1,457,097 results match your criteria cancer patients

RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression.

Biochem Biophys Res Commun 2021 Apr 14;557:135-142. Epub 2021 Apr 14.

Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an Jiangsu, 223300, China. Electronic address:

Gastric cancer (GC) is the most common cancer worldwide. Although advances in the treatments, the oncogenic mechanisms are still largely unknown. RNF168 (ring-finger nuclear factor 168) is an important regulator of DNA double-strand break (DSB) repair, and its defects have been involved in the pathogenesis of a number of human diseases including cancer. Read More

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Phyllodes tumors of the breast: Adjuvant radiation therapy revisited.

Breast 2021 Apr 7;58:1-5. Epub 2021 Apr 7.

Radiation Oncology Department, National Cancer Institute, Cairo University, Egypt.

Background: Phyllodes tumors (PT) are rare entity and surgical resection is the cornerstone of treatment. No standard of care exists regarding adjuvant treatment especially radiation therapy (RT).

Patients And Methods: We analyzed all patients with non-metastatic, resected phyllodes tumors who presented to our institution from January 2005 through December 2019. Read More

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Functional measurement of mitogen-activated protein kinase pathway activation predicts responsiveness of RAS-mutant cancers to MEK inhibitors.

Eur J Cancer 2021 Apr 14;149:184-192. Epub 2021 Apr 14.

Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA, USA. Electronic address:

Background: RAS variant-related functional impact on the mitogen-activated protein kinase (MAPK) pathway, and correlation between MAPK activation and MAPK/ERK kinase (MEK) inhibitor responsiveness, is not established.

Patients And Methods: Of 1,693 tumours sequenced, 576 harboured a RAS alteration; 62 patients received an MEK inhibitor (MEKi) and had RAS mutations that were functionally characterised. We report that RAS mutants have variable levels of MAPK activity, as measured by a functional cell-based assay that quantified MAPK pathway activation after transfection with a variety of RAS mutations. Read More

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Late-onset and long-lasting immune-related adverse events from immune checkpoint-inhibitors: An overlooked aspect in immunotherapy.

Eur J Cancer 2021 Apr 14;149:153-164. Epub 2021 Apr 14.

Department of Oncology, Lausanne University Hospital, Switzerland; Ludwig Institute for Cancer Research, Lausanne, Switzerland. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy but frequently cause immune-related adverse events (irAEs). Description of late-onset and duration of irAEs in the literature is often incomplete.

Methods: To investigate reporting and incidence of late-onset and long-lasting irAEs, we reviewed all registration trials leading to ICI's approval by the US FDA and/or EMA up to December 2019. Read More

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Combining immunotherapy with an epidrug in squamous cell carcinomas of different locations: rationale and design of the PEVO basket trial.

ESMO Open 2021 Apr 14;6(3):100106. Epub 2021 Apr 14.

Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France; Inserm U900 Research Unit, Saint Cloud, France; Paris-Saclay University, Paris, France. Electronic address:

Squamous cell carcinomas (SCCs) are among the most frequent solid tumors in humans. SCCs, related or not to the human papillomavirus, share common molecular features. Immunotherapies, and specifically immune checkpoint inhibitors, have been shown to improve overall survival in multiple cancer types, including SCCs. Read More

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Towards standardization of lymph-node ratio classifications: Validation and comparison of different lymph node ratio classifications for predicting prognosis of patients with resected gastric cancer.

Ann Diagn Pathol 2021 Mar 31;52:151738. Epub 2021 Mar 31.

Complutense University of Madrid, Av. Séneca 2, 28040 Madrid, Spain; Hospital General Universitario Gregorio Marañón, c/ Dr. Esquerdo n° 46, 28007 Madrid, Spain.

Introduction: The TNM staging system is the main prognostic tool for GC, but the number of metastatic lymph nodes (LN) can be affected by surgical, pathological, tumor or host factors. Several authors have shown that lymph node ratio (LNR) may be superior to TNM staging in GC. However, cut-off values vary between studies and LNR assessment is not standardized. Read More

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Characteristics of clinically node negative breast cancer patients needing preoperative MRI.

Surg Oncol 2021 Mar 31;38:101552. Epub 2021 Mar 31.

Department of Oncology, Turku University Hospital, Finland; University of Turku, Turku, Finland; Finnish Nuclear and Radiation Safety, Helsinki, Finland.

Background: International guidelines do not recommend magnetic resonance imaging (MRI) for all breast cancer patients at primary diagnostics. This study aimed to understand which patient or tumor characteristics are associated with the use of MRI. The role of MRI among other preoperative imaging methods in clinically node negative breast cancer was studied. Read More

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Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis.

Eur J Med Chem 2021 Apr 5;219:113430. Epub 2021 Apr 5.

China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology Tianjin University of Science and Technology, No.29 of 13 th Avenue, TEDA, Tianjin, 300457, PR China. Electronic address:

Metastasis is the main cause of death in cancer patients; therefore, new strategies or technologies that can inhibit the growth of primary tumors and their metastatic spread are extremely valuable. In this study, we selected an E-selectin-binding peptide as a targeting ligand and an inhibitor of metastasis, and conjugated this peptide with SN38 and PEG to produce an amphiphilic PEGylated peptide-drug conjugate (PDC). Novel self-assembled nanoparticles were then formed by the amphiphilic conjugate. Read More

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Improved outcome prediction of oropharyngeal cancer by combining clinical and MRI features in machine learning models.

Eur J Radiol 2021 Apr 8;139:109701. Epub 2021 Apr 8.

Department of Radiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Radiology, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Objectives: New markers are required to predict chemoradiation response in oropharyngeal squamous cell carcinoma (OPSCC) patients. This study evaluated the ability of magnetic resonance (MR) radiomics to predict locoregional control (LRC) and overall survival (OS) after chemoradiation and aimed to determine whether this has added value to traditional clinical outcome predictors.

Methods: 177 OPSCC patients were eligible for this study. Read More

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Bioengineered microfluidic blood-brain barrier models in oncology research.

Transl Oncol 2021 Apr 14;14(7):101087. Epub 2021 Apr 14.

Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713 Doha, Qatar. Electronic address:

Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the 'blood-brain barrier' (BBB). Moreover, changes in the structure and function of BBB can lead to the onset and progression of diseases including neurological disorders and brain-metastases. Read More

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The effect of warm salt water foot bath on the management of chemotherapy-induced fatigue.

Eur J Oncol Nurs 2021 Apr 3;52:101954. Epub 2021 Apr 3.

Istanbul University-Cerrahpasa Florence Nightingale Faculty of Nursing, Department of Internal Medical Nursing, Istanbul, Turkey. Electronic address:

Purpose: Several studies have shown that the warm water bath can be a beneficial approach in the management of fatigue. This experimental study was conducted to evaluate the effect of warm salt water foot bath in the management of chemotherapy-induced fatigue.

Methods: This randomized controlled trial was perfomed between November 2017-February 2018. Read More

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Safety of surgical fertility preservation procedures in children prior to Hematopoietic Stem Cell Transplant.

Transplant Cell Ther 2021 Apr 14. Epub 2021 Apr 14.

Division of Pediatric Oncology, Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA; Department of Pediatrics, Harvard University Medical School, Boston, MA.

Background: Long-term survival following hematopoietic stem cell transplant (HSCT) in childhood continues to improve and patients are thus increasingly faced with the late effects of treatment. Infertility is very common for both males and females following HSCT and is one of the most distressing sequelae. Adoption and surrogate egg or sperm donation are possibilities for some patients but post-HSCT reversal of gonadal failure is not possible. Read More

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High levels of Tim-3Foxp3Treg cells in the tumor microenvironment is a prognostic indicator of poor survival of diffuse large B cell lymphoma patients.

Int Immunopharmacol 2021 Apr 14;96:107662. Epub 2021 Apr 14.

Department of Geriatrics, Gastroenterology Ward, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China. Electronic address:

Foxp3Treg cells display phenotypic and functional heterogeneity, which express high levels of T cell immunoglobulin and mucin-domain containing-3 (Tim-3) in the tumor microenvironment (TME) of colorectal and lung cancer. High abundance of Tim-3Foxp3Treg (TFT) cells are associated with poor prognosis in these patients. However, the expression patterns and roles of TFT cells in TME of diffuse large B cell lymphoma (DLBCL) remain to be established. Read More

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Role of IGFBP-2 in oral cancer metastasis.

Biochim Biophys Acta Mol Basis Dis 2021 Apr 14:166143. Epub 2021 Apr 14.

Department of Medical Science, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:

Cancer metastasis is one of most main causes of failure in cancer treatment. Nonetheless, more than half of oral cancer patients were diagnosed as advanced oral cancer with dramatically decreased 5-year survival rate to lower than 20%, while the stages become more advanced. In order to improve oral cancer treatment, the identification of cancer metastatic biomarkers and mechanisms is critical. Read More

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Surgical outcomes of different approaches in robotic assisted thyroidectomy for thyroid cancer: A systematic review and Bayesian network meta-analysis.

Int J Surg 2021 Apr 14:105941. Epub 2021 Apr 14.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, PR China. Electronic address:

Background: The aim of the study was to assess the feasibility, safety, and potential benefits of four approaches of robotic assisted thyroidectomy (RT). The approaches mentioned above are also compared with traditional open thyroidectomy (OPEN).

Materials And Methods: Medline, Embase, Cochrane library (CENTRAL) and Web of Science databases were searched up to 13 Dec, 2019. Read More

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Transjugular intrahepatic portosystemic shunt creation for the prevention of gastric variceal rebleeding in patients with hepatocellular carcinoma: a multicenter retrospective study.

J Vasc Interv Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Purpose: To evaluate the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) creation for the prevention of gastric variceal rebleeding in patients with Hepatocellular carcinoma (HCC).

Materials And Methods: This multicenter retrospective study included 126 cirrhotic patients (mean age, 54.1 ± 10. Read More

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Increasing Readiness for Early Integrated Palliative Oncology Care: Development and Initial Evaluation of the EMPOWER 2 Intervention.

J Pain Symptom Manage 2021 Apr 14. Epub 2021 Apr 14.

Tulane University; University Medical Center New Orleans. Electronic address:

Context: Early integrated palliative care improves quality of life, but palliative care programs are underutilized. Psychoeducational interventions explaining palliative care may increase patients' readiness for palliative care.

Objectives: To (1) collaborate with stakeholders to develop the EMPOWER 2 intervention explaining palliative care, (2) examine acceptability, (3) evaluate feasibility and preliminary efficacy. Read More

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Modeling of Tumor Control Probability in Stereotactic Body Radiation Therapy for Adrenal Tumors.

Int J Radiat Oncol Biol Phys 2021 May;110(1):217-226

Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.

Purpose: Stereotactic body radiation therapy (SBRT) in the management of adrenal metastases is emerging as a well-tolerated, effective method of treatment for patients with limited metastatic disease. SBRT planning and treatment utilization are widely variable, and publications report heterogeneous radiation dose fractionation schemes and treatment outcomes. The objective of this analysis was to review the current literature on SBRT for adrenal metastases and to develop treatment guidelines and a model for tumor control probability of SBRT for adrenal metastases based on these publications. Read More

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Brain Metastases: An Update on Multi-disciplinary Approach of Clinical Management.

Neurochirurgie 2021 Apr 14. Epub 2021 Apr 14.

Department of Neurosurgery, University of Wisconsin School of Medicine & Public Health, UW Carbone Cancer Center, Madison, WI, USA. Electronic address:

Importance: Brain metastasis (BM) is the most common malignant intracranial neoplasm in adults with over 100,000 new cases annually in the United States and outnumbering primary brain tumors 10:1.

Observations:  The incidence of BM in adult cancer patients ranges from 10-40%, and is increasing with improved surveillance, effective systemic therapy, and an aging population. The overall prognosis of cancer patients is largely dependent on the presence or absence of brain metastasis, and therefore, a timely and accurate diagnosis is crucial for improving long-term outcomes, especially in the current era of significantly improved systemic therapy for many common cancers. Read More

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Surgical precision is pivotal and "Decisions are more important than incisions": Two decades of Pelican Cancer Face to Face Workshops.

Colorectal Dis 2021 Apr 17. Epub 2021 Apr 17.

Department Colorectal Surgery, Basingstoke Hospital, North Hampshire Hospitals Foundation Trust, Aldermaston Road Basingstoke, RG24 9NA, UK.

"Hands, Face, Space" has become the slogan of our times as the world grapples with the COVID 19 pandemic. While this strategy of washing hands, covering one's face and keeping at a distance from other humans may reduce infectious disease, some aspects of this strategy are the opposite of what best constitutes surgical care of patients with colorectal cancer. The strategy is also at odds with Pelican Cancer Foundation "Face to Face" educational activities over the past two decades. Read More

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Risk factors and characteristics associated with persistent smell loss in coronavirus disease 2019 (COVID-19) patients.

Int Forum Allergy Rhinol 2021 Apr 17. Epub 2021 Apr 17.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, San Diego, California, USA.

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Intravenous high-dose methotrexate based systemic therapy in the treatment of isolated primary vitreoretinal lymphoma: an LOC network study.

Am J Hematol 2021 Apr 17. Epub 2021 Apr 17.

Neurology, APHP, Sorbonne Université, Paris, France.

The treatment of primary vitreoretinal lymphoma (PVRL) remains controversial regarding the use of local, systemic, or combined treatments. The aim of this study was to analyze the efficacy and toxicity of intravenous high-dose methotrexate (IV HD-MTX) based systemic therapy in a uniformly treated population of PVRL patients. From a nationwide French database, we retrospectively selected 59 patients (median age: 70 years, median Karnofsky Performance Status: 90%) with isolated PVRL at diagnosis who received first-line treatment with HD-MTX between 2011-2018. Read More

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[Combination of tumors of different histogenesis in pediatric neurosurgery].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):80-90

Almazov National Medical Research Center, St. Petersburg, Russia.

Multiple gliomas are determined by synchronous two or more tumors located in different brain regions. It is important to distinguish multiple primary tumors and metastatic brain lesion. In the first case, tumor spread can`t be explained by dissemination along the cerebrospinal fluid pathways, commissural fibers or local metastases. Read More

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January 2021

[Influence of resection quality on postoperative outcomes in children with atypical teratoid-rhabdoid tumor of the central nervous system].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):17-25

Voino-Yasenetsky Research and Practical Center for Specialized Medical Care, Moscow, Russia.

The purpose of this study was to assess the influence of resection quality on overall survival and disease-free survival in children with atypical teratoid-rhabdoid tumors (ATRT). The study included children younger than 18 years old for the period from 2008 to 2019. There were 134 interventions in 105 patients with ATRT including 11 redo resections («second-look» surgery) and 18 procedures for tumor recurrence. Read More

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January 2021

Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Gastroenterology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610000, P.R. China.

In recent years, increasing evidence has confirmed that exosomal circular RNAs (circRNAs) serve a crucial role in the prognostic prediction and diagnosis of liver cancer (LC). The present study compared the expression patterns of exosomal circRNAs during transarterial chemoembolization (TACE). CircRNA sequencing analysis identified 390 differentially expressed circRNAs between the prior TACE and following the first TACE operation groups and 489 differentially expressed circRNAs between the prior to TACE and following the second TACE operation groups. Read More

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The deep inferior epigastric lymphatic cable flap connected to gastroepiploic lymph node flap for treatment of refractory chylous ascites: Report of two cases.

Microsurgery 2021 Apr 17. Epub 2021 Apr 17.

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.

Chylous ascites is the leakage of lipid-rich lymph into the peritoneal cavity usually due to disruption of lymphatics or increased peritoneal lymphatic pressure. Various surgical options have been proposed to treat chylous ascites but most have shown suboptimal outcomes. The gastroepiploic vascularized lymph node (GE-VLN) flap has been described previously for the treatment of lymphedema. Read More

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Surgical Margin Status and Survival Following Resection of Sinonasal Mucosal Melanoma.

Laryngoscope 2021 Apr 17. Epub 2021 Apr 17.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objectives: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer usually managed with surgical resection. This study evaluates the impact of treatment modality and positive surgical margin (PSM) on survival following resection of SNMM.

Study Design: Retrospective study of a national cancer registry. Read More

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Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1α axis.

A Liu J Xu

Clin Transl Oncol 2021 Apr 17. Epub 2021 Apr 17.

Department of Gastrointestinal Surgery, The First People's Hospital of Yueyang, Yueyang Avenue, Yueyang Tower District, Yueyang City, 414000, Hunan Province, China.

Objectives: Former studies found that circRNAs play an important part in the occurrence of a variety of malignant biological characteristics that are critical for cancer progression. It has been shown that circ_03955 is highly expressed and implicated with quantities of biological processes in solid tumor. However, whether circ_03955 regulates the tumorigenesis and Warburg effect of pancreatic cancer (PC) remains largely unknown. Read More

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Comparison between MGI and Illumina sequencing platforms for whole genome sequencing.

Genes Genomics 2021 Apr 17. Epub 2021 Apr 17.

Personalized Genomic Medicine Research Center, KRIBB, 34141, Daejeon, South Korea.

Background: Illumina next generation sequencing (NGS) systems are the major sequencing platform in worldwide next-generation sequencing market. On the other hand, MGI Tech launched a series of new NGS equipment that promises to deliver high-quality sequencing data faster and at lower prices than Illumina's sequencing instruments.

Objective: In this study, we compared the performance of the two platform's major sequencing instruments-Illumina's NovaSeq 6000 and MGI's MGISEQ-2000 and DNBSEQ-T7-to test whether the MGISEQ-2000 and DNBSEQ-T7 sequencing instruments are also suitable for whole genome sequencing. Read More

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