109 results match your criteria canada 2011-2015


Evidence of Arctic Fox Survival following Exposure to Rabies Virus.

J Wildl Dis 2021 Nov 23. Epub 2021 Nov 23.

US Department of Agriculture, National Wildlife Research Center, 4101 Laporte Avenue, Fort Collins, Colorado 80521, USA.

The arctic fox variant of the rabies virus (RABV) is enzootic in the circumpolar north. Reports of abortive RABV exposures motivated a retrospective analysis of sera from 41 arctic foxes captured at Karrak Lake in Nunavut, Canada, during 2011-2015. Estimated RABV antibody prevalence among foxes was 14% (95% confidence interval, 7-28%). Read More

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November 2021

The Association of Drug-Funding Reimbursement With Survival Outcomes and Use of New Systemic Therapies Among Patients With Advanced Pancreatic Cancer.

JAMA Netw Open 2021 Nov 1;4(11):e2133388. Epub 2021 Nov 1.

Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Importance: Gemcitabine-nab-paclitaxel (GEMNAB) and fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) both improve survival of patients with advanced pancreatic cancer when compared with single-agent gemcitabine in clinical trials.

Objective: To describe changes in the survival of patients with advanced pancreatic cancer associated with sequential drug-funding approvals and to determine if there exist distinct patient populations for whom GEMNAB and FOLFIRINOX are associated with survival benefit.

Design, Setting, And Participants: This population-based, retrospective cohort study examined all incident cases of advanced pancreatic cancer treated with first-line chemotherapy in Ontario, Canada (2008-2018) that were identified from the Cancer Care Ontario (Ontario Health) New Drug Funding Program database. Read More

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November 2021

Re-exploring the early relationship between teenage cigarette and e-cigarette use using price and tax changes.

Health Econ 2021 Oct 20. Epub 2021 Oct 20.

Department of Economics, Dalhousie University, Halifax, Nova Scotia, Canada.

In 2016, the Surgeon General used longitudinal cohort studies to conclude that youth e-cigarette use is strongly associated with cigarette use. We re-evaluate data from the period of time before the writing of the Surgeon General report, using quasi-experimental methods, and reach the opposite conclusion. We study contemporaneous and intertemporal effects of e-cigarette and cigarette price and tax changes. Read More

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October 2021

Sub-regional disparities in the use of antenatal care service in Mauritania: findings from nationally representative demographic and health surveys (2011-2015).

BMC Public Health 2021 10 9;21(1):1818. Epub 2021 Oct 9.

School of International Development and Global Studies, Faculty of Social Sciences, University of Ottawa, 120 University Private, Ottawa, ON, K1N 6N5, Canada.

Background: Skilled antenatal care (ANC) has been identified as a proven intervention to reducing maternal deaths. Despite improvements in maternal health outcomes globally, some countries are signaling increased disparities in ANC services among disadvantaged sub-groups. Mauritania is one of sub-Saharan countries in Africa with a high maternal mortality ratio. Read More

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October 2021

Do volatility indices diminish gold's appeal as a safe haven to investors before and during the COVID-19 pandemic?

J Econ Behav Organ 2021 Nov 13;191:214-235. Epub 2021 Sep 13.

Center for Energy and Environmental Policy Research, Beijing Institute of Technology, China.

This study addresses the research question of whether volatility indices of different asset classes reduce gold's appeal as a safe-haven asset before and during the COVID-19 pandemic. We use daily data for seven volatility indices and gold prices and apply the suitable nonlinear autoregressive distributed lag method to analyze the data. Our results indicate that during COVID-19, only the negative Eurocurrency volatility has diminished gold prices in the long term, whereas in the short term, the positive gold, silver, emerging market, and (lagged) financial market volatilities have diminished gold prices. Read More

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November 2021

Association Between Physical Activity, Screen Time and Sleep, and School Readiness in Canadian Children Aged 4 to 6 Years.

J Dev Behav Pediatr 2021 Aug 11. Epub 2021 Aug 11.

Child Health Evaluative Sciences, Hospital for Sick Children Research Institute, Toronto, ON, Canada; Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Division of Paediatric Medicine and the Paediatric Outcomes Research Team (PORT), Hospital for Sick Children, Toronto, ON, Canada; Offord Centre for Child Studies, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Healthy Active Living and Obesity Research, CHEO Research Institute, Ottawa, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, Temetry Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, St. Michael's Hospital, Toronto, Ontario, Canada; Dalla Lana Faculty of Public Health, University of Toronto, Toronto, ON, Canada; Unity Health Toronto, Toronto, ON, Canada; Department of Medicine, Temetry Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON, Canada.

Objective: School readiness is strongly associated with a child's future school success and well-being. The primary objective of this study was to determine whether meeting 24-hour movement guidelines (national physical activity, sedentary behaviors, and sleep recommendations) was associated with school readiness measured with mean scores in each of the 5 developmental domains of the Early Development Instrument (EDI) in Canadian children aged 4 to 6 years. Secondary objectives include examining the following: (1) the association between meeting 24-hour movement guidelines and overall vulnerability in school readiness and (2) the association between meeting individual physical activity, screen use and sleep recommendations, and overall school readiness. Read More

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Outcomes and Healthcare Utilization among New Persistent Opioid Users and Non-opioid Users after Curative-intent Surgery for Cancer.

Ann Surg 2021 Jul 29. Epub 2021 Jul 29.

The Center for Health Informatics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Department of Economics, Faculty of Arts, University of Calgary, Calgary, Alberta, Canada Department of Oncology, Cumming School of Medicine, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: The aim of the study was to compare the health outcomes and resource use of cancer patients who were new persistent opioid users with those who were not, after undergoing curative intent surgery for cancer.

Background: Little is known about long-term health outcomes (overdose, mortality) and resource utilization of new persistent opioid users among cancer patients undergoing curative-intent surgery.

Methods: This retrospective cohort study included all adults with a diagnosis of solid cancers who underwent curative-intent surgery during the study period (2011-2015) in Alberta, Canada and were opioid-naïve before surgery, with a follow-up period until December 31, 2019. Read More

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Clustering of obesity-related characteristics: A latent class analysis from the Canadian Longitudinal Study on Aging.

Prev Med 2021 Dec 21;153:106739. Epub 2021 Jul 21.

Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4L8, Canada; Centre for Health Economics and Policy Analysis, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4K1, Canada. Electronic address:

Measures of obesity, including body mass index (BMI) and waist circumference (WC), do not fully capture the complexity of obesity-related health risks. This study identified distinct classes of obesity-related characteristics and evaluated their associations with BMI, WC, and percent body fat (%BF) using cross-sectional data from 30,096 participants aged 45-85 in the Canadian Longitudinal Study on Aging (2011-2015). Sixteen obesity-related variables, including behavioural, metabolic, physical health, and mental health/social factors, were included in a latent class analysis to identify distinct classes of participants. Read More

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December 2021

Milk, Yogurt, and Cheese Intake Is Positively Associated With Cognitive Executive Functions in Older Adults of the Canadian Longitudinal Study on Aging.

J Gerontol A Biol Sci Med Sci 2021 Nov;76(12):2223-2231

School of Human Nutrition, McGill University, Montreal, Quebec, Canada.

Background: Dairy products provide essential nutrients such as calcium and vitamins B12 and D, and include bioactive peptides and fermented products, which may be beneficial for cognition, especially in older adults. Yet, few studies of large contemporary cohorts have investigated this relationship using sensitive domain-specific cognitive tests.

Method: In community-dwelling older adults of the Canadian Longitudinal Study on Aging (2011-2015), we examined cross-sectional associations between total and specific dairy product intake and performance in 3 cognitive domains (executive functions, memory, and psychomotor speed). Read More

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November 2021

Decoupling of wastewater eco-environmental damage and China's economic development.

Sci Total Environ 2021 Oct 25;789:147980. Epub 2021 May 25.

Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering, Wuhan University of Science & Technology, Wuhan 430081, China.

Wastewater pollution has been considered as a prominent bottleneck restricting global sustainable development. China is one of the largest discharges and eco-environmental damages of wastewater in the world. Through analyzing wastewater discharge data using emergy method in China from 2011 to 2017, the wastewater eco-environmental damage of 31 provinces is calculated with GDP and area to reveal the fundamental origins of inflection point of wastewater discharge in China. Read More

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October 2021

Traffic crashes in Dhaka, Bangladesh: analysing crashes involving unconventional modes, pedestrians and public transit.

Int J Inj Contr Saf Promot 2021 Sep 1;28(3):347-359. Epub 2021 Jun 1.

Department of Civil Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh.

Road safety is a global concern; particularly, in developing countries due to the significantly high collision occurrences and subsequent deaths. This study presents a spatial and temporal analysis of collision frequency and injury severity of crashes in Dhaka, Bangladesh. The focus is to understand the spatio-temporal trend of collisions involving pedestrians, public transit and unconventional modes, which are the key collision factors in Dhaka. Read More

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September 2021

Characteristics and conflicts of interest at Food and Drug Administration Gastrointestinal Drug Advisory Committee meetings.

PLoS One 2021 26;16(5):e0252155. Epub 2021 May 26.

Department of Medicine, University of Toronto, Toronto, Canada.

Introduction: The United States Food and Drug Administration (FDA) Gastrointestinal Drug Advisory Committee (GIDAC) is involved in gastrointestinal drug application reviews. Characteristics and conflicts of interest (COI) in GIDAC meetings are not well described. This study analyzed FDA GIDAC meetings and characteristics that predict recommendations. Read More

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October 2021

Trends in mental health inequalities in urban Canada.

Can J Public Health 2021 08 20;112(4):629-637. Epub 2021 Apr 20.

Department of Community Health and Epidemiology, University of Saskatchewan, Health Science Building 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada.

Objectives: Canadians do not all enjoy equal levels of health. The presence of income-related health inequalities has been well established in Canada, but there is a lack of consistent reporting of mental health inequalities in Canada's largest cities. This study reports the prevalence and inequalities in mental health outcomes at the city, provincial, and national levels over time. Read More

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Risk of Cancer Following an Ischemic Stroke in the Canadian Longitudinal Study on Aging.

Can J Neurol Sci 2021 Mar 26:1-6. Epub 2021 Mar 26.

Department of Neurosciences, University of Montreal, Montreal, Quebec, Canada.

Background: Stroke survivors may be at higher risk of incident cancer, although the magnitude and the period at risk remain unclear. We conducted a retrospective cohort study to compare the risk of cancer in stroke survivors to that of the general population.

Methods: The Canadian Longitudinal Study on Aging is a large population-based cohort of individuals aged 45-85 years when recruited (2011-2015). Read More

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Regional variation in cost of neonatal intensive care for extremely preterm infants.

BMC Pediatr 2021 03 17;21(1):134. Epub 2021 Mar 17.

Medicine and Health Policy Management and Evaluation, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.

Background: Regional variation in cost of neonatal intensive care for extremely preterm infant is not documented. We sought to evaluate regional variation that may lead to benchmarking and cost saving.

Methods: An analysis of a Canadian national costing data from the payor perspective. Read More

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Geographical variation and clustering are found in atrial fibrillation beyond socioeconomic differences: a Danish cohort study, 1987-2015.

Int J Health Geogr 2021 03 1;20(1):11. Epub 2021 Mar 1.

National Institute of Public Health, University of Southern Denmark, Studiestræde 6, 1455, Copenhagen K, Denmark.

Background: The prevalence and incidence rate of atrial fibrillation (AF) increase worldwide and AF is a risk factor for more adverse cardiovascular diseases including stroke. Approximately 44% of AF cases cannot be explained by common individual risk factors and risk might therefore also be related to the environment. By studying geographical variation and clustering in risk of incident AF adjusted for socioeconomic position at an individual level, potential neighbourhood risk factors could be revealed. Read More

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Measurement and determinants of catastrophic health expenditure among elderly households in China using longitudinal data from the CHARLS.

Int J Equity Health 2021 02 19;20(1):62. Epub 2021 Feb 19.

Center for Social Security Studies of Wuhan University, Wuhan, Hubei, China.

Background: Catastrophic health expenditure (CHE) among the Chinese elderly warrants attention. However, the incidence, intensity and determinants of CHE have not been fully investigated. This study explores the incidence, intensity and determinants of CHE among elderly Chinese citizens, i. Read More

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February 2021

Recent Trends and Potential Drivers of Non-invasive Cardiovascular Imaging Use in the United States of America and England.

Front Cardiovasc Med 2020 26;7:617771. Epub 2021 Jan 26.

Department of Health Policy, The London School of Economics and Political Science, London, United Kingdom.

Non-invasive Cardiovascular imaging (NICI), including cardiovascular magnetic resonance (CMR) imaging provides important information to guide the management of patients with cardiovascular conditions. Current rates of NICI use and potential policy determinants in the United States of America (US) and England remain unexplored. We compared NICI activity in the US (Medicare fee-for-service, 2011-2015) and England (National Health Service, 2012-2016). Read More

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January 2021

Will I publish this abstract? Determining the characteristics of medical education oral abstracts linked to publication.

Can Med Educ J 2020 Dec 7;11(6):e46-e53. Epub 2020 Dec 7.

Department of Medicine, University of Ottawa, Ontario, Canada.

Background: Prior studies have shown that most conference submissions fail to be published. Understanding factors that facilitate publication may be of benefit to authors. Using data from the Canadian Conference on Medical Education (CCME), our goal was to identify characteristics of conference submissions that predict the likelihood of publication with a specific focus on the utility of peer-review ratings. Read More

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December 2020

Calculating physician supply using a service day method and the income percentiles method: a descriptive analysis.

CMAJ Open 2020 Oct-Dec;8(4):E747-E753. Epub 2020 Nov 24.

Department of Family Medicine (McDonald), and Clinical Research Unit (Lethebe), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Department of Family Medicine (Green), University of Alberta, Edmonton, Alta.

Background: It is important to have an accurate count of physicians and a measurable understanding of their service provision for physician resource planning. Our objective was to compare 2 methods (income percentiles [IP] and service day activities [SVD]) for calculating the supply of full-time (FT) and part-time (PT) primary care physicians (PCPs) as measures of both physician supply counts and level of provider continuity.

Methods: Using an observational study design, we compared 2 methods of calculating the supply of PT and FT PCPs for 2011-2015. Read More

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Incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate pneumococcal vaccine in British Columbia: A retrospective cohort study.

PLoS One 2020 30;15(9):e0239848. Epub 2020 Sep 30.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

Background: A significant reduction in invasive pneumococcal disease (IPD) has been reported, across all ages, following the implementation of 7-valent conjugate pneumococcal vaccine (PCV7) globally, as part of infant immunization programs. We explored the additional impact of PCV13 on IPD over a 14-year period.

Methods: Using provincial laboratory surveillance and hospitalization data (N = 5791), we calculated the annual incidence of IPD following the implementation of PCV13 vaccine. Read More

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December 2020

Do Different Ascertainment Techniques Identify the Same Individuals as Sarcopenic in the Canadian Longitudinal Study on Aging?

J Am Geriatr Soc 2021 01 16;69(1):164-172. Epub 2020 Sep 16.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Background/objectives: Sarcopenia is associated with poor health outcomes such as disability, institutionalization, and mortality. Efforts to manage sarcopenia clinically have been hindered by challenges in determining how to ascertain sarcopenia status correctly. The objective of this project was to assess the agreement between the different methods of ascertaining sarcopenia recommended by expert groups. Read More

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January 2021

Latent class analysis of obesity-related characteristics and associations with body mass index among young children.

Obes Sci Pract 2020 Aug 7;6(4):390-400. Epub 2020 Apr 7.

Division of Child Health Evaluative Sciences (CHES) Sick Kids Research Institute Toronto Ontario Canada.

Objective: Identifying how obesity-related characteristics cluster in populations is important to understand disease risk. Objectives of this study were to identify classes of children based on obesity-related variables and to evaluate the associations between the identified classes and overweight and obesity.

Methods: A cross-sectional study was conducted among children 3-11 years of age ( = 5185) from the network (2008-2018). Read More

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Patient-reported psychosocial distress in adolescents and young adults with germ cell tumours.

Support Care Cancer 2021 Apr 31;29(4):2105-2110. Epub 2020 Aug 31.

Division of Medical Oncology, BC Cancer, Vancouver, Canada.

Purpose: Germ cell tumours are the most common cancer of male adolescents and young adults (AYA, age 18-39). Men in this age group have been healthy much of their lives, and a diagnosis of cancer can cause significant psychosocial distress. We therefore sought to examine the psychosocial needs of patients with germ cell tumour and determine whether needs vary based on age (AYA vs non-AYA). Read More

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Disagreements Within the US Food and Drug Administration Regarding Approval of Novel Therapeutic Agents, 2011-2015.

JAMA Netw Open 2020 07 1;3(7):e209498. Epub 2020 Jul 1.

Health Law Institute, Schulich School of Law, Dalhousie University, Halifax, Nova Scotia, Canada.

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Associations between Multimorbidity and Physical Performance in Older Chinese Adults.

Int J Environ Res Public Health 2020 06 24;17(12). Epub 2020 Jun 24.

Medical Informatics Center, Peking University, Beijing 100191, China.

: Evidence on the association between physical performance and multimorbidity is scarce in Asia. This study aimed to identify multimorbidity patterns and their association with physical performance among older Chinese adults. : Individuals aged ≥60 years from the China Health and Retirement Longitudinal Study 2011-2015 ( = 10,112) were included. Read More

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Cow's Milk Fat Obesity pRevention Trial (CoMFORT): a primary care embedded randomised controlled trial protocol to determine the effect of cow's milk fat on child adiposity.

BMJ Open 2020 05 7;10(5):e035241. Epub 2020 May 7.

Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada

Introduction: Cow's milk is a dietary staple for children in North America. Though clinical guidelines suggest children transition from whole (3.25% fat) milk to reduced (1% or 2%) fat milk at age 2 years, recent epidemiological evidence supports a link between whole milk consumption and lower adiposity in children. Read More

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Oyster copper levels in the northern South China Sea from 1989 to 2015: spatiotemporal trend detection and human health implications.

Environ Sci Pollut Res Int 2020 Oct 6;27(30):37384-37394. Epub 2020 May 6.

Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, Guangdong, China.

Coastal heavy metal pollution has become an important topic for seafood safety and marine environmental protection. Unlike toxic heavy metals such as cadmium or chromium, copper is essential for oysters' growth but can inhibit their immune response to exotic stress when going above normal levels. Oysters with high copper levels can easily accumulate and transfer abnormal amounts of copper to upper trophic levels, and generate health risks for humans. Read More

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October 2020