Ann Surg 2021 Jul 26. Epub 2021 Jul 26.
Department of Surgery, Trinity St. James's Cancer Institute, Dublin, Ireland Division of Thoracic and Upper Gastrointestinal Surgery, Montreal General Hospital - McGill University Health Centre, Montreal, Quebec, Canada Northern Oesophago-Gastric Unit, Royal Victoria Infirmary, and School of Medical Education, Newcastle upon Tyne, UK.
Background And Aims: The FLOT4-AIO trial established the FLOT regimen (Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel) as a compelling option for gastric, junctional and esophageal adenocarcinoma. Data on FLOT with en-bloc transthoracic esophagectomy (TTE) are limited. This study explored operative complications, tolerance, toxicity, physiological impact, and oncologic outcomes. Read More