (EGFR) gene mutations plays a critical role in guiding lung cancer therapeutics. Until now, convenient and accurate recognition of the specific deletion of EGFR exons has remained particularly challenging. Herein, we propose a palindromic-assisted self-annealing transcription amplification (PASTA) strategy for the reliable detection of circulating EGFR exon mutations. Read More

View Article and Full-Text PDF
September 2021

Lesion-level heterogeneity of radiologic progression in patients treated with pembrolizumab.

Ann Oncol 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

Background: Disease progression is often considered a binary state reflecting presence or absence of response. However, meaningful heterogeneity between metastatic sites of a given patient may exist and may impact therapeutic outcomes. To characterize the heterogeneity of progression with immunotherapy, we evaluated lesion-level dynamics of pembrolizumab-treated patients across three tumor types. Read More

View Article and Full-Text PDF
September 2021

Prognostic value of cribriform size, percentage, and intraductal carcinoma in Gleason Score 7 prostate cancer with Cribriform Gleason Pattern 4.

Hum Pathol 2021 Sep 17. Epub 2021 Sep 17.

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. Electronic address:

Cribriform Gleason pattern 4 (CGP4) is an indicator of poor prognosis in Gleason Score 7 prostate cancer, however, the significance of the size and percentage of this pattern and the presence of concomitant intraductal carcinoma (IDC) in these patients is unclear. To study the significance of these parameters in radical prostatectomy specimens, 165 cases with CGP4 were identified and reviewed (2017 to 2019). The size and percentage cribriform pattern and presence of IDC were noted and correlated with adverse pathological features and biochemical recurrence (BCR) free survival. Read More

View Article and Full-Text PDF
September 2021

Androgen receptor transactivates KSHV noncoding RNA PAN to promote lytic replication-mediated oncogenesis: A mechanism of sex disparity in KS.

PLoS Pathog 2021 Sep 20;17(9):e1009947. Epub 2021 Sep 20.

Key Laboratory of Gastrointestinal Cancer (Ministry of Education), School of Basic Medical Sciences, Fujian Medical University, Fuzhou, P.R. China.

Kaposi's sarcoma-associated herpesvirus (KSHV) preferentially infects and causes Kaposi's sarcoma (KS) in male patients. However, the biological mechanisms are largely unknown. This study was novel in confirming the extensive nuclear distribution of the androgen receptor (AR) and its co-localization with viral oncoprotein of latency-associated nuclear antigen in KS lesions, indicating a transcription way of AR in KS pathogenesis. Read More

View Article and Full-Text PDF
September 2021

A Comparison of Two Molecular Methods for Detecting CALR Mutations in Myeloproliferative Neoplasms.

Clin Lab 2021 Sep;67(9)

Background: Myeloproliferative neoplasms (MPN) are hematopoietic disorders characterized by abnormal proliferation of the myeloid lineage. Three classic subtypes are polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). These disorders are well known for their association with the JAK2 V617F mutation, in addition to mutations in MPL exon 10, and JAK2 exon 12. Read More

View Article and Full-Text PDF
September 2021

Soluble B7-H3 in Ovarian Cancer and Its Predictive Value.

Bull Exp Biol Med 2021 Sep 20. Epub 2021 Sep 20.

N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.

The content of the soluble form of protein of the key point of immunity B7-H3 (sB7-H3) in the blood plasma of 75 patients with epithelial ovarian cancer before treatment was measured by ELISA. It is known that B7-H3 belongs to the immunoglobulin superfamily (B7 molecule family) and is involved in the regulation of the immune response mediated by T cells. The sB7-H3 concentration correlated with the clinical and morphological parameters of ovarian cancer. Read More

View Article and Full-Text PDF
September 2021

Toxicities Caused by Head and Neck Cancer Treatments and Their Influence on the Development of Malnutrition: Review of the Literature.

Eur J Investig Health Psychol Educ 2020 Oct 2;10(4):935-949. Epub 2020 Oct 2.

Faculty of Health, University of Canberra, Bruce, 2617 ACT, Australia.

Malnutrition poses a significant problem for oncology patients, resulting in fatalities within this population. Patients with head and neck cancer (HNC) are at high risk, with up to 90% developing malnutrition. Common treatments used for HNC can often lead to adverse side effects, including oral health conditions, gastrointestinal upsets, and several metabolic changes. Read More

View Article and Full-Text PDF
October 2020

Gaps in Public Awareness About BRCA and Genetic Testing in Prostate Cancer: Social Media Landscape Analysis.

JMIR Cancer 2021 Sep 20;7(3):e27063. Epub 2021 Sep 20.

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.

Background: Genetic testing, particularly for BRCA1/2, is increasingly important in prostate cancer (PCa) care, with impact on PCa management and hereditary cancer risk. However, the extent of public awareness and online discourse on social media is unknown, and presents opportunities to identify gaps and enhance population awareness and uptake of advances in PCa precision medicine.

Objective: The objective of this study was to characterize activity and engagement across multiple social media platforms (Twitter, Facebook, and YouTube) regarding BRCA and genetic testing for PCa compared with breast cancer, which has a long history of public awareness, advocacy, and prominent social media presence. Read More

View Article and Full-Text PDF
September 2021

Microenvironment-responsive DNA-conjugated albumin nanocarriers for targeted therapy.

J Mater Chem B 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

Drug delivery with accurate targeting and efficient treatment has become an essential strategy for cancer therapy. Two nanocarriers based on bovine serum albumin (BSA) and DNA were synthesized click chemistry and DNA hybridization reactions (DNA-BSA1 and DNA-BSA2). One of the hybridized oligonucleotides, Linker1, in DNA-BSA1 included a pH-sensitive i-motif sequence and a cancer cell-targeted guanine-quadruplex-structured AS1411 aptamer sequence, and the other, Linker2, in DNA-BSA2 had only the same pH-sensitive i-motif sequence. Read More

View Article and Full-Text PDF
September 2021

Incorporation of electroendocytosis and nanosecond pulsed electric field in electrochemotherapy of breast cancer cells.

Electromagn Biol Med 2021 Sep 20:1-10. Epub 2021 Sep 20.

Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdul-Aziz University, Alkharj, KSA.

The study aimed to evaluate the possibility to perform electrochemotherapy using nanosecond pulsed electric field (nsPEF) and low electric field (LEF) monopolar electrical impulses to alleviate the problems of conventional electroporation. Two types of pulses have been used to treat MCF-7 human breast carcinoma cell line: very low voltage (electric field strength) long trains of short unipolar electric pulses, and low frequencies of extremely intense (40kV/cm), ultra-short (10ns) electric pulses. The electropermeabilization efficiency of the formed endocytotic vesicles was measured using the cloning efficacy test. Read More

View Article and Full-Text PDF
September 2021

Symbols of Hope on Pediatric Oncology Ward: Children's Perspective Using Photovoice.

J Pediatr Oncol Nurs 2021 Sep 20:10434542211041934. Epub 2021 Sep 20.

School of Nursing, 70439University of British Colombia, Vancouver, BC, Canada V6T 2B5.

Hope nurtures confidence and enhances positivity. It is known to be a critical factor in illness, recovery and healing. This study aimed to identify the views of hospitalized children with cancer about the circumstances and factors that create hope for them in the oncology ward. Read More

View Article and Full-Text PDF
September 2021

Minimal Extrathyroidal Extension in Predicting 1-Year Outcomes: A Longitudinal Multicenter Study of Low-to-Intermediate-Risk Papillary Thyroid Carcinoma (ITCO#4).

Thyroid 2021 Sep 19. Epub 2021 Sep 19.

Istituto Nazionale Tumori IRCCS Fondazione Pascale, 18730, Struttura Complessa Chirurgia Oncologica della Tiroide, Napoli, Campania, Italy;

Background: The role of minimal extrathyroidal extension (mETE) as a risk factor for persistent papillary thyroid carcinoma (PTC) is still debated. The aim of this study was to assess the clinical impact of mETE as a predictor of worse initial treatment response in PTC patients and to verify the impact of radioiodine therapy after surgery in patients with mETE.

Methods: We reviewed all records in the Italian Thyroid Cancer Observatory (ITCO) database and selected 2237 consecutive patients with PTC who satisfied the inclusion criteria (PTC with no lymph node metastases and at least 1 year of follow-up). Read More

View Article and Full-Text PDF
September 2021

Fractional CO laser treatment as adjunctive therapy to topical steroids for managing vulvar lichen sclerosus.

Lasers Surg Med 2021 Sep 20. Epub 2021 Sep 20.

Lumina Med Spa, South Burlington, Vermont, USA.

Objectives: Uncontrolled vulvar lichen sclerosus (VLS) is often associated with distressful symptoms of genital itch, irritation, and pain and can lead to a pathological process including anatomical changes, scarring, and an elevated risk of cancer in the genital area. First-line topical corticosteroid as monotherapy is frequently not adequate to fully suppress disease activity and control symptoms. This study evaluated the efficacy of fractional CO laser treatments as adjunctive therapy where recalcitrant VLS had been improved, but not adequately controlled, with topical corticosteroid treatment. Read More

View Article and Full-Text PDF
September 2021

Prognostic factors and outcome of pineoblastoma: 10 years single-center experience.

J Egypt Natl Canc Inst 2021 Sep 20;33(1):26. Epub 2021 Sep 20.

Pediatric Oncology, National Cancer Institute (NCI), Cairo University and Children Cancer Hospital of Egypt (CCHE), Cairo, Egypt.

Background: The survival of pineoblastoma patients is low, particularly in infants and those with metastatic disease. This study aimed to analyze the prognostic factors affecting the outcome of Pineoblastoma in different age groups.

Methods: A retrospective study included 33 patients. Read More

View Article and Full-Text PDF
September 2021

Genomic stability at the coding regions of the multidrug transporter gene : insights into the development of alternative drug resistance mechanisms in human leukemia cells.

Cancer Drug Resist 2020 3;3:959-979. Epub 2020 Nov 3.

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Aim: Despite considerable efforts to reverse clinical multidrug resistance (MDR), targeting the predominant multidrug transporter ABCB1/P-glycoprotein (P-gp) using small molecule inhibitors has been unsuccessful, possibly due to the emergence of alternative drug resistance mechanisms. However, the non-specific P-gp inhibitor cyclosporine (CsA) showed significant clinical benefits in patients with acute myeloid leukemia (AML), which likely represents the only proof-of-principle clinical trial using several generations of MDR inhibitors. Nevertheless, the mutational mechanisms that may underlie unsuccessful MDR modulation by CsA are not elucidated because of the absence of CsA-relevant cellular models. Read More

View Article and Full-Text PDF
November 2020

Magnetostrictive alloys: Promising materials for biomedical applications.

Bioact Mater 2022 Feb 30;8:177-195. Epub 2021 Jun 30.

State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, China.

Magnetostrictive alloys have attracted increasing attention in biomedical applications because of the ability to generate reversible deformation in the presence of external magnetic fields. This review focuses on the advances in magnetostrictive alloys and their biomedical applications. The theories of magnetostriction are systematically summarized. Read More

View Article and Full-Text PDF
February 2022

The classical and updated models of androgen receptor nucleocytoplasmic trafficking.

Am J Clin Exp Urol 2021 25;9(4):287-291. Epub 2021 Aug 25.

Department of Urology, University of Pittsburgh School of Medicine Pittsburgh, PA 15232, USA.

This mini-review covers the classical model of androgen receptor (AR) nucleocytoplasmic trafficking and provides an overview of new data that updates the existing paradigm. The classical model of androgen receptor trafficking involves AR translocating to the nucleus in the presence of androgens and subsequently being exported back to the cytoplasm following the withdrawal of androgens. New data challenges and updates the fate of nuclear AR. Read More

View Article and Full-Text PDF

Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.

Am J Clin Exp Urol 2021 25;9(4):277-286. Epub 2021 Aug 25.

Department of Chemistry & Biochemistry and Institute of Molecular Biophysics, Florida State University Tallahassee, FL 32306, USA.

First established by Dr. Leland W. K. Read More

View Article and Full-Text PDF

Excess Body Weight and Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD).

Authors:
Elke Roeb

Visc Med 2021 Aug 13;37(4):273-280. Epub 2021 Apr 13.

Gastroenterology, Justus Liebig University and University Hospital Gießen, Gießen, Germany.

Background: Nonalcoholic fatty liver disease (NAFLD) describes a continuum of liver abnormalities from simple nonalcoholic fatty liver (NAFL) to nonalcoholic fatty liver hepatitis or steatohepatitis (NASH) to NASH fibrosis. It has a variable course, but just like alcoholic fatty liver disease, it can lead to liver cirrhosis and cancer (hepatocellular carcinoma).

Summary: NAFLD is a clinical entity characterized by the presence of liver steatosis, which affects at least 5% of hepatocytes. Read More

View Article and Full-Text PDF

Rat Hepatitis E Virus: Presence in Humans in South-Western France?

Front Med (Lausanne) 2021 3;8:726363. Epub 2021 Sep 3.

Virology Laboratory, National Reference Centre of Hepatitis E Viruses, Federal Institute of Biology, University Hospital, Toulouse, France.

Hepatitis E Virus (HEV) is one of the most common causes of hepatitis worldwide, and South-Western France is a high HEV seroprevalence area. While most cases of HEV infection are associated with the species Orthohepevirus-A, several studies have reported a few cases of HEV infections due to Orthohepevirus-C (HEV-C) that usually infects rats. Most of these human cases have occurred in immunocompromised patients. Read More

View Article and Full-Text PDF
September 2021

Prevalence and Risk Factors of Developing Fistula or Organ Perforation in Patients Treated with Lenvatinib for Radioiodine-Refractory Thyroid Cancer.

Eur Thyroid J 2021 Jul 23;10(5):399-407. Epub 2021 Mar 23.

Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy.

Introduction: Tyrosine kinase inhibitors represent a better treatment in patients with radioiodine-refractory differentiated thyroid cancer (RAI-R DTC). Lenvatinib is usually well-tolerated, but sometimes, it is associated with serious and even life-threatening side effects. The aim of this study was to evaluate the prevalence of and the potential risk factors for fistula and/or organ perforation in RAI-R DTC patients treated with lenvatinib. Read More

View Article and Full-Text PDF

Prognostic Factors for Overall Survival in Nasopharyngeal Cancer and Implication for TNM Staging by UICC: A Systematic Review of the Literature.

Front Oncol 2021 2;11:703995. Epub 2021 Sep 2.

Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

This study aims to identify prognostic factors in nasopharyngeal carcinoma (NPC) to improve the current 8th edition TNM classification. A systematic review of the literature reported between 2013 and 2019 in PubMed, Embase, and Scopus was conducted. Studies were included if (1) original clinical studies, (2) ≥50 NPC patients, and (3) analyses on the association between prognostic factors and overall survival. Read More

View Article and Full-Text PDF
September 2021

Analysing "tear-drop" prints of acute promyelocytic leukemia (APML): immunophenotypic prognostication of APML by FCM.

Am J Blood Res 2021 15;11(4):446-457. Epub 2021 Aug 15.

ICMR-National Institute of Pathology, Safdarjung Hospital Campus Ansari Nagar, New Delhi, India.

Introduction: Acute promyelocytic leukemia (APML), although genetically and morphologically distinct from other AML (acute myeloid leukemia) subtypes, is one of the most best responsive acute myeloid leukemia. -Conventional diagnostic methods and morphological hints often fail in the majority of the cases in the peripheral laboratories owing to resource constraints, unavailability of cytogenetic work-up, hypogranular variants, morphological mimicry by AML-monocytic and myelo-monocytic, etc. Flowcytometry (FCM), however, can be utilized as a feasible and reliable immunophenotypic diagnostic and prognostic tool for prompt identification of APML. Read More

View Article and Full-Text PDF

An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report.

Radiol Case Rep 2021 Nov 9;16(11):3494-3498. Epub 2021 Sep 9.

Department of Ophthalmology, The 964th Hospital of the Chinese People's Liberation Army, Changchun, China.

Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a risk factor for the development of adenocarcinoma. However, the presence of a component of sarcomatoid carcinoma in the malignant tumor has rarely been described in the literature. A 30-year-old Chinese woman was admitted to our hospital with vague abdominal pain and a poor appetite for 2 months. Read More

View Article and Full-Text PDF
November 2021

Insuline-Like Growth Factor-2 (IGF2) and Hepatocyte Growth Factor (HGF) Promote Lymphomagenesis in p53-null Mice in Tissue-specific and Estrogen-signaling Dependent Manners.

J Cancer 2021 21;12(20):6021-6030. Epub 2021 Aug 21.

Center for Prevention and Therapy of Gynecological Cancers, Department of Research, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan, ROC.

mice are prone to develop lymphomas at old ages. Factors promoting this tumorigenesis are unknown. Here, we showed human ovulatory follicular fluid (FF) largely promotes lymphomagenesis in mice at earlier ages. Read More

View Article and Full-Text PDF

Role of Toll-like receptors in natural killer cell function in acute lymphoblastic leukemia.

Oncol Lett 2021 Nov 24;22(5):748. Epub 2021 Aug 24.

Immunology and Proteomics Research Unit, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico.

Natural killer (NK) cells are specialized lymphocytes primarily involved in the response to infection and tumors. NK cells are characterized by the presence of specific surface molecules, as well as a wide repertoire of receptors that impart microenvironment-dependent effector functions. Among these receptors, Toll-like receptors (TLRs) can be activated to condition the NK response to either a cytotoxic or immunoregulatory phenotype. Read More

View Article and Full-Text PDF
November 2021

TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy.

Front Immunol 2021 3;12:716710. Epub 2021 Sep 3.

Cancer Institute, Xuzhou Medical University, Xuzhou, China.

To date, immune checkpoint inhibitors have been successively approved and widely used in clinical cancer treatments, however, the overall response rates are very low and almost all cancer patients eventually progressed to drug resistance, this is mainly due to the intricate tumor microenvironment and immune escape mechanisms of cancer cells. One of the main key mechanisms leading to the evasion of immune attack is the presence of the immunosuppressive microenvironment within tumors. Recently, several studies illustrated that triggering receptor expressed on myeloid cells-2 (TREM2), a transmembrane receptor of the immunoglobulin superfamily, was a crucial pathology-induced immune signaling hub, and it played a vital negative role in antitumor immunity, such as inhibiting the proliferation of T cells. Read More

View Article and Full-Text PDF
September 2021

Prognostic Gene Expression Signature in Patients With Distinct Glioma Grades.

Front Immunol 2021 1;12:685213. Epub 2021 Sep 1.

Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.

Background: Glioma is the most common type of primary brain tumor in adults. Patients with the most malignant form have an overall survival time of <16 months. Although considerable progress has been made in defining the adapted therapeutic strategies, measures to counteract tumor escape have not kept pace, due to the developed resistance of malignant glioma. Read More

View Article and Full-Text PDF
September 2021

Health Behavior and Associated Factors in Young Adult Cancer Patients.

Front Psychol 2021 1;12:697096. Epub 2021 Sep 1.

Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Leipzig, Germany.

Having cancer in young adulthood increases the risk of adverse long-term health effects. These risks can be influenced by one's health behavior (HB). The aim of this study is therefore to investigate the presence of health behavior in adolescents and young adults (AYAs) and to identify associated factors. Read More

View Article and Full-Text PDF
September 2021